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Challenges faced by patients with mast cell disorders
As an allergist/immunologist, the spectrum of mast cell disorders, including mastocytosis, idiopathic anaphylaxis, chronic hives, and angioedema, is not a new concept. That said, in recent years, we have seen an uptick in patients presenting with a spectrum of symptoms attributed to misbehaving mast cells. Although the medical community has acquired extensive knowledge of these Read more… Challenges faced by patients with mast cell disorders originally appeared in KevinMD.com. (Source: Kevin, M.D. - Medical Weblog)
Source: Kevin, M.D. - Medical Weblog - October 15, 2023 Category: General Medicine Authors: Tags: Conditions Rheumatology Source Type: blogs

Fight Aging! Newsletter, October 16th 2023
In conclusion, a number of studies have shown that CD4+ Treg cells are crucial in the maintenance of peripheral tolerance and have an important role in the control of atherosclerosis-related inflammation. Therefore, Treg cells are a promising target of major research efforts focused on immune-modulating therapies against atherosclerosis. Developing anti-atherosclerotic Treg-based therapies faces challenges. However, rapid progress in genetic, epigenetic, and molecular aspects of cellular immunology gives hope for a fast-track solution. « Back to Top Delivering Senolytic Nanoparticles to Atheroscle...
Source: Fight Aging! - October 15, 2023 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs

Towards More Selective Ways to Block Unwanted Inflammation
Control of chronic inflammation may turn out to be one of the more important themes in the treatment of aging as a medical condition. Senescent cells generate inflammatory signaling, but removing that contribution is likely the easiest aspect of the problem. Many forms of age-related cellular damage and dysfunction generate constant, unwanted, excess inflammation through interactions and signals that are used during a normal, desirable inflammatory reaction, such as to injury or infection. Thus interfering in these mechanisms must be very selective; simply blockading a given signal has undesirable side-effects, such as a w...
Source: Fight Aging! - October 13, 2023 Category: Research Authors: Reason Tags: Daily News Source Type: blogs

Navigating grief: a doctor ’ s personal journey [PODCAST]
Subscribe to The Podcast by KevinMD. Catch up on old episodes! Join Humeira Badsha, a rheumatologist, as she shares her recent, unexpected journey through grief, offering profound insights into the emotional challenges faced by medical professionals. From a tearful moment of vulnerability with a patient to the traumatic experience of watching her beloved mother in Read more… Navigating grief: a doctor’s personal journey [PODCAST] originally appeared in KevinMD.com. (Source: Kevin, M.D. - Medical Weblog)
Source: Kevin, M.D. - Medical Weblog - October 8, 2023 Category: General Medicine Authors: Tags: Podcast Critical Care Rheumatology Source Type: blogs

Everyday dangers unknowingly impacting our health
When we think of symptoms or ailments, they are often a signal to us that there’s something off with our health. Yet, many of us, as well as doctors, often don’t think so much outside the traditional box when it comes to what may be influencing or causing these health issues. I have even experienced Read more… Everyday dangers unknowingly impacting our health originally appeared in KevinMD.com. (Source: Kevin, M.D. - Medical Weblog)
Source: Kevin, M.D. - Medical Weblog - October 1, 2023 Category: General Medicine Authors: Tags: Conditions Rheumatology Source Type: blogs

Fight Aging! Newsletter, September 25th 2023
In conclusion, this individual patient data meta-analysis of longitudinal cohort studies found that antihypertensive use was associated with decreased dementia risk compared with individuals with untreated hypertension through all ages in late life. Individuals with treated hypertension had no increased risk of dementia compared with healthy controls. « Back to Top Results from Human Clinical Trials Do Not Support Metformin as a Longevity Drug https://www.fightaging.org/archives/2023/09/results-from-human-clinical-trials-do-not-support-metformin-as-a-longevity-drug/ The SENS Research Fou...
Source: Fight Aging! - September 24, 2023 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs

Different Invasive Bacterial Species are Found in Alzheimer's Brains versus Normal Brains
Research into the effects of the human microbiome on health and aging has progressed quite rapidly in recent years. It now costs little to sequence a sample to determine the which bacterial species are present and in what proportions. With age, the intestinal barrier, blood vessels, and blood-brain barrier begin to leak, allowing greater passage of microbes into the body. Additionally, the immune system declines in function, reducing the ability to clear these microbes from tissues. In the case of patients with Alzheimer's disease, researchers are finding that the gut microbiome exhibits characteristic differences w...
Source: Fight Aging! - September 20, 2023 Category: Research Authors: Reason Tags: Daily News Source Type: blogs

Navigating chronic diseases and menopause: healthier habits for aging
An excerpt from The Menopause Menu. Whether it’s heart disease or cognitive decline, arthritis or diabetes, getting older is linked to an increased incidence of many different chronic diseases. The menopausal journey adds an extra layer of health risks to some of them but is also an opportunity to fine-tune healthy living goals in a Read more… Navigating chronic diseases and menopause: healthier habits for aging originally appeared in KevinMD.com. (Source: Kevin, M.D. - Medical Weblog)
Source: Kevin, M.D. - Medical Weblog - September 12, 2023 Category: General Medicine Authors: Tags: Conditions OB/GYN Rheumatology Source Type: blogs

Challenges of prolonging hospital stays
In a recent article in the New England Journal of Medicine, a rheumatologist at a teaching hospital lamented about “hospital problems,” a phenomenon where patients are not allowed to stay in the hospital when they no longer have a medical necessity for hospital care, even though the physician may want to keep the patient longer Read more… Challenges of prolonging hospital stays originally appeared in KevinMD.com. (Source: Kevin, M.D. - Medical Weblog)
Source: Kevin, M.D. - Medical Weblog - September 11, 2023 Category: General Medicine Authors: Tags: Physician Hospital-Based Medicine Source Type: blogs

Medical gaslighting: a growing challenge in today ’ s medical landscape
Chances are, you or someone you know has fallen victim to medical gaslighting at some point, especially as we see an increase in this unfortunate practice in today’s modern health care system. Maybe you have experienced medical gaslighting without even realizing it. What exactly is medical gaslighting? It’s a term given to a practice stemming Read more… Medical gaslighting: a growing challenge in today’s medical landscape originally appeared in KevinMD.com. (Source: Kevin, M.D. - Medical Weblog)
Source: Kevin, M.D. - Medical Weblog - September 5, 2023 Category: General Medicine Authors: Tags: Conditions Rheumatology Source Type: blogs

Fight Aging! Newsletter, September 4th 2023
In conclusion, although the contribution of CRF to GrimAgeAccel and FitAgeAccel is relatively low compared to lifestyle-related factors such as smoking, the results suggest that the maintenance of CRF is associated with delayed biological ageing in older men. « Back to Top Release of Acetylcholine is Necessary for the Aging Brain to Compensate for a Lack of Neurogenesis https://www.fightaging.org/archives/2023/09/release-of-acetylcholine-is-necessary-for-the-aging-brain-to-compensate-for-a-lack-of-neurogenesis/ Neurogenesis is the process by which new neurons are created by neural stem c...
Source: Fight Aging! - September 3, 2023 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs

Transferring the Naked Mole Rat Hyaluronan Synthase 2 Gene Into Mice Reduces Cancer Incidence, Extends Life
Naked mole rats live far longer than similarly sized mammals, and are near immune to cancer. One of the mechanisms of cancer resistance involves the production of a different form of high molecular weight hyaluronan, and much more of it, improving the anti-cancer mechanism of contact inhibition. In addition, other mechanisms derived from changes in hyaluronan may affect life span through improved cellular function, but this is less well explored. Researchers here take the naked mole-rat version of the gene for high molecular weight hyoluronan, hyaluronan synthase 2, and put it into mice. The result is less cancer, improved...
Source: Fight Aging! - August 31, 2023 Category: Research Authors: Reason Tags: Daily News Source Type: blogs

Heart disease in the shadows: a closer look at cardiac sarcoidosis
My new internist began my annual checkup with a nervous confession: “You are my first patient with cardiac sarcoidosis.” Even during an urgent care visit for potential cellulitis, I was met with raised eyebrows from the treating physician who reviewed my chart: “Very interesting, I’ve never seen a case of this heart disease.” With over Read more… Heart disease in the shadows: a closer look at cardiac sarcoidosis originally appeared in KevinMD.com. (Source: Kevin, M.D. - Medical Weblog)
Source: Kevin, M.D. - Medical Weblog - August 14, 2023 Category: General Medicine Authors: Tags: Conditions Rheumatology Source Type: blogs

Ehlers-Danlos Syndrome and regenerative injection therapy [PODCAST]
Subscribe to The Podcast by KevinMD. Catch up on old episodes! Join Francisco M. Torres, an interventional physiatrist, and Felix S. Linetsky, a pain management physician, as they delve into the world of chronic pain and its often misunderstood connection to Ehlers-Danlos Syndrome (EDS). They discuss the challenges of diagnosing and treating EDS, the limitations Read more… Ehlers-Danlos Syndrome and regenerative injection therapy [PODCAST] originally appeared in KevinMD.com. (Source: Kevin, M.D. - Medical Weblog)
Source: Kevin, M.D. - Medical Weblog - August 5, 2023 Category: General Medicine Authors: Tags: Podcast Rheumatology Source Type: blogs

I am 49 … not out, how about you TAVI ?
This post was written after coming across a case report  Oxford medical case report.   What is the life of a prosthetic Aortic valve? The standard answer needs to be, mechanical valves can last up to 25  years or more. But, we are in a techno-conflict era.  Instead of working on the longevity of the valve, ( with concerns for long-term OAC )  we fell for the biological valves. Curiously, this has made the durability of the valve, a less relevant discussion in many centers. We get excited when some company brings out a long-lasting bio-prosthetic valve that can live up to a maximum of 15 years. Now, ...
Source: Dr.S.Venkatesan MD - August 1, 2023 Category: Cardiology Authors: dr s venkatesan Tags: Uncategorized prosthetic aortic valve starr edwards valve tavi valve Source Type: blogs