Relaxant Effects of Piperine and Piperlongumine from Piper longum Linn. Fruits on Porcine Coronary Artery
Biol Pharm Bull. 2023 Nov 21. doi: 10.1248/bpb.b23-00694. Online ahead of print.ABSTRACTSince ancient times, Piper longum Linn. fruits have been recognized for exhibiting various effects, including the diaphoretic effects linked to enhanced blood flow. Piperine and piperlongumine coexist in Piper longum Linn. fruits, although the cardiovascular effects of both compounds remain elusive. We investigated their action of piperine and piperlongumine in porcine coronary arteries, comparing them to the Ca2+ channel antagonist diltiazem. Piperlongumine, unlike piperine or diltiazem, concentration-dependently inhibited basal contra...
Source: Biological and Pharmaceutical Bulletin - November 21, 2023 Category: Drugs & Pharmacology Authors: Kazuo Noguchi Moka Teramura Ayano Kitagawa Miyuki Ejima Chinami Ueda Haruna Kanae Source Type: research
Relaxant Effects of Piperine and Piperlongumine from Piper longum Linn. Fruits on Porcine Coronary Artery
Biol Pharm Bull. 2023 Nov 21. doi: 10.1248/bpb.b23-00694. Online ahead of print.ABSTRACTSince ancient times, Piper longum Linn. fruits have been recognized for exhibiting various effects, including the diaphoretic effects linked to enhanced blood flow. Piperine and piperlongumine coexist in Piper longum Linn. fruits, although the cardiovascular effects of both compounds remain elusive. We investigated their action of piperine and piperlongumine in porcine coronary arteries, comparing them to the Ca2+ channel antagonist diltiazem. Piperlongumine, unlike piperine or diltiazem, concentration-dependently inhibited basal contra...
Source: Biological and Pharmaceutical Bulletin - November 21, 2023 Category: Drugs & Pharmacology Authors: Kazuo Noguchi Moka Teramura Ayano Kitagawa Miyuki Ejima Chinami Ueda Haruna Kanae Source Type: research
Relaxant Effects of Piperine and Piperlongumine from Piper longum Linn. Fruits on Porcine Coronary Artery
Biol Pharm Bull. 2023 Nov 21. doi: 10.1248/bpb.b23-00694. Online ahead of print.ABSTRACTSince ancient times, Piper longum Linn. fruits have been recognized for exhibiting various effects, including the diaphoretic effects linked to enhanced blood flow. Piperine and piperlongumine coexist in Piper longum Linn. fruits, although the cardiovascular effects of both compounds remain elusive. We investigated their action of piperine and piperlongumine in porcine coronary arteries, comparing them to the Ca2+ channel antagonist diltiazem. Piperlongumine, unlike piperine or diltiazem, concentration-dependently inhibited basal contra...
Source: Biological and Pharmaceutical Bulletin - November 21, 2023 Category: Drugs & Pharmacology Authors: Kazuo Noguchi Moka Teramura Ayano Kitagawa Miyuki Ejima Chinami Ueda Haruna Kanae Source Type: research
Relaxant Effects of Piperine and Piperlongumine from Piper longum Linn. Fruits on Porcine Coronary Artery
Biol Pharm Bull. 2023 Nov 21. doi: 10.1248/bpb.b23-00694. Online ahead of print.ABSTRACTSince ancient times, Piper longum Linn. fruits have been recognized for exhibiting various effects, including the diaphoretic effects linked to enhanced blood flow. Piperine and piperlongumine coexist in Piper longum Linn. fruits, although the cardiovascular effects of both compounds remain elusive. We investigated their action of piperine and piperlongumine in porcine coronary arteries, comparing them to the Ca2+ channel antagonist diltiazem. Piperlongumine, unlike piperine or diltiazem, concentration-dependently inhibited basal contra...
Source: Biological and Pharmaceutical Bulletin - November 21, 2023 Category: Drugs & Pharmacology Authors: Kazuo Noguchi Moka Teramura Ayano Kitagawa Miyuki Ejima Chinami Ueda Haruna Kanae Source Type: research
Relaxant Effects of Piperine and Piperlongumine from Piper longum Linn. Fruits on Porcine Coronary Artery
Biol Pharm Bull. 2023 Nov 21. doi: 10.1248/bpb.b23-00694. Online ahead of print.ABSTRACTSince ancient times, Piper longum Linn. fruits have been recognized for exhibiting various effects, including the diaphoretic effects linked to enhanced blood flow. Piperine and piperlongumine coexist in Piper longum Linn. fruits, although the cardiovascular effects of both compounds remain elusive. We investigated their action of piperine and piperlongumine in porcine coronary arteries, comparing them to the Ca2+ channel antagonist diltiazem. Piperlongumine, unlike piperine or diltiazem, concentration-dependently inhibited basal contra...
Source: Biological and Pharmaceutical Bulletin - November 21, 2023 Category: Drugs & Pharmacology Authors: Kazuo Noguchi Moka Teramura Ayano Kitagawa Miyuki Ejima Chinami Ueda Haruna Kanae Source Type: research
Simultaneous realization of heavy metal Cd solidification and chloride separation in municipal solid waste incineration fly ash: Mechanism and DFT analysis
This study achieved the solidification of the excessive heavy metal Cd by transforming MSWI fly ash into a solidified body mainly composed of ettringite, while also purifying the calcium and sulfate ions in the chloride solution. The research results demonstrate that the introduction of aluminum ions rapidly decreases the pH value of the MSWI fly ash reaction system. By adjusting the reaction system to a pH value of 11.50, the conversion rate of calcium ions reaches 99.68%, the separation rate of chloride reaches 95.99%, and the solidification rate of heavy metal Cd reaches 98.92%. Density functional theory (DFT) calculati...
Source: Chemosphere - November 18, 2023 Category: Chemistry Authors: Fuli Liu Ze Liu Yu Gao Rui Liu Dongmin Wang Baomin Wang Yan You Source Type: research
Simultaneous realization of heavy metal Cd solidification and chloride separation in municipal solid waste incineration fly ash: Mechanism and DFT analysis
This study achieved the solidification of the excessive heavy metal Cd by transforming MSWI fly ash into a solidified body mainly composed of ettringite, while also purifying the calcium and sulfate ions in the chloride solution. The research results demonstrate that the introduction of aluminum ions rapidly decreases the pH value of the MSWI fly ash reaction system. By adjusting the reaction system to a pH value of 11.50, the conversion rate of calcium ions reaches 99.68%, the separation rate of chloride reaches 95.99%, and the solidification rate of heavy metal Cd reaches 98.92%. Density functional theory (DFT) calculati...
Source: Chemosphere - November 18, 2023 Category: Chemistry Authors: Fuli Liu Ze Liu Yu Gao Rui Liu Dongmin Wang Baomin Wang Yan You Source Type: research
Effects of two oral electrolyte solutions in healthy newborn lambs
This study aimed to evaluate the effects of two oral electrolyte solutions (OES), commercialized for the hydration of calves, on the water, electrolyte, and acid-base balance of newborn lambs. Twenty healthy crossbred Santa Inês lambs, 10 days old, 4-5 kg of body weight (BW), and fed on mother's milk, were included. The OES tested were slightly hyposmolar (OES 1: 279 mOsm/L; and OES 2: 283 mOsm/L) and had an alkalizing potential with an effective strong ion difference (SID3) of 76 mmol/L (OES 1) and 58 mmol/L (OES 2). In a crossover design, all lambs received the two OES, one at a time, with an interval of 7 days. On the ...
Source: Cell Research - November 18, 2023 Category: Cytology Authors: Nicoly Nayana Marcom Lisandra de Camargo Campos Mayara Cardoso Dos Anjos Vinicius Maciel Cunha Mateus Greg ório Dos Santos Priscilla Fajardo Valente Pereira Karina Keller Marques da Costa Flaiban J úlio Augusto Naylor Lisbôa Source Type: research
Simultaneous realization of heavy metal Cd solidification and chloride separation in municipal solid waste incineration fly ash: Mechanism and DFT analysis
This study achieved the solidification of the excessive heavy metal Cd by transforming MSWI fly ash into a solidified body mainly composed of ettringite, while also purifying the calcium and sulfate ions in the chloride solution. The research results demonstrate that the introduction of aluminum ions rapidly decreases the pH value of the MSWI fly ash reaction system. By adjusting the reaction system to a pH value of 11.50, the conversion rate of calcium ions reaches 99.68%, the separation rate of chloride reaches 95.99%, and the solidification rate of heavy metal Cd reaches 98.92%. Density functional theory (DFT) calculati...
Source: Chemosphere - November 18, 2023 Category: Chemistry Authors: Fuli Liu Ze Liu Yu Gao Rui Liu Dongmin Wang Baomin Wang Yan You Source Type: research
Simultaneous realization of heavy metal Cd solidification and chloride separation in municipal solid waste incineration fly ash: Mechanism and DFT analysis
This study achieved the solidification of the excessive heavy metal Cd by transforming MSWI fly ash into a solidified body mainly composed of ettringite, while also purifying the calcium and sulfate ions in the chloride solution. The research results demonstrate that the introduction of aluminum ions rapidly decreases the pH value of the MSWI fly ash reaction system. By adjusting the reaction system to a pH value of 11.50, the conversion rate of calcium ions reaches 99.68%, the separation rate of chloride reaches 95.99%, and the solidification rate of heavy metal Cd reaches 98.92%. Density functional theory (DFT) calculati...
Source: Chemosphere - November 18, 2023 Category: Chemistry Authors: Fuli Liu Ze Liu Yu Gao Rui Liu Dongmin Wang Baomin Wang Yan You Source Type: research
Growth and production of cowpea beans under potassium doses in soil of cerrado in Amap á, Brazil
The objective of this work was to evaluate parameters of growth and production in cowpea culture, as a function of potassium fertilization in soil of the cerrado of Amapá. The parameters of growth and production of the cowpea culture were evaluated, as a function of potassium fertilization in the soil of the cerrado of Amapá. The experiment was conducted in a greenhouse, using a completely randomized experimental design, with four replications, in a 5x2 factorial scheme, totaling 40 experimental units, which were composed of plastic pots containing 7 dm3 of soil collected from the arable layer (0-20 cm ) of a typical Hyp...
Source: Braz J Biol - November 16, 2023 Category: Biology Authors: K S Q Costa C F Oliveira M P Melo H C Lima R L C Ferreira N C Melo F K C Moraes F J R Cruz L C Souza V R Nascimento Source Type: research
Growth and production of cowpea beans under potassium doses in soil of cerrado in Amap á, Brazil
The objective of this work was to evaluate parameters of growth and production in cowpea culture, as a function of potassium fertilization in soil of the cerrado of Amapá. The parameters of growth and production of the cowpea culture were evaluated, as a function of potassium fertilization in the soil of the cerrado of Amapá. The experiment was conducted in a greenhouse, using a completely randomized experimental design, with four replications, in a 5x2 factorial scheme, totaling 40 experimental units, which were composed of plastic pots containing 7 dm3 of soil collected from the arable layer (0-20 cm ) of a typical Hyp...
Source: Braz J Biol - November 16, 2023 Category: Biology Authors: K S Q Costa C F Oliveira M P Melo H C Lima R L C Ferreira N C Melo F K C Moraes F J R Cruz L C Souza V R Nascimento Source Type: research
Growth and production of cowpea beans under potassium doses in soil of cerrado in Amap á, Brazil
The objective of this work was to evaluate parameters of growth and production in cowpea culture, as a function of potassium fertilization in soil of the cerrado of Amapá. The parameters of growth and production of the cowpea culture were evaluated, as a function of potassium fertilization in the soil of the cerrado of Amapá. The experiment was conducted in a greenhouse, using a completely randomized experimental design, with four replications, in a 5x2 factorial scheme, totaling 40 experimental units, which were composed of plastic pots containing 7 dm3 of soil collected from the arable layer (0-20 cm ) of a typical Hyp...
Source: Braz J Biol - November 16, 2023 Category: Biology Authors: K S Q Costa C F Oliveira M P Melo H C Lima R L C Ferreira N C Melo F K C Moraes F J R Cruz L C Souza V R Nascimento Source Type: research
Growth and production of cowpea beans under potassium doses in soil of cerrado in Amap á, Brazil
The objective of this work was to evaluate parameters of growth and production in cowpea culture, as a function of potassium fertilization in soil of the cerrado of Amapá. The parameters of growth and production of the cowpea culture were evaluated, as a function of potassium fertilization in the soil of the cerrado of Amapá. The experiment was conducted in a greenhouse, using a completely randomized experimental design, with four replications, in a 5x2 factorial scheme, totaling 40 experimental units, which were composed of plastic pots containing 7 dm3 of soil collected from the arable layer (0-20 cm ) of a typical Hyp...
Source: Braz J Biol - November 16, 2023 Category: Biology Authors: K S Q Costa C F Oliveira M P Melo H C Lima R L C Ferreira N C Melo F K C Moraes F J R Cruz L C Souza V R Nascimento Source Type: research
Hypokalemic periodic paralysis in a teenage boy after an intense period of exercise: A rare case report
Key Clinical Messages
Diagnosis of rare even can be missed due to less familiarity with the disorder.
In patients with muscle weakness, infectious causes are prioritized.
Electrolyte profile not only identifies the problem, but also prevents unnecessary workup.AbstractIn underdeveloped countries, diagnosis of rare disorders is usually delayed due to less familiarity of the clinicians to such disorders. As a result, infectious and inflammatory causes for an ailment are prioritized as compared to non-infectious etiologies. Hypokalemic periodic paralysis (PP) is a rare disorder, characterized by episodic muscle weakness th...
Source: Clinical Case Reports - November 15, 2023 Category: General Medicine Authors: Sahar Noor,
Abdul Jamil Rasooly,
Sultan Mahmood Alikozai,
Tooryalai Jalalzai,
Ahmed Maseh Haidary,
Najla Nasir,
Sarah Noor,
Masooma Farooqi,
Husna Mansoori Tags: CASE REPORT Source Type: research
