PD-1 Blocks Lytic Granule Polarization with Concomitant Impairment of Integrin 'Outside-in' Signaling in Natural Killer Cell Immunological Synapse.

CONCLUSION: Our results suggest that NK cell cytotoxicity is inhibited by PD-1 engagement, which blocks lytic granule polarization to NK cell immunological synapse with concomitant impairment of integrin 'outside-in' signaling. This study provides novel mechanistic insights into how PD-1 inhibition disrupts NK cell function. PMID: 29679656 [PubMed - as supplied by publisher]

https://www.ncbi.nlm.nih.gov/pubmed/29679656?dopt=Abstract

Source: Clinical Lymphoma and Myeloma - April 18, 2018 Category: Cancer & Oncology Authors: Huang Y, Chen Z, Jang JH, Baig MS, Bertolet G, Schroeder C, Huang S, Hu Q, Zhao Y, Lewis DE, Qin L, Zhu MX, Liu D Tags: J Allergy Clin Immunol Source Type: research