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Total 872 results found since Jan 2013.

Some implications of melatonin use in Chronopharmacology of insomnia.
Abstract The last decade has witnessed the emergence of new chronopharmacological perspectives. In the case of sleep disorders, the accumulating evidence suggests that even a minor dysfunction in the biological clock can impact broadly upon body physiology causing increases in sleep onset latency, phase delays or advances in sleep initiation, frequent nocturnal awakenings, reduced sleep efficiency, delayed and shortened rapid eye movement sleep and increased periodic leg movements, among others. Thus, restoration of the adequate circadian pattern of by proper sleep hygiene, targeted exposure to light and the use o...
Source: European Journal of Pharmacology - May 21, 2015 Category: Drugs & Pharmacology Authors: Golombek DA, Pandi-Perumal SR, Brown GM, Cardinali DP Tags: Eur J Pharmacol Source Type: research

Tattoo complaints and complications: diagnosis and clinical spectrum.
Authors: Serup J, Carlsen KH, Sepehri M Abstract Tattoos cause a broad range of clinical problems. Mild complaints, especially sensitivity to sun, are very common and seen in 1/5 of cases. Medical complications are dominated by allergy to tattoo pigment haptens or haptens generated in the skin, especially in red tattoos but also in blue and green tattoos. Symptoms are major and can be compared to cumbersome pruritic skin diseases. Tattoo allergies and local reactions show distinct clinical manifestations, with plaque-like, excessive hyperkeratotic, ulcero-necrotic, lymphopathic, neuro-sensory, and scar patterns. Re...
Source: Current Problems in Dermatology - June 4, 2015 Category: Dermatology Tags: Curr Probl Dermatol Source Type: research

Mechanisms of Immunological Tolerance.
Abstract There is increasing interest in establishing diagnostic markers of immunological tolerance applicable to efforts to minimize drug immunosuppression in transplantation and chronic immunological diseases. It is hoped that an understanding of the diverse mechanisms that can contribute to tolerance will guide efforts to establish diagnostic tolerance biomarkers. Not only would these be valuable for management of autoimmune diseases, transplants and allergies, but they might also guide efforts to override tolerance processes in cancer and vaccine development. Where tolerance is generated by deletion or inactiv...
Source: Clinical Biochemistry - May 30, 2015 Category: Biochemistry Authors: Waldmann H Tags: Clin Biochem Source Type: research

A Scalable Framework to Detect Personal Health Mentions on Twitter
Conclusions: It is possible to automatically detect personal health status mentions on Twitter in a scalable manner. These mentions correspond to the health issues of the Twitter users themselves, but also other individuals. Though this study did not investigate the veracity of such statements, we anticipate such information may be useful in supplementing traditional health-related sources for research purposes.
Source: Journal of Medical Internet Research - June 5, 2015 Category: Journals (General) Authors: Zhijun YinDaniel FabbriS Trent RosenbloomBradley Malin Source Type: research

Anaphylaxis as a cause of hospitalization - a single academic centre experience.
CONCLUSIONS: It is difficult to forecast the course of the reaction based on the causative factor, for anaphylactic reaction is characterised by a great individual changeability and intensity of the first symptoms. PMID: 26050978 [PubMed - in process]
Source: Pneumonologia i Alergologia Polska - June 10, 2015 Category: Respiratory Medicine Authors: Baran K, Pałgan K, Szortyka M, Bitner A, Bartuzi Z, Klawe JJ Tags: Pneumonol Alergol Pol Source Type: research

My Body Makes My Brain Look Like an Idiot...
I'm getting older. I hurt more. I creak more. My ankles sound like they're each having their own personal fireworks display every single morning when I walk downstairs to feed the dog. He's getting old, too. We commiserate. "Another gray hair?" I tease. "Pot, meet kettle," he'd respond if he could. Touché, Bear. Each day brings a new malady, depending on what I eat, how I exercise, how much sleep I get, or if I have one too many glasses of wine. My liver has given up having even a shred of compassion for my unintelligence. And for some reason, my allergies whalloped me very hard this year. I can tolerate almost anythi...
Source: Healthy Living - The Huffington Post - June 16, 2015 Category: Consumer Health News Source Type: news

PI3K inhibitors in inflammation, autoimmunity and cancer.
Abstract The healthy immune system protects against infection and malignant transformation without causing significant damage to host tissues. Immune dysregulation results in diverse pathologies including autoimmune disease, chronic inflammatory disorders, allergies as well as immune deficiencies and cancer. Phosphoinositide 3-kinase (PI3K) signalling has been shown to be a key pathway in the regulation of the immune response and continues to be the focus of intense research. In recent years we have gained detailed understanding of PI3K signalling, and saw the development of potent and highly selective small molec...
Source: Current Opinion in Pharmacology - June 17, 2015 Category: Drugs & Pharmacology Authors: Stark AK, Sriskantharajah S, Hessel EM, Okkenhaug K Tags: Curr Opin Pharmacol Source Type: research

The expanding role of immunopharmacology ‐ IUPHAR Review 16
Abstract Drugs targeting the immune system such as corticosteroids, antihistamines and immunosuppressants have been widely exploited in the treatment of inflammatory, allergic and autoimmune disorders during the second half of the 20th century. The recent advances in immunopharmacological research made available new classes of clinically relevant drugs. These comprise protein kinase inhibitors and biologics, such as monoclonal antibodies that selectively modulate the immune response not only in cancer and autoimmunity but also in a number of additional human pathologies. Likewise, more effective vaccines utilising novel an...
Source: British Journal of Pharmacology - July 14, 2015 Category: Drugs & Pharmacology Authors: Ekaterini Tiligada, Masaru Ishii, Carlo Riccardi, Michael Spedding, Hans‐Uwe Simon, Mauro Martins Teixeira, Mario Landys Chovel Cuervo, Stephen T. Holgate, Francesca Levi‐Schaffer Tags: NC‐IUPHAR Review Source Type: research

The expanding role of immunopharmacology – IUPHAR Review 16
Drugs targeting the immune system such as corticosteroids, antihistamines and immunosuppressants have been widely exploited in the treatment of inflammatory, allergic and autoimmune disorders during the second half of the 20th century. The recent advances in immunopharmacological research have made available new classes of clinically relevant drugs. These comprise protein kinase inhibitors and biologics, such as monoclonal antibodies, that selectively modulate the immune response not only in cancer and autoimmunity but also in a number of other human pathologies. Likewise, more effective vaccines utilizing novel antigens a...
Source: British Journal of Pharmacology - July 21, 2015 Category: Drugs & Pharmacology Authors: Ekaterini Tiligada, Masaru Ishii, Carlo Riccardi, Michael Spedding, Hans‐Uwe Simon, Mauro Martins Teixeira, Mario Landys Chovel Cuervo, Stephen T Holgate, Francesca Levi‐Schaffer Tags: INTERNATIONAL UNION OF BASIC AND CLINICAL PHARMACOLOGY REVIEW Source Type: research

The expanding role of immunopharmacology: IUPHAR Review 16
Drugs targeting the immune system such as corticosteroids, antihistamines and immunosuppressants have been widely exploited in the treatment of inflammatory, allergic and autoimmune disorders during the second half of the 20th century. The recent advances in immunopharmacological research have made available new classes of clinically relevant drugs. These comprise protein kinase inhibitors and biologics, such as monoclonal antibodies, that selectively modulate the immune response not only in cancer and autoimmunity but also in a number of other human pathologies. Likewise, more effective vaccines utilizing novel antigens a...
Source: British Journal of Pharmacology - July 21, 2015 Category: Drugs & Pharmacology Authors: Ekaterini Tiligada, Masaru Ishii, Carlo Riccardi, Michael Spedding, Hans‐Uwe Simon, Mauro Martins Teixeira, Mario Landys Chovel Cuervo, Stephen T Holgate, Francesca Levi‐Schaffer Tags: INTERNATIONAL UNION OF BASIC AND CLINICAL PHARMACOLOGY REVIEW Source Type: research

Interior life: UCLA doctors use the body's own microorganisms to fight disease
This may strike many people as distasteful, but human stool now is used as a medical therapy against at least one dangerous infection. It is happening at UCLA and at a small number of other major medical centers, where processed stool from healthy donors is being introduced into the gastrointestinal tracts of patients with Clostridium difficile, or C. diff. The infection is most commonly acquired in the hospital, causing diarrhea, intestinal pain and cramps, fever and potentially worse — 14,000 people die from C. diff in the U.S. each year. While the cure may sound worse than the disease, the therapy, known as fecal micr...
Source: UCLA Newsroom: Health Sciences - August 6, 2015 Category: Universities & Medical Training Source Type: news

Abstract 871: The association between periodontal disease and pancreatic cancer
Conclusions: Our analysis showed a significantly positive association between PD and pancreatic cancer risk. Further investigation is needed to explain the underlying biological mechanisms for the positive association between PD and pancreatic cancer.Citation Format: Jeffrey S. Chang, Chia-Rung Tsai, Yan-Shen Shan, Li-Tzong Chen. The association between periodontal disease and pancreatic cancer. [abstract]. In: Proceedings of the 106th Annual Meeting of the American Association for Cancer Research; 2015 Apr 18-22; Philadelphia, PA. Philadelphia (PA): AACR; Cancer Res 2015;75(15 Suppl):Abstract nr 871. doi:10.1158/1538-7445.AM2015-871
Source: Cancer Research - August 2, 2015 Category: Cancer & Oncology Authors: Chang, J. S., Tsai, C.-R., Shan, Y.-S., Chen, L.-T. Tags: Epidemiology Source Type: research

Scientists reveal cellular clockwork underlying inflammation
Researchers have uncovered key cellular functions that help regulate inflammation -- a discovery that could have important implications for the treatment of allergies, heart disease, and certain forms of cancer. The discovery explains how two particular proteins, Tollip and Tom1, work together to contribute to the turnover of cell-surface receptor proteins that trigger inflammation.
Source: ScienceDaily Headlines - August 27, 2015 Category: Science Source Type: news

Helios, and not FoxP3, is the marker of activated Tregs expressing GARP/LAP.
Authors: Elkord E, Abd Al Samid M, Chaudhary B Abstract Regulatory T cells (Tregs) are key players of immune regulation/dysregulation both in physiological and pathophysiological settings. Despite significant advances in understanding Treg function, there is still a pressing need to define reliable and specific markers that can distinguish different Treg subpopulations. Herein we show for the first time that markers of activated Tregs [latency associated peptide (LAP) and glycoprotein A repetitions predominant (GARP, or LRRC32)] are expressed on CD4+FoxP3- T cells expressing Helios (FoxP3-Helios+) in the steady sta...
Source: Oncotarget - September 8, 2015 Category: Cancer & Oncology Tags: Oncotarget Source Type: research