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The relationship between tissue differentiation-inducing non-protein coding RNA expression and tumor size in patients with breast cancer
This study aimed to evaluate the expression level of Tissue Differentiation-Inducing Non-Protein Coding RNA (TINCR) in adjacent tumor and non-tumor tissues of 60 women with invasive ductal breast cancer. The relationship between TINCR expression and the clinical characteristics of patients has also been studied. For this purpose, total RNA was isolated from breast cancer patients' adjacent tumor and non-tumor tissue. RT Prime Script reagent was then used to convert total RNA to cDNA. The qRT-PCR quantified the TINCR expression level and analyzed the results by paired t-test. In addition, ROC curve analysis was used to eval...
Source: Mol Biol Cell - September 16, 2023 Category: Molecular Biology Authors: Shen Tan Aimin Cui Nan Bai Zicui Zhang Source Type: research
Three cases of colon cancer in four generations of the Saudi family, caused by endogamous germline mutations
Cell Mol Biol (Noisy-le-grand). 2023 Aug 31;69(8):163-171. doi: 10.14715/cmb/2023.69.8.25.ABSTRACTVarious research pieces of evidence have been published in recent years, establishing the increasing prevalence of early colon cancer among young people. In this background, the current study aimed to analyze the reasons behind colon cancer recurrence among endogamous consanguineous cases in four generations of a single Saud family. For this study, the authors conducted the whole-exome sequencing analysis to screen for germline mutations in DNA samples from consanguineous cases within the family. After collecting the colon sam...
Source: Mol Biol Cell - September 16, 2023 Category: Molecular Biology Authors: Dalal S Alshaya Tahani Mohamed Ibrahim Al-Hazani Mashael Alhumaidi Alotaibi Dalia Mostafa Domiaty Eman Alshehri Maha Abdulla Alwaili Amani Mohammed Alotaibi Areej Saud Jalal Alaa Ali AlQahtani Fatima Abdullah AlQassim Gadah Albasher Wedad Saeed Al-Qahtani Source Type: research
Imaging immune checkpoint networks in cancer tissues with supermultiplexed SERS nanoprobes
Biomaterials. 2023 Sep 12;302:122327. doi: 10.1016/j.biomaterials.2023.122327. Online ahead of print.ABSTRACTCombined immune checkpoint (ICP) inhibitors maximize immune response rates of patients compared to the single-drug treatment strategy in cancer immunotherapy, and prediction of such optimal combinations requires high-throughput imaging techniques and suitable data analysis. In this work, we report a rational strategy for predicting combined drugs of ICP inhibitors based on supermultiplexed surface-enhanced Raman scattering (SERS) imaging and correlation network analysis. To this end, we first built an ultrasensitive...
Source: Biomaterials - September 16, 2023 Category: Materials Science Authors: Jin Li Fugang Liu Xinyuan Bi Jian Ye Source Type: research
Scutellarin suppresses the metastasis of triple-negative breast cancer via targeting TNF α/TNFR2-RUNX1-triggered G-CSF expression in endothelial cells
In this study, supernatant from tumor necrosis factorα (TNFα)-treated human mammary microvascular endothelial cell (HMMEC) promoted cell migration and pseudopod formation in TNBC cells, but these phenomena were disappeared in SC-co-treated HMMEC. TNFα enhanced the expression of granulocyte colony-stimulating factor (G-CSF) and granulocyte-macrophage colony-stimulating factor (GM-CSF) in both HMMEC and human umbilical vein endothelial cell (HUVEC). G-CSF promoted TNBC migration and invasion in vitro, while G-CSF neutralization antibody and SC both inhibited TNBC metastasis in Balb/c mice. SC had no inhibition on the G-CS...
Source: Biochemical Pharmacology - September 16, 2023 Category: Drugs & Pharmacology Authors: Xiyu Mei Hao Ouyang Hong Zhang Wangya Jia Bin Lu Jingnan Zhang Lili Ji Source Type: research
Interplay Between Estrogen, Kynurenine, and AHR Pathways: An Immunosuppressive Axis with Therapeutic Potential for Breast Cancer Treatment
Biochem Pharmacol. 2023 Sep 14:115804. doi: 10.1016/j.bcp.2023.115804. Online ahead of print.ABSTRACTBreast cancer is one of the most common malignancies among women worldwide. Estrogen exposure via endogenous and exogenous sources during a lifetime, together with environmental exposure to estrogenic compounds, represent the most significant risk factor for breast cancer development. As breast tumors establish, multiple pathways are deregulated. Among them is the aryl hydrocarbon receptor (AHR) signaling pathway. AHR, a ligand-activated transcription factor associated with the metabolism of polycyclic aromatic hydrocarbons...
Source: Biochemical Pharmacology - September 16, 2023 Category: Drugs & Pharmacology Authors: Jorge Humberto Lim ón Pacheco Guillermo Elizondo Source Type: research
Label-free drug response evaluation of human derived tumor spheroids using three-dimensional dynamic optical coherence tomography
This study aims at demonstrating label-free drug-response-patterns assessment of different tumor spheroids and drug types by dynamic optical coherence tomography (D-OCT). The study involved human breast cancer (MCF-7) and colon cancer (HT-29) spheroids. The MCF-7 and HT-29 spheroids were treated with paclitaxel (Taxol; PTX) and the active metabolite of irinotecan SN-38, respectively. The drugs were applied with 0 (control), 0.1, 1, and 10 μM concentrations and the treatment durations were 1, 3, and 6 days. A swept-source OCT microscope equipped with a repeated raster scanning protocol was used to scan the spheroids. Logar...
Source: Cancer Control - September 16, 2023 Category: Cancer & Oncology Authors: Ibrahim Abd El-Sadek Larina Tzu-Wei Shen Tomoko Mori Shuichi Makita Pradipta Mukherjee Antonia Lichtenegger Satoshi Matsusaka Yoshiaki Yasuno Source Type: research
Delineation and detection of breast cancer using novel label-free fluorescence
CONCLUSIONS: This exploratory work presents a potential avenue for improving "in-vivo" disease characterization using optical technology, specifically our LIF technique combined with the advanced K-mc approach, facilitating early tumor diagnosis in BC.PMID:37716994 | DOI:10.1186/s12880-023-01095-2
Source: Cancer Control - September 16, 2023 Category: Cancer & Oncology Authors: Alaaeldin Mahmoud Yasser H El-Sharkawy Source Type: research
TAZ facilitates breast tumor growth by promoting an immune-suppressive tumor microenvironment
Mol Oncol. 2023 Sep 16. doi: 10.1002/1878-0261.13525. Online ahead of print.ABSTRACTThe core Hippo pathway module consists of a tumor-suppressive kinase cascade that inhibits the transcriptional coactivators Yes-associated protein (YAP) and WW domain-containing transcription regulator protein 1 (WWTR1; also known as TAZ). When the Hippo pathway is downregulated, as often occurs in breast cancer, YAP/TAZ activity is induced. To elaborate the roles of TAZ in triple-negative breast cancer (TNBC), we depleted Taz in murine TNBC 4T1 cells, using either CRISPR/Cas9 or small hairpin RNA (shRNA). TAZ-depleted cells and their contr...
Source: Cancer Control - September 16, 2023 Category: Cancer & Oncology Authors: Anat Gershoni Ori Hassin Nishanth Belugali Nataraj Sivan Baruch Adi Avioz-Seligman Anna Chiara Pirona Liat Fellus-Alyagor Tomer Meir Salame Saptaparna Mukherjee Giuseppe Mallel Yosef Yarden Yael Aylon Moshe Oren Source Type: research
Interplay Between Estrogen, Kynurenine, and AHR Pathways: An Immunosuppressive Axis with Therapeutic Potential for Breast Cancer Treatment
Biochem Pharmacol. 2023 Sep 14:115804. doi: 10.1016/j.bcp.2023.115804. Online ahead of print.ABSTRACTBreast cancer is one of the most common malignancies among women worldwide. Estrogen exposure via endogenous and exogenous sources during a lifetime, together with environmental exposure to estrogenic compounds, represent the most significant risk factor for breast cancer development. As breast tumors establish, multiple pathways are deregulated. Among them is the aryl hydrocarbon receptor (AHR) signaling pathway. AHR, a ligand-activated transcription factor associated with the metabolism of polycyclic aromatic hydrocarbons...
Source: Cancer Control - September 16, 2023 Category: Cancer & Oncology Authors: Jorge Humberto Lim ón Pacheco Guillermo Elizondo Source Type: research
Additional intraoperative subpectoral plane block vs conventional pain control: A comparison of shoulder movement in patients with mastectomy
CONCLUSIONS: Compared to conventional analgesia, intraoperative pectoral nerve block under direct vision enhances shoulder mobility in forward elevation, external rotation, and arm abduction after mastectomy in breast cancer patients.PMID:37716023 | DOI:10.1016/j.breast.2023.103579
Source: Cancer Control - September 16, 2023 Category: Cancer & Oncology Authors: Sivaporn Pondeenana Chao Saenghirunvattana Patcharin Intarakhao Sorasit Inchan Panuwat Chuemor Atthakorn Jarusriwanna Source Type: research
SRRM4-mediated REST to REST4 dysregulation promotes tumor growth and neural adaptation in breast cancer leading to brain metastasis
CONCLUSIONS: Collectively, our findings identify SRRM4 as a regulator of brain metastasis colonization, and a potential therapeutic target in breast cancer.PMID:37716001 | DOI:10.1093/neuonc/noad175
Source: Cancer Control - September 16, 2023 Category: Cancer & Oncology Authors: Krutika Deshpande Vahan Martirosian Brooke N Nakamura Diganta Das Mukund Iyer Max Reed Ling Shao Daniella Bamshad Noel J Buckley Josh Neman Source Type: research
Adjuvant olaparib - High risk early breast cancer with BRCA1 or BRCA2 germline mutation
Bull Cancer. 2023 Sep 14:S0007-4551(23)00340-5. doi: 10.1016/j.bulcan.2023.07.004. Online ahead of print.NO ABSTRACTPMID:37716861 | DOI:10.1016/j.bulcan.2023.07.004
Source: Bulletin du Cancer - September 16, 2023 Category: Cancer & Oncology Authors: Ma ëva Bonneau Audrey Bellesoeur Source Type: research
Cancer cell-intrinsic PD-1: Its role in malignant progression and immunotherapy
Biomed Pharmacother. 2023 Sep 14;167:115514. doi: 10.1016/j.biopha.2023.115514. Online ahead of print.ABSTRACTProgrammed cell death protein-1 (PD-1), also called CD279, is coded by the PDCD1 gene and is constitutively expressed on the surface of immune cells. As a receptor and immune checkpoint, PD-1 can bind to programmed death ligand-1/programmed death ligand-2 (PD-L1/PD-L2) in tumor cells, leading to tumor immune evasion. Anti-PD-1 and anti-PD-L1 are important components in tumor immune therapy. PD-1 is also expressed as an intrinsic variant (iPD-1) in cancer cells where it plays important roles in malignant progression...
Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie - September 16, 2023 Category: Drugs & Pharmacology Authors: Muhua Chen Lei Bie Jieer Ying Source Type: research
The combination of the HDC1 inhibitor SAHA and doxorubicin has synergic efficacy in triple negative breast cancer in vivo
In this study, we investigated the synergistic potential of these two drugs in combination against TNBC. Our results suggested that the combination of these two drugs could enhance the inhibitory effect on cancer cell proliferation, resulting in alterations in cell mitotic phase, and suppression of cancer cell stemness. Moreover, our in vivo study unveiled that when SAHA was combined with DOX, it not only exhibited an inhibitory effect on tumor metastasis but also played a role in regulating the immune microenvironment within tumors. Overall, the combination of DOX and SAHA presents a promising avenue for innovative combin...
Source: Cell Research - September 16, 2023 Category: Cytology Authors: Yuheng Pang Runze Shi Liujia Chan Yu Lu Di Zhu Tong Liu Meisi Yan Yuji Wang Wenjing Wang Source Type: research
Additional intraoperative subpectoral plane block vs conventional pain control: A comparison of shoulder movement in patients with mastectomy
CONCLUSIONS: Compared to conventional analgesia, intraoperative pectoral nerve block under direct vision enhances shoulder mobility in forward elevation, external rotation, and arm abduction after mastectomy in breast cancer patients.PMID:37716023 | DOI:10.1016/j.breast.2023.103579
Source: Breast - September 16, 2023 Category: Cancer & Oncology Authors: Sivaporn Pondeenana Chao Saenghirunvattana Patcharin Intarakhao Sorasit Inchan Panuwat Chuemor Atthakorn Jarusriwanna Source Type: research
