Restrictive Cardiomyopathy Research This is an RSS file. You can use it to subscribe to this data in your favourite RSS reader or to display this data on your own website or blog.

The new European Society of Cardiology guideline for the management of cardiomyopathies: key messages for cardiac electrophysiologists
AbstractElectrocardiographic findings and arrhythmias are common in cardiomyopathies. Both may be an early indication of a specific diagnosis or may occur due to myocardial fibrosis and/or reduced contractility. Brady- and tachyarrhythmias significantly contribute to increased morbidity and mortality in patients with cardiomyopathies. Antiarrhythmic therapy including risk stratification is often challenging and plays a major role for these patients. Thus, an “electrophysiological” perspective on guidelines on cardiomyopathies may be warranted. As the European Society of Cardiology (ESC) has recently published a new...
Source: Herzschrittmachertherapie und Elektrophysiologie - November 16, 2023 Category: Cardiology Source Type: research

Clinical features, etiology and survival in patients with restrictive cardiomyopathy: A single center experience
CONCLUSIONS: Genetic testing should be considered in every patient with RCM where light-chain amyloidosis has been excluded. Survival remains poor regardless of etiology. Increased concentrations of GDF15, hs-TNT, NT-proBNP and pericardial effusion are associated with worse prognosis. Further studies are warranted.PMID:37937352 | DOI:10.33963/v.kp.97879 (Source: Polish Heart Journal)
Source: Polish Heart Journal - November 8, 2023 Category: Cardiology Authors: Justyna A Szczygie ł Piotr Micha łek Gra żyna Truszkowska Joann Drozd-Soko łowska Aleksandra Wr óbel Maria Franaszczyk Monika Gawor-Prokopczyk Łukasz Mazurkiewicz Mateusz Ziarkiewicz Anna Waszczuk-Gajda Marta Legatowicz-Koprowska Ewa Walczak Piotr S Source Type: research

Clinical features, etiology and survival in patients with restrictive cardiomyopathy: A single center experience
CONCLUSIONS: Genetic testing should be considered in every patient with RCM where light-chain amyloidosis has been excluded. Survival remains poor regardless of etiology. Increased concentrations of GDF15, hs-TNT, NT-proBNP and pericardial effusion are associated with worse prognosis. Further studies are warranted.PMID:37937352 | DOI:10.33963/v.kp.97879 (Source: Kardiologia Polska)
Source: Kardiologia Polska - November 8, 2023 Category: Cardiology Authors: Justyna A Szczygie ł Piotr Micha łek Gra żyna Truszkowska Joann Drozd-Soko łowska Aleksandra Wr óbel Maria Franaszczyk Monika Gawor-Prokopczyk Łukasz Mazurkiewicz Mateusz Ziarkiewicz Anna Waszczuk-Gajda Marta Legatowicz-Koprowska Ewa Walczak Piotr S Source Type: research

Unveiling the structural and functional consequences of the p.D109G pathogenic mutation in human αB-Crystallin responsible for restrictive cardiomyopathy and skeletal myopathy
In this study, we generated this mutation in the α-Cry domain (ACD) which is crucial for forming the active chaperone dimeric state, using site-directed mutagenesis. After inducing expression in the bacterial host, we purified the mutant and wild-type recombinant proteins using anion exchange chromatography. Various spectroscopic evaluations revealed significant changes in the secondary, tertiary, and quaternary structures of human αB-Cry caused by this mutation. Furthermore, this pathogenic mutation led to the formation of protein oligomers with larger sizes than those of the wild-type protein counterpart. The mutant pr...
Source: International Journal of Biological Macromolecules - November 8, 2023 Category: Biochemistry Authors: Mehrnaz Hosseini Jafari Mohammad Bagher Shahsavani Masaru Hoshino Jun Hong Ali Akbar Saboury Ali Akbar Moosavi-Movahedi Reza Yousefi Source Type: research

Clinical features, etiology and survival in patients with restrictive cardiomyopathy: A single center experience
CONCLUSIONS: Genetic testing should be considered in every patient with RCM where light-chain amyloidosis has been excluded. Survival remains poor regardless of etiology. Increased concentrations of GDF15, hs-TNT, NT-proBNP and pericardial effusion are associated with worse prognosis. Further studies are warranted.PMID:37937352 | DOI:10.33963/v.kp.97879 (Source: Kardiologia Polska)
Source: Kardiologia Polska - November 8, 2023 Category: Cardiology Authors: Justyna A Szczygie ł Piotr Micha łek Gra żyna Truszkowska Joann Drozd-Soko łowska Aleksandra Wr óbel Maria Franaszczyk Monika Gawor-Prokopczyk Łukasz Mazurkiewicz Mateusz Ziarkiewicz Anna Waszczuk-Gajda Marta Legatowicz-Koprowska Ewa Walczak Piotr S Source Type: research