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Supplements for Coronavirus Probably Won ’t Help, and May Harm
Worried Americans are scrambling to buy wellness products they think will protect against coronavirus. Some may do harm.
Source: NYT Health - March 23, 2020 Category: Consumer Health News Authors: Anahad O ’Connor Tags: Vitamins Quarantines Dietary Supplements and Herbal Remedies Colds Anxiety and Stress Diet and Nutrition Coronavirus (2019-nCoV) Influenza Vitamin D Zinc Sleep Drugstores Herbs Health Foods Melatonin (Hormone) Source Type: news

Keeping Kids Healthy in the Age of Coronavirus: Dr. Greene on The People ’ s Pharmacy
Transcript [00:00:00] Joe Graedon: I’m Joe Graedon. [00:00:01] Terry Graedon: And I’m Terry Graedon. Welcome to this podcast of the People’s Pharmacy. [00:00:06] Joe Graedon: You can find previous podcasts and more information on a range of health topics at PeoplesPharmacy.com.  [00:00:14] How’s your family holding up during the coronavirus pandemic? Isolation can be especially challenging for children. [00:00:22] This is the People’s Pharmacy with Terry and Joe Graedon. [00:00:33] Terry Graedon:  Children appear less susceptible than older adults to serious complications of COVID-19...
Source: Conversations with Dr Greene - April 21, 2020 Category: Child Development Authors: Alan Greene MD Tags: Dr. Greene's Blog COVID COVID-19 Viral Infection Source Type: blogs

Keeping Kids Healthy in the Age of Coronavirus: Dr. Greene on The People s Pharmacy
Transcript [00:00:00] Joe Graedon: I’m Joe Graedon. [00:00:01] Terry Graedon: And I’m Terry Graedon. Welcome to this podcast of the People’s Pharmacy. [00:00:06] Joe Graedon: You can find previous podcasts and more information on a range of health topics at PeoplesPharmacy.com.  [00:00:14] How’s your family holding up during the coronavirus pandemic? Isolation can be especially challenging for children. [00:00:22] This is the People’s Pharmacy with Terry and Joe Graedon. [00:00:33] Terry Graedon:  Children appear less susceptible than older adults to serious complications of COVID-19...
Source: Conversations with Dr Greene - April 21, 2020 Category: Child Development Authors: Alan Greene MD Tags: Dr. Greene's Blog COVID COVID-19 Viral Infection Source Type: blogs

The Popularity of the Dietary Supplements and Functional Foods in The Coronavirus Pandemic Among The Google Users in the USA, UK, Germany, Italy and France.
CONCLUSION: Google Trends can be a beneficial tool for following public interest in identifying outbreak-related misinformation, and scientific studies and statements from authorities and the media play a potential role in driving internet searches. PMID: 33601014 [PubMed - as supplied by publisher]
Source: Complementary Therapies in Medicine - February 15, 2021 Category: Complementary Medicine Authors: Günalan E, Cebioğlu İK, Çonak Ö Tags: Complement Ther Med Source Type: research

The Popularity of the Dietary Supplements and Functional Foods in The Coronavirus Pandemic Among The Google Users in the USA, UK, Germany, Italy and France
CONCLUSION: Google Trends can be a beneficial tool for following public interest in identifying outbreak-related misinformation, and scientific studies and statements from authorities and the media play a potential role in driving internet searches.PMID:33601014 | PMC:PMC7883724 | DOI:10.1016/j.ctim.2021.102682
Source: Complementary Therapies in Medicine - February 18, 2021 Category: Complementary Medicine Authors: Elif G ünalan İrem Kaya Cebioğlu Özge Çonak Source Type: research

Molecules, Vol. 25, Pages 5501: Novel Small-Molecule Scaffolds as Candidates against the SARS Coronavirus 2 Main Protease: A Fragment-Guided in Silico Approach
Rahman The ongoing pandemic caused by the novel coronavirus has been the greatest global health crisis since the Spanish flu pandemic of 1918. Thus far, severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has resulted in over 1 million deaths, and there is no cure or vaccine to date. The recently solved crystal structure of the SARS-CoV-2 main protease has been a major focus for drug-discovery efforts. Here, we present a fragment-guided approach using ZINCPharmer, where 17 active fragments known to bind to the catalytic centre of the SARS-CoV-2 main protease (SARS-CoV-2 Mpro) were used as pharmacophore querie...
Source: Molecules - November 24, 2020 Category: Chemistry Authors: Teresa L. Augustin Roxanna Hajbabaie Matthew T. Harper Taufiq Rahman Tags: Article Source Type: research

Donald Trump receiving Covid-19 treatment yet to be peer-reviewed
President ’s doctor reveals treatment with experimental antibody cocktail REGN-COV2Coronavirus – latest updatesSee all our coronavirus coverageDonald Trump is being treated with an experimental antibody drug that has shown promising initial early results but has yet to be peer-reviewed. According to statement from his doctor, the president has received a single eight-gram dose of anantibody cocktail called REGN-COV2– a combination of two human neutralising antibodies against the virus.The treatment was developed by Regeneron Pharmaceuticals, which previously developed a similar antibody drug against Ebola. He is also...
Source: Guardian Unlimited Science - October 2, 2020 Category: Science Authors: Melissa Davey, Ian Sample and agencies Tags: Donald Trump Coronavirus outbreak US news Infectious diseases Microbiology Medical research Science Source Type: news

Association Between Low Zinc Levels and Severity of Acute Respiratory Distress Syndrome by New Coronavirus (SARS-CoV-2).
CONCLUSION: Critically ill patients infected by SARS-CoV-2 with severe ARDS have a high prevalence of low serum zinc levels. PMID: 33368619 [PubMed - as supplied by publisher]
Source: Nutrition in Clinical Practice - December 23, 2020 Category: Nutrition Authors: Gonçalves TJM, Gonçalves SEAB, Guarnieri A, Risegato RC, Guimarães MP, de Freitas DC, Razuk-Filho A, Junior PBB, Parrillo EF Tags: Nutr Clin Pract Source Type: research

Viruses, Vol. 14, Pages 1053: Infectivity and Morphology of Bovine Coronavirus Inactivated In Vitro by Cationic Photosensitizers
Strakhovskaya Bovine coronaviruses (BCoVs), which cause gastrointestinal and respiratory diseases in cattle, and are genetically related to the human coronavirus HCoV-OC43, which is responsible for up to 10% of common colds, attract increased attention. We applied the method of photodynamic inactivation with cationic photosensitizers (PSs) to reduce the titers of BCoV and studied the morphological structure of viral particles under various modes of photodynamic exposure. The samples of virus containing liquid with an initial virus titer of 5 Log10 TCID50/mL were incubated with methylene blue (MB) or octakis(cholinyl)zi...
Source: Viruses - May 15, 2022 Category: Virology Authors: Vladimir Zhukhovitsky Natalia Shevlyagina Margarita Zubasheva Leonid Russu Vladimir Gushchin Gennady Meerovich Marina Strakhovskaya Tags: Article Source Type: research

A randomized controlled trial of combined ivermectin and zinc sulfate versus combined hydroxychloroquine, darunavir/ritonavir, and zinc sulfate among adult patients with asymptomatic or mild coronavirus-19 infection
Conclusion: We demonstrated that both treatment regimens were safe, but both treatment regimens had no virological or clinical benefit. Based on this result and current data, there is no supporting evidence for the clinical benefit of ivermectin for coronavirus-19.
Source: Journal of Global Infectious Diseases - June 29, 2022 Category: Infectious Diseases Authors: Sireethorn Nimitvilai Yupin Suputtamongkol Ussanee Poolvivatchaikarn Dechatorn Rassamekulthana Nuttawut Rongkiettechakorn Anek Mungaomklang Susan Assanasaen Ekkarat Wongsawat Chompunuch Boonarkart Waritta Sawaengdee Source Type: research

Molecules, Vol. 28, Pages 988: Coronavirus Inhibitors Targeting nsp16
mas Efferth During the past three decades, humans have been confronted with different new coronavirus outbreaks. Since the end of the year 2019, COVID-19 threatens the world as a rapidly spreading infectious disease. For this work, we targeted the non-structural protein 16 (nsp16) as a key protein of SARS-CoV-2, SARS-CoV-1 and MERS-CoV to develop broad-spectrum inhibitors of nsp16. Computational methods were used to filter candidates from a natural product-based library of 224,205 compounds obtained from the ZINC database. The binding of the candidates to nsp16 was assessed using virtual screening with VINA LC, and mol...
Source: Molecules - January 18, 2023 Category: Chemistry Authors: Ejlal A. Omer Sara Abdelfatah Max Riedl Christian Meesters Andreas Hildebrandt Thomas Efferth Tags: Article Source Type: research

The eye as the discrete but defensible portal of coronavirus infection.
Abstract Oculo-centric factors may provide a key to understanding invasion success by SARS-CoV-2, a highly contagious, potentially lethal, virus with ocular tropism. Respiratory infection transmission via the eye and lacrimal-nasal pathway elucidated during the 1918 influenza pandemic, remains to be explored in this crisis. The eye and its adnexae represent a large surface area directly exposed to airborne viral particles and hand contact. The virus may bind to corneal and conjunctival angiotensin converting enzyme 2 (ACE2) receptors and potentially to the lipophilic periocular skin and superficial tear film with ...
Source: The Ocular Surface - May 20, 2020 Category: Opthalmology Authors: Theodore Coroneo M Tags: Ocul Surf Source Type: research

Gold Metallodrugs to Target Coronavirus Proteins : Inhibitory Effects on the Spike-ACE2 Interaction and on PLpro Protease Activity by Auranofin and Gold Organometallics.
Abstract Gold complexes have a long tradition in medicine and for many examples antirheumatic, anticancer or anti-infective effects have been confirmed. Here we evaluated the lead compound Auranofin and five selected gold organometallics as inhibitors of two relevant drug targets of severe acute respiratory syndrome coronaviruses (SARS-CoV). The gold metallodrugs were effective inhibitors of the interaction of the SARS-CoV-2 spike protein with the angiotensin converting enzyme 2 (ACE2) host receptor and might thus interfere with the viral entry process. The gold metallodrugs were also efficient inhibitors of the p...
Source: Chemistry - September 10, 2020 Category: Chemistry Authors: Gil-Moles M, Basu U, Büssing R, Hoffmeister H, Türck S, Varchmin A, Ott I Tags: Chemistry Source Type: research

The coronavirus disease (COVID-19) - A supportive approach with selected micronutrients.
Authors: Gröber U, Holick MF Abstract Worldwide the pandemic of COVID-19 spreads rapidly and has had an enormous public health impact with substantial morbidity and mortality especially in high-risk groups, such as older people and patients with comorbidities like diabetes, dementia or cancer. In the absence of a vaccine against COVID-19 there is an urgent need to find supportive therapies that can stabilize the immune system and can help to deal with the infection, especially for vulnerable groups such as the elderly. This is especially relevant for our geriatric institutions and nursing homes. A major potential...
Source: International Journal for Vitamin and Nutrition Research - January 27, 2021 Category: Nutrition Tags: Int J Vitam Nutr Res Source Type: research

Don't be fooled: Covid won't be cured by a panacea | Philip Ball
‘Cure-alls’ such as vitamin D and ivermectin seem appealing. But the truth is, specific diseases demand specific medicinesIf the coronavirus had struck in the middle ages, there would have been a cure. You could have got it at all good apothecaries, though not cheaply. It was calledtheriac, and it also cured epilepsy, indigestion, heart trouble and swellings and fevers of all kinds. The recipes were often secret but were said to include the roasted flesh of vipers – it was the original snake-oil remedy. Sugar may have been a common ingredient, too, as the name is the root of the English “treacle”.Theriac dates ba...
Source: Guardian Unlimited Science - March 26, 2021 Category: Science Authors: Philip Ball Tags: Coronavirus Science Infectious diseases Medical research Microbiology UK news Source Type: news