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Case Report: Case Series of Kocuria palustris Bacteremia among Immunocompromised Patients
We present three cases of bacteremia in immunocompromised patients admitted to our hospital; one patient was receiving chemotherapy for gall bladder carcinoma, the second was on maintenance hemodialysis for chronic kidney disease, and the third was receiving chemotherapy for acute myeloid leukemia. All three patients presented with a fever in the setting of neutropenia during the course of treatment with chemotherapy (in Cases 1 and 3) or hemodialysis (in Case 2). The blood culture samples of all the patients had pure isolates of Kocuria species K. palustris, which was identified by matrix assisted laser desorption ionisat...
Source: The American Journal of Tropical Medicine and Hygiene - September 18, 2023 Category: Tropical Medicine Authors: Gerlin Varghese Ashima Jamwal Deepika Sarawat Chinmoy Sahu Sangram Singh Patel Nidhi Tejan Source Type: research
Mast cell leukaemia progressed from myelodysplastic syndrome after acquiring KIT mutation
Int J Lab Hematol. 2023 Sep 18. doi: 10.1111/ijlh.14174. Online ahead of print.NO ABSTRACTPMID:37723128 | DOI:10.1111/ijlh.14174
Source: International Journal of Laboratory Hematology - September 18, 2023 Category: Hematology Authors: Ke Xu Anna Childerhouse Rajeev Gupta Source Type: research
Synthesis and anti-tumor activities in human leukemia-derived cells of polyenylpyrroles with a methyl group at the conjugated polyene terminus
This study provides useful structural information for designing novel drugs treating T-ALL and AML.PMID:37717362 | DOI:10.1016/j.bmcl.2023.129471
Source: Bioorganic and Medicinal Chemistry Letters - September 17, 2023 Category: Chemistry Authors: Tomoya Higashi Chihiro Yoshida Yoshifumi Hachiro Chihiro Nakata Azusa Takechi Takuya Yagi Kazuya Miyashita Nobuo Kitada Rika Obata Takashi Hirano Takahiko Hara Shojiro A Maki Source Type: research
High-throughput screening as a drug repurposing strategy for poor outcome subgroups of pediatric B-cell precursor Acute Lymphoblastic Leukemia
Biochem Pharmacol. 2023 Sep 15:115809. doi: 10.1016/j.bcp.2023.115809. Online ahead of print.ABSTRACTAlthough a great cure rate has been achieved for pediatric BCP-ALL, approximately 15% of patients do not respond to conventional chemotherapy and experience disease relapse. A major effort to improve the cure rates by treatment intensification would result in an undesirable increase in treatment-related toxicity and mortality, raising the need to identify novel therapeutic approaches. High-throughput (HTP) drug screening enables the profiling of patients' responses in vitro and allows the repurposing of compounds currently ...
Source: Biochemical Pharmacology - September 17, 2023 Category: Drugs & Pharmacology Authors: Athanasios Oikonomou Luigia Valsecchi Manuel Quadri Titus Watrin Katerina Scharov Simona Procopio Jia-Wey Tu Melina Vogt Angela Maria Savino Daniela Silvestri Maria Grazia Valsecchi Andrea Biondi Arndt Borkhardt Sanil Bhatia Giovanni Cazzaniga Grazia Fazi Source Type: research
miR-125b-5p-MAPK1-C/EBP α feedback loop regulates all-trans retinoic acid resistance in acute promyelocytic leukemia
Gene. 2023 Sep 15:147806. doi: 10.1016/j.gene.2023.147806. Online ahead of print.NO ABSTRACTPMID:37717613 | DOI:10.1016/j.gene.2023.147806
Source: Gene - September 17, 2023 Category: Genetics & Stem Cells Authors: Wenjuan Jiang Yongkang Hu Xian Wang Qi Zhang Xinlong Guo Siyu Cheng Langqun Chen Jiahui Ying Liang Zhang Baoping Jiang Source Type: research
Synthesis and anti-tumor activities in human leukemia-derived cells of polyenylpyrroles with a methyl group at the conjugated polyene terminus
This study provides useful structural information for designing novel drugs treating T-ALL and AML.PMID:37717362 | DOI:10.1016/j.bmcl.2023.129471
Source: Bioorganic and Medicinal Chemistry Letters - September 17, 2023 Category: Chemistry Authors: Tomoya Higashi Chihiro Yoshida Yoshifumi Hachiro Chihiro Nakata Azusa Takechi Takuya Yagi Kazuya Miyashita Nobuo Kitada Rika Obata Takashi Hirano Takahiko Hara Shojiro A Maki Source Type: research
High-throughput screening as a drug repurposing strategy for poor outcome subgroups of pediatric B-cell precursor Acute Lymphoblastic Leukemia
Biochem Pharmacol. 2023 Sep 15:115809. doi: 10.1016/j.bcp.2023.115809. Online ahead of print.ABSTRACTAlthough a great cure rate has been achieved for pediatric BCP-ALL, approximately 15% of patients do not respond to conventional chemotherapy and experience disease relapse. A major effort to improve the cure rates by treatment intensification would result in an undesirable increase in treatment-related toxicity and mortality, raising the need to identify novel therapeutic approaches. High-throughput (HTP) drug screening enables the profiling of patients' responses in vitro and allows the repurposing of compounds currently ...
Source: Biochemical Pharmacology - September 17, 2023 Category: Drugs & Pharmacology Authors: Athanasios Oikonomou Luigia Valsecchi Manuel Quadri Titus Watrin Katerina Scharov Simona Procopio Jia-Wey Tu Melina Vogt Angela Maria Savino Daniela Silvestri Maria Grazia Valsecchi Andrea Biondi Arndt Borkhardt Sanil Bhatia Giovanni Cazzaniga Grazia Fazi Source Type: research
Synthesis and anti-tumor activities in human leukemia-derived cells of polyenylpyrroles with a methyl group at the conjugated polyene terminus
This study provides useful structural information for designing novel drugs treating T-ALL and AML.PMID:37717362 | DOI:10.1016/j.bmcl.2023.129471
Source: Bioorganic and Medicinal Chemistry Letters - September 17, 2023 Category: Chemistry Authors: Tomoya Higashi Chihiro Yoshida Yoshifumi Hachiro Chihiro Nakata Azusa Takechi Takuya Yagi Kazuya Miyashita Nobuo Kitada Rika Obata Takashi Hirano Takahiko Hara Shojiro A Maki Source Type: research
Chronic lymphocytic leukemia: disease biology
Acta Haematol. 2023 Sep 16. doi: 10.1159/000533610. Online ahead of print.ABSTRACTB cell receptor (BCR) signaling is crucial for normal B cell development and adaptive immunity. In chronic lymphocytic leukemia (CLL), the malignant B cells display many features of normal mature B lymphocytes, including the expression of functional B cell receptors (BCR). Cross talk between CLL cells and the microenvironment in secondary lymphatic organs results in BCR signaling and BCR-driven proliferation of the CLL cells. This critical pathomechanism can be targeted by blocking BCR-related kinases (BTK, PI3K, SYK) using small molecule inh...
Source: Acta Haematologica - September 17, 2023 Category: Hematology Authors: Stefan Koehrer Jan A Burger Source Type: research
A case-control study in NAT2 gene polymorphism studies in patients diagnosed with acute myeloid leukemia
CONCLUSION: The study results revealed a negative correlation as well as a protective factor for AML with the C481T and G857A polymorphisms in the NAT2 gene.PMID:37715989 | DOI:10.18388/abp.2020_6235
Source: Acta Biochim Pol - September 16, 2023 Category: Biochemistry Authors: Abdullah Farasani Source Type: research
Long-term incidence of haematological cancer after bariatric surgery or usual care in the Swedish Obese Subjects study: a prospective cohort study
This study is registered with ClinicalTrials.gov (NCT01479452) and is ongoing.FINDINGS: A total of 4047 individuals with obesity were enrolled between Sept 1, 1987, and Jan 31, 2001. Overall, 34 participants in the surgery group and 51 participants in the usual care control group were diagnosed with haematological cancer during follow-up (hazard ratio [HR] 0·60; 95% CI 0·39-0·92; p=0·020). Moreover, there were three deaths by haematological cancer in the surgery group and 13 deaths in the control group (0·22; 0·06-0·76; p=0·017). Surgery was also associated with a reduced incidence of lymphoma (0·45; 0·23-0·88; ...
Source: Cancer Control - September 16, 2023 Category: Cancer & Oncology Authors: Kajsa Sj öholm Johanna C Andersson-Assarsson Felipe M Kristensson Stephan Hjorth Hege Gravdahl Garelius Peter Jacobson Per-Arne Svensson Sofie Ahlin Bj örn Carlsson Markku Peltonen Lena M S Carlsson Magdalena Taube Source Type: research
A case-control study in NAT2 gene polymorphism studies in patients diagnosed with acute myeloid leukemia
CONCLUSION: The study results revealed a negative correlation as well as a protective factor for AML with the C481T and G857A polymorphisms in the NAT2 gene.PMID:37715989 | DOI:10.18388/abp.2020_6235
Source: Cancer Control - September 16, 2023 Category: Cancer & Oncology Authors: Abdullah Farasani Source Type: research
