Underfunding Research Of Female Health Leaves Huge Amounts Of Money On The Table
“Did you know that at least one-third of women have lower back pain before their periods every month, and yet, nobody seems to fully understand why?” – asked a Medical Futurist team member a little while ago. The question led to a discussion about the differences in research, funding and understanding of male-only and female-only health issues, and consequently, to this article.
It is a well-known fact that some diseases or conditions dominantly affect one gender or the other. There are the trivial ones, like prostate cancer or ovarian, cervical, uterine cancers. But there is a long list of diseases and condit...
Source: The Medical Futurist - May 12, 2022 Category: Information Technology Authors: Andrea Koncz Tags: TMF Future of Medicine Healthcare Policy Medical Education women female health under-reseached gender gap in healthcare Source Type: blogs
Women, partner violence and pain
As the potential for greater repression of women’s autonomy grows (Afghanistan, United States, Mexico), along with racist and misogynist statements from business leaders (DGL CEO Simon Henry) it’s timely to look at pain in women. We already know that more women than men present with persistent pain (Blyth, n.d.), while women who are seen for their pain are more often misdiagnosed, offered psychiatric medication or psychological intervention only and have their experiences dismissed as “hysterical, fabricated, or nonexistent” (Samulowitz, et al., 2018). My daughter, when attending Emergency Departmen...
Source: HealthSkills Weblog - May 8, 2022 Category: Anesthesiology Authors: BronnieLennoxThompson Tags: Chronic pain Professional topics Research Science in practice biopsychosocial gender Health pain management partner violence Source Type: blogs
Fight Aging! Newsletter, May 2nd 2022
In this study, we tested the therapeutic potential of VHHASC and a newly generated VHH against murine ASC (VHHmASC) to target ASC specks in vitro and in vivo. We show that pre-incubation of extracellular ASC specks with VHHASC abrogated their inflammatory functions in vitro. Recombinant VHHASC rapidly disassembled pre-formed ASC specks and thus inhibited their ability to seed the nucleation of soluble ASC. Notably, VHHASC required prior cytosolic access to prevent inflammasome activation within cells, but it was effective against extracellular ASC specks released following caspase-1-dependent loss of membrane integrity, an...
Source: Fight Aging! - May 1, 2022 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
ASC Specks as a Sizable Contribution to Chronic Inflammation
In this study, we tested the therapeutic potential of VHHASC and a newly generated VHH against murine ASC (VHHmASC) to target ASC specks in vitro and in vivo. We show that pre-incubation of extracellular ASC specks with VHHASC abrogated their inflammatory functions in vitro. Recombinant VHHASC rapidly disassembled pre-formed ASC specks and thus inhibited their ability to seed the nucleation of soluble ASC. Notably, VHHASC required prior cytosolic access to prevent inflammasome activation within cells, but it was effective against extracellular ASC specks released following caspase-1-dependent loss of membrane integrity, an...
Source: Fight Aging! - April 26, 2022 Category: Research Authors: Reason Tags: Medicine, Biotech, Research Source Type: blogs
Towards Control of Inflammation as an Important Goal in the Treatment of Aging
Today I'll point out a review article that laments the present state of progress towards the control of inflammation in the human body. While acknowledging that great strides have been made in ways to interfere in inflammatory signaling, benefiting many patients, present tools are crude in comparison to the technologies that will most likely be needed in order to truly control unresolved, chronic inflammation and eliminate its contribution to age-related disease. True control of inflammation would imply the ability to (a) trigger resolution mechanisms with specificity, avoiding impairment of the operation of inflammation w...
Source: Fight Aging! - April 25, 2022 Category: Research Authors: Reason Tags: Medicine, Biotech, Research Source Type: blogs
DNA Vibe Jazz Band Therapy: A Review
Made in the USA, the DNA Jazz Band Vibe joins a newer class of sports medicine-related healing therapies that include photobiomodulation. Photobiomodulation is a form of light therapy that uses specific wavelengths of red light and near-infrared light to help stimulate, heal, regenerate, and protect cells. However, this product goes beyond light therapy by including two additional proprietary modes of micro-vibration and magnetic stimulation.
Think about the importance of vitamin D and the sun in our lives. Sunlight contains a broad spectrum of light, all the way from UV to red and infrared wavelengths. Light therapy ...
Source: Medgadget - April 19, 2022 Category: Medical Devices Authors: Alice Ferng Tags: Exclusive OTC Pain Management Sports Medicine Source Type: blogs
Discovering What's Behind Older Adults' Fear of Falling May Encourage More Activity
Photo credit Jonas Kakaroto
Dear Carol: My mother lives with pain from rheumatoid arthritis and she’s also experiencing early symptoms of Alzheimer’s. She’s used a cane for years and was confident with these aids but recently she’s become terrified of falling. I bought her a walker, and she says that makes her feel more stable. Still, she’s fearful when she moves around so she’s become extraordinarily sedentary. I can understand caution, but I’m afraid that if she avoids all activity, her health will decline even faster. She lives with me and there can be friction when I make suggestions. Is ther...
Source: Minding Our Elders - April 3, 2022 Category: Geriatrics Authors: Carol Bradley Bursack Source Type: blogs
poem
Winter BreaksI ’m that scraggly tree over thereLooming over all the rest,A wicker brush dustingOff a film of sootAn arthritic claw Grasping at empty gray,Ruing all the lovely thingsNo longer there to clutch I think I ’m the oneScratching at the sky Shaking my fistIn a shivering anger But it ’s just the MarchWind rushing inTo fill a void leftBy your fleeing chillThat sways my trunk and limbsAnd thesaplings and hibiscuses And the reeds and grasses,And all the world I ’m standing inSo I give up the scratchingAnd imagine the winds asA shaman blowing into being One more fecund s...
Source: Buckeye Surgeon - March 31, 2022 Category: Surgery Authors: Jeffrey Parks MD FACS Source Type: blogs
A woman in her 50s with shortness of breath
Case written by Neha Ray, MD, with edits by Meyers, Smith, GrauerA woman in her 50s presented for evaluation of multiple episodes of syncope with shortness of breath. On EMS arrival, she was GCS 15 with HR 110s. En route to the ED, the patient had 4 more episodes of syncope and became hemodynamically unstable with SBP in the 80s and HR 160s. The first recorded SpO2 was 73%. On arrival to the ED, patient was diaphoretic and in extremis. Her initial EKG is below. Paramedics arrive to the ED and state that they are worried about inferior STEMI. What do you see? What do you think?The ECG shows sinus tachycardia...
Source: Dr. Smith's ECG Blog - March 28, 2022 Category: Cardiology Authors: Pendell Source Type: blogs
Fight Aging! Newsletter, March 28th 2022
In conclusion, we summarized here evidence for a novel therapeutic approach to exploit the incredible ability of mitochondria to engage multifaceted neuroprotective stress response triggered by partial complex I inhibition. This approach promises relief for multiple human conditions, and to promote healthy aging to delay the onset of neurogenerative diseases, AD in particular, where age is the greatest risk factor. There is a mounting body of evidence generated in model organisms and humans in support of the safety of chronic application of complex I inhibitors. However, a better understanding of the molecular mechanisms i...
Source: Fight Aging! - March 27, 2022 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
Overall, Healthspan is Incrementally Trending Upward
The number of healthy years of life, or life lived free from disability, is increasing over time in much the same way as overall human life span. The dynamics of the process are somewhat different, but the causes are much the same, some combination of public health measures and advances in medical technology. When considering healthspan rather than lifespan, there are also more marked differences between the consequences of age-related diseases. As noted here, neurodegeneration produces more of a burden than other classes of condition.
There have been advances in healthcare over recent decades that mean many peopl...
Source: Fight Aging! - March 23, 2022 Category: Research Authors: Reason Tags: Daily News Source Type: blogs
Whither Covid?
I recommend this Twitter thread by John Burn-Murdoch, as most Americans and their political leaders have apparently decided that the pandemic is over. It isn ' t, although here in the U.S. we are in a better place than we were a year ago. In a nutshell, new cases and hospitalizations are rising in much of the world, including much of Europe. This isn ' t so much because of loosened mitigation measures, but because of the emergence of a new variant, Omicron B.A2 which is evidently even more contagious than the original Omicron and perhaps a bit better at getting around existing immunity. It ' s just starting to show up...
Source: Stayin' Alive - March 18, 2022 Category: American Health Source Type: blogs
8 Summer Excursions for Elders and Their Caregivers
Summer is on its way. This is a time when it’s generally easier for elders to be out and about than when snow and ice are an issue. Even if our loved ones have dementia, severe arthritis, lung issues, or a combination of ailments, there are things we, their caregivers, can do to relieve a sense of being left out of life that can affect people in their situation. Think about the personality of your ailing elders and consider excursions or entertainment that they may enjoy. A short outing of some type can leave a lasting memory, or it can simply mean that there were some enjoyable moments, but either way...
Continue readin...
Source: Minding Our Elders - March 18, 2022 Category: Geriatrics Authors: Carol Bradley Bursack Source Type: blogs
poem
Verge of SpringThis feels like the verge of springEven though winter clingsWith the last of its waning powersNaked trees clutch At a dullard gray skyWith bony arthritic hands A random pile of dirty ice,Last remnant of week ago snow,Glaciers against a curbIf you look closeYou can see white buds of cherry treesAnd daffodil stems just piercing the soilIf you look closerYou can see an empty patchOf grass that won ’t ever come back 3/15/22 (Source: Buckeye Surgeon)
Source: Buckeye Surgeon - March 15, 2022 Category: Surgery Authors: Jeffrey Parks MD FACS Source Type: blogs
Pain and Dementia: Observing Body Language Important When People Can't Articulate Pain
Photo credit Josh Appel
A number of years back, my dad, who had developed dementia after surgery to correct problems from a World War II brain injury, was seized by sudden, horrendous pain. While Dad had to cope with considerable pain from arthritis and some back issues, this was different. I knew his pain was acute and extreme by his body language and vocalizations, even though he couldn't articulate exactly what was wrong. Dad generally had the ability to communicate, though his dementia often skewed the information he was trying to share. However, this pain was more than he could put into words. He was writh...
Source: Minding Our Elders - March 9, 2022 Category: Geriatrics Authors: Carol Bradley Bursack Source Type: blogs
