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Cancer: Epithelial Cancer
Procedure: Transplants
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Total 292 results found since Jan 2013.
Telocytes protect against lung tissue fibrosis through hexokinase 2-dependent pathway by secreting hepatocyte growth factor
In conclusion, TCs can protect against lung tissue fibrosis by releasing HGF, a process dependent on HK2.PMID:37715611 | DOI:10.1111/1440-1681.13823
Source: Clinical Lung Cancer - September 16, 2023 Category: Cancer & Oncology Authors: Shaoyuan Zhang Linyi Sun Borong Chen Siyun Lin Jianmin Gu Lijie Tan Miao Lin Source Type: research
Fight Aging! Newsletter, September 11th 2023
This article reviews the current regulatory role of miR-7 in inflammation and related diseases, including viral infection, autoimmune hepatitis, inflammatory bowel disease, and encephalitis. It expounds on the molecular mechanism by which miR-7 regulates the occurrence of inflammatory diseases. Finally, the existing problems and future development directions of miR-7-based intervention on inflammation and related diseases are discussed to provide new references and help strengthen the understanding of the pathogenesis of inflammation and related diseases, as well as the development of new strategies for clinical interventi...
Source: Fight Aging! - September 10, 2023 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
Cultivated autologous limbal epithelial cell (CALEC) transplantation: Development of manufacturing process and clinical evaluation of feasibility and safety
Sci Adv. 2023 Aug 18;9(33):eadg6470. doi: 10.1126/sciadv.adg6470. Epub 2023 Aug 18.ABSTRACTTo treat unilateral limbal stem cell (LSC) deficiency, we developed cultivated autologous limbal epithelial cells (CALEC) using an innovative xenobiotic-free, serum-free, antibiotic-free, two-step manufacturing process for LSC isolation and expansion onto human amniotic membrane with rigorous quality control in a good manufacturing practices facility. Limbal biopsies were used to generate CALEC constructs, and final grafts were evaluated by noninvasive scanning microscopy and tested for viability and sterility. Cultivated cells maint...
Source: Cancer Control - August 18, 2023 Category: Cancer & Oncology Authors: Ula V Jurkunas Jia Yin Lynette K Johns Sanming Li Helene Negre Kit L Shaw Lassana Samarakoon Allison R Ayala Ahmad Kheirkhah Kishore Katikireddy Alex Gauthier Stephan Ong Tone Aaron R Kaufman Stacey Ellender Diego E Hernandez Rodriguez Heather Daley Reza Source Type: research
Cancer stem cells as the source of tumor associated myoepithelial cells in the tumor microenvironment developing ductal carcinoma in situ
Biomaterials. 2023 Jul 20;301:122249. doi: 10.1016/j.biomaterials.2023.122249. Online ahead of print.ABSTRACTThe heterogeneous cell population in the stromal microenvironment is considered to be attributed to the multiple sources from which the cells originate. Tumor associated myoepithelial cells (TAMEs) are one of the most important populations in the tumor microenvironment (TME) especially in breast cancer. On the other hand, cancer stem cells (CSCs) have previously been described to be the origin of tumor-associated cellular components in the TME. We prepared a cancer stem cell model converting mouse-induced pluripoten...
Source: Biomaterials - July 28, 2023 Category: Materials Science Authors: Said M Afify Ghmkin Hassan Maram H Zahra Hend M Nawara Hagar A Abu Quora Amira Osman Hager Mansour Kazuki Kumon Akimasa Seno Ling Chen Ayano Satoh David S Salomon Masaharu Seno Source Type: research
UCA1 executes an oncogenic role in pancreatic cancer by regulating miR-582-5p/BRCC3
ConclusionUCA1 acted as an oncogene in pancreatic cancer by partly regulating miR-582-5p/BRCC3, which could be a new therapeutic target for pancreatic cancer.
Source: Frontiers in Oncology - July 25, 2023 Category: Cancer & Oncology Source Type: research
Intestinal microbiota controls graft-versus-host disease independent of donor-host genetic disparity
Immunity. 2023 Jul 17:S1074-7613(23)00281-9. doi: 10.1016/j.immuni.2023.06.024. Online ahead of print.ABSTRACTAcute graft-versus-host disease (aGVHD) remains a major limitation of allogeneic stem cell transplantation (SCT), and severe intestinal manifestation is the major cause of early mortality. Intestinal microbiota control MHC class II (MHC-II) expression by ileal intestinal epithelial cells (IECs) that promote GVHD. Here, we demonstrated that genetically identical mice of differing vendor origins had markedly different intestinal microbiota and ileal MHC-II expression, resulting in discordant GVHD severity. We utilize...
Source: Cancer Control - July 22, 2023 Category: Cancer & Oncology Authors: Motoko Koyama Daniel S Hippe Sujatha Srinivasan Sean C Proll Oriana Miltiadous Naisi Li Ping Zhang Kathleen S Ensbey Noah G Hoffman Christine R Schmidt Albert C Yeh Simone A Minnie Susan M Strenk Tina L Fiedler Namita Hattangady Jacob Kowalsky Willian M G Source Type: research
Fight Aging! Newsletter, July 17th 2023
In conclusion, the longevity-associated genotype of FLT1 may confer increased lifespan by protecting against mortality risk posed by hypertension. We suggest that FLT1 expression in individuals with longevity genotype boosts vascular endothelial resilience mechanisms to counteract hypertension-related stress in vital organs and tissues.
Resistance Exercise Slows the Onset of Pathology in a Mouse Model of Alzheimer's Disease
https://www.fightaging.org/archives/2023/07/resistance-exercise-slows-the-onset-of-pathology-in-a-mouse-model-of-alzheimers-disease/
With the caveat that mouse models of Alzheimer's...
Source: Fight Aging! - July 16, 2023 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
Fight Aging! Newsletter, July 3rd 2023
In this study, cultured adipose-derived stem cells (ASCs) were derived from subcutaneous white adipose tissue isolated from mice fed a normal diet. We performed senescence-associated-β-galactosidase (SA-β-gal) staining, real-time PCR, and Western blot to evaluate the levels related to cellular senescence markers.
The mRNA expression levels of senescence markers were significantly increased in the later passages of ASCs. We show that light activation reduced the expression of senescent genes, and SA-β-Gal in all cells at passages. Moreover, the light-activated ASCs-derived exosomes decrease the expression of senes...
Source: Fight Aging! - July 2, 2023 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
Targeting microRNA-125b inhibited the metastasis of Alisertib resistance cells through mediating p53 pathway
Conclusions: Silencing of p53 by miR-125b could be one of the mechanisms that contributes to Alisertib resistance. Targeting miR-125b could be a strategy to overcome Alisertib resistance.PMID:37355468 | DOI:10.3760/cma.j.cn112152-20200511-00438
Source: Cancer Control - June 24, 2023 Category: Cancer & Oncology Authors: F L Yang X Chen F Zheng X X Liu N Sun R Q Li Z Jiang J Han J Yang Source Type: research
Tumour stemness and poor clinical outcomes in haemochromatosis patients with hepatocellular carcinoma
CONCLUSIONS: This study demonstrates that the clinical course of patients with HFE-HCC is more aggressive and provides the first data indicating that their tumours have increased expression of progenitor markers. These findings suggest patients with HFE-HCC may need to be considered for transplant at an earlier stage.PMID:37253536 | DOI:10.1136/jcp-2022-208679
Source: Cancer Control - May 30, 2023 Category: Cancer & Oncology Authors: Daniel M Di Capua William Shanahan Michele Bourke Navneet Ramlaul Josh Appel Aoife Canney Neil G Docherty Erinn McGrath Eabha Ring Fiona Jones Marie Boyle Janet McCormack Tom Gallagher Emir Hoti Niamh Nolan John D Ryan Diarmaid D Houlihan Aurelie Fabre Source Type: research
Identification of Recurrence-Related mRNAs and Noncoding RNAs in Hepatocellular Carcinoma Following Liver Transplantation
CONCLUSION: Our results reveal key mRNAs, long non-coding RNAs, and circular RNAs associated with recurrence in hepatocellular carcinoma patients after liver transplantation.PMID:37089051 | DOI:10.5152/tjg.2023.22656
Source: The Turkish Journal of Gastroenterology - April 24, 2023 Category: Gastroenterology Authors: Qiang Zeng Jinglin Cao Yishan Niu Xin Zhao Yang Wang Wenpeng Liu Baowang Liu Yajie Chen Yize Fan Jian Dou Source Type: research
