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Immunogenicity and protective potential of chimeric virus-like particles containing SARS-CoV-2 spike and H5N1 matrix 1 proteins
This study designed and prepared four kinds of virus-like particles (VLPs) using an insect expression system. Two constructs encoded wild-type SARS-CoV-2 spike (S) fused with or without H5N1 matrix 1 (M1) (S and SM). The other two constructs contained a codon-optimized spike gene and/or M1 gene (mS and mSM) based on protein expression, stability, and ADE avoidance. The results showed that the VLP-based vaccine could induce high SARS-CoV-2 specific antibodies in mice, including specific IgG, IgG1, and IgG2a. Moreover, the mSM group has the most robust ability to stimulate humoral immunity and cellular immunity than the othe...
Source: Frontiers in cellular and infection microbiology - July 18, 2022 Category: Microbiology Source Type: research

Bicycle industry as a post-pandemic green recovery driver in an emerging economy: a SWOT analysis
Environ Sci Pollut Res Int. 2022 Jul 16. doi: 10.1007/s11356-022-21985-2. Online ahead of print.ABSTRACTThe COVID-19 pandemic has exposed socioeconomic vulnerabilities around the world. After fighting the coronavirus for more than 1 and a half years now, the countries are recovering from the epidemic with the help of cutting-edge medical research. The policymakers are implementing stimulus packages for post-pandemic economic recovery. However, sustainable "green recovery" plans are yet to get adequate attention. Sustainable investment in green industries can create green jobs, promote a low-carbon economy, and foster long-...
Source: Environmental Science and Pollution Research International - July 16, 2022 Category: Environmental Health Authors: Md Doulotuzzaman Xames Jannatul Shefa Ferdous Sarwar Source Type: research

Viruses, Vol. 14, Pages 1553: Think Like a Virus: Toward Improving Nanovaccine Development Against SARS-CoV-2
Luisa Zupin There is no doubt that infectious diseases present global impact on the economy, society, health, mental state, and even political aspects, causing a long-lasting dent, and the situation will surely worsen if and when the viral spread becomes out of control, as seen during the still ongoing coronavirus disease 2019 (COVID-19) pandemic. Despite the considerable achievements made in viral prevention and treatment, there are still significant challenges that can be overcome through careful understanding of the viral mechanism of action to establish common ground for innovating new preventative and treatment st...
Source: Viruses - July 15, 2022 Category: Virology Authors: Nura A. Mohamed Haissam Abou-Saleh Hana A. Mohamed Mohammad A. Al-Ghouti Sergio Crovella Luisa Zupin Tags: Review Source Type: research

COVID-19 vaccines and treatments helped save millions of lives and billions in health care costs
As the world braves year three of the COVID-19 pandemic and confronts a virus that continues to evolve and challenge us, we ’ve come a long way in how we combat this ongoing threat. Since the start of this pandemic, vaccine manufacturers have produced more than 14 billion COVID-19 vaccine doses and built capacity to vaccinate everyone in the world. That’s quite the feat considering where we started – at zero – ju st over two years ago. These innovations have also resulted in greater efficiencies within the health care system – benefiting our economy through billions in cost savings.
Source: The Catalyst - July 7, 2022 Category: Pharmaceuticals Authors: John Corea Tags: Research and Development Economic Impact Coronavirus Source Type: news

Genes, Vol. 13, Pages 1210: Drug-Target Network Study Reveals the Core Target-Protein Interactions of Various COVID-19 Treatments
Kim Guo Zhao The coronavirus disease 2019 (COVID-19) pandemic has caused a dramatic loss of human life and devastated the worldwide economy. Numerous efforts have been made to mitigate COVID-19 symptoms and reduce the death rate. We conducted literature mining of more than 250 thousand published works and curated the 174 most widely used COVID-19 medications. Overlaid with the human protein–protein interaction (PPI) network, we used Steiner tree analysis to extract a core subnetwork that grew from the pharmacological targets of ten credible drugs ascertained by the CTD database. The resultant core...
Source: Genes - July 6, 2022 Category: Genetics & Stem Cells Authors: Dai Yu Yan Li Liu Liu Jiang Kim Guo Zhao Tags: Article Source Type: research

BioAutoML: automated feature engineering and metalearning to predict noncoding RNAs in bacteria
Brief Bioinform. 2022 Jun 27:bbac218. doi: 10.1093/bib/bbac218. Online ahead of print.ABSTRACTRecent technological advances have led to an exponential expansion of biological sequence data and extraction of meaningful information through Machine Learning (ML) algorithms. This knowledge has improved the understanding of mechanisms related to several fatal diseases, e.g. Cancer and coronavirus disease 2019, helping to develop innovative solutions, such as CRISPR-based gene editing, coronavirus vaccine and precision medicine. These advances benefit our society and economy, directly impacting people's lives in various areas, s...
Source: Briefings in Bioinformatics - June 26, 2022 Category: Bioinformatics Authors: Robson P Bonidia Anderson P Avila Santos Breno L S de Almeida Peter F Stadler Ulisses N da Rocha Danilo S Sanches Andr é C P L F de Carvalho Source Type: research

EE188 COVID-19 Vaccine Hesitancy Among Early Adaptors in Jordan
The current coronavirus pandemic (COVID-19) is having an impact on global health and economy. Over 37 million confirmed cases and 1 million fatalities have been registered globally shorlty before the COVID-19 vaccine was authorized for emergency use. The purpose of this study was to determine people's willingness to pay (WTP) for a COVID-19 vaccination in Jordan, as well as the impact of vaccine properties (safety and efficacy) on this assessment.
Source: Value in Health - June 26, 2022 Category: International Medicine & Public Health Authors: S Muflih Source Type: research

The Impact of COVID-19 Pandemic on Seafood Safety and Human Health
This article focused on the effects of COVID-19 pandemic on potential safety issues with seafood products and their processing methods. Moreover, the potential impacts of coronavirus transmission through seafood on human health were evaluated. The role of authenticity, traceability, and antimicrobials from natural sources to preserve seafood and the possible interaction of functional foods on the human immune system are also discussed. Although seafood is not considered a principal vector of SARS-CoV-2 transmission, the possible infections through contaminated surfaces of such food products cannot be neglected. The positiv...
Source: Frontiers in Microbiology - June 22, 2022 Category: Microbiology Source Type: research

Food insecurity and health outcomes during the coronavirus pandemic in South Africa: a longitudinal study
ConclusionsThese results show the enormity of the hunger problem in South Africa and its adverse effects on health. In the face of economic uncertainty and the removal of COVID-19 palliatives like the grant top-ups, we enjoin policy makers to protect the vulnerable from food insecurity by continuing the implementation of anti-hunger policies and other measures that enhance food security in the country.
Source: Health Economics Review - June 20, 2022 Category: International Medicine & Public Health Source Type: research

Decontamination Assessment of Nanofiber-based N95 Masks
Environ Sci Pollut Res Int. 2022 Jun 18. doi: 10.1007/s11356-022-20903-w. Online ahead of print.ABSTRACTAs the world battles with the outbreak of the novel coronavirus, it also prepares for future global pandemics that threaten our health, economy, and survivor. During the outbreak, it became evident that use of personal protective equipment (PPE), specially face masks, can significantly slow the otherwise uncontrolled spread of the virus. Nevertheless, the outbreak and its new variants have caused shortage of PPE in many regions of the world. In addition, waste management of the enormous economical and environmental footp...
Source: Environmental Science and Pollution Research International - June 18, 2022 Category: Environmental Health Authors: Raheleh Faridi-Majidi Faezeh Norouz Safieh Boroumand Seyed Nasrollah Tabatabaei Reza Faridi-Majidi Source Type: research

Clinical and Genetic Characteristics of Coronaviruses with Particular Emphasis on SARS-CoV-2 Virus
Pol J Microbiol. 2022 Jun 19;71(2):141-159. doi: 10.33073/pjm-2022-022.ABSTRACTThe rapidly spreading Coronavirus Disease 2019 (COVID-19) pandemic has led to a global health crisis and has left a deep mark on society, culture, and the global economy. Despite considerable efforts made to contain the disease, SARS-CoV-2 still poses a threat on a global scale. The current epidemiological situation caused an urgent need to understand the basic mechanisms of the virus transmission and COVID-19 severe course. This review summarizes current knowledge on clinical courses, diagnostics, treatment, and prevention of COVID-19. Moreover...
Source: Polish Journal of Microbiology - June 18, 2022 Category: Microbiology Authors: Joanna Iwanicka Tomasz Iwanicki Marcin Kaczmarczyk W łodzimierz Mazur Source Type: research

Decontamination Assessment of Nanofiber-based N95 Masks
Environ Sci Pollut Res Int. 2022 Jun 18. doi: 10.1007/s11356-022-20903-w. Online ahead of print.ABSTRACTAs the world battles with the outbreak of the novel coronavirus, it also prepares for future global pandemics that threaten our health, economy, and survivor. During the outbreak, it became evident that use of personal protective equipment (PPE), specially face masks, can significantly slow the otherwise uncontrolled spread of the virus. Nevertheless, the outbreak and its new variants have caused shortage of PPE in many regions of the world. In addition, waste management of the enormous economical and environmental footp...
Source: Environmental Science and Pollution Research International - June 18, 2022 Category: Environmental Health Authors: Raheleh Faridi-Majidi Faezeh Norouz Safieh Boroumand Seyed Nasrollah Tabatabaei Reza Faridi-Majidi Source Type: research