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Raised CK and acute kidney injury following intense exercise in three patients with a history of exercise intolerance due to homozygous mutations in SLC2A9.
Acute rhabdomyolysis (AR) leads to myoglobinuria, which in turn may cause acute kidney injury requiring dialysis. The most useful biomarker for AR is the serum creatine kinase (CK) which is acutely elevated to at least 5-10x the upper limit of normal, although the level may be considerably higher due to extensive skeletal muscle damage [1]. There are many causes of acute rhabdomyolysis [2], however, the most common presentation to emergency departments follows some form of physical activity in people with either metabolic muscle disease (glycogen storage disorders and fatty acid oxidation disorders) or following intense un...
Source: Neuromuscular Disorders - December 6, 2023 Category: Neurology Authors: Ros Quinlivan, Elaine Murphy, Shpresa Pula, Alexandra Pain, Henrietta Brain, Grace Scopes, Frenki Gjika, Naim Ahmadouk, Andreea Manole, Henry Houlden Source Type: research

Pregabalin-induced rhabdomyolysis in hemodialysis patient
Korean J Intern Med. 2023 Nov 30. doi: 10.3904/kjim.2023.379. Online ahead of print.NO ABSTRACTPMID:38031363 | DOI:10.3904/kjim.2023.379 (Source: The Korean Journal of Internal Medicine)
Source: The Korean Journal of Internal Medicine - November 30, 2023 Category: Internal Medicine Authors: Dong Eon Kim Sang Heon Song Source Type: research

HMG CoA reductase inhibitors (statins) for people with chronic kidney disease not requiring dialysis
CONCLUSIONS: Statins reduce death and major cardiovascular events by about 20% and probably make no difference to stroke or kidney failure in people with CKD not requiring dialysis. However, due to limited reporting, the effect of statins on elevated creatinine kinase or rhabdomyolysis is unclear. Statins have an important role in the primary prevention of cardiovascular events and death in people who have CKD and do not require dialysis. Editorial note: This is a living systematic review. We will search for new evidence every three months and update the review when we identify relevant new evidence. Please refer to the Co...
Source: Cochrane Database of Systematic Reviews - November 29, 2023 Category: General Medicine Authors: David J Tunnicliffe Suetonia C Palmer Brydee A Cashmore Valeria M Saglimbene Rathika Krishnasamy Kelly Lambert David W Johnson Jonathan C Craig Giovanni Fm Strippoli Source Type: research

A case of Legionella pneumophila serogroup 13 pneumonia based on the detection of serogroup-specific genes in culture-negative sputum
Jpn J Infect Dis. 2023 Nov 30. doi: 10.7883/yoken.JJID.2023.302. Online ahead of print.ABSTRACTLegionella pneumophila serogroup (SG) 1, the main cause of Legionnaires' disease, can be diagnosed with urinary antigen testing kits; however, lower respiratory tract specimen culture is necessary to identify L. pneumophila SG 2-15. We attempted to detect L. pneumophila SG-specific genes in a culture-negative sputum specimen from a patient with pneumonia suspected to have Legionnaires' disease. Two multiplex PCR methods targeting L. pneumophila were modified and amplicons considered to be SG13 specific were detected. Direct seque...
Source: Japanese Journal of Infectious Diseases - November 29, 2023 Category: Infectious Diseases Authors: Junji Seto Jun Takahashi Mika Sampei Tatsuya Ikeda Katsumi Mizuta Source Type: research