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Cancer: Lymphoma

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Total 590 results found since Jan 2013.

Diagnoses and Management of Drug Hypersensitivity and Anaphylaxis in Cancer and Chronic Inflammatory Diseases: Reactions to Taxanes and Monoclonal Antibodies.
Abstract Due to the increase in utilization of chemotherapies and antibodies, drug hypersensitivity reactions have increased dramatically worldwide, preventing the use of first-line therapies and impacting patients' survival and quality of life. Some of the more frequently used medications in cancer include taxanes for ovarian, lung, breast, and prostate cancers. Monoclonal antibodies are used in the treatment of neoplastic, autoimmune, and inflammatory diseases, and their clinical applications are becoming broader. Monoclonal antibody targets include CD20, HER-2, EGFR, IL-6 receptor, TNF-α, CD30, VEGF-A, IgE, an...
Source: Clinical Colorectal Cancer - June 7, 2016 Category: Cancer & Oncology Authors: Bonamichi-Santos R, Castells M Tags: Clin Rev Allergy Immunol Source Type: research

Kite Immunotherapy Drug Helps Blood Cancer Patients in Study Kite Immunotherapy Drug Helps Blood Cancer Patients in Study
Kite Pharma Inc on Monday said its experimental CAR T-cell therapy, which helps the immune system fight cancer, was highly effective in treating aggressive non-Hodgkin lymphoma, although two deaths were related to the drug, according to interim data from a midstage trial.Reuters Health Information
Source: Medscape Allergy Headlines - September 28, 2016 Category: Allergy & Immunology Tags: Allergy & Clinical Immunology News Source Type: news

Ibrutinib, a Bruton ’s tyrosine kinase inhibitor used for treatment of lymphoproliferative disorders, eliminates both aeroallergen skin test and basophil activation test reactivity
Approximately 15 million people, including 8% of children, in the United States have food allergy and are at risk of having life-threatening anaphylactic reactions.1 There is an unmet need for the prevention of such reactions. Tyrosine kinases, including Bruton's tyrosine kinase (BTK), have been shown to be critical for allergen reactivity by transducing Fc εRI crosslinking signals into cellular activation and mediator release from mast cells and basophils.2 Pharmacyclics, Inc, together with Janssen Pharmaceuticals, recently received Food and Drug Administration approval of ibrutinib (Imbruvica, PCI-32765) as a selective,...
Source: Journal of Allergy and Clinical Immunology - April 4, 2017 Category: Allergy & Immunology Authors: Jennifer A. Regan, Yun Cao, Melanie C. Dispenza, Shuo Ma, Leo I. Gordon, Adam M. Petrich, Bruce S. Bochner Tags: Letter to the Editor Source Type: research

PD-1 Blocks Lytic Granule Polarization with Concomitant Impairment of Integrin 'Outside-in' Signaling in Natural Killer Cell Immunological Synapse.
CONCLUSION: Our results suggest that NK cell cytotoxicity is inhibited by PD-1 engagement, which blocks lytic granule polarization to NK cell immunological synapse with concomitant impairment of integrin 'outside-in' signaling. This study provides novel mechanistic insights into how PD-1 inhibition disrupts NK cell function. PMID: 29679656 [PubMed - as supplied by publisher]
Source: Clinical Lymphoma and Myeloma - April 18, 2018 Category: Cancer & Oncology Authors: Huang Y, Chen Z, Jang JH, Baig MS, Bertolet G, Schroeder C, Huang S, Hu Q, Zhao Y, Lewis DE, Qin L, Zhu MX, Liu D Tags: J Allergy Clin Immunol Source Type: research

Rapid desensitization for brentuximab vedotin (Adceteris ®) allergy: a case report
Brentuximab vedotin (BV) is an antibody –drug conjugate formed by an anti-CD30 chimeric IgG1 conjugated with monomethyl-auristatin-E. BV targets the CD30+ cells, which characterize Hodgkin lymphoma as well as anap...
Source: Clinical and Molecular Allergy - October 29, 2018 Category: Allergy & Immunology Authors: Attilio Di Girolamo, Marcello Albanesi, Alessandro Sinisi, Eustachio Nettis, Danilo Di Bona, Maria Filomena Caiaffa and Luigi Macchia Tags: Case Report Source Type: research

Hematopoietic stem cell transplantation as treatment for patients with DOCK8 deficiency
ConclusionHSCT is curative in most DOCK8 deficient patients, confirming this approach as the treatment of choice. HSCT using a reduced toxicity regimen may offer the best chance for survival.
Source: The Journal of Allergy and Clinical Immunology: In Practice - November 3, 2018 Category: Allergy & Immunology Source Type: research

Differentiation of angioimmunoblastic T-cell lymphoma from DRESS syndrome
Publication date: Available online 14 December 2018Source: The Journal of Allergy and Clinical Immunology: In PracticeAuthor(s): Jiung Jeong, Da Woon Sim, Ji Eun Yu, Yoo Duk Choi, Seul Kee Kim, Woong Yoon, Young-Il Koh
Source: The Journal of Allergy and Clinical Immunology: In Practice - December 15, 2018 Category: Allergy & Immunology Source Type: research

Adult-Onset Atopic Dermatitis
Publication date: January 2019Source: The Journal of Allergy and Clinical Immunology: In Practice, Volume 7, Issue 1Author(s): Jonathan I. SilverbergOne in 4 adults with atopic dermatitis (AD) report adult-onset disease. Adult-onset AD appears to be associated with a different disease phenotype compared with childhood-onset AD. A broad differential diagnosis must be considered in a patient presenting with an adult-onset eczematous eruption, including allergic contact dermatitis, mycosis fungoides/cutaneous T-cell lymphoma, psoriasis, scabies, and so forth. This review will specifically address the diagnosis, workup, and ma...
Source: The Journal of Allergy and Clinical Immunology: In Practice - December 29, 2018 Category: Allergy & Immunology Source Type: research

Rituximab-induced Henoch-Schonlein purpura in a patient with mantle cell lymphoma
Publication date: Available online 10 August 2019Source: The Journal of Allergy and Clinical Immunology: In PracticeAuthor(s): Watcharoot Kanchongkittiphon, Jennifer Monroy
Source: The Journal of Allergy and Clinical Immunology: In Practice - August 11, 2019 Category: Allergy & Immunology Source Type: research

The First Korean Case of Epstein-Barr Virus-positive Natural Killer/T-cell Lymphoma That Progressed From Severe Mosquito Bite Allergy, With Coexistence of Hemophagocytic Lymphohistiocytosis.
Authors: Lee S, Park CJ, Cho YU, Jang S, Huh J, Kim H PMID: 31432645 [PubMed - in process]
Source: Annals of Laboratory Medicine - August 23, 2019 Category: Laboratory Medicine Tags: Ann Lab Med Source Type: research

Pathogenesis and Therapy of Primary Cutaneous T-Cell Lymphoma: Collegium Internationale Allergologicum (CIA) Update 2020
Cutaneous T-cell lymphoma (CTCL) is a heterogeneous disease group of unknown etiology with a complex immunological background. As CTCL arises from T cells that have a vital role in the antitumor response, their therapy is largely aimed at reversing the immunological mechanisms leading to or manifesting during this malignancy. Early disease stages can be controlled with skin-directed therapy in most CTCL cases. Still, advanced CTCL has a dismal prognosis and warrants systemic therapy. Despite considerable progress in understanding the pathophysiology of the disease and the numerous systemic treatment options available, long...
Source: International Archives of Allergy and Immunology - July 20, 2020 Category: Allergy & Immunology Source Type: research

Acquired Angioedema due to C1 Inhibitor Deficiency Preceding Splenic Marginal Zone Lymphoma: Further Insights from Clinical Practice
Conclusions: Close follow-up, including detailed clinical history, physical examination, and laboratory tests, of our patients with AAE-C1-INH was essential for the early diagnosis and successful treatment of the lymphoproliferative disease, leading to the resolution of the angioedema attacks.Int Arch Allergy Immunol
Source: International Archives of Allergy and Immunology - September 7, 2020 Category: Allergy & Immunology Source Type: research

Acquired Angioedema with C1 Inhibitor Deficiency: Occurrence, Clinical Features, and Management: A Nationwide Retrospective Study in the Czech Republic Patients
Conclusions: The prevalence of AAE-C1-INH in the Czech Republic is about 1:760,000. This rare condition occurs in approximately 8% of the patients with angioedema with C1 inhibitor deficiency. AAE-C1-INH is strongly associated with lymphoproliferative disorders, and treating these conditions may improve the control of angioedema symptoms.Int Arch Allergy Immunol
Source: International Archives of Allergy and Immunology - January 20, 2021 Category: Allergy & Immunology Source Type: research

Increased Expression of B Lymphocyte Induced Maturation Protein 1 (BLIMP1) in Patients with Common Variable Immunodeficiency (CVID)
Iran J Allergy Asthma Immunol. 2020 Aug 25;19(4):437-446. doi: 10.18502/ijaai.v19i4.4118.ABSTRACTCommon variable immunodeficiency (CVID) is a primary immune deficiency disorder characterized by a failure in B cell differentiation, impaired immunoglobulin production,and defect in response to vaccines. As a result of defective B cell maturation and differentiation in CVID, the affected patients commonly present with reduced numbers of memory B cell and antibody-secreting plasma cells. B-cell lymphoma 6 protein (BCL6) and B lymphocyte induced maturation protein 1 (BLIMP1) molecules are two important transcription factors that...
Source: Iranian Journal of Allergy, Asthma and Immunology - January 19, 2021 Category: Allergy & Immunology Authors: Shockrollah Farrokhi Faezeh Abbasi-Rad Nafiseh Esmaeil Roya Sherkat Reza Yazdani Sanaz Afshar-Ghasemlou Saba Fekrvand Mazdak Ganjalikhani-Hakemi Source Type: research