[Editors' Choice] Combined Treatment for Rett Syndrome
Treatment with the growth factor IGF1 and the β2-adrenergic receptor agonist clenbuterol may benefit patients with Rett Syndrome. (Source: Signal Transduction Knowledge Environment)
Source: Signal Transduction Knowledge Environment - July 16, 2014 Category: Science Authors: Nancy Gough (mailto:ngough at aaas.org) Source Type: news
Clinical Trial of Rett Syndrome Drug Shows Promise
Rett syndrome, a rare genetic disorder that causes mental retardation, autism, and physical deformities, has no cure. However, a small clinical trial has found that a growth factor known as IGF1 can help treat some symptoms of the disease. (Source: Disabled World)
Source: Disabled World - June 23, 2014 Category: Disability Tags: Clinical Trials Source Type: news
Rett syndrome drug shows promise in clinical trial
(Massachusetts Institute of Technology) MIT neuroscientists report more detail on how the disease arises. (Source: EurekAlert! - Social and Behavioral Science)
Source: EurekAlert! - Social and Behavioral Science - June 23, 2014 Category: Global & Universal Source Type: news
What are the Most Common Motor and Vocal Tics?
Discussion
Tics are usually single repetitive, non-rhythmic, non-purposeful movements or utterances. Tics can be multiple and complex however. Tics may be preceeded by a premonitory urge where the person has a feeling that a certain type of tic is going to occur and then this feeling goes away after the tic is produced.
Tics, especially simple motor tics, are very common with ~10-15% of elementary age children having a tic at some time. In one community-based study, the overall prevalence was 3-9% with an overall frequency of 24% of elementary school children during one school year. Tics are more common in boys and prese...
Source: PediatricEducation.org - June 23, 2014 Category: Pediatrics Authors: pediatriceducationmin Tags: Uncategorized Source Type: news
Effective drugs for Parkinson's reduce symptoms of Rett syndrome in mice
A combination of effective drugs for Parkinson's disease in mice that are used as a model of human Rett syndrome reduces some of the symptoms associated with this disease. Rett syndrome is the second most common cause of mental retardation in women, after Down syndrome. It is a neurodevelopmental disease whose clinical picture begins to appear 6-18 months after birth and involves a loss of intellectual, social and motor skills, accompanied by autistic behaviors, such as repetitive movements of the hands. (Source: ScienceDaily Headlines)
Source: ScienceDaily Headlines - June 16, 2014 Category: Science Source Type: news
Effective drugs for Parkinson's reduce symptoms of Rett syndrome in mice
(IDIBELL-Bellvitge Biomedical Research Institute) IDIBELL researchers, led by the director of the Program for Epigenetics and Cancer Biology, ICREA researcher and Professor of Genetics at the University of Barcelona, Manel Esteller, have shown that a combination of effective drugs for Parkinson's disease in mice that are used as a model of human Rett syndrome reduces some of the symptoms associated with this disease. (Source: EurekAlert! - Medicine and Health)
Source: EurekAlert! - Medicine and Health - June 16, 2014 Category: Global & Universal Source Type: news
New drug offers hope for devastating childhood disease
A powerful new drug which could relieve the symptoms of devastating childhood disease Rett syndrome is on the horizon thanks to a funding injection of £180,000. (Source: University of Bristol news)
Source: University of Bristol news - April 9, 2014 Category: Universities & Medical Training Tags: Grants and Awards, Research; Faculty of Medical and Veterinary Sciences, School of Physiology and Pharmacology, Faculty of Medical and Veterinary Sciences; Press Release Source Type: news
MECP2 Mutation Type and Disease Severity in Rett SyndromeMECP2 Mutation Type and Disease Severity in Rett Syndrome
Do specific MECP2 mutations lead to different degrees of disease severity in Rett syndrome? Journal of Medical Genetics (Source: Medscape Today Headlines)
Source: Medscape Today Headlines - March 19, 2014 Category: Consumer Health News Tags: Pathology & Lab Medicine Journal Article Source Type: news
Rett syndrome sees glimmer of hope in Phase I trial
We report and comment on medical innovations and advances – from bench to bedside – touching on scientific, business and policy issues. Our ranks include science writers, physicians, lab researchers, market analysts and others inside and outside the hospital.
By Nancy Fliesler
This post is the first in a two-part series on clinical trials in autism spectrum disorders. Read part 2.
Boston Children's HospitalNews Well, Vector Blog, Autism, Blog, Neurologicalread more (Source: Mass Device)
Source: Mass Device - March 18, 2014 Category: Medical Equipment Authors: MassDevice Tags: Vector Blog Source Type: news
Rett Syndrome: Mecasermin (rh-IGF-1) treatment is safe and well-tolerated
The results from Boston Children's Hospital's Phase 1 human clinical trial in Rett syndrome have been released. A team of investigators successfully completed a Phase 1 clinical trial using mecasermin [recombinant human insulin-like growth factor 1 (IGF-1)], showing proof-of-principle that treatments like IGF-1 which are based on the neurobiology of Rett syndrome, are possible. (Source: Health News from Medical News Today)
Source: Health News from Medical News Today - March 12, 2014 Category: Consumer Health News Tags: Pediatrics / Children's Health Source Type: news
Mecasermin (rh-IGF-1) treatment for Rett Syndrome is safe and well-tolerated
(International Rett Syndrome Foundation) The results from Boston Children's Hospital's Phase 1 human clinical trial in Rett syndrome came out today. A team of investigators successfully completed a Phase 1 clinical trial using mecasermin [recombinant human insulin-like growth factor 1 (IGF-1)], showing proof-of-principle that treatments like IGF-1 which are based on the neurobiology of Rett syndrome, are possible. (Source: EurekAlert! - Biology)
Source: EurekAlert! - Biology - March 10, 2014 Category: Biology Source Type: news
IRSF announces 2013 awards and implements new Translational Program
(International Rett Syndrome Foundation) The International Rett Syndrome Foundation announces today 10 new research grants at leading global research institutions, a new Translational Research Program, and additional funding for current human clinical trials. (Source: EurekAlert! - Biology)
Source: EurekAlert! - Biology - February 24, 2014 Category: Biology Source Type: news
Rett syndrome genetic variants now available for advance testing, diagnosis & research
Through collaboration between the Centers for Disease Control and Prevention (CDC) and members of the clinical-laboratory and non-profit–research communities, 35 DNA samples containing many common RS genetic variants have now been characterized and made publicly available, eliminating a major stumbling-block for investigators and opening the possibility of earlier, more accurate diagnosis of Rett syndrome. (Source: ScienceDaily Headlines)
Source: ScienceDaily Headlines - February 7, 2014 Category: Science Source Type: news
Rett syndrome genetic variants now available for advance testing, diagnosis and research
Through collaboration between the Centers for Disease Control and Prevention (CDC) and members of the clinical-laboratory and non-profit–research communities, 35 DNA samples containing many common RS genetic variants have now been characterized and made publicly available, eliminating a major stumbling-block for investigators and opening the possibility of earlier, more accurate diagnosis of Rett syndrome. (Source: ScienceDaily Headlines)
Source: ScienceDaily Headlines - February 7, 2014 Category: Science Source Type: news
Rett syndrome genetic variants now available for advance testing, diagnosis & research
(Elsevier Health Sciences) Through collaboration between the Centers for Disease Control and Prevention (CDC) and members of the clinical-laboratory and non-profit-research communities, 35 DNA samples containing many common RS genetic variants have now been characterized and made publicly available, eliminating a major stumbling-block for investigators and opening the possibility of earlier, more accurate diagnosis of Rett syndrome, reports The Journal of Molecular Diagnostics. (Source: EurekAlert! - Biology)
Source: EurekAlert! - Biology - February 7, 2014 Category: Biology Source Type: news
