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Condition: Stroke
Cancer: Lymphoma
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Total 355 results found since Jan 2013.
Large-vessel vasculitis in graft-versus-host disease: a case report
ConclusionThe life-threatening vascular complications associated with large-vessel vasculitis include arterial aneurysms and dissections, and ischemic or hemorrhagic stroke. Thus, this rare immunological association needs to be recognized and treated in a timely manner to prevent the long-term complications.
Source: Journal of Medical Case Reports - September 28, 2021 Category: General Medicine Source Type: research
Indolent nonendemic central nervous system histoplasmosis presenting as an isolated intramedullary enhancing spinal cord lesion
CONCLUSION: Disseminated histoplasmosis should be considered in granulomatous disease, even if the patient resides in a nonendemic region. Furthermore, clinicians should be mindful that CNS histoplasmosis may present in an atypical fashion.PMID:34513158 | PMC:PMC8422457 | DOI:10.25259/SNI_345_2021
Source: Surgical Neurology International - September 13, 2021 Category: Neurosurgery Authors: Matthew J Recker Steven B Housley Lindsay J Lipinski Source Type: research
Prevalence and economic burden of major comorbidities in multiple sclerosis
ConclusionsOur study provides evidence of the burden of comorbidities in MS. Comorbidity is common in MS and produce additive costs.Key messagesThe use of administrative data for tracking the MS comorbidity could help knowledge gaps.When additivity situation is involved, preventive policies could lead to monetary savings.
Source: The European Journal of Public Health - October 20, 2021 Category: General Medicine Source Type: research
New Analyses Suggest Favorable Results for STELARA ® (ustekinumab) When Used as a First-Line Therapy for Bio-Naïve Patients with Moderately to Severely Active Crohn’s Disease and Ulcerative Colitis
SPRING HOUSE, PENNSYLVANIA, October 25, 2021 – The Janssen Pharmaceutical Companies of Johnson & Johnson today announced data from two new analyses of STELARA® (ustekinumab) for the treatment of adults with moderately to severely active Crohn’s disease (CD) and ulcerative colitis (UC).1,2 In a modelled analysisa focused on treatment sequencing using data from randomized controlled trials, network meta-analysis and literature, results showed patient time spent in clinical remission or response was highest when STELARA was used as a first-line advanced therapy for bio-naïve patients with moderately to severely acti...
Source: Johnson and Johnson - October 25, 2021 Category: Pharmaceuticals Tags: Innovation Source Type: news
Molecular Mechanisms of Ferroptosis and Its Roles in Hematologic Malignancies
Cell death is essential for the normal metabolism of human organisms. Ferroptosis is a unique regulated cell death (RCD) mode characterized by excess accumulation of iron-dependent lipid peroxide and reactive oxygen species (ROS) compared with other well-known programmed cell death modes. It has been currently recognized that ferroptosis plays a rather important role in the occurrence, development, and treatment of traumatic brain injury, stroke, acute kidney injury, liver damage, ischemia–reperfusion injury, tumor, etc. Of note, ferroptosis may be explained by the expression of various molecules and signaling components...
Source: Frontiers in Oncology - October 27, 2021 Category: Cancer & Oncology Source Type: research
Informing Radiotherapy Decisions in Stage I/IIa Hodgkin Lymphoma: Modelling Life Expectancy Using Radiation Dosimetry
Blood Adv. 2021 Dec 6:bloodadvances.2021006254. doi: 10.1182/bloodadvances.2021006254. Online ahead of print.ABSTRACTIn recent randomized trials, omitting consolidative radiotherapy in early-stage Hodgkin lymphoma (ESHL) increased relapses. However, decades of follow-up are required to observe whether lower initial disease control is compensated by reduced risk of late effects. Extrapolation beyond trial follow-up is therefore necessary to inform current treatment decisions. To this end, we developed a microsimulation model to estimate lifetime quality-adjusted life years (QALYs) after combined modality treatment (CMT) or ...
Source: Cancer Control - December 6, 2021 Category: Cancer & Oncology Authors: David Andrew Jones Paolo Candio Rebecca Shakir Georgios Ntentas Johanna Ramroth Alastair M Gray David John Cutter Source Type: research
Cardiovascular Event Reporting in Modern Cancer Radiation Therapy Trials
CONCLUSION: In contemporary chest RT-based clinical trials, reported CVD rates were lower than expected population rates.PMID:35198835 | PMC:PMC8844682 | DOI:10.1016/j.adro.2021.100888
Source: Cancer Control - February 24, 2022 Category: Cancer & Oncology Authors: Rahul N Prasad Mark McIntyre Avirup Guha Rebecca R Carter Vedat O Yildiz Electra Paskett Maryam Lustberg Patrick Ruz Terence M Williams Onaopepo Kola-Kehinde Eric D Miller Daniel Addison Source Type: research
Plaque Evaluation by Ultrasound and Transcriptomics Reveals BCLAF1 as a Regulator of Smooth Muscle Cell Lipid Transdifferentiation in Atherosclerosis
CONCLUSIONS: Plaque echogenicity correlated with enrichment of distinct molecular pathways and identified BCLAF1, previously not described in atherosclerosis, as the most significant gene. Functionally, BCLAF1 seems necessary for survival and transdifferentiation of SMCs into a macrophage-like phenotype. The role of BCLAF1 in plaque vulnerability should be further evaluated.PMID:35321563 | DOI:10.1161/ATVBAHA.121.317018
Source: Arteriosclerosis, Thrombosis and Vascular Biology - March 24, 2022 Category: Cardiology Authors: Urszula Rykaczewska Quanyi Zhao Peter Saliba-Gustafsson Mariette Lengquist Malin Kronqvist Otto Bergman Zhiqiang Huang Kent Lund Katarina Waden Vila Z Pons Kenneth Caidahl Josefin Skogsberg Vladana Vukojevic Jan H N Lindeman Joy Roy G öran K Hansson Ecka Source Type: research
