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Specialty: Biomedical Science
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Total 5325 results found since Jan 2013.
Overexpression of the nucleocapsid protein of Middle East Respiratory Syndrome coronavirus up-regulates CXCL10.
Abstract
Middle East Respiratory Syndrome coronavirus (MERS-CoV) causes respiratory diseases in humans and has a high mortality rate. During infection, MERS-CoV regulates several host cellular processes including antiviral response genes. In order to determine if the nucleocapsid protein of MERS-CoV (MERS-N) plays a role in viral-host interactions, a murine monoclonal antibody was generated so as to allow detection of the protein in infected cells as well as in overexpression system. Then, MERS-N was stably overexpressed in A549 cells and a PCR array containing 84 genes was used to screen for genes transcriptional...
Source: Bioscience Reports - September 21, 2018 Category: Biomedical Science Authors: Aboagye JO, Yew CW, Ng OW, Monteil VM, Mirazimi A, Tan YJ Tags: Biosci Rep Source Type: research
The First Case of 2019 Novel Coronavirus Pneumonia Imported into Korea from Wuhan, China: Implication for Infection Prevention and Control Measures.
This report suggests that in the early phase of 2019-nCoV pneumonia, chest radiography would miss patients with pneumonia and highlights taking travel history is of paramount importance for early detection and isolation of 2019-nCoV cases.
PMID: 32030925 [PubMed - in process]
Source: Journal of Korean Medical Science - February 8, 2020 Category: Biomedical Science Tags: J Korean Med Sci Source Type: research
Clinical characteristics and therapeutic procedure for four cases with 2019 novel coronavirus pneumonia receiving combined Chinese and Western medicine treatment.
We report here the clinical characteristics and therapeutic procedure for four patients with mild or severe 2019-nCoV pneumonia admitted to Shanghai Public Health Clinical Center. All the patients were given antiviral treatment including lopinavir/ritonavir (Kaletra®), arbidol, and Shufeng Jiedu Capsule (SFJDC, a traditional Chinese medicine) and other necessary support care. After treatment, three patients gained significant improvement in pneumonia associated symptoms, two of whom were confirmed 2019-nCoV negative and discharged, and one of whom was virus negative at the first test. The remaining patient with severe pne...
Source: BioScience Trends - February 12, 2020 Category: Biomedical Science Tags: Biosci Trends Source Type: research
Challenges to the system of reserve medical supplies for public health emergencies: reflections on the outbreak of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) epidemic in China.
Authors: Wang X, Zhang X, He J
Abstract
On December 31, 2019, the Wuhan Municipal Health Commission announced an outbreak of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), China is now at a critical period in the control of the epidemic. The Chinese Government has been taking a series of rapid, comprehensive, and effective prevention and control measures. As the pandemic has developed, a fact has become apparent: there is a serious dearth of emergency medical supplies, and especially an extreme shortage of personal protective equipment such as masks and medical protective clothing. This is one of the...
Source: BioScience Trends - February 20, 2020 Category: Biomedical Science Tags: Biosci Trends Source Type: research
Report on the Epidemiological Features of Coronavirus Disease 2019 (COVID-19) Outbreak in the Republic of Korea from January 19 to March 2, 2020.
This report summarizes the epidemiologic features and the snapshots of the outbreak in the Republic of Korea from January 19 and March 2, 2020.
PMID: 32174069 [PubMed - in process]
Source: Journal of Korean Medical Science - March 18, 2020 Category: Biomedical Science Tags: J Korean Med Sci Source Type: research
Analysis on 54 Mortality Cases of Coronavirus Disease 2019 in the Republic of Korea from January 19 to March 10, 2020.
Authors: Korean Society of Infectious Diseases and Korea Centers for Disease Control and Prevention
Abstract
Since the identification of the first case of coronavirus disease 2019 (COVID-19), the global number of confirmed cases as of March 15, 2020, is 156,400, with total death in 5,833 (3.7%) worldwide. Here, we summarize the morality data from February 19 when the first mortality occurred to 0 am, March 10, 2020, in Korea with comparison to other countries. The overall case fatality rate of COVID-19 in Korea was 0.7% as of 0 am, March 10, 2020.
PMID: 32233161 [PubMed - in process]
Source: Journal of Korean Medical Science - April 2, 2020 Category: Biomedical Science Tags: J Korean Med Sci Source Type: research
Coronavirus COV-19/SARS-CoV-2 affects women less than men: clinical response to viral infection.
Authors: Conti P, Younes A
Abstract
CoV-19/SARS-CoV-2 is a highly pathogenic virus that causes coronavirus-19 disease (COVID-19) an acute respiratory distress syndrome which provokes serious problems for global health. Studies suggest that there are many differences between men and women in the immune response to CoV-19 infection and inflammatory diseases. Women, compared to men, are less susceptible to viral infections based on a different innate immunity, steroid hormones and factors related to sex chromosomes. The presence of two X chromosomes in women emphasize the immune system even if one is inactive. The imm...
Source: Journal of Biological Regulators and Homeostatic Agents - April 8, 2020 Category: Biomedical Science Tags: J Biol Regul Homeost Agents Source Type: research
Predictors for imaging progression on chest CT from coronavirus disease 2019 (COVID-19) patients.
CONCLUSION: Age, MLR, homocysteine and period from onset to admission could predict imaging progression on chest CT from COVID-19 patients.
METHODS: The primary outcome was imaging progression on chest CT. Baseline parameters were collected at the first day of admission. Imaging manifestations on chest CT were followed-up at (6±1) days.
PMID: 32275643 [PubMed - as supplied by publisher]
Source: Aging - April 9, 2020 Category: Biomedical Science Authors: Yang Z, Shi J, He Z, Lü Y, Xu Q, Ye C, Chen S, Tang B, Yin K, Lu Y, Chen X Tags: Aging (Albany NY) Source Type: research
Clinical and immunological features of severe and moderate coronavirus disease 2019
CONCLUSION The SARS-CoV-2 infection may affect primarily T lymphocytes, particularly CD4+ and CD8+ T cells, resulting in a decrease in numbers as well as IFN-γ production by CD4+ T cells. These potential immunological markers may be of importance because of their correlation with disease severity in COVID-19.TRIAL REGISTRATION This is a retrospective observational study without a trial registration number.FUNDING This work is funded by grants from Tongji Hospital for the Pilot Scheme Project, and partly supported by the Chinese National Thirteenth Five Years Project in Science and Technology for Infectious Disease (2017ZX10202201).
Source: Journal of Clinical Investigation - April 14, 2020 Category: Biomedical Science Authors: Guang Chen, Di Wu, Wei Guo, Yong Cao, Da Huang, Hongwu Wang, Tao Wang, Xiaoyun Zhang, Huilong Chen, Haijing Yu, Xiaoping Zhang, Minxia Zhang, Shiji Wu, Jianxin Song, Tao Chen, Meifang Han, Shusheng Li, Xiaoping Luo, Jianping Zhao, Qin Ning Source Type: research
Update on use of chloroquine/hydroxychloroquine to treat coronavirus disease 2019 (COVID-19).
Authors: Gao J, Hu S
Abstract
Drugs that are specifically efficacious against SARS-CoV-2 have yet to be established. Chloroquine and hydroxychloroquine have garnered considerable attention for their potential to treat coronavirus disease 2019 (COVID-19). Increasing evidence obtained from completed clinical studies indicates the prospects for chloroquine/hydroxychloroquine to treat COVID-19. More randomized control clinical studies are warranted to determine the feasibility of these two drugs in treating COVID-19.
PMID: 32281583 [PubMed - as supplied by publisher]
Source: BioScience Trends - April 15, 2020 Category: Biomedical Science Tags: Biosci Trends Source Type: research
Suggestions on surgical treatment during coronavirus disease 2019 (COVID-19) pandemic.
Authors: Zhao Z, Li M, Liu R
Abstract
Coronavirus disease 2019 (COVID-19), caused by SARS-CoV-2 virus, is now generating a global epidemic, leading to a severe public health emergency. Until April 12, 2020 around 1,700,954 confirmed cases and 105,633 deaths have been reported all over the world. The World Health Organization (WHO) has declared COVID-19 as a Public Health Emergency of International Concern. Under this circumstance, surgical activities should be carefully evaluated to avoid excessive occupation of limited medical resources, and to reduce the possibility of hospital infection. China has achieved an in...
Source: BioScience Trends - April 28, 2020 Category: Biomedical Science Tags: Biosci Trends Source Type: research
Typical radiological progression and clinical features of patients with coronavirus disease 2019.
Abstract
We aimed to describe typical radiological features and progression of Coronavirus disease 2019 (COVID-19) patients. We reviewed the chest CT scans, laboratory findings, and clinical records of 66 COVID-19 patients who were admitted to affiliated hospitals of Nanchang university, Nanchang, China, from Jan 21 to Feb 2, 2020. CT was used to evaluate the radiological characteristics of COVID-19 patients. Only 4 patients (4/66, 6%) claimed their exposure to COVID-19 pneumonia patients. The major symptoms were fever (60/66, 91%) and cough (37/66, 56%). The predominant features of lesion were scattered (43/66, 6...
Source: Aging - May 1, 2020 Category: Biomedical Science Authors: Wang M, Guo L, Chen Q, Xia G, Wang B Tags: Aging (Albany NY) Source Type: research
Severe acute respiratory illness surveillance for coronavirus disease 2019, India, 2020.
We describe here the positivity for COVID-19 among SARI patients and their characteristics.
Methods: SARI patients admitted at 41 sentinel sites from February 15, 2020 onwards were tested for COVID-19 by real-time reverse transcription-polymerase chain reaction, targeting E and RdRp genes of SARS-CoV-2. Data were extracted from Virus Research and Diagnostic Laboratory Network for analysis.
Results: A total of 104 (1.8%) of the 5,911 SARI patients tested were positive for COVID-19. These cases were reported from 52 districts in 20 States/Union Territories. The COVID-19 positivity was higher among males and patient...
Source: The Indian Journal of Medical Research - January 31, 2020 Category: Biomedical Science Authors: Gupta N, Praharaj I, Bhatnagar T, Vivian Thangaraj JW, Giri S, Chauhan H, Kulkarni S, Murhekar M, Singh S, Gangakhedkar RR, Bhargava B, ICMR COVID Team Tags: Indian J Med Res Source Type: research
Prudent public health intervention strategies to control the coronavirus disease 2019 transmission in India: A mathematical model-based approach.
The objectives of this study were to find out if it was possible to prevent, or delay, the local outbreaks of COVID-19 through restrictions on travel from abroad and if the virus has already established in-country transmission, to what extent would its impact be mitigated through quarantine of symptomatic patients?
Methods: These questions were addressed in the context of India, using simple mathematical models of infectious disease transmission. While there remained important uncertainties in the natural history of COVID-19, using hypothetical epidemic curves, some key findings were illustrated that appeared insensit...
Source: The Indian Journal of Medical Research - January 31, 2020 Category: Biomedical Science Authors: Mandal S, Bhatnagar T, Arinaminpathy N, Agarwal A, Chowdhury A, Murhekar M, Gangakhedkar RR, Sarkar S Tags: Indian J Med Res Source Type: research
Guidance for building a dedicated health facility to contain the spread of the 2019 novel coronavirus outbreak.
This article describes elements of design of such unit (e.g., space, infection control, waste disposal, safety of healthcare workers, partners to be involved in design and plan) which can be adapted to the context of either a new construction or makeshift construction on top of an existing structure. In view of a potential epidemic of COVID-19, specific requirements to handle it are also given.
PMID: 32362643 [PubMed - in process]
Source: The Indian Journal of Medical Research - January 31, 2020 Category: Biomedical Science Authors: Agarwal A, Nagi N, Chatterjee P, Sarkar S, Mourya D, Sahay RR, Bhatia R Tags: Indian J Med Res Source Type: research
