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Doses to Carotid Arteries After Modern Radiation Therapy for Hodgkin Lymphoma: Is Stroke Still a Late Effect of Treatment?
Conclusions: INRT reduces the dose delivered to the carotid arteries and corresponding estimated risk of stroke for HL survivors. Even for the subset of patients with lymphoma close to the carotid arteries, the estimated risk is low.
Source: International Journal of Radiation Oncology * Biology * Physics - August 2, 2013 Category: Radiology Authors: Maja V. Maraldo, Patrick Brodin, Marianne C. Aznar, Ivan R. Vogelius, Per Munck af Rosenschöld, Peter M. Petersen, Lena Specht Tags: Lymphomas Source Type: research

Medical Conditions Among Survivors of Adolescent and Young Adult Non-Hodgkin Lymphoma (NHL), Acute Lymphoblastic Leukemia (ALL) and Acute Myeloid Leukemia (AML)
Conclusion: This study found that sociodemographic factors were associated with the risk of developing medical conditions in AYA NHL, ALL and AML survivors. As expected, the risk of medical conditions varied by cancer type and treatment, with those undergoing SCT having a higher risk of medical conditions regardless of cancer type. NHL and ALL survivors who were uninsured or publicly insured were at a consistently higher risk of developing medical conditions, as were Hispanic ALL survivors and Black AML survivors. Our findings highlight the higher burden of medical conditions in subgroups of cancer survivors that may relat...
Source: Blood - November 21, 2018 Category: Hematology Authors: Keegan, T. H. M., Muffly, L. S., Li, Q., Alvarez, E., Brunson, A. M., Malogolowkin, M., Wun, T. Tags: 904. Outcomes Research-Malignant Conditions: Real World Outcomes Source Type: research

NAMPT as a Dedifferentiation-Inducer Gene: NAD+ as Core Axis for Glioma Cancer Stem-Like Cells Maintenance
Conclusion and Perspectives Gliomas are the most prevalent primary brain cancer in adults and include a broad category of tumors including astrocytoma, oligodendroglioma, and GBM. Regardless of tumor aggressiveness, malignancy, and infiltration, these glia-derived tumors rarely exceed a median survival time of 12–14 months. Driven by the infiltrative nature of these tumors, the clinical approach is difficult and relapses often occur with fatal consequences. These unsuccessful attempts to control glioma's fate have fostered research looking for more effective therapies. (GSCs) are a small subset of CD133&#...
Source: Frontiers in Oncology - May 2, 2019 Category: Cancer & Oncology Source Type: research

Outcomes of cardiac surgery after mediastinal radiation therapy: A single ‐center experience
ConclusionThis study shows that cardiac surgery after mediastinal radiotherapy is associated with increased short ‐ and long‐term mortality when compared to preoperative mortality risks predicted by the Euroscore II. Surgery‐related events caused all short‐term mortality cases, while malignancy‐related events were the main cause of death during the follow‐up. Mortality was higher in patients with a previous stroke and a lower estimated glomerular filtration rate.
Source: Journal of Cardiac Surgery - January 22, 2020 Category: Cardiovascular & Thoracic Surgery Authors: Onur B. Dolmaci, Emile S. Farag, S. Matthijs Boekholdt, Wim J. P. Boven, Abdullah Kaya Tags: ORIGINAL ARTICLE Source Type: research

Cardiovascular Event Reporting in Modern Cancer Radiation Therapy Trials
CONCLUSION: In contemporary chest RT-based clinical trials, reported CVD rates were lower than expected population rates.PMID:35198835 | PMC:PMC8844682 | DOI:10.1016/j.adro.2021.100888
Source: Cancer Control - February 24, 2022 Category: Cancer & Oncology Authors: Rahul N Prasad Mark McIntyre Avirup Guha Rebecca R Carter Vedat O Yildiz Electra Paskett Maryam Lustberg Patrick Ruz Terence M Williams Onaopepo Kola-Kehinde Eric D Miller Daniel Addison Source Type: research

Contribution of nuclear medicine to the diagnosis and management of primary brain tumours
Rev Neurol (Paris). 2023 Mar 16:S0035-3787(23)00874-3. doi: 10.1016/j.neurol.2023.03.002. Online ahead of print.ABSTRACTPositron emission tomography (PET) is a powerful tool that can help physicians manage primary brain tumours at diagnosis and follow-up. In this context, PET imaging is used with three main types of radiotracers: 18F-FDG, amino acid radiotracers, and 68Ga conjugated to somatostatin receptor ligands (SSTRs). At initial diagnosis, 18F-FDG helps to characterize primary central nervous system (PCNS) lymphomas and high-grade gliomas, amino acid radiotracers are indicated for gliomas, and SSTR PET ligands are in...
Source: Revue Neurologique - March 18, 2023 Category: Neurology Authors: T Horowitz E Tabouret T Graillon B Salgues O Chinot A Verger E Guedj Source Type: research