Fight Aging! Newsletter, May 22nd 2017
In this study, researchers analysed data of millions of British patients between 1995 and 2015 to see if this claim held true. They tracked people who were obese at the start of the study, defined as people with a body mass index (BMI) of 30 or more, who had no evidence of heart disease, high blood pressure, high cholesterol or diabetes at this point. They found these people who were obese but "metabolically healthy" were at higher risk of developing heart disease, strokes and heart failure than people of normal weight.
No such thing as 'fat but fit', major study finds
Several studies in the past have sug...
Source: Fight Aging! - May 21, 2017 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
Comparing Regeneration of Fingertips Between Species
As a sidebar to yesterday's post on regeneration in mammals, here is a review paper that just considers fingertip regeneration in various species. This can occur in mammals, and even on rare occasions in adult humans, though it isn't well understood as to why it happens at all given the inability to regenerate most other lost appendages. It is possible that this is a useful point of investigation in order to better understand why mammals do not regenerate like salamanders, and how that state of affairs might be changed for the better.
Mammalian fingertips and toes can partially regrow under certain conditions; how...
Source: Fight Aging! - May 17, 2017 Category: Research Authors: Reason Tags: Daily News Source Type: blogs
Can Cellular Senescence be Reversed in the Near Future, and is Reversal Desirable?
Cellular senescence is one of the causes of degenerative aging. Normal somatic cells in adults become senescent at the end of their replicative life span, when they reach the Hayflick limit on cell divisions, or in response to damage or a toxic environment. Most such cells self-destruct or are destroyed by the immune system, but some linger to cause problems, ever more of them over the years. A senescent cell generates a mix of signals known as the senescence-associated secretory phenotype (SASP) that promotes inflammation, damages surrounding tissue structures, and alters the behavior of nearby cells for the worse. Senesc...
Source: Fight Aging! - December 14, 2016 Category: Research Authors: Reason Tags: Medicine, Biotech, Research Source Type: blogs
Choroidal Involvement by Retinoblastoma
(Source: neuropathology blog)
Source: neuropathology blog - June 6, 2016 Category: Radiology Tags: neoplasms ophthalmic pathology Source Type: blogs
File under “only in America”
After a busy day yesterday and falling asleep early on the couch, I only have time for a quick take today. So file this under “only in America”: A 23-year-old Metro Detroit man robbed a South Lyon credit union earlier this month for his daughter, he told investigators according to South Lyon Police Lt. Chris… (Source: Respectful Insolence)
Source: Respectful Insolence - August 27, 2015 Category: Surgery Authors: Orac Tags: Cancer Medicine Politics Popular culture Asia Dupree bank bank robbery Brialynn Dupree Brian Randolph chemotherapy Obamacare retinoblastoma Source Type: blogs
Designer viruses for killing tumor cells
A major goal of viral oncotherapy – the use of viruses to destroy tumors – is to design viruses that kill tumor cells but not normal cells. Two adenoviruses provide perfect examples of how this specificity can be achieved.
Adenovirus CG0070, designed to treat bladder cancer, and adenovirus Oncorine, for head and neck tumors, replicate only in tumor cells. The selectivity is caused by mutations introduced into the viral genomes.
When adenovirus infects a cell, the first event is synthesis of mRNA that encodes the E1 proteins. These proteins are needed to start cellular DNA synthesis. Most cells in our bodies ...
Source: virology blog - May 8, 2015 Category: Virology Authors: Vincent Racaniello Tags: Basic virology Information adenovirus E1 region E1A E1b-55k GC0070 oncolysis Oncorine oncotherapy p53 Rb retinoblastoma viral Source Type: blogs
On the Potential Treatment of Cellular Senescence in Aging
With advancing age ever more cells in any given tissue in the body are found to be in a senescent state. These cells have permanently exited the cell cycle in response to damage or stress, most likely in order to suppress cancer risk, but their accumulation causes progressive harm to tissue structure. One promising approach to removing this contribution to degenerative aging is the use of targeted cell destruction therapies, such as those under development in the cancer research community. Periodic clearance of senescent cells would prevent the dysfunction they cause, and while this research is poorly funded in comparison ...
Source: Fight Aging! - February 9, 2015 Category: Research Authors: Reason Tags: Daily News Source Type: blogs
The Future of Cord Blood Research
You may have heard that the stem cells in your baby’s umbilical-cord blood can save lives, but if you’re like most people, you have only a vague notion of how stem cells work — or which diseases they can treat. Right now, certain cancers, blood disorders, and immune disorders, among other conditions, are being successfully treated with cord-blood stem cells — and thanks to cord blood research, the list of conditions and diseases that may be treated by these stem cells is growing.
Why is it important to know about the cord blood research and what types of diseases it can treat? Knowing what cord blood can and...
Source: Cord Blood News - December 15, 2014 Category: Perinatology & Neonatology Authors: joyce at mazelabs.com Tags: babies blood disorder brain development Cord Blood medical research parents pregnancy stem cells affordable cord blood banking bone marrow breast feeding cerebral palsy cord blood banking fees cord blood banking information cor Source Type: blogs
Causes of Intraocular Calcifications
REMEMBER, these are the causes of intraocular calcification:
Retinoblastoma (>50% of all cases)
Astrocytic hamartoma
Choroidal osteoma
Optic drusen
Scleral calcifications
in systemic hypercalcemic states
Retrolental fibroplasia
Phthisis bulbi
From Sumer's Radiology Site http://www.sumerdoc.blogspot.com -The Top Radiology Magazine. Teleradiology Providers at www.teleradproviders.com Mail us at sales@teleradproviders.com (Source: Sumer's Radiology Site)
Source: Sumer's Radiology Site - May 13, 2013 Category: Radiologists Authors: Sumer Sethi Source Type: blogs
Retinoblastoma-MRI
7 months
baby diagnosed as retinoblastoma on MRI shows T1 hyperintensity , T2 low signal with regions of low signals on all sequences ( calcium) & multicentricity or bilaterality with subretinal fluid and intense and heterogenous enhancement
including in the anterior eye segment / choroidal involvement / extension along
the optic nerve on the right. There is no intracranial extension / no pineal
region SOL with ‘J’ shaped sella.
Teaching
points by Dr MGK Murthy, Mr Venkat, Mr Abdul Hamid:
1. Retinoblastoma
is a most common pediatric intra ocular neoplasm.
2. MRI...
Source: Sumer's Radiology Site - March 6, 2013 Category: Radiologists Authors: Sumer Sethi Source Type: blogs
USMLE Questions – Characteristic Disease Findings
The United States Medical Licensing Examination (USMLE) is designed to emphasize knowledge of clinical scenarios and clinical pearls, even on Step I. Listed below are some commonly encountered disease findings and characteristics.
Feature
Disease
45, X chromosome
Turner’s syndrome
5-HIAA increased in urine
Carcinoid syndrome
Aganglionic rectum
Hirschsrpung’s disease
Apple-core sign on barium enema
Colon cancer
Arched back (opisthotonos)
Tetanus
Argyll-Robertson pupil
Syphilis
Ash leaf on forehead
Tuberous sclerosis
Auer rods
Acute myelogenous leukemia
Austin Flint murmur
Aortic regurgitation...
Source: Inside Surgery - January 18, 2013 Category: Surgeons Authors: Editor Tags: Surgpedia USMLE diseases findings VMA water hammer pulse Source Type: blogs
