Progressive Supranuclear Palsy: MRI

PSP on MRI shows midbrain atrophy, normal pons. Case submitted by Dr MGK Murthy.Humming bird sign or penguin sign, flattening or concave outline to the superior aspect of the midbrain Mickey mouse appearance: reduction of AP midline midbrain diameter, at the level of the superior colliculiMorning glory sign: loss of the lateral convex margin of the tegmentum  Famous Radiology Blog http://www.sumerdoc.blogspot.com TeleRad Providers at www.teleradproviders.com Mail us at sales@teleradproviders.com
Source: Sumer's Radiology Site - Category: Radiology Authors: Source Type: blogs

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Frontotemporal dementia (FTD) encompasses a group of clinical syndromes, including behavioral variant FTD, nonfluent variant primary progressive aphasia, semantic variant primary progressive aphasia, FTD motor neuron disease, progressive supranuclear palsy syndrome, and corticobasal syndrome. Early on in its course, FTD is commonly seen in psychiatric clinics. In this article the authors review the neuroimaging, pathology, genetics, and therapeutic interventions for FTD spectrum disorders.
Source: The Psychiatric Clinics of North America - Category: Psychiatry Authors: Source Type: research
Frontotemporal dementia (FTD) encompasses a group of clinical syndromes, including behavioral-variant FTD, nonfluent variant primary progressive aphasia, semantic variant primary progressive aphasia, FTD motor neuron disease, progressive supranuclear palsy syndrome, and corticobasal syndrome. Early on in its course, FTD is commonly seen in psychiatric clinics. We review the clinical features and diagnostic criteria in FTD spectrum disorders.
Source: The Psychiatric Clinics of North America - Category: Psychiatry Authors: Source Type: research
This study aimed to investigate the distribution and degree of tau pathology-associated neurodegeneration, with an emphasis on the hypoglossal nucleus, in patients with PSP-RS. Six clinicopathologically proven PSP-RS cases were included in this study. All patients were clinicopathologically and immunohistochemically re-evaluated. This study confirmed the following neuropathological characteristics of PSP-RS: (1) neurodegeneration usually affects the striatonigral system and cerebellar dentate nucleus; (2) the cerebellar afferent system in PSP-RS is affected by absent-to-mild neurodegeneration; and (3) the extent of tau dis...
Source: Revue Neurologique - Category: Neurology Tags: Rev Neurol (Paris) Source Type: research
Consider consumption of annonacin-containing plant products, including pawpaw, as a possible environmental risk factor for atypical parkinsonism.
Source: Neurology Clinical Practice - Category: Neurology Authors: Tags: Parkinson's disease/Parkinsonism, Progressive supranuclear palsy, Other toxicology Case Source Type: research
Progressive supranuclear palsy (PSP) is a rare movement disorder with poor prognosis. This retrospective study aimed to characterize the natural history of PSP and to find predictors of shorter survival and fa...
Source: BMC Neurology - Category: Neurology Authors: Tags: Research article Source Type: research
ConclusionAlthough available studies in patients with APS and dementia suffer from methodological limitations, the expert consensus emerged from the EANM/EAN recommendations was in favor of its use for specific clinical questions in these group of patients. Studies in a larger number of patients published after the publication of the joint recommendations have further supported the use of18F-FDG PET in patients with APS associated with dementia.
Source: Clinical and Translational Imaging - Category: Radiology Source Type: research
Progressive supranuclear palsy is a taupathy disorder often mistaken on diagnosis by other neurocognitive disorders such as Parkinson's (PD) and Alzheimer's (AD) disease amongst other. PSP tends to be diagnosed in the later course of the disease and by time of diagnosis, individuals have a median survival of 7?years. PSP is a disease in which a diagnosis and treatment is done in a multidisiplinary approach involving collaboration of Psychiatry and Neurology. As it was seen in this clinical case which describes a patient with undetected progressive supranuclear palsy who were referred to a university hospital psychiatric em...
Source: The American Journal of Geriatric Psychiatry - Category: Geriatrics Authors: Tags: Poster Number: EI-36 Source Type: research
Improved knowledge of the prediagnostic phase of progressive supranuclear palsy (PSP) might provide information on when and how the disease starts, along with the opportunity to test therapies in disease stages with lesser neurodegeneration.
Source: Parkinsonism and Related Disorders - Category: Neurology Authors: Source Type: research
Conclusions In line with known neuropathological changes, the spatial pattern and magnitude of 11C-PBB3 tau binding differ between CBS, PSP, and AD, which may be of diagnostic utility. Thus, 11C-PBB3 offers a promising lead structure for development of ligands for tau imaging, including 4R-tauopathies.
Source: Clinical Nuclear Medicine - Category: Nuclear Medicine Tags: Original Articles Source Type: research
Progressive Supranuclear Palsy (PSP) and Parkinson's Disease (PD), especially in their early stages, show overlapping clinical manifestations. The criteria for the diagnosis of PSP, released in 2017, indicate four basic features of the disease—postural instability (P), akinesia (A), oculomotor dysfunction (O) and cognitive and lingual disorders (C), which clarify the interpretation of the disease. There is growing interest in the second most common variant of PSP—parkinsonism predominant PSP-P. It is observed in up to 35% of cases. The diagnosis of PSP-P requires the presence of akinetic-rigid predominantly axi...
Source: Frontiers in Neurology - Category: Neurology Source Type: research
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