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Toxic Tau Aggregates Alter Cell Nucleus Structure in Harmful Ways
The set of neurodegenerative diseases characterized by aggregation of altered tau protein are collectively known as tauopathies. Alzheimer's disease is the best known of these conditions. The later stage of Alzheimer's disease, in which cell death is widespread, is characterized by tau aggregation and chronic inflammation of brain tissue. As noted here, how exactly tau alteration and aggregation causes dysfunction is still an active area of research that may result in ways to sabotage the progression of tauopathies. Tauopathies are characterized by the buildup of tau inside the brain. Alzheimer's disease is well k...
Source: Fight Aging! - December 27, 2023 Category: Research Authors: Reason Tags: Daily News Source Type: blogs

Fight Aging! Newsletter, January 23rd 2023
This study explored the association between tap drinking water and longevity in Cilento, Italy, to understand whether trace elements in local drinking water may have an influence on old, nonagenarian, and centenarian people and promote their health and longevity. Data on population and water sources were collected through the National Demographic Statistics, the Cilento Municipal Archives, and the Cilento Integrated Water Service. Ordinary least squares (OLS) regression and a geographically weight regression (GWR) model were used to study the spatial relationship between the explanatory and outcome variables of long...
Source: Fight Aging! - January 22, 2023 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs

Tau Aggregation Drives Neuroinflammation via Transposable Element Activation
Evidence suggests that there is a bidirectional relationship between tau aggregation and inflammation in the aging brain. Both occur in all brains, and when present to a greater degree contribute to the neurodegenerative conditions termed tauopathies. The most well known of these is Alzheimer's disease, in which tau aggregates and their surrounding toxic biochemistry cause the widespread cell death and severe symptoms that characterize the final stages of the condition. Various studies individually support each of the two directions of the relationship between tau and inflammation. Removing senescent cells from the ...
Source: Fight Aging! - January 20, 2023 Category: Research Authors: Reason Tags: Medicine, Biotech, Research Source Type: blogs

Fight Aging! Newsletter, March 14th 2022
This study tests the feasibility of chronically elevating skeletal muscle NAD+ in mice and investigates the putative effects on mitochondrial respiratory capacity, insulin sensitivity, and gene expression. The metabolic effects of NR and PT treatment were modest. We conclude that the chronic elevation of skeletal muscle NAD+ by the intravenous injection of NR is possible but does not affect muscle respiratory capacity or insulin sensitivity in either sedentary or physically active mice. Our data have implications for NAD+ precursor supplementation regimens. Muscle Strengthening Activities in Later Life Correlate ...
Source: Fight Aging! - March 13, 2022 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs

TMEM106B Aggregates in Neurodegenerative Disease
Researchers here report on their identification of a novel form of protein aggregate in the aging human brain, involving altered TMEM106B, associated with multiple types of neurodegenerative condition. It is far too early to talk about how greatly this dysfunction contributes to specific conditions, versus other, better characterized mechanisms. Determining whether it is important or a curiosity will be the work of years yet. The pace at which novel mechanisms such as this are discovered might give us some insight into how much more there is to be discovered in the biochemistry of the aging brain. TDP-43, another protein c...
Source: Fight Aging! - March 11, 2022 Category: Research Authors: Reason Tags: Daily News Source Type: blogs

Fight Aging! Newsletter, January 27th 2020
Fight Aging! publishes news and commentary relevant to the goal of ending all age-related disease, to be achieved by bringing the mechanisms of aging under the control of modern medicine. This weekly newsletter is sent to thousands of interested subscribers. To subscribe or unsubscribe from the newsletter, please visit: https://www.fightaging.org/newsletter/ Longevity Industry Consulting Services Reason, the founder of Fight Aging! and Repair Biotechnologies, offers strategic consulting services to investors, entrepreneurs, and others interested in the longevity industry and its complexities. To find out m...
Source: Fight Aging! - January 26, 2020 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs

Notes on the SENS Research Foundation Pitch Day, January 2020
The J.P. Morgan Healthcare conference runs every year in San Francisco, a big draw for the biotech industry, and many organizations take the opportunity to host events at the same time. Among these, the SENS Research Foundation has for the past few years hosted a pitch day in which biotech companies in the longevity industry, largely startups, present to that portion of the Bay Area investor community interested in funding the treatment of aging as a medical condition. I was there to present on progress at Repair Biotechnologies, and took some notes on the other companies as they talked about their work. Kimera Labs ...
Source: Fight Aging! - January 20, 2020 Category: Research Authors: Reason Tags: Investment Source Type: blogs

Bullet List
Too much going on for one post today.1. Sock puppet?We have a reader who is obsessed with his false conclusion that the commenter Don Quixote is actually my sock puppet. I ask you please to stop wasting your time and mine with this delusion. We do know each other, but we have seen each other once in the past 15 years or so. I live in Connecticut and he lives in the midwest, more than 1,000 miles away. Whatever I have to say, I am more than happy to say in my own name, and I do. BTW I am not known as Michael.2. Mad KingYour Intertubes are all aflutter with speculation and discussion about the neurodegenerative disease many ...
Source: Stayin' Alive - January 3, 2020 Category: American Health Source Type: blogs

Progressive Supranuclear Palsy: MRI
PSP on MRI shows midbrain atrophy, normal pons. Case submitted by Dr MGK Murthy.Humming bird sign or penguin sign, flattening or concave outline to the superior aspect of the midbrain Mickey mouse appearance: reduction of AP midline midbrain diameter, at the level of the superior colliculiMorning glory sign: loss of the lateral convex margin of the tegmentum Famous Radiology Blog http://www.sumerdoc.blogspot.com TeleRad Providers at www.teleradproviders.com Mail us at sales@teleradproviders.com (Source: Sumer's Radiology Site)
Source: Sumer's Radiology Site - November 23, 2019 Category: Radiology Authors: Sumer Sethi Source Type: blogs

EnClear Therapies: Working to Filter Cerebrospinal Fluid
Older people have a lot of metabolic waste in their cerebrospinal fluid, of which the amyloid-β associated with Alzheimer's disease is probably of greatest interest at the present time. It is an interesting question as to why this increase over time occurs, particularly considering the point that the presence of amyloid-β and other molecules is dynamic, a constant process of creation and destruction. A number of groups, such as Leucadia Therapeutics, make the case for failure of mechanical systems of drainage by which cerebrospinal fluid leaves the brain. Without that drainage to act as a sink for metabolic waste, the wa...
Source: Fight Aging! - December 21, 2018 Category: Research Authors: Reason Tags: Daily News Source Type: blogs

MKSAP: 56-year-old woman with a 1-year history of tremor
Test your medicine knowledge with the MKSAP challenge, in partnership with the American College of Physicians. A 56-year-old woman is evaluated for a 1-year history of tremor. The tremor is more prominent on the right side. She also reports increasing problems with balance and numerous falls, especially when arising from a chair or turning. The patient does not have any significant cognitive symptoms. She has occasional urinary incontinence, intermittent constipation, and a history of acting out of dreams during sleep. On physical examination, blood pressure is 115/75 mm Hg sitting and 85/70 mm Hg standing, pulse rate is...
Source: Kevin, M.D. - Medical Weblog - September 8, 2018 Category: General Medicine Authors: < a href="https://www.kevinmd.com/blog/post-author/mksap" rel="tag" > mksap < /a > Tags: Conditions Neurology Source Type: blogs

Fight Aging! Newsletter, August 27th 2018
Fight Aging! provides a weekly digest of news and commentary for thousands of subscribers interested in the latest longevity science: progress towards the medical control of aging in order to prevent age-related frailty, suffering, and disease, as well as improvements in the present understanding of what works and what doesn't work when it comes to extending healthy life. Expect to see summaries of recent advances in medical research, news from the scientific community, advocacy and fundraising initiatives to help speed work on the repair and reversal of aging, links to online resources, and much more. This content is...
Source: Fight Aging! - August 26, 2018 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs

Clearing Senescent Cells from the Brain Reduces Tau Aggregation and Improves Function in Mouse Models of Alzheimer's Disease
Over the past few years researchers have demonstrated, numerous times, that using senolytic therapies to remove a significant fraction of senescent cells from old tissues in mice can reverse aspects of aging, successfully treat multiple age-related diseases that presently have no viable treatment options, and extend healthy life. In an exciting recent addition to this field of research, scientists used the dasatinib and quercetin combination in mouse models of Alzheimer's disease. The result is a restoration of function and a reduction of the characteristic tau aggregation that is a feature of this condition. The researche...
Source: Fight Aging! - August 23, 2018 Category: Research Authors: Reason Tags: Medicine, Biotech, Research Source Type: blogs

Fight Aging! Newsletter, April 23rd 2018
In conclusion, a debate exists on whether aging is a disease in itself. Some authors suggest that physiological aging (or senescence) is not really distinguishable from pathology, while others argue that aging is different from age-related diseases and other pathologies. It is interesting to stress that the answer to this question has important theoretical and practical consequences, taking into account that various strategies capable of setting back the aging clock are emerging. The most relevant consequence is that, if we agree that aging is equal to disease, all human beings have to be considered as patients to be treat...
Source: Fight Aging! - April 22, 2018 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs

CXCR4 as an Indicator of Microglial Involvement in Neurodegenerative Diseases
The open access paper noted here reports on the use of a genetic analysis to shed further light on the relative importance of shared mechanisms across a range of neurodegenerative conditions in which tau aggregation is thought to be important. The researchers find associations in gene expression between these conditions that suggesting microglial dysfunction is an important common determinant of disease progression. If one looks over all of the most common neurodegenerative diseases, patients exhibit a number of overlapping mechanisms that appear plausible as proximate causes of brain cell dysfunction and death. Som...
Source: Fight Aging! - April 19, 2018 Category: Research Authors: Reason Tags: Daily News Source Type: blogs