In Rett syndrome model, team shows how adult learning is impaired in females
(Cold Spring Harbor Laboratory) In mouse models of Rett syndrome -- which in humans is seen overwhelmingly in females -- researchers have demonstrated how failure of Mecp2, the mouse equivalent of the human gene of the same name, has biological consequences that prevent adult females from learning how to gather newborn pups in the days immediately following the pups' birth. They reversed the defect. (Source: EurekAlert! - Medicine and Health)
Source: EurekAlert! - Medicine and Health - January 18, 2017 Category: Global & Universal Source Type: news
Rettsyndrome.org reaches milestone of $40 million in research funding
(Rettsyndrome.org) The International Rett Syndrome Foundation, now doing business as Rettsyndrome.org, announces today that Rettsyndrome.org has reached a milestone in research funding. The leading foundation for Rett research has distributed over $40 million dollars to accelerate treatments for Rett syndrome. (Source: EurekAlert! - Medicine and Health)
Source: EurekAlert! - Medicine and Health - January 9, 2017 Category: Global & Universal Source Type: news
Neuren Pharmaceuticals completes enrolment for Phase II trial of trofinetide to treat Rett syndrome
US-based biopharmaceutical company Neuren has completed enrolment for its Phase II clinical trial of trofinetide in pediatric Rett syndrome. (Source: Drug Development Technology)
Source: Drug Development Technology - November 15, 2016 Category: Pharmaceuticals Source Type: news
Ed Sheeran serenades a nine-year-old superfan at her hospital bed
Rocker Ed Sheeran has made a young superfan's dream come true by visiting her in hospital in Surrey to serenade her. Melody Driscoll, nine, suffers from the rare brain condition, Rett syndrome. (Source: the Mail online | Health)
Source: the Mail online | Health - November 10, 2016 Category: Consumer Health News Source Type: news
Newron begins STARS study of sarizotan to treat Rett syndrome
Italian-based biopharmaceutical company Newron Pharmaceuticals has begun the Sarizotan Treatment of Apneas in Rett Syndrome (STARS) study of sarizotan to treat Rett syndrome. (Source: Drug Development Technology)
Source: Drug Development Technology - July 24, 2016 Category: Pharmaceuticals Source Type: news
Insights into neurons that cause symptoms of Rett syndrome could guide new therapy search
Two studies in mice reveal new insights into neurons that mediate symptoms typical of the postnatal neurological disorder Rett syndrome. (Source: ScienceDaily Headlines)
Source: ScienceDaily Headlines - June 28, 2016 Category: Science Source Type: news
Insights into neurons that cause symptoms of Rett syndrome could guide new therapy search
(eLife ) Two studies in mice from Baylor College of Medicine, Texas, reveal new insights into neurons that mediate symptoms typical of the postnatal neurological disorder Rett syndrome. (Source: EurekAlert! - Medicine and Health)
Source: EurekAlert! - Medicine and Health - June 28, 2016 Category: Global & Universal Source Type: news
i-Fect used to Study Epigenetics in Nerve Injury
Conclusions: The study shows a regulatory role for MeCP2 in that changes in global redistribution can result in direct and indirect modulation of gene expression in the DRG. Alterations in genome-wide binding of MeCP2 therefore provide a molecular basis for a better understanding of epigenetic regulation-induced molecular changes underlying nerve injury. (Source: siRNA and DsiRNA Transfection Efficiency)
Source: siRNA and DsiRNA Transfection Efficiency - June 20, 2016 Category: Neuroscience Tags: i-Fect MeCP2 Methyl-CpG-binding protein 2 miR-126 miRNA Delivery Methods Nerve Injury. Source Type: news
MeCP2 and Nerve Injury
Conclusions: The study shows a regulatory role for MeCP2 in that changes in global redistribution can result in direct and indirect modulation of gene expression in the DRG. Alterations in genome-wide binding of MeCP2 therefore provide a molecular basis for a better understanding of epigenetic regulation-induced molecular changes underlying nerve injury. (Source: Neuromics)
Source: Neuromics - June 20, 2016 Category: Neuroscience Tags: Delivering siRNA to the CNS epigenetics gene expression analysis i-Fect MECP2 methyl-CpG-binding protein 2 miR-126 Nerve Injury Nerve Sprouting Source Type: news
Dad Fights For Cure For His Daughter's Disorder In Emotional Video
In August 2014, dad A.J. Tesler created a short video with the title "Save My Daughter. Share This Video."
Eight months earlier, his toddler daughter Magnolia (aka "Maggie") had been diagnosed with a rare neurological disorder called Rett syndrome, and all YouTube ad revenue generated from the video would go toward funding clinical trial research to find a cure.
Now the dad is continuing his fight to find a cure -- for his daughter and the 350,000 other girls and women affected by Rett syndrome. The debilitating disorder almost exclusively affects girls and generally involves slowed development, seizures and a pr...
Source: Science - The Huffington Post - May 18, 2016 Category: Science Source Type: news
Dad Fights For Cure For His Daughter's Disorder In Emotional Video
In August 2014, dad A.J. Tesler created a short video with the title "Save My Daughter. Share This Video."
Eight months earlier, his toddler daughter Magnolia (aka "Maggie") had been diagnosed with a rare neurological disorder called Rett syndrome, and all YouTube ad revenue generated from the video would go toward funding clinical trial research to find a cure.
Now the dad is continuing his fight to find a cure -- for his daughter and the 350,000 other girls and women affected by Rett syndrome. The debilitating disorder almost exclusively affects girls and generally involves slowed development, seizures and a pr...
Source: Healthy Living - The Huffington Post - May 18, 2016 Category: Consumer Health News Source Type: news
Rett Syndrome Research Trust Awards $9 Million to Accelerate...
Today the Rett Syndrome Research Trust (RSRT) announced research awards totaling nearly $9 million in 2015. This is the most research ever awarded in a given year by any Rett Syndrome organization.(PRWeb March 10, 2016)Read the full story at http://www.prweb.com/releases/2016/03/prweb13254722.htm (Source: PRWeb: Medical Pharmaceuticals)
Source: PRWeb: Medical Pharmaceuticals - March 11, 2016 Category: Pharmaceuticals Source Type: news
The Rett Syndrome Research Trust Names Randall L. Carpenter as Chief...
The Rett Syndrome Research Trust (RSRT) is delighted to announce that Randall L. Carpenter is joining the organization in the role of Chief Scientific Officer. In this newly created position, Dr....(PRWeb February 25, 2016)Read the full story at http://www.prweb.com/releases/2016/02/prweb13230397.htm (Source: PRWeb: Medical Pharmaceuticals)
Source: PRWeb: Medical Pharmaceuticals - February 25, 2016 Category: Pharmaceuticals Source Type: news
Nemmers Prize in Medical Science awarded by Northwestern
(Northwestern University) Dr. Huda Zoghbi, a Howard Hughes Medical Institute investigator and professor at Baylor College of Medicine known for her groundbreaking research on Rett syndrome and other neurological disorders, is the inaugural recipient of the Mechthild Esser Nemmers Prize in Medical Science at Northwestern University. (Source: EurekAlert! - Medicine and Health)
Source: EurekAlert! - Medicine and Health - February 3, 2016 Category: Global & Universal Source Type: news
New drug target for Rett syndrome
A faulty signaling pathway has been identified that, when corrected, in mice ameliorates the symptoms of Rett syndrome, a devastating neurological condition. The findings could lead to the discovery of compounds or drugs that may benefit children affected by the disease. (Source: ScienceDaily Headlines)
Source: ScienceDaily Headlines - February 2, 2016 Category: Science Source Type: news
