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Cardiovascular Risks in Testicular Cancer: Assessment, Prevention, and Treatment
AbstractPurpose of ReviewTesticular cancer (TC) is the leading cancer in men between 18 and 39  years of age. Current treatment involves tumor resection followed by surveillance and/or one or more lines of cisplatin-based chemotherapy (CBCT) and/or bone marrow transplant (BMT). Ten years after treatment, CBCT has been associated with significant atherosclerotic cardiovascular disease (CVD) i ncluding myocardial infarction (MI), stroke, and heightened rates of hypertension, dyslipidemia, diabetes mellitus, and metabolic syndrome (MetS). Additionally, low testosterone levels and hypogonadism contribute to MetS and may furth...
Source: Current Oncology Reports - March 3, 2023 Category: Cancer & Oncology Source Type: research

Janssen Data at ASCO GU Support Ambition to Transform Treatment of Prostate and Bladder Cancer Through Precision Medicine and Early Intervention
RARITAN, N.J., February 13, 2023 – The Janssen Pharmaceutical Companies of Johnson & Johnson today announced plans to present more than 20 abstracts featuring seven oncology therapies from its robust portfolio and pipeline at the annual American Society of Clinical Oncology (ASCO) Genitourinary (GU) Cancers Symposium, taking place in San Francisco on February 16-18. Building on more than a decade of leadership in the development of medicines for people diagnosed with GU cancers, Janssen will present data demonstrating its ambition to advance patient-centered treatment through precision medicine, real-world evidence a...
Source: Johnson and Johnson - February 13, 2023 Category: Pharmaceuticals Tags: Latest News Source Type: news

How AI Is Changing Medical Imaging to Improve Patient Care
That doctors can peer into the human body without making a single incision once seemed like a miraculous concept. But medical imaging in radiology has come a long way, and the latest artificial intelligence (AI)-driven techniques are going much further: exploiting the massive computing abilities of AI and machine learning to mine body scans for differences that even the human eye can miss. Imaging in medicine now involves sophisticated ways of analyzing every data point to distinguish disease from health and signal from noise. If the first few decades of radiology were about refining the resolution of the pictures taken of...
Source: TIME: Health - November 4, 2022 Category: Consumer Health News Authors: Alice Park and Video by Andrew D. Johnson Tags: Uncategorized Frontiers of Medicine 2022 healthscienceclimate Innovation sponsorshipblock Source Type: news

Janssen Data at ASCO GU Demonstrate Longstanding Leadership in Prostate Cancer and Commitment to Advancing Potential New Therapeutic Options for Genitourinary Cancers
Raritan, NJ, Feb. 1, 2022 – The Janssen Pharmaceutical Companies of Johnson & Johnson announced today that 17 presentations will be featured at the 2022 American Society of Clinical Oncology Genitourinary (ASCO GU) Cancers Symposium, taking place in San Francisco and virtually from February 17-19. Building on its long-term leadership in prostate cancer, Janssen is committed to advancing innovative treatments and transforming patient experiences, while focusing on research that may drive better outcomes for people across the genitourinary cancer spectrum. Data to be presented include Phase 3 results for the selective ...
Source: Johnson and Johnson - February 1, 2022 Category: Pharmaceuticals Tags: Innovation Source Type: news

Janssen Demonstrates Commitment to Advancing Science and Innovation in the Treatment of Solid Tumors at ESMO Annual Congress
September 8, 2021 (RARITAN, N.J.) – The Janssen Pharmaceutical Companies of Johnson & Johnson announced today that more than ten data presentations from its lung cancer, bladder cancer and prostate cancer portfolio and pipeline will be featured during the European Society for Medical Oncology (ESMO) Annual Congress 2021 virtual meeting, September 16–21. Further details about these data and the science Janssen is advancing will be made available throughout ESMO via the Janssen Oncology Virtual Newsroom.“With a diverse oncology portfolio and pipeline spanning bladder cancer, lung cancer and prostate cancer, Janssen...
Source: Johnson and Johnson - September 8, 2021 Category: Pharmaceuticals Tags: Innovation Source Type: news

Consumer Health: Chemotherapy and heart disease -- is there a connection?
Chemotherapy works by killing rapidly dividing cancer cells. But chemotherapy also can destroy fast-growing healthy cells at the same time. This may cause side effects. Some conventional chemotherapy drugs used to treat cancer also can increase your risk of heart problems later in life, including heart attack, stroke and high blood pressure. Learn more about [...]
Source: News from Mayo Clinic - February 2, 2021 Category: Databases & Libraries Source Type: news

Vitamin C: historical perspectives and heart failure
AbstractVitamin C (Vit C) is an ideal antioxidant as it is easily available, water soluble, very potent, least toxic, regenerates other antioxidants particularly Vit E, and acts as a cofactor for different enzymes. It has received much attention due to its ability in limiting reactive oxygen species, oxidative stress, and nitrosative stress, as well as it helps to maintain some of the normal metabolic functions of the cell. However, over 140 clinical trials using Vit C in different pathological conditions such as myocardial infarction, gastritis, diabetes, hypertension, stroke, and cancer have yielded inconsistent results....
Source: Heart Failure Reviews - October 8, 2020 Category: Cardiology Source Type: research

Black pleural effusion as the presenting feature of lung cancer.
Conclusion: In the present case, the black stain most likely results from intrapleural haemolysis following haemorrhage. Pleural fluid bilirubin may be useful in evaluating pleural effusion, especially if black.
Source: European Respiratory Journal - November 19, 2018 Category: Respiratory Medicine Authors: Fernandes, V., Alfaro, T. M., Cruz, C., Cordeiro, C. R. Tags: Clinical Problems Source Type: research

New Insights from Studies of Clonal Hematopoiesis.
Abstract Clonal hematopoiesis (CH) describes an asymptomatic expansion of blood cells descended from a single hematopoietic stem cell. Recent studies have shown that CH increases in frequency with aging, and is often driven by somatic mutations in genes that are recurrently mutated in hematologic malignancies. When CH is associated with a mutation in a leukemia-associated gene at a variant allele frequency of 0.02 or greater, it is termed "clonal hematopoiesis of indeterminate potential" (CHIP).  CHIP has a 0.5-1% risk per year of progression to hematological neoplasia, and increases both all-cause mortality and ...
Source: Clinical Cancer Research - April 27, 2018 Category: Cancer & Oncology Authors: Gibson CJ, Steensma DP Tags: Clin Cancer Res Source Type: research

New-Onset Cardiovascular Morbidity in Older Adults With Stage I to III Colorectal Cancer.
Conclusion Older patients with colorectal cancer are at increased risk of developing CVD and CHF. Diabetes and hypertension interact with chemotherapy to increase the risk of cardiovascular morbidity. Future studies should assess the potential for personalized therapeutic options for those with preexisting morbidities and for structured monitoring for patients with a history of exposure to chemotherapy regimens, as well as explore the management of preexisting comorbidities to address long-term cardiovascular morbidity. PMID: 29337636 [PubMed - as supplied by publisher]
Source: Clinical Colorectal Cancer - January 16, 2018 Category: Cancer & Oncology Authors: Kenzik KM, Balentine C, Richman J, Kilgore M, Bhatia S, Williams GR Tags: J Clin Oncol Source Type: research

Patty Duke's Death Announcement Is A Milestone For Sepsis Awareness
Oscar-winning actress Patty Duke, star of "The Patty Duke Show" and the Broadway play and film “The Miracle Worker,” died of sepsis from a ruptured intestine on Tuesday. Simple though it may seem, her death announcement is a major milestone for the sepsis awareness movement, said Thomas Heymann, executive director of the Sepsis Alliance. The more people are aware of this condition, Heymann said, the stronger their likelihood of saving their own lives or the lives of their loved ones. "The fact that they said Patty Duke’s cause of death was sepsis is relatively new," Heymann said. "It very often ...
Source: Science - The Huffington Post - March 30, 2016 Category: Science Source Type: news

Acute ischaemic stroke and myocardial infarction after chemotherapy with vinorelbine for non-small cell lung cancer: a case report.
We report about a 70-year-old male with metastatic non-small cell lung cancer who received vinorelbine as an outpatient. The patient presents with a cardiovascular risk profile. He was admitted to the hospital 3 days later with acute left-sided hemiplegia and hemianopia. Brain computed tomography (CT) demonstrated acute right hemispheric ischaemic stroke. Nine days after admission, the patient additionally suffered ST elevation myocardial infarction. A coronary angiogram demonstrated high grade stenosis of the right coronary artery treated with two bare-metal stents. Caution should be noted in patients who present with a c...
Source: Journal of Chemotherapy - November 18, 2015 Category: Cancer & Oncology Tags: J Chemother Source Type: research

Patient preference and decision-making for initiating metastatic colorectal cancer medical treatment.
CONCLUSIONS: Variations in patients' willingness to tolerate different treatment-related adverse events underscore the need for improved communications between physicians and patients about the risks and benefits of their medical treatment, which helps make a more personalized decision for metastatic CRC treatment. PMID: 26577827 [PubMed - as supplied by publisher]
Source: Clinical Colorectal Cancer - November 18, 2015 Category: Cancer & Oncology Authors: Fu AZ, Graves KD, Jensen RE, Marshall JL, Formoso M, Potosky AL Tags: J Cancer Res Clin Oncol Source Type: research

Patient preference and decision-making for initiating metastatic colorectal cancer medical treatment
Conclusions Variations in patients’ willingness to tolerate different treatment-related adverse events underscore the need for improved communications between physicians and patients about the risks and benefits of their medical treatment, which helps make a more personalized decision for metastatic CRC treatment.
Source: Journal of Cancer Research and Clinical Oncology - November 18, 2015 Category: Cancer & Oncology Source Type: research

Kids and flu shots: Two common myths
As a pediatrician, I am really passionate about the flu shot. Influenza can be a nasty illness; every year, thousands of people are hospitalized with influenza and its complications, and some of those people die. The flu shot can protect my patients and their families, and I enthusiastically recommend it to all of them. And yet many of them refuse, despite my best efforts. What is particularly frustrating is that many of them refuse because of misunderstandings about the flu shot. There is all sorts of misinformation out there, but here are the two most common myths: 1. The flu shot can make you sick. This is the one I hea...
Source: New Harvard Health Information - October 9, 2015 Category: Consumer Health News Authors: Claire McCarthy, MD Tags: Cold and Flu Vaccines flu vaccine Source Type: news

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