Fight Aging! Newsletter, November 22nd 2021
This study nicely illustrates the importance of the cellular metabolic state of myeloid cells: it highlights that not only the availability of glucose, but also its channeling into different pathways (glycolysis versus glycogen synthesis) contributes to maintaining proper myeloid function. On the Ability of Redundant Blood Vessels to Lower Cardiovascular Mortality https://www.fightaging.org/archives/2021/11/on-the-ability-of-redundant-blood-vessels-to-lower-cardiovascular-mortality/ A few strategies offer the possibility of growing additional redundant blood vessels, though this is far from rigorously p...
Source: Fight Aging! - November 21, 2021 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs

A Senolytic Treatment Improves Visual Function in a Small Trial for Macular Degeneration
UNITY Biotechnology recently reported positive results for their senolytic drug candidate UBX1325, probably derived from navitoclax. Senolytic therapies selectively destroy senescent cells in aged tissues, reducing their inflammatory signaling and contribution to tissue dysfunction. In this case, macular degeneration patients showed improved visual function after treatment, though one should wait for a larger study group before calling this an unqualified success. UNITY Biotechnology's trials are essentially testing the thesis that localized removal of senescent cells can address pathology, and thus low, localized doses of...
Source: Fight Aging! - November 18, 2021 Category: Research Authors: Reason Tags: Daily News Source Type: blogs

Collagen: The Anti-Aging Protein?
The post Collagen: The Anti-Aging Protein? appeared first on Dr. William Davis. (Source: Wheat Belly Blog)
Source: Wheat Belly Blog - November 13, 2021 Category: Cardiology Authors: Dr. Davis Tags: Wheat Belly Lifestyle alzheimer's arthritis cartilage cognition cognitive dementia joint pain skin wrinkles Source Type: blogs

Food Intolerances: A Warning of Bad Things Ahead
I’ve recently discussed how the majority of food intolerances, whether to FODMAPs, histamine, nightshades, fructose, etc., are really manifestations of dysbiosis and SIBO. Here is another way to view these phenomena: Food intolerances are your body’s signal to you that serious deterioration in your health is coming. In other words, if all you do is choose to reduce or eliminate the offending food, you are still left with the massive disruption of your intestinal microbiome that caused the food intolerance in the first place, along with increased intestinal permeability and endotoxemia. So say you eliminate ferm...
Source: Wheat Belly Blog - November 1, 2021 Category: Cardiology Authors: Dr. Davis Tags: Open microbiota prebiotic probiotic sibo small intestinal bacterial super gut undoctored wheat belly Source Type: blogs

Fight Aging! Newsletter, October 25th 2021
This study confirmed that the PSI could be a quantitative index of vascular aging and has potential for use in inferring arterial stiffness with an advantage over the rAIx. A Profile of Michael Greve and the Segment of the Longevity Industry that He Supports https://www.fightaging.org/archives/2021/10/a-profile-of-michael-greve-and-the-segment-of-the-longevity-industry-that-he-supports/ Would that the popular media produced more popular science articles about the longevity industry like this one. It is not just a profile of someone trying to make a difference in the world by advancing the state of medic...
Source: Fight Aging! - October 24, 2021 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs

B2M as a Surface Marker of Cellular Senescence
Before the advent of the first senolytic drugs capable of selectively destroying senescent cells, it was thought by many that progress towards producing rejuvenation in the old via the safe elimination of senescent cells from the body would require the identification of surface markers that are distinctive to the state of senescence. Given a surface marker that clearly and distinctively identifies a cell population, a broad range of strategies become available for the development of targeted therapies. As it turned out,, however, the first senolytics took advantage of the peculiarities of the internal state of senescent ce...
Source: Fight Aging! - October 21, 2021 Category: Research Authors: Reason Tags: Medicine, Biotech, Research Source Type: blogs

ELMO1 Inhibition as a Basis for Osteoporosis Therapies
Osteoporosis is the name given to the characteristic loss of bone mass and strength that takes place with age. Bone is constantly remodeled, and this condition is the consequence of a growing imbalance between the activity of osteoclasts, responsible for breaking down bone, and osteoblasts, responsible for building bone. Researchers here make the observation that osteoclasts perform functions related to bone construction even as they break down bone, meaning that therapies intended to limit osteoclast populations may not work as well as hoped. Instead, specifically dialing back only the breakdown of bone tissue by altering...
Source: Fight Aging! - October 21, 2021 Category: Research Authors: Reason Tags: Daily News Source Type: blogs

A Jekyll And Hyde Emotion? Research On Anger, Digested
This study provided evidence of “the important role of anger in the psychological process underlying moral courage,” the team wrote. Of course, a person’s individual moral framework is crucial here, though. If the sight of women venturing outdoors alone or going to work, say, deeply offends you, then your resulting outrage will likely propel you to action, too. Expressing anger can also make you seem more authentic and sincere. At least, this was suggested by a 2021 study of Kickstarter pitch videos. Entrepreneurs are often encouraged to be only positive about their ventures, commented the researchers. But they fo...
Source: BPS RESEARCH DIGEST - October 12, 2021 Category: Psychiatry & Psychology Authors: BPS Research Digest Tags: Anger Source Type: blogs

Big Pharma, Big Money: Johnson & Johnson, Pfizer, Bayer, Novartis in digital health
In a recent series of articles, we explored the latest moves of Tech Giants like Amazon, NVIDIA and Microsoft in the field of digital health. Analysing these recent developments can give us a better idea regarding where they are focusing the efforts, and how it might shape the future path of healthcare.  But equally, if not more, strong players in this field are pharmaceutical giants, as their resources and influence can significantly shape or alter the course of this path. As such, we are kickstarting a new series of articles focusing on the digital health efforts of 14 global pharma companies. While those heavywe...
Source: The Medical Futurist - October 12, 2021 Category: Information Technology Authors: Pranavsingh Dhunnoo Tags: Future of Medicine Future of Pharma digital health novartis pfizer J&J big pharma Johnson&Johnson Bayer Source Type: blogs

Thought experiment: Would therapists be out of a job if we could “ fix ” persistent pain?
Every few years someone, somewhere, announces that “it won’t be long before we have a treatment to rid the world of persistent pain.” And there’s a hiss and roar to celebrate this momentous finding, and much ado about how wonderful it will be. I’m still waiting. BUT I thought it might be an interesting thought experiment to wonder what might happen if a “cure” was available for fibromyalgia. As readers will know, I have lived with what eventually was named “fibromyalgia” since my early 20’s, and probably longer. I’ve dabbled in various treatments ove...
Source: HealthSkills Weblog - October 10, 2021 Category: Anesthesiology Authors: BronnieLennoxThompson Tags: Chronic pain Pain conditions Professional topics Research Science in practice biopsychosocial pain management Therapeutic approaches Source Type: blogs

Caregiving During Middle Age Inspired Author to Start Foundation to Help Caregivers
When people think about caregiving spouses, they often think of older adults. We only have to look at a young mother diagnosed with multiple sclerosis (MS), a young husband diagnosed with rheumatoid arthritis (RA), or in this case, a woman whose healthy husband had a sudden, massive stroke, to know differently. Kathi Koll, author of “Kick-Ass Kinda Girl: A Memoir of Life, Love, and Caregiving” knows the drill. She and her husband, Don, lived a life of glitz and glamour, working and playing alongside friends who were celebrities and politicians... Continue reading on HealthCentral for more about Kathi Koll's foundation:...
Source: Minding Our Elders - October 8, 2021 Category: Geriatrics Authors: Carol Bradley Bursack Source Type: blogs

The emergence of direct specialty care
One day, a primary care physician located about two hours away called my office in a desperate attempt to find a rheumatologist. His lovely 64-year-old patient, very healthy otherwise, recently developed a severe and disabling inflammatory arthritis. After conservative treatments failed, he tried to refer the patient to the traditional medical system. However, they couldRead more …The emergence of direct specialty care originally appeared inKevinMD.com. (Source: Kevin, M.D. - Medical Weblog)
Source: Kevin, M.D. - Medical Weblog - September 6, 2021 Category: General Medicine Authors: < span itemprop="author" > < a href="https://www.kevinmd.com/blog/post-author/diana-girnita" rel="tag" > Diana M. Girnita, MD, PhD < /a > < /span > Tags: Physician Rheumatology Source Type: blogs

The Futility of Prior Authorization
Two independent nationwide surveys, one by the American Medical Association (AMA) and the other from the American College of Rheumatology shows broad physician dissatisfaction with the insidious practices of prior-authorization and step therapy – specifically the ways in which it impacts the ability of physicians to treat patients. (Source: drugwonks.com Blog)
Source: drugwonks.com Blog - August 25, 2021 Category: Pharmaceuticals Source Type: blogs

Watching Parents Withdraw Due to Health Problems Is Worrying
Photo credit Lotte Meijer Dear Carol: Our parents were always active and social, the type of people involved in everything from community events to church. Unfortunately, now that they are in their 80s, their health problems have changed that. It seems that since Mom is limited in what she can do because of eye issues and arthritis pain, Dad’s pulled back as well. It’s true that he does a lot for Mom, and he also has health concerns, so it’s possible that what they are doing is valid, but we kids aren’t sure. All three of us are very social so maybe we’re projecting, but we think that now that they can get ...
Source: Minding Our Elders - August 15, 2021 Category: Geriatrics Authors: Carol Bradley Bursack Source Type: blogs

When therapists get hurt
“Physician, heal thyself” – usually used to suggest that the person should fix their own problems before trying to fix someone else. And when a therapist gets hurt all the armchair critics (social media proclamists) go off pointing the finger and telling that person what to do – even when the therapist is doing exactly what evidence suggests is the right thing to do. Adam Meakins has hurt his back while lifting weights in the gym – he’s documenting his progress on social media, which I think is both a very brave thing to do and also something I’d love to see more of. If you want...
Source: HealthSkills Weblog - August 8, 2021 Category: Anesthesiology Authors: BronnieLennoxThompson Tags: Back pain Coping strategies Low back pain Pain conditions Professional topics Resilience/Health Science in practice pain management Source Type: blogs