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Procedure: Lung Transplant

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Total 1013 results found since Jan 2013.

Gut and airway microbiota dysbiosis and their role in COVID-19 and long-COVID
The gut microbiota plays a crucial role in human health and disease. Gut dysbiosis is known to be associated with increased susceptibility to respiratory diseases and modifications in the immune response and homeostasis of the lungs (the so-called gut-lung axis). Furthermore, recent studies have highlighted the possible role of dysbiosis in neurological disturbances, introducing the notion of the “gut-brain axis.” During the last 2 years, several studies have described the presence of gut dysbiosis during coronavirus disease 2019 (COVID-19) and its relationship with disease severity, SARS-CoV-2 gastrointestinal replica...
Source: Frontiers in Immunology - March 8, 2023 Category: Allergy & Immunology Source Type: research

Modeling structure –activity relationships with machine learning to identify GSK3-targeted small molecules as potential COVID-19 therapeutics
Coronaviruses induce severe upper respiratory tract infections, which can spread to the lungs. The nucleocapsid protein (N protein) plays an important role in genome replication, transcription, and virion assembly in SARS-CoV-2, the virus causing COVID-19, and in other coronaviruses. Glycogen synthase kinase 3 (GSK3) activation phosphorylates the viral N protein. To combat COVID-19 and future coronavirus outbreaks, interference with the dependence of N protein on GSK3 may be a viable strategy. Toward this end, this study aimed to construct robust machine learning models to identify GSK3 inhibitors from Food and Drug Admini...
Source: Frontiers in Endocrinology - March 6, 2023 Category: Endocrinology Source Type: research

Current and Emerging Therapies for COVID-19 in Lung Transplantation
AbstractPurpose of ReviewThe landscape of the coronavirus disease 2019 (COVID-19) pandemic has rapidly changed over the past 3 years. Paralleling this evolution, the scientific and medical communities have reported many novel findings relating to the infection ’s epidemiology, transmission, diagnosis, and treatment. We review pertinent studies of COVID-19 therapeutics with an emphasis on their application to lung transplant recipients.Recent FindingsAgents that have been well-studied for treating COVID-19 include antivirals (remdesivir, nirmatrelvir/ritonavir, molnupiravir), monoclonal antibodies, and immunomodulators (f...
Source: Current Respiratory Care Reports - February 16, 2023 Category: Respiratory Medicine Source Type: research

Extracorporeal membrane oxygenation for COVID-19-related acute respiratory distress syndrome: a narrative review
AbstractA growing body of evidence supports the use of extracorporeal membrane oxygenation (ECMO) for severe acute respiratory distress syndrome (ARDS) refractory to maximal medical therapy. ARDS may develop in a proportion of patients hospitalized for coronavirus disease 2019 (COVID-19) and ECMO may be used to manage patients refractory to maximal medical therapy to mitigate the risk of ventilator-induced lung injury and provide lung rest while awaiting recovery. The mortality of COVID-19-related ARDS was variously reassessed during the pandemic. Veno-venous (VV) ECMO was the default choice to manage refractory respirator...
Source: Journal of Intensive Care - February 8, 2023 Category: Intensive Care Source Type: research

The History of Extracorporeal Membrane Oxygenation and the Development of Extracorporeal Membrane Oxygenation Anticoagulation
Semin Thromb Hemost DOI: 10.1055/s-0043-1761488Extracorporeal membrane oxygenation (ECMO) was first started for humans in early 1970s by Robert Bartlett. Since its inception, there have been numerous challenges with extracorporeal circulation, such as coagulation and platelet activation, followed by consumption of coagulation factors and platelets, and biocompatibility of tubing, pump, and oxygenator. Unfractionated heparin (heparin hereafter) has historically been the defacto anticoagulant until recently. Also, coagulation monitoring was mainly based on bedside activated clotting time and activated partial thromboplastin ...
Source: Seminars in Thrombosis and Hemostasis - February 7, 2023 Category: Hematology Authors: Bartlett, Robert Arachichilage, Deepa J. Chitlur, Meera Hui, Shiu-Ki Rocky Neunert, Cindy Doyle, Andrew Retter, Andrew Hunt, Beverley J Lim, Hoong Sern Saini, Arun Renn é, Thomas Kostousov, Vadim Teruya, Jun Tags: Review Article Source Type: research

Fight Aging! Newsletter, January 30th 2023
In conclusion, deletion of p16Ink4a cells did not negatively impact beta-cell mass and blood glucose under basal and HFD conditions and proliferation was restored in a subset of HFD mice opening further therapeutic targets in the treatment of diabetes. Communication Between Blood and Brain in Aging and Rejuvenation https://www.fightaging.org/archives/2023/01/communication-between-blood-and-brain-in-aging-and-rejuvenation/ As noted here, joining the circulatory systems of an old and young mouse results in some degree of rejuvenation in the old mouse. Where brain function is improved, researchers are inter...
Source: Fight Aging! - January 29, 2023 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs

Efficacy of three COVID-19 vaccine doses in lung transplant recipients: a multicentre cohort study
Conclusions Few lung transplant recipients achieved a serological response to three COVID-19 vaccine doses, indicating a need for other protective measures. Older age and use of mycophenolate or corticosteroids were associated with absence of a response. The low incidence of COVID-19 might reflect vaccine protection via cellular immunity and/or good adherence to shielding measures.
Source: European Respiratory Journal - January 19, 2023 Category: Respiratory Medicine Authors: Dauriat, G., Beaumont, L., Luong Nguyen, L. B., Renaud Picard, B., Penhouet, M., Coiffard, B., Salpin, M., Demant, X., Saint Raymond, C., Carlier, N., Messika, J., Reynaud Gaubert, M., Danner, I., Gallais, F., Roux, A., Le Pavec, J. Tags: Respiratory infections and tuberculosis Original Articles: Lung transplantation Source Type: research

Pneumothorax/pneumomediastinum and pre-existing lung pathology in ventilated COVID-19 patients: a cohort study
CONCLUSIONS: Pre-existing lung pathology does not increase the risk of onset of pneumothorax or pneumomediastinum in comparation with previously healthy lungs of ventilated COVID-19 patients.PMID:36647498 | PMC:PMC9840012 | DOI:10.21037/jtd-22-817
Source: Journal of Thoracic Disease - January 17, 2023 Category: Respiratory Medicine Authors: Gabriella Kecskes Albert Szabo David Sutori Peter Maroti Gergely Marovics Tamas F Molnar Source Type: research