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Cancer Incidence Has Increased in Patients Under Age 50 Cancer Incidence Has Increased in Patients Under Age 50
The results of recent studies call into question the traditional views regarding which cancers are ' typical ' among adults younger than 50 years.Medscape Medical News
Source: Medscape Medical News Headlines - September 22, 2023 Category: Consumer Health News Tags: Hematology-Oncology News Source Type: news
Have Early-Onset Cancer Cases Soared? Not So Fast: Experts Have Early-Onset Cancer Cases Soared? Not So Fast: Experts
A recent study reported that global cancer cases in younger people had increased by almost 80% over the past 30 years. But, experts say, the analysis was deeply flawed.Medscape Medical News
Source: Medscape Hematology-Oncology Headlines - September 22, 2023 Category: Cancer & Oncology Tags: Hematology-Oncology News Source Type: news
High-Risk Polyps at Colonoscopy Linked to Liver Cancer Death High-Risk Polyps at Colonoscopy Linked to Liver Cancer Death
A large retrospective study found a high risk for death from liver and biliary cancer in adults with high-risk polyps detected at screening colonoscopy.Medscape Medical News
Source: Medscape Hematology-Oncology Headlines - September 22, 2023 Category: Cancer & Oncology Tags: Gastroenterology News Source Type: news
Upstate to cut the ribbon on the Upstate Cancer Center at Verona Sept. 26
A highlight of the 30,000 square foot facility is the Varian TrueBeam, a radiotherapy system that helps deliver powerful cancer treatments with pinpoint accuracy.
Source: SUNY Upstate Medical - September 22, 2023 Category: Universities & Medical Training Tags: News Source Type: news
The role of LOXL2 induced by glucose metabolism-activated NF- κB in maintaining drug resistance through EMT and cancer stemness in gemcitabine-resistant PDAC
J Mol Med (Berl). 2023 Sep 22. doi: 10.1007/s00109-023-02369-6. Online ahead of print.ABSTRACTGemcitabine is considered a standard treatment for pancreatic cancer, but developing drug resistance greatly limits the effectiveness of chemotherapy and increases the rate of recurrence. Lysyl oxide-like 2 (LOXL2) is highly expressed in pancreatic cancer and is involved in carcinogenesis and EMT regulation. However, studies on the role of LOXL2 in drug resistance are limited. Here, we investigated the mechanism of LOXL2 induction and the effect of LOXL2 on EMT and CSC in gemcitabine-resistant pancreatic cancer. Glucose metabolism...
Source: Molecular Medicine - September 22, 2023 Category: Molecular Biology Authors: Yun Sun Lee Hyung Sun Kim Hyo Jung Kim Hyeon Woong Kang Da Eun Lee Myeong Jin Kim Woosol Chris Hong Ju Hyun Kim Minsoo Kim Jae-Ho Cheong Joon Seong Park Source Type: research
Interaction between N < sup > 6 < /sup > -methyladenosine modification and the tumor microenvironment in colorectal cancer
Mol Med. 2023 Sep 22;29(1):129. doi: 10.1186/s10020-023-00726-2.ABSTRACTThe incidence and mortality of colorectal cancer (CRC) are rapidly increasing worldwide. Recently, there has been significant attention given to N6-methyladenosine (m6A), the most common mRNA modification, especially for its effects on CRC development. It is important to note that the progression of CRC would be greatly hindered without the tumor microenvironment (TME). The interaction between CRC cells and their surroundings can activate and influence complex signaling mechanisms of epigenetic changes to affect the survival of tumor cells with a malig...
Source: Molecular Medicine - September 22, 2023 Category: Molecular Biology Authors: Jiali Yao Yeke Song Xiaoping Yu Zhijie Lin Source Type: research
The prognostic significance of a negative PSMA-PET scan prior to salvage radiotherapy following radical prostatectomy
CONCLUSION: Favorable bRFS after SRT in patients with BR and negative PSMA-PET following RP was achieved. These data support the usage of early SRT for patients with negative PSMA-PET findings.PMID:37736808 | DOI:10.1007/s00259-023-06438-3
Source: Molecular Medicine - September 22, 2023 Category: Molecular Biology Authors: Sonja Adebahr Alexander Althaus Sophia Scharl Iosif Strouthos Andrea Farolfi Francesca Serani Helena Lanzafame Christian Trapp Stefan A Koerber Jan C Peeken Marco M E Vogel Alexis Vrachimis Simon K B Spohn Anca-Ligia Grosu Stephanie G C Kroeze Matthias Gu Source Type: research
Evaluation of enhanced permeability effect and different linear energy transfer of radionuclides in a prostate cancer xenograft model
In conclusion, we found that specific targeting might negatively influence normal organ uptake when targeting secreted antigens. Furthermore, different energy deposition i.e. linear energy transfer of a radionuclide might have diverse effects on receptor expression and cell proliferation in tumors.PMID:37736493 | PMC:PMC10509292
Source: Molecular Medicine - September 22, 2023 Category: Molecular Biology Authors: Oskar Vilhelmsson Timmermand Marcella Safi Bo Holmqvist Joanna Strand Source Type: research
Initial experience with an electron FLASH research extension (FLEX) for the Clinac system
CONCLUSION: Our studies characterized the non-clinical Clinac-FLEX system as a viable solution to conduct FLASH research that could substantially increase access to ultra-high-dose-rate capabilities for scientists.PMID:37735808 | DOI:10.1002/acm2.14159
Source: Journal of Applied Clinical Medical Physics - September 22, 2023 Category: Physics Authors: Kyuhak Oh Kyle J Gallagher Megan Hyun Diane Schott Sarah Wisnoskie Yu Lei Samuel Hendley Jeffrey Wong Shuo Wang Brendan Graff Christopher Jenkins Frank Rutar Md Ahmed Joshua McNeur Jeffrey Taylor Marty Schmidt Lasitha Senadheera Wendy Smith Donald Umstadt Source Type: research
Cancer-associated fibroblasts express CD1d and activate invariant natural killer T cells under cellular stress
Cell Mol Immunol. 2023 Sep 21. doi: 10.1038/s41423-023-01082-1. Online ahead of print.NO ABSTRACTPMID:37735500 | DOI:10.1038/s41423-023-01082-1
Source: Cellular and Molecular Immunology - September 22, 2023 Category: Molecular Biology Authors: Shengduo Pei Jonas Sj ölund Yueyun Pan Kristian Pietras Mikael C I Karlsson Source Type: research
PARylated PDHE1 α generates acetyl-CoA for local chromatin acetylation and DNA damage repair
Nat Struct Mol Biol. 2023 Sep 21. doi: 10.1038/s41594-023-01107-3. Online ahead of print.ABSTRACTChromatin relaxation is a prerequisite for the DNA repair machinery to access double-strand breaks (DSBs). Local histones around the DSBs then undergo prompt changes in acetylation status, but how the large demands of acetyl-CoA are met is unclear. Here, we report that pyruvate dehydrogenase 1α (PDHE1α) catalyzes pyruvate metabolism to rapidly provide acetyl-CoA in response to DNA damage. We show that PDHE1α is quickly recruited to chromatin in a polyADP-ribosylation-dependent manner, which drives acetyl-CoA generation to su...
Source: Mol Biol Cell - September 22, 2023 Category: Molecular Biology Authors: Jun Zhang Feng Chen Yuan Tian Wenchao Xu Qian Zhu Zhenhai Li Lingyu Qiu Xiaopeng Lu Bin Peng Xiangyu Liu Haiyun Gan Baohua Liu Xingzhi Xu Wei-Guo Zhu Source Type: research
Epigenetic reprogramming of a distal developmental enhancer cluster drives SOX2 overexpression in breast and lung adenocarcinoma
Nucleic Acids Res. 2023 Sep 22:gkad734. doi: 10.1093/nar/gkad734. Online ahead of print.ABSTRACTEnhancer reprogramming has been proposed as a key source of transcriptional dysregulation during tumorigenesis, but the molecular mechanisms underlying this process remain unclear. Here, we identify an enhancer cluster required for normal development that is aberrantly activated in breast and lung adenocarcinoma. Deletion of the SRR124-134 cluster disrupts expression of the SOX2 oncogene, dysregulates genome-wide transcription and chromatin accessibility and reduces the ability of cancer cells to form colonies in vitro. Analysis...
Source: Cell Research - September 22, 2023 Category: Cytology Authors: Luis E Abatti Patricia Lado-Fern ández Linh Huynh Manuel Collado Michael M Hoffman Jennifer A Mitchell Source Type: research
Fructose-induced mTORC1 Activation Promotes Pancreatic Cancer Progression through Inhibition of Autophagy
In this study, we investigated the functional association between fructose utilization and pancreatic ductal adenocarcinoma (PDAC) progression. Fructose could be taken up and metabolized by PDAC cells and provided an adaptive survival mechanism for PDAC cells under glucose deficient conditions. GLUT5-mediated fructose metabolism maintained the survival, proliferation, and invasion capacities of PDAC cells in vivo and in vitro. Fructose metabolism not only provided ATP and biomass to PDAC cells but also conferred metabolic plasticity to the cells, making them more adaptable to the tumor microenvironment. Mechanistically, fr...
Source: Cell Research - September 22, 2023 Category: Cytology Authors: Yanfen Cui Jianfei Tian Zhaosong Wang Hui Guo He Zhang Zhiyong Wang Hui Liu Weijie Song Liming Liu Ruinan Tian Xiaoyan Zuo Sixin Ren Ruifang Niu Fei Zhang Source Type: research
Single-cell and bulk sequencing analyses reveal the immune suppressive role of PTPN6 in glioblastoma
Aging (Albany NY). 2023 Sep 21;15. doi: 10.18632/aging.205052. Online ahead of print.ABSTRACTGlioblastoma (GBM) is a highly malignant brain cancer with a poor prognosis despite standard treatments. This investigation aimed to explore the feasibility of PTPN6 to combat GBM with immunotherapy. Our study employed a comprehensive analysis of publicly available datasets and functional experiments to assess PTPN6 gene expression, prognostic value, and related immune characteristics in glioma. We evaluated the influence of PTPN6 expression on CD8+ T cell exhaustion, immune suppression, and tumor growth in human GBM samples and mo...
Source: Aging - September 22, 2023 Category: Biomedical Science Authors: Xiaonan Zhang Jie Chen Ming Zhang Saisai Liu Tao Wang Tianyu Wu Baiqing Li Shidi Zhao Hongtao Wang Li Li Chun Wang Li Huang Source Type: research
The oncogenic miR-429 promotes triple-negative breast cancer progression by degrading DLC1
In conclusion, our findings reveal the mechanism of tumorigenic miR-429 in TNBC, which paves the way for target therapies translation in clinical settings.PMID:37737712 | DOI:10.18632/aging.205051
Source: Aging - September 22, 2023 Category: Biomedical Science Authors: Yao Li Xue Meng Yuqing Luo Shuai Luo Jin Li Jiafei Zeng Xiang Huang Jinjing Wang Source Type: research
