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BET Bromodomain Inhibitor iBET151 Impedes Human ILC2 Activation and Prevents Experimental Allergic Lung Inflammation
This study was supported by grants from GSK and the UK Medical Research Council (U105178805). Conflict of Interest Statement AM has grant funding from GSK and AstraZeneca/MedImmune. MB, DJ, AP, DT, and AvO are employees of GSK. The remaining authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. Acknowledgments We are grateful to the Ares staff, genotyping facility, and flow cytometry core for their technical assistance. We thank Jen Walker for advice on the manuscript. Supplementary Material The Supplem...
Source: Frontiers in Immunology - April 8, 2019 Category: Allergy & Immunology Source Type: research

All Itching Is Not Benign; A Case of Refractory Hypereosinophilic Syndrome Treated with Off Label CD52 Inhibitor-Alemtuzumab
CONCLUSIONOur patient responded well to alemtuzumab, without any notable side effects. Therapy should be reserved due to early and late adverse affects but this agent has proved to be an effective treatment for HES in terms of both complete hematologic response and duration (Strati, P. et. al Clinical Lymphoma, Myeloma & Leukemia 2012). Moreover resistance is not seen, as patients with relapse were able to achieve a second remission. Data about efficacy and safety in the long-term remains lacking, but for treatment resistant and refractory HES, Alemtuzmab may be a suitable choice.DisclosuresNo relevant conflicts of interest to declare.
Source: Blood - November 21, 2018 Category: Hematology Authors: Ansari, R., Osuna Salazar, E. N., Sarhill, N., Garcia, L. E., Hanley, J. Tags: 634. Myeloproliferative Syndromes: Clinical Source Type: research

Drought in the Semiarid Region of Brazil: Exposure, Vulnerabilities and Health Impacts from the Perspectives of Local Actors
Conclusion The results obtained from this research shows, in general, the fragility in the social and political infrastructure necessary to improve the living conditions of populations, particularly those that depend on family agriculture in drought prone areas. The conditions of social, economic and environmental vulnerabilities presented in the region can be amplified by the drought process, and can aggravate the impacts resulting drought events, thus disadvantaging the population of this region, as shown in the Fig. 1. The general perception of the interviewees of the health sector shows an agreement with what is found...
Source: PLOS Currents Disasters - October 29, 2018 Category: International Medicine & Public Health Authors: Aderita Sena Source Type: research

Humoral Immunity in Arsenic-Exposed Children in Rural Bangladesh: Total Immunoglobulins and Vaccine-Specific Antibodies
Conclusions: Arsenic exposure increased tIgG and tIgE in plasma, and tended to decrease mumps-specific IgG in children at 9 years of age. https://doi.org/10.1289/EHP318 Received: 09 April 2016 Revised: 09 October 2016 Accepted: 24 October 2016 Published: 14 June 2017 Address correspondence to R. Raqib, Immunobiology, Nutrition and Toxicology Laboratory, Infectious Diseases Division, icddr,b, 68 Shaheed Tajuddin Ahmed Sarani, Mohakhali, Dhaka-1212, Bangladesh. Telephone: 880-2-9827068. E-mail: rubhana@icddrb.org Supplemental Material is available online (https://doi.org/10.1289/EHP318). The authors declare they have n...
Source: EHP Research - June 15, 2017 Category: Environmental Health Authors: Karla Gonzalez Tags: Research Source Type: research

Diet of hookworms to tackle a bread allergy
James Logan, a biologist at the School of Hygiene and Tropical Medicine also tried leeches and is thinking about maggot therapy• Read about more scientists who go to extremes lengthsA lot of people don't realise that just one metre below your feet walking along Gower Street or Malet Street in London, you have thousands upon thousands of very hungry, potentially dangerous insects.In the basement we have our insectary colonies where we keep lots of different species of mosquitoes, found in all parts of the world. None of them are infected with malaria, but they are in very high numbers. We also have bed bugs, house dust mi...
Source: Guardian Unlimited Science - December 1, 2013 Category: Science Authors: Josh Davis Tags: Allergies Health Medical research Society Technology Features Animals Insects The Observer Environment Science Wildlife Source Type: news