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Pain management following major intracranial surgery in pediatric patients: a prospective cohort study in three academic children's hospitals
ConclusionsDespite considerable variation in modality and route of analgesic administration, there were no differences in average pain score, length of stay, or parental satisfaction with care. Pain scores were low, side effects were minimal, and parental satisfaction was high, providing equipoise for future blinded prospective randomized trials in this patient population.
Source: Pediatric Anesthesia - July 29, 2014 Category: Anesthesiology Authors: Lynne G. Maxwell, George M. Buckley, Sapna R. Kudchadkar, Elizabeth Ely, Emily L. Stebbins, Christine Dube, Athir Morad, Ebaa A. Jastaniah, Navil F. Sethna, Myron Yaster Tags: Original Article Source Type: research
Effects of Honey on Oral Mucositis among Pediatric Cancer Patients Undergoing Chemo/Radiotherapy Treatment at King Abdulaziz University Hospital in Jeddah, Kingdom of Saudi Arabia.
This study evaluates the therapeutic effects of honey with the focus on grade III and IV oral mucositis, reduction of bacterial and fungal infections, duration of episodes of oral mucositis, and body weight in pediatric leukemic patients undergoing chemo/radiotherapy. This is an open labeled randomized controlled study conducted at our hospital on 40 pediatric cancer patients undergoing chemo/radiotherapy. All the 40 patients included in this study experienced a sum total of 390 episodes of fever and neutropenia associated with oral mucositis. A significant reduction of oral mucositis, associated Candida, and aerobic patho...
Source: Evidence-based Complementary and Alternative Medicine - March 10, 2017 Category: Complementary Medicine Tags: Evid Based Complement Alternat Med Source Type: research
Enteral Nutrition in Pediatric High-risk Head and Neck Cancer Patients Receiving Proton Therapy: Identifying Risk Factors and Quality of Life Concerns to Optimize Care
Conclusions:
Pediatric patients with head and neck cancer can be risk-stratified based on clinical and dosimetric factors. This data, combined with parent and patient perceptions, is key to the development of rational guidelines.
Source: Journal of Pediatric Hematology Oncology - April 24, 2019 Category: Hematology Tags: Online Articles: Original Articles Source Type: research
Communication, Counseling and Compassionate Care: The least explored and challenging Palliative Care approaches among Primary Care Physicians - Clinical Case series of Oral Potentially malignant disorders in Tamil Nadu
J Family Med Prim Care. 2021 Jan;10(1):572-577. doi: 10.4103/jfmpc.jfmpc_1502_20. Epub 2021 Jan 30.ABSTRACTBACKGROUND: Globally, the sixth most common malignancy is oral cancer, which is predominantly due to consumption of potent, proven carcinogens which includes smoking and smokeless form of tobacco and areca nut. Habits associated oral malignancies are mostly preceded by clinically asymptomatic oral lesions collectively referred under the umbrella term as oral potentially malignant disorders (OPMDs). There is a delayed presentation of oral pre cancer and oral cancer in India, as approximately 50% of patients are diagnos...
Source: Primary Care - May 21, 2021 Category: Primary Care Authors: Praveena Raman Source Type: research
Image gently: enhancing radiation protection during pediatric imaging
The amount of radiation that people receive from health care sources has been increasing, and this includes children. It also includes dental patients. While it is difficult to show directly that diagnostic radiation leads to cancer in a particular individual, x-radiation is a carcinogen according to the US Food and Drug Administration, and there are good population data to indicate that there are increased cancers in people who have been exposed to radiation at levels that can be encountered during diagnostic imaging procedures. This is particularly important for children, whose tissues are more radiosensitive and whose l...
Source: Oral Surgery, Oral Medicine, Oral Pathology, Oral Radiology, and Endodontics - March 13, 2014 Category: ENT & OMF Authors: Allan G. Farman Tags: Editorial Source Type: research
The intersection of oral medicine and interprofessional education
Medicine, nursing, dentistry, pharmacy, dental hygiene, physician assistants, physical therapy, nutrition, and many other health care professions aim to provide the best and the safest available health care to patients with a variety of health conditions. Owing to advances of medical sciences observed in recent years, patients have their diseases diagnosed earlier, receive adequate treatment, and survive much longer. Nevertheless, what quality of life do they have, and what complications may result from their health care? A patient may be receiving treatment for several medical diseases/conditions and being managed by a nu...
Source: Oral Surgery, Oral Medicine, Oral Pathology, Oral Radiology, and Endodontics - March 14, 2014 Category: ENT & OMF Authors: Cesar A. Migliorati, Rui Amaral Mendes Tags: Letter to the Editor Source Type: research
Egypt’s Poor Easy Victims of Quack Medicine
Many pharmacies and herbalists in Egypt prescribe their own 'wasfa' (secret drug or herbal elixir). Credit: Cam McGrath/IPSBy Cam McGrathCAIRO, Aug 10 2014 (IPS) Magda Ibrahim first learnt that she had endometrial cancer when she went to a clinic to diagnose recurring bladder pain and an abnormal menstrual discharge. Unable to afford the recommended hospital treatment, the uninsured 53-year-old widow turned to what she hoped would be a quicker and cheaper therapy.
A local Muslim sheikh claimed religious incantations, and a suitable donation to his pocket, could cure the cancer. But when her symptoms persisted, Ibrahim cons...
Source: IPS Inter Press Service - Health - August 10, 2014 Category: Global & Universal Authors: Cam McGrath Tags: Civil Society Education Featured Headlines Health Human Rights Middle East & North Africa Poverty & MDGs Projects Women's Health AIDS avian flu blood dialysis clinics Corruption Doctors Egypt Health care Hepatitis C h Source Type: news
Pediatric phase I trial of oral sorafenib and topotecan in refractory or recurrent pediatric solid malignancies
Abstract
Targeted kinase inhibitors and camptothecins have shown preclinical and clinical activity in several cancers. This trial evaluated the maximum tolerated dose (MTD) and dose‐limiting toxicities of sorafenib and topotecan administered orally in pediatric patients with relapsed solid tumors. Sorafenib was administered twice daily and topotecan once daily on days 1–5 and 8–12 of each 28‐day course. The study utilized a standard 3 + 3 dose escalation design. Three dose levels (DL) were evaluated: (1) sorafenib 150 mg/m2 and topotecan 1 mg/m2; (2) sorafenib 150 mg/m2 and topotecan 1.4 mg/m2; and (3) sorafe...
Source: Cancer Medicine - December 29, 2015 Category: Cancer & Oncology Authors: Damon R. Reed, Leo Mascarenhas, Kathleen Manning, Gregory A. Hale, John Goldberg, Jonathan Gill, Eric Sandler, Michael S. Isakoff, Tiffany Smith, Jamie Caracciolo, Richard M. Lush, Tzu‐Hua Juan, Jae K. Lee, Anthony M. Neuger, Daniel M. Sullivan Tags: Original Research Source Type: research
Animal models of mucositis: critical tools for advancing pathobiological understanding and identifying therapeutic targets
Purpose of review
Mucositis remains a prevalent, yet poorly managed side effect of anticancer therapies. Mucositis affecting both the oral cavity and gastrointestinal tract predispose to infection and require extensive supportive management, contributing to the growing economic burden associated with cancer care. Animal models remain a critical aspect of mucositis research, providing novel insights into its pathogenesis and revealing therapeutic targets. The current review aims to provide a comprehensive overview of the current animal models used in mucositis research.
Recent findings
A wide variety of animal models o...
Source: Current Opinion in Supportive and Palliative Care - May 3, 2019 Category: Palliative Care Tags: GASTROINTESTINAL SYMPTOMS: Edited by Nicole Blijlevens and Andrea M. Stringer Source Type: research
Salivary gland epithelial neoplasms in pediatric population: a single-institute experience
ConclusionsSalivary gland epithelial neoplasms in Chinese pediatric patients are rare. There was a roughly equal sex distribution. The vast majority of patients were diagnosed in the 10–18 year age group. Parotid gland was most common involved site, and pleomorphic adenoma was the most common tumor overall. Among the malignant tumors, mucoepidermoid carcinoma was the most common type, followed by secretory carcinoma and acinic cell carcinoma.
Source: Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology - June 13, 2019 Category: ENT & OMF Source Type: research
Beneficial Effects of Early Enteral Nutrition After Major Rectal Surgery: A Possible Role for Conditionally Essential Amino Acids? Results of a Randomized Clinical Trial
Objectives: To investigate direct postoperative outcome and plasma amino acid concentrations in a study comparing early enteral nutrition versus early parenteral nutrition after major rectal surgery. Previously, it was shown that a low plasma glutamine concentration represents poor prognosis in ICU patients.
Design: A preplanned substudy of a previous prospective, randomized, open-label, single-centre study, comparing early enteral nutrition versus early parenteral nutrition in patients at high risk of postoperative ileus after surgery for locally advanced or locally recurrent rectal cancer. Early enteral nutrition reduce...
Source: Critical Care Medicine - May 17, 2016 Category: Emergency Medicine Tags: Online Clinical Investigations Source Type: research
Risk factors for bacteremia and central line –associated blood stream infections in children with acute myelogenous leukemia: A single‐institution report
ConclusionsIntensified line care efforts cannot eliminate all CLABSIs in the patients with AML. Exploring the role of mucosal barrier breakdown and/or the use of antibiotic prophylaxis may be effective strategies for further prevention of CLABSIs, supporting ongoing trials in this patient population.
Source: Pediatric Blood and Cancer - September 11, 2016 Category: Cancer & Oncology Authors: Ashley E. J. Rogers, Kristen M. Eisenman, Susan A. Dolan, Kristin M. Belderson, Jocelyn R. Zauche, Suhong Tong, Jane Gralla, Joanne M. Hilden, Michael Wang, Kelly W. Maloney, Samuel R. Dominguez Tags: Research Article Source Type: research
Prevalence of gingivitis in oncology pediatric patients
Many side effects of oncology treatment and reduction in self-respect can compromise the quality of oral hygiene of pediatric patients, affecting their periodontal healthy status. The aim of this research was to determine the prevalence of inflammatory gum disease in a pediatric population under cancer treatment.
Source: Oral Surgery, Oral Medicine, Oral Pathology, Oral Radiology, and Endodontics - July 28, 2017 Category: ENT & OMF Authors: JULIANA CAVALCANTE DE OLIVEIRA, MARCELA CARLA PEREIRA DO NASCIMENTO, KELLY MEIRELES VARELA, V ÂNIA CAVALCANTI RIBEIRO DA SILVA, GUSTAVO PINA GODOY Tags: RP - Research Poster Source Type: research
