Pleuropulmonary Blastoma Research This is an RSS file. You can use it to subscribe to this data in your favourite RSS reader or to display this data on your own website or blog.

Outcomes for Children With Type II and Type III Pleuropulmonary Blastoma Following Chemotherapy: A Report From the International PPB/ DICER1 Registry
CONCLUSION: The use of IVADo in children with type II and type III PPB resulted in similar-to-improved outcomes compared with historical controls. Inferior outcomes with metastatic disease suggest the need for novel therapies. This large cohort of uniformly treated children with advanced PPB serves as a benchmark for future multicenter therapeutic studies for this rare pediatric tumor.PMID:36137255 | DOI:10.1200/JCO.21.02925 (Source: Cancer Control)
Source: Cancer Control - September 22, 2022 Category: Cancer & Oncology Authors: Kris Ann P Schultz Anne K Harris Alexander T Nelson Dave Watson John T Lucas Doug Miniati Douglas R Stewart Kelly N Hagedorn William Mize Junne Kamihara Sarah G Mitchell David B Wilson Katie Gettinger Arun A Rangaswami Laura A Harney Carlos Rodriguez Gali Source Type: research

Outcomes for Children With Type II and Type III Pleuropulmonary Blastoma Following Chemotherapy: A Report From the International PPB/ DICER1 Registry
CONCLUSION: The use of IVADo in children with type II and type III PPB resulted in similar-to-improved outcomes compared with historical controls. Inferior outcomes with metastatic disease suggest the need for novel therapies. This large cohort of uniformly treated children with advanced PPB serves as a benchmark for future multicenter therapeutic studies for this rare pediatric tumor.PMID:36137255 | DOI:10.1200/JCO.21.02925 (Source: Clinical Lung Cancer)
Source: Clinical Lung Cancer - September 22, 2022 Category: Cancer & Oncology Authors: Kris Ann P Schultz Anne K Harris Alexander T Nelson Dave Watson John T Lucas Doug Miniati Douglas R Stewart Kelly N Hagedorn William Mize Junne Kamihara Sarah G Mitchell David B Wilson Katie Gettinger Arun A Rangaswami Laura A Harney Carlos Rodriguez Gali Source Type: research

Bilateral Ovarian Sertoli-Leydig Cell Tumors Harboring DICER1 Germline and Distinct Somatic Mutations: Case Report and Literature Review
We describe a 15-year-old female with bilateral, asynchronous Sertoli-Leydig cell tumors (SLCT). Both tumors harbored an identical germline frameshift mutation as well as unique somatic DICER1 hot-spot point mutations. Discussion: A review of bilateral SLCTs demonstrates that all patients with available DICER1 mutation status carried a germline DICER1 mutation (100%, 9 of 9). In cases with known somatic DICER1 status on bilateral tumors, all harbored distinct somatic mutations (100%, 5 of 5). Our findings support the notion that bilateral ovarian SLCTs are indeed separate events and do not represent recurrent or metastatic...
Source: Fetal and Pediatric Pathology - September 19, 2022 Category: Pathology Authors: Caitlin E Hughes Jiancong Liang Vera Paulson Huiying Wang Source Type: research

Proteomic methods identified P75 as marker of poor prognosis in pleuropulmonary blastoma
CONCLUSIONS: MCM4, PCNA and P75 may all play an important role in the progression of pleuropulmonary blastoma. Among them, P75 is related to the prognosis and may be used as a marker to predict the prognosis of pleuropulmonary blastoma.PMID:36067610 | DOI:10.1016/j.prp.2022.154067 (Source: Pathology, Research and Practice)
Source: Pathology, Research and Practice - September 6, 2022 Category: Pathology Authors: Fenghua Wang Wei Liu Jianhua Liang Hui Wang Jue Tang Jiahang Zeng Dongmei Huang Qinglin Yang Le Li Source Type: research

Clinical and molecular features of pleuropulmonary blastoma in children in Hong Kong: case reports
Hong Kong Med J. 2022 Aug;28(4):328-330. doi: 10.12809/hkmj219503.NO ABSTRACTPMID:35989435 | DOI:10.12809/hkmj219503 (Source: Hong Kong Med J)
Source: Hong Kong Med J - August 22, 2022 Category: General Medicine Authors: A P Y Liu M K L Fung M Lee J L F Fung M H Y Tsang C W Luk B H Y Chung G C F Chan Source Type: research

Clinical and molecular features of pleuropulmonary blastoma in children in Hong Kong: case reports
Hong Kong Med J. 2022 Aug;28(4):328-330. doi: 10.12809/hkmj219503.NO ABSTRACTPMID:35989435 | DOI:10.12809/hkmj219503 (Source: Hong Kong Medical Journal)
Source: Hong Kong Medical Journal - August 22, 2022 Category: General Medicine Authors: A P Y Liu M K L Fung M Lee J L F Fung M H Y Tsang C W Luk B H Y Chung G C F Chan Source Type: research