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Specialty: Biomedical Science
Condition: SARS
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Total 2718 results found since Jan 2013.
SARS-CoV-2 egress from Vero cells: a morphological approach
This study aimed to shed light on the morphological features of SARS-CoV-2 egress by utilizing transmission and high-resolution scanning electron microscopy, along with serial electron tomography, to describe the route of nascent virions towards the extracellular medium. Electron microscopy revealed that the clusters of viruses in the paracellular space did not seem to result from collective virus release. Instead, virus accumulation was observed on incurved areas of the cell surface, with egress primarily occurring through individual vesicles. Additionally, our findings showed that the emission of long membrane projection...
Source: Histochemistry and Cell Biology - September 22, 2023 Category: Biomedical Science Source Type: research
Nanoparticles: a breakthrough in COVID-19 prevention, diagnosis and treatment
Arch Med Sci. 2021 Oct 15;19(5):1410-1420. doi: 10.5114/aoms/142103. eCollection 2023.ABSTRACTCoronavirus disease 2019 (COVID-19) is an infectious disease caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), declared a global pandemic by the World Health Organization (WHO). The three key principles in management of the COVID-19 pandemic are prevention, early detection and targeted treatment. Vaccine-based prevention together with early detection has already proven its efficacy in controlling the pandemic. Early detection of infected patients could substantially accelerate the implementation of treatment,...
Source: Archives of Medical Science - September 21, 2023 Category: Biomedical Science Authors: Aleksandra Skwarek Aleksandra G ąsecka Mi łosz J Jaguszewski Łukasz Szarpak Tomasz Dzieci ątkowski Krzysztof J Filipiak Source Type: research
Reduction of lymphocyte count at early stage elevates severity and death risk of COVID-19 patients: a hospital-based case-cohort study
CONCLUSIONS: Older COVID-19 patients are more susceptible to lymphopenia. Multiple organ injuries were more serious in COVID-19 patients with lymphopenia. Lymphopenia at an early stage aggravates the severity and elevates the death risk of COVID-19 patients.PMID:37732034 | PMC:PMC10507779 | DOI:10.5114/aoms.2020.99006
Source: Archives of Medical Science - September 21, 2023 Category: Biomedical Science Authors: Jun Fei Lin Fu Ying Li Hui-Xian Xiang Ying Xiang Meng-Die Li Fang-Fang Liu De-Xiang Xu Hui Zhao Source Type: research
Bioactive lipid-based therapeutic approach to COVID-19 and other similar infections
Arch Med Sci. 2021 Apr 23;19(5):1327-1359. doi: 10.5114/aoms/135703. eCollection 2023.ABSTRACTCOVID-19 is caused by SARS-CoV-2 infection. Epithelial and T, NK, and other immunocytes release bioactive lipids especially arachidonic acid (AA) in response to microbial infections to inactivate them and upregulate the immune system. COVID-19 (coronavirus) and other enveloped viruses including severe acute respiratory syndrome (SARS-CoV-1 of 2002-2003) and Middle East respiratory syndrome (MERS; 2012-ongoing) and hepatitis B and C (HBV and HCV) can be inactivated by AA, γ-linolenic acid (GLA, dihomo-GLA (DGLA), eicosapentaenoic ...
Source: Archives of Medical Science - September 21, 2023 Category: Biomedical Science Authors: Undurti N Das Source Type: research
Clinical Utility of Sero-Immunological Responses Against SARS-CoV-2 Nucleocapsid Protein During Subsequent Prevalence of Wild-Type, Delta Variant, and Omicron Variant
In conclusion, nucleocapsid antibody provides instructive clues about the immunogenicity of nucleocapsid proteins by different seroconversion rates and titers according to the severity of infection, host immune status, and different variants of concern.PMID:37724496 | PMC:PMC10506902 | DOI:10.3346/jkms.2023.38.e292
Source: Journal of Korean Medical Science - September 19, 2023 Category: Biomedical Science Authors: Beomki Lee Jae-Hoon Ko Jin Yang Baek Haein Kim Kyungmin Huh Sun Young Cho Cheol-In Kang Doo Ryeon Chung Kyong Ran Peck Eun-Suk Kang Source Type: research
Animal efficacy study of a plant extract complex (BEN815) as a potential treatment for COVID-19
by Moon Ho Do, Hua Li, Su Yeon Cho, Subin Oh, Ju Hwan Jeong, Min-Suk Song, Jong-Moon Jeong
In a short time, several types of injectable and oral therapeutics have been developed and used to effectively manage patients with coronavirus disease 2019 (COVID-19). BEN815 is an improved mixture of three extracts (Psidium guajava,Camellia sinensis, andRosa hybrida) recognized by the Ministry of Food and Drug Safety of Korea as a health food ingredient that alleviates allergic rhinitis. The current animal efficacy study was performed to assess its probability of improving COVID-19 symptoms. BEN815 treatment significantly increase...
Source: PLoS One - September 14, 2023 Category: Biomedical Science Authors: Moon Ho Do Source Type: research
Optimal age-specific vaccination control for COVID-19: An Irish case study
by Eleni Zavrakli, Andrew Parnell, David Malone, Ken Duffy, Subhrakanti Dey
The outbreak of a novel coronavirus causing severe acute respiratory syndrome in December 2019 has escalated into a worldwide pandemic. In this work, we propose a compartmental model to describe the dynamics of transmission of infection and use it to obtain the optimal vaccination control. The mod el accounts for the various stages of the vaccination, and the optimisation is focused on minimising the infections to protect the population and relieve the healthcare system. As a case study, we selected the Republic of Ireland. We use data provided by...
Source: PLoS One - September 5, 2023 Category: Biomedical Science Authors: Eleni Zavrakli Source Type: research
15-lipoxygenase and cyclooxygenase expression profile and their related modulators in COVID-19 infection
After the outbreak of COVID-19 infection, the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection led to disability, hospitalization and death of a large number of people around the world [1]. This virus belongs to the Coronaviridae family that is a single-stranded RNA virus (positive-sense) and causes the spectrum of clinical manifestations in infected patients ranging from fever, cough, chest and body pain, myalgia, dyspnea, headache to mortality [2]. Adult male and elderly are more vulnerable to the disease, and cardiac, diabetic, and metabolic diseases are considered as main risk factors for this infection [3].
Source: Prostaglandins, Leukotrienes and Essential Fatty Acids - September 3, 2023 Category: Biomedical Science Authors: Sara Kianfar, Vahid Salimi, Alireza Jahangirifard, Seyed Bashir Mirtajani, Mohammad Amin Vaezi, Jila Yavarian, Talat Mokhtari-Azad, Masoumeh Tavakoli-Yaraki Tags: Original research article Source Type: research
Pulmonary embolism in COVID-19 pneumonia patients admitted to temporary hospital - The follow-up study
CONCLUSIONS: Ongoing SARS-CoV-2 infection along with massive involvement of lung tissue and concomitant thrombi in pulmonary arteries are challenging for physicians. It seems that simple D-dimer concentration assessment at admission may be a helpful tool not only to predict PE but also to estimate the long-term prognosis.PMID:37633116 | DOI:10.1016/j.advms.2023.08.002
Source: Advances in Medical Sciences - August 26, 2023 Category: Biomedical Science Authors: Tomasz Lewczuk Remigiusz Kazimierczyk Bozena Sobkowicz Anna Lisowska Source Type: research
Regulation of coronavirus nsp15 cleavage specificity by RNA structure
In this study we investigate the role of RNA secondary structure in SARS-CoV-2 nsp15 endonuclease activity. Using a series ofin vitro endonuclease assays, we observed that thermodynamically stable RNA structures were protected from nsp15 cleavage relative to RNAs lacking stable structure. We leveraged the s2m RNA from the SARS-CoV-1 3 ’UTR as a model for our structural studies as it adopts a well-defined structure with several uridines, two of which are unpaired and thus highly probable targets for nsp15 cleavage. We found that SARS-CoV-2 nsp15 specifically cleaves s2m at the unpaired uridine within the GNRNA pentaloop o...
Source: PLoS One - August 24, 2023 Category: Biomedical Science Authors: Indraneel Salukhe Source Type: research
Single-cell RNA sequencing and multiple bioinformatics methods to identify the immunity and ferroptosis related biomarkers of SARS-CoV-2 infections to ischemic stroke
CONCLUSION: We believe these genes (B4GALT5, CRISPLD2, F5, ACSL1, CREB5) may regulate the immune response and ferroptosis of multiple immune cells, mainly including monocytes, which may contribute to the development of COVID-19-related IS. In addition, these genes may be potential targets for the treatment of COVID-19-related IS.PMID:37606960 | DOI:10.18632/aging.204966
Source: Aging - August 22, 2023 Category: Biomedical Science Authors: Xiang Zhao Qingyu Liang Hao Li Zhitao Jing Dongmei Pei Source Type: research
Nanograms of SARS-CoV-2 spike protein delivered by exosomes induce potent neutralization of both delta and omicron variants
by Mafalda Cacciottolo, Yujia Li, Justin B. Nice, Michael J. LeClaire, Ryan Twaddle, Ciana L. Mora, Stephanie Y. Adachi, Meredith Young, Jenna Angeles, Kristi Elliott, Minghao Sun
Exosomes are emerging as potent and safe delivery carriers for use in vaccinology and therapeutics. A better vaccine for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is needed to provide improved, broader, longer lasting neutralization of SARS-CoV-2, a more robust T cell response, enable widespread global usage, and further enhance the safety profile of vaccines given the likelihood of repeated booster vaccinations. Here, we use ...
Source: PLoS One - August 22, 2023 Category: Biomedical Science Authors: Mafalda Cacciottolo Source Type: research
