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Neuroscientists Receive The Brain Prize for Crucial Alzheimer's Disease Research
The tireless efforts of these four leading scientists to understand Alzheimer's have provided the foundation for treatment of one of the most devastating diseases of our era. For this, they are receiving the world's most valuable prize for brain research, The Lundbeck Foundation Brain Prize, worth 1 million euros.byAlzheimer's Reading RoomThere is still no cure for dementia such as Alzheimer's, we can only provide medication fortemporary alleviation of symptoms.Thanks to four leading European scientists and their many years of intense research in the laboratory,the way is now paved for better treatment and, in time, preven...
Source: Alzheimer's Reading Room, The - March 8, 2018 Category: Neurology Tags: alzheimer's research brain brain health brain prize brain research dementia research science Source Type: blogs

Executive Functions in Health and Disease: New book to help integrate Cognitive Neuroscience and Neuropsychology
__________ Neuroscience used to be the monopoly of a few elite universities located in a handful of countries. Neuropsychology used to be a quaint niche discipline relatively unconnected to the larger world of neuroscience and content in its methods with paper-and-pencil tests. Neuroscience itself was relatively unconcerned with higher-order cognition, and the very term “cognitive neuroscience” was often met with rolled eyes by scientists working in more established areas of brain research (a personal observation made in the 1980s and even 1990s on more than one occasion). And the interest...
Source: SharpBrains - August 8, 2017 Category: Neuroscience Authors: Dr. Elkhonon Goldberg Tags: Cognitive Neuroscience Health & Wellness Professional Development Alexander-Luria clinical psychologists cognition cognitive-psychologists disease Executive-Functions frontal-lobe medical neurologists neuropsychologists Neuropsyc Source Type: blogs

Drug Halts Alzheimer ’s Related Tau Damage in Brain
In some people, the brain protein tau collects into toxic tangles that damage brain cells and contribute to diseases such as Alzheimer ’s.By Alzheimer's Reading RoomResearchers at Washington University School of Medicine in St. Louis have found a drug that can lower tau levels and prevent some neurological damage.I thought this information was interesting so I decided to bring this research summary up for all to read.Note: Oligonucleotide treatments have been approved by the Food and Drug Administration for two neuromuscular diseases.How to Adapt the Caregiver Brain to Alzheimer's and DementiaSubscribe to the Alzheimer's...
Source: Alzheimer's Reading Room, The - January 27, 2017 Category: Neurology Tags: alzheimer alzheimers drug alzheimers treatment dementia care health help alzheimer's help with dementia care science tau Source Type: blogs

Testing the Prospects for Therapies that Target Tau Protein
This popular science article looks at efforts to build therapies that target aggregations of tau, thought to contribute to neurodegenerative conditions such as Alzheimer's disease, but also present in a range of diseases known as tauopathies. Some tauopathies may in effect come to serve as testbeds for later efforts to treat Alzheimer's by clearing tau aggregates, because the link between tau and pathology is more clear in these conditions: About 100 times rarer than Parkinson's disease, and often mistaken for it, progressive supranuclear palsy (PSP) afflicts fewer than 20,000 people in the U.S. This little-known ...
Source: Fight Aging! - June 10, 2016 Category: Research Authors: Reason Tags: Daily News Source Type: blogs

Infectious agents with no genome
If the reader does not believe that viroids and satellites are distinctive, then surely prions, infectious agents composed only of protein, must impress. The question of whether infectious agents exist without genomes arose with the discovery and characterization of infectious agents associated with a group of diseases called transmissible spongiform encephalopathies (TSEs). These diseases are rare, but always fatal, neurodegenerative disorders that afflict humans and other mammals. They are characterized by long incubation periods, spongiform changes in the brain associated with loss of neurons, and the absence of host re...
Source: virology blog - January 30, 2015 Category: Virology Authors: Vincent Racaniello Tags: Basic virology Information bovine spongiform encephalopathy cervid wasting disease Creutzfeldt-Jakob disease Fatal familial insomnia mad cow disease prion scrapie Stanley Prusiner transmissible spongiform encephalopathy TSE viral Source Type: blogs

More Correlation of Dementia with Many Tiny Strokes
Studies of many aged brains shows that the progression of various types of dementia correlates with a history of many small, unnoticed strokes. These leave behind small infarcts, areas of tissue death in the brain caused by a local blockage of small blood vessels. The brains of people suffering neurodegeneration tend to have more of these infarcts. Is this causative, however? Some of the past evidence is fairly compelling with regard to causation, but this remains an open question: since aging is a global phenomenon many of its aspects should be expected to correlate with one another regardless of any direct linkage. Here...
Source: Fight Aging! - December 30, 2014 Category: Research Authors: Reason Tags: Daily News Source Type: blogs

How Does Tau Protein Accumulation Harm Brain Cells in Age-Related Neurodegenerative Conditions?
One of the discoveries of past years in Alzheimer's disease research is that the β-amyloid accumulating between cells is less harmful to neurons than other associated proteins involved in the creation of that amyloid. Here is a paper that suggests much the same sort of thing for neurofibillary tangles, the other characteristic form of protein deposit associated with Alzheimer's: Pathological aggregation of the microtubule-associated protein tau and subsequent accumulation of neurofibrillary tangles (NFTs) or other tau-containing inclusions are defining histopathological features of many neurodegenerative diseases, which ...
Source: Fight Aging! - September 26, 2014 Category: Research Authors: Reason Tags: Daily News Source Type: blogs

PET Scans of Brain for Tau Protein an Early Predictor of Memory Loss
For the past few years, one of the most important research areas in radiology has been the search for reliable imaging techniques to diagnose early Alzheimer's disease. This has involved attempts to identify deposits of both beta amyloid and tau protein (see: Diagnosing Alzheimer's Disease with Imaging and Biomarkers; Brain Plaque Diagnostic Imaging Procedure Approved by FDA; Alzheimer's Amyloid Tangle Theory Will Be Tested with Merck Drug Trial). A recent article provides a progress report on this research relating to tau protein (see: Tau Imaging Strong Predictor of Memory Loss): Tau protein in ke...
Source: Lab Soft News - July 31, 2014 Category: Pathologists Authors: Bruce Friedman Tags: Hospitals and Healthcare Delivery Imaging Other Than Pathology Medical Research Source Type: blogs

What Rare Diseases Teach Us About the Cellular Basis of Aging
In June, 2014, my book, entitled Rare Diseases and Orphan Drugs: Keys to Understanding and Treating the Common Diseases was published by Elsevier. The book builds the argument that our best chance of curing the common diseases will come from studying and curing the rare diseases. Chapter 4 explains that much what we think we know about the aging process comes from studying rare diseases of premature aging, such as Hutchinson–Gilford progeria syndrome, Bloom syndrome, Werner syndrome, Cockayne syndrome, dyskeratosis congenita, Fanconi anemia, Wolfram syndrome, and xeroderma pigmentosum. Lessons learned from these rare...
Source: Specified Life - July 4, 2014 Category: Pathologists Tags: ageing aging biology of aging cancer cause of aging cell renewal common disease genetic disease orphan disease orphan drugs rare disease Source Type: blogs