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The Calcineurin-TFEB-p62 Pathway Mediates the Activation of Cardiac Macroautophagy by Proteasomal Malfunction.
Conclusions: (1) The activation of cardiac macroautophagy by proteasomal malfunction is mediated by the Mocln1-calcineurin-TFEB-p62 pathway; (2) p62 unexpectedly exerts a feed-forward effect on TFEB activation by proteasome malfunction; and (3) targeting the Mcoln1-calcineurin-TFEB-p62 pathway may provide new means to intervene cardiac ALP activation during proteasome malfunction. PMID: 32366200 [PubMed - as supplied by publisher]
Source: Circulation Research - May 4, 2020 Category: Cardiology Authors: Pan B, Li J, Parajuli N, Tian Z, Wu P, Lewno MT, Zou J, Wang W, Bedford L, Mayer RJ, Fang J, Liu J, Cui T, Su H, Wang X Tags: Circ Res Source Type: research

Role of TGF-β co-receptor CD109 in extracellular matrix production of smooth muscle cells
Publication date: April 2018Source: Archives of Cardiovascular Diseases Supplements, Volume 10, Issue 2Author(s): Y. Li, H. Louis, J. Gao-Li, A. Parlakian, O. Agbulut, P. Lacolley, V. Regnault, Z. LiCD109 is a glycosylphosphatidylinositol (GPI)-linked glycoprotein located on the plasma membrane and has no intracellular domain. It has been reported that it attenuates the TGF-β signaling in skin fibroblastes and cancer cells by competitive binding to TGF-β factors and promoting internalization and degradation of TGF-β receptors. We found less production of extracellular matrix (ECM) and higher expression of CD109 in the c...
Source: Archives of Cardiovascular Diseases Supplements - July 10, 2018 Category: Cardiology Source Type: research

A hyaluronan-based nanosystem enables combined anti-inflammation of mTOR gene silencing and pharmacotherapy.
In this study, we synthesized a hyaluronan-based ROS-sensitive polymer which was expected to release loaded chemical drugs in inflammatory environment and further developed a stable and nontoxic co-delivery nanosystem of siRNA targeting autophagy suppressive gene and chemotherapeutic agents. The in vitro transfection study of this nanosystem revealed improved intracellular accumulation of siRNA and excellent gene silencing efficacy comparable to that of conventional cationic liposome. Moreover, the mRNA expression of inflammatory cytokines was remarkably decreased by our nanosystem. Considering its biocompatibility, transf...
Source: Atherosclerosis - May 31, 2018 Category: Cardiology Authors: Hou C, Bai H, Wang Z, Qiu Y, Kong LL, Sun F, Wang D, Yin H, Zhang X, Mu H, Duan J Tags: Carbohydr Polym Source Type: research

High-Throughput RNAi Screening Identifies a Role for the Osteopontin Pathway in Proliferation and Migration of Human Aortic Smooth Muscle Cells
Conclusions A phenotypic high-throughput siRNA screen could be applied to identify genes relevant for the cell biology of HaoSMCs. Novel genes were identified which play a role in proliferation, apoptosis, mitosis and migration of HaoSMCs. These may represent potential drug candidates in the future.
Source: Cardiovascular Drugs and Therapy - April 18, 2016 Category: Cardiology Source Type: research

Carfilzomib reverses pulmonary arterial hypertension
Conclusion The addition of anti-tumour agents such as CFZ along with cardioprotectants to currently available vasodilators may be a promising way to improve PAH therapy.
Source: Cardiovascular Research - April 18, 2016 Category: Cardiology Authors: Wang, X., Ibrahim, Y. F., Das, D., Zungu-Edmondson, M., Shults, N. V., Suzuki, Y. J. Tags: Integrative physiology and pathophysiology Source Type: research

In Pulmonary Arterial Hypertension, Reduced BMPR2 Promotes Endothelial-to-Mesenchymal Transition via HMGA1 and its Target Slug.
CONCLUSIONS: -Increased HMGA1 in PAECs resulting from dysfunctional BMPR2 signaling can transition endothelium to SM-like cells associated with PAH. PMID: 27045138 [PubMed - as supplied by publisher]
Source: Circulation - April 3, 2016 Category: Cardiology Authors: Hopper RK, Moonen JA, Diebold I, Cao A, Rhodes CJ, Tojais NF, Hennigs JK, Gu M, Wang L, Rabinovitch M Tags: Circulation Source Type: research

Abstract P207: Role of (Pro)Renin Receptor in the Pathogenesis of Colon Cancer Session Title: Angiotensin Action and Signaling/Renin Angiotensin System 2
(Pro)renin receptor ((P)RR) is a component of the Wnt receptor complex (Science, 2010). We have recently demonstrated that (P)RR plays an important role in the tumorigenesis of pancreatic ductal adenocarcinoma via the activation of Wnt/β-catenin signaling pathway (Shibayama et al. Sci Rep. 2015). Since the patients with colon cancer often show aberrantly activated Wnt/β-catenin-dependent signaling pathway by the mutations of its components, we investigated the possible role of (P)RR and Wnt/β-catenin signaling pathway in carcinogenesis of colon cancer. Real-time PCR was used for measuring mRNA levels of (P)R...
Source: Hypertension - November 3, 2015 Category: Cardiology Authors: Nishiyama, A., Wang, J., Yachida, S., Nguyen, G., Hirose, T., Shibayama, Y. Tags: Session Title: Angiotensin Action and Signaling/Renin Angiotensin System 2 Source Type: research

Bromodomain Containing Protein-4: The Epigenetic Origin of Pulmonary Arterial Hypertension.
CONCLUSIONS: BRD4 plays a key role in the pathological phenotype in PAH, which could offer new therapeutic perspectives for PAH patients. PMID: 26224795 [PubMed - as supplied by publisher]
Source: Circulation Research - July 29, 2015 Category: Cardiology Authors: Meloche J, Potus F, Vaillancourt M, Bourgeois A, Johnson IH, Deschamps L, Chabot S, Ruffenach GN, Henry S, Breuils-Bonnet S, Tremblay È, Nadeau V, Lambert CM, Paradis R, Provencher S, Bonnet S Tags: Circ Res Source Type: research

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