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Cancer: Colorectal Cancer
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Total 286 results found since Jan 2013.
Non-coding RNAs in cancer immunotherapy: Predictive biomarkers and targets
CONCLUSION: This review summarises important predictive ncRNA biomarkers that were reported in cancer patients treated with different immunotherapeutic modalities, including monoclonal antibodies, small molecule inhibitors, cancer vaccines and CAR-T cells. In addition, a concise discussion on forthcoming perspectives is provided, outlining technical approaches for the optimal utilisation of immunomodulatory ncRNA biomarkers as predictive tools and therapeutic targets.PMID:37735815 | DOI:10.1002/ctm2.1425
Source: Clinical Lung Cancer - September 22, 2023 Category: Cancer & Oncology Authors: Murad Alahdal Eyad Elkord Source Type: research
Growing Deficit in New Cancer Diagnoses 2 Years Into the COVID-19 Pandemic: A National Multicenter Study
CONCLUSION: Disruptions in new diagnoses of four common cancers (prostate, lung, bladder, and colorectal) seen early in the COVID-19 pandemic have persisted for 2 years. Although reductions improved from the early pandemic, new reductions during the Delta and Omicron waves demonstrate the continued impact of the COVID-19 pandemic on cancer care.PMID:37695458 | DOI:10.1245/s10434-023-14217-5
Source: Ann Oncol - September 11, 2023 Category: Cancer & Oncology Authors: Brian R Englum Shalini Sahoo Minerva Mayorga-Carlin Hilary Hayssen Tariq Siddiqui Douglas J Turner John D Sorkin Brajesh K Lal Source Type: research
Potential applications of using tissue-specific EVs in targeted therapy and vaccinology
In conclusion, recently published works have shown that EVs could become biomarkers and modern vehicles of advanced drug forms.PMID:37660644 | DOI:10.1016/j.biopha.2023.115308
Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie - September 3, 2023 Category: Drugs & Pharmacology Authors: Tomasz P Lehmann Marta Golik Jolanta Olejnik Marianna Łukaszewska Dominika Markowska Martyna Dro żdżyńska Aleksander Kotecki Maciej G łowacki Pawe ł P Jagodziński Source Type: research
Predictors of Colonoscopy Use Among Asian Indians in New York City, 2003 to 2016
CONCLUSIONS: Among Asian Indians living in New York City, several demographic, socioeconomic, and health-related characteristics predict colonoscopy use. These findings highlight the importance of examining determinants of colonoscopy uptake in this understudied population to inform future public health interventions.PMID:37556383 | DOI:10.1097/MCG.0000000000001900
Source: Clinical Colorectal Cancer - August 9, 2023 Category: Cancer & Oncology Authors: Neha Nagpal Taylor M McCready Yuhe Xia Kevin Lin Matthew Glenn Sandy Ng Chau Trinh-Shevrin Andrea B Troxel Simona C Kwon Peter S Liang Source Type: research
Targeted vaccine development against Bilophila wadsworthia to curb colon diseases: A multiepitope approach based on reverse vaccinology and computational analysis
Int J Biol Macromol. 2023 Jul 26:126002. doi: 10.1016/j.ijbiomac.2023.126002. Online ahead of print.ABSTRACTThe presence of excessive hydrogen sulfide (H2S)-producing bacteria, particularly Bilophila wadsworthia in appendices, is linked to a weaker colonic mucus barrier, inflammatory bowel disease, and colorectal cancer. Thus, targeting this bacterium could reduce sulfide levels and address associated health concerns. Here, we utilized reverse vaccinology and immunoinformatics to design a chimeric vaccine against B. wadsworthia, focusing on membrane-bound and extracellular proteins. Subtractive proteome analysis identified...
Source: International Journal of Biological Macromolecules - July 28, 2023 Category: Biochemistry Authors: Sara Khan Shahkaar Aziz Muhammad Waqas Muhammad Azam Kakar Sohail Ahmad Source Type: research
Blockade of tumor-derived colony-stimulating factor 1 (CSF1) promotes an immune-permissive tumor microenvironment
In this study, we demonstrate, for the first time, that treating established syngeneic murine colon and breast carcinoma tumors with a CSF1R-blocking antibody also promotes the expansion of neoepitope-specific T cells. To assess the role of tumor-derived CSF1 in these model systems, we generated and characterized CSF1 CRISPR-Cas9 knockouts. Eliminating tumor-derived CSF1 results in decreased tumor growth and enhanced immunity against tumor-associated neoepitopes, potentially promoting an immune permissive tumor microenvironment in tumor-bearing mice. The combination of neoepitope vaccine with anti-PDL1 in the MC38 CSF1-/- ...
Source: Cancer Control - July 28, 2023 Category: Cancer & Oncology Authors: Maria Del Mar Maldonado Jeffrey Schlom Duane H Hamilton Source Type: research
Escrutinio para el c áncer de colon: ¿cuál fue el impacto en los primeros 2 años de la pandemia de COVID-19? Experiencia en una clínica privada ambulatoria
CONCLUSION: In conclusion, the impact of the decrease in screening colonoscopy procedures for CRC detection was similar to what was seen worldwide. In this period no increase in cancer cases, although this effect may be observed in the long term.PMID:37441724 | DOI:10.24875/CIRU.22000564
Source: Cirugia y Cirujanos - July 13, 2023 Category: Surgery Authors: Óscar T Teramoto-Matsubara Sergio Sobrino-Coss ío Juan M Abdo-Francis Francisco De la Vega-Gonz ález Gualberto Mateos-P érez Source Type: research
