Fight Aging! Newsletter, May 3rd 2021
Fight Aging! publishes news and commentary relevant to the goal of ending all age-related disease, to be achieved by bringing the mechanisms of aging under the control of modern medicine. This weekly newsletter is sent to thousands of interested subscribers. To subscribe or unsubscribe from the newsletter,
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Longevity Industry Consulting Services
Reason, the founder of Fight Aging! and Repair Biotechnologies, offers strategic consulting services to investors, entrepreneurs, and others interested in the longevity industry and its complexities. To find out m...
Source: Fight Aging! - May 2, 2021 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
Accelerating Progress Towards the Reversible Cryopreservation of Organs
There is a growing level of interest and funding for the goal of reversible cryopreservation of whole organs. If achieved, this would radically improve the logistics of organ donation, allowing organs to be kept indefinitely before use. Proof of principle demonstrations have been carried out, but the field has lacked the funding and impetus to rapidly build upon that starting point. Hopefully this will change. The ability to reliably vitrify and thaw large tissue sections with minimal ice crystal formation, cell death, or other structural damage will add legitimacy to the goal of human cryopreservation, storing patients at...
Source: Fight Aging! - April 29, 2021 Category: Research Authors: Reason Tags: Daily News Source Type: blogs
Fight Aging! Newsletter, April 19th 2021
In conclusion, airway pressure treatment and adherence are independently associated with lower odds of incident AD diagnoses in older adults. Results suggest that treatment of OSA may reduce risk of subsequent dementia. (Source: Fight Aging!)
Source: Fight Aging! - April 18, 2021 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
The Future of Cryopreservation
The ability to cryopreserve and thaw organs via vitrification, without ice formation and significant tissue damage, allowing for indefinite storage time, would go a long way towards simplifying the logistics and reducing the costs of present organ donation and future tissue engineering of organs for transplantation. Cryopreservation via vitrification also offers the possibility of indefinitely storing the terminally ill and recently deceased until such time as medical science advances to the point of restoration. This has been practiced for several decades by the small cryonics industry.
Cryonics is a long shot, but...
Source: Fight Aging! - April 12, 2021 Category: Research Authors: Reason Tags: Medicine, Biotech, Research Source Type: blogs
3D Bioprinting: Eradicating Transplantation Waiting Lists And Testing Drugs On Living Tissues
From time to time, news arises about 3D printed organs. On such occasions, people usually think that a machine can already create readily available, implantable human organs. However, the reality is far from this optimistic image.
Researchers worldwide are working on possible solutions: from a group that printed a miniature kidney, through technological solutions like BioAssemblyBot we wrote about earlier, to entirely new methods that can lead to patient-specific heart tissue printing. The list is long and set in a clinical setting. We checked out where the technology stands today and where it might lead us in healthcar...
Source: The Medical Futurist - March 11, 2021 Category: Information Technology Authors: berci.mesko Tags: 3D Printing Artificial Intelligence in Medicine Biotechnology Digital Health Research Future of Medicine Future of Pharma Healthcare Design Healthcare Policy bioprinting fda Innovation Personalized medicine rna science fiction Source Type: blogs
Flowers, chocolates, organ donation — are you in?
Chocolates and flowers are great gifts for Valentine’s Day. But what if the gifts we give this year could be truly life-changing? A gift that could save someone’s life, or free them from dialysis?
You can do this. For people in need of organ, tissue, or blood donation, a donor can give them a gift that exceeds the value of anything that you can buy. That’s why February 14th is not only Valentine’s Day — it’s also National Donor Day, a time when health organizations nationwide sponsor blood drives and sign-ups for organ and tissue donation. Read on if you’ve ever wondered what can be donated, had reservations ...
Source: Harvard Health Blog - February 11, 2021 Category: Consumer Health News Authors: Robert H. Shmerling, MD Tags: Health Heart Health Kidney and urinary tract Lung disease Source Type: blogs
MissionGO and MediGO Complete Successful Organ Deliveries in Unmanned Flights
MissionGO, a provider of unmanned aviation solutions, and Nevada Donor Network, an organ procurement organization (OPO) serving the state of Nevada, have recently completed two successful test flights in Las Vegas carrying a human organ and human tissue via an Unmanned Aircraft System (UAS). MediGO provided the technological services needed for collection and communication of critical data about OPO resources and organs across the transplant ecosystem.
The first flight transported research corneas in an urban environment—from Southern Hills Hospital and Medical Center to Dignity Health-St. Rose Dominican, San Martín ...
Source: Medgadget - December 4, 2020 Category: Medical Devices Authors: Alice Ferng Tags: Cardiac Surgery Emergency Medicine Exclusive Pediatrics Thoracic Surgery Source Type: blogs
Fight Aging! Newsletter, November 30th 2020
We examined specific aspects of metabolism in male PolG+/mut mice at 6 and 12 months of age under three dietary conditions: normal chow (NC) feeding, high-fat feeding (HFD), and 24-hr starvation. We performed mitochondrial proteomics and assessed dynamics and quality control signaling in muscle and liver to determine whether mitochondria respond to mtDNA point mutations by altering morphology and turnover. In the current study, we observed that the accumulation of mtDNA point mutations failed to disrupt metabolic homeostasis and insulin action in male mice, but with aging, metabolic health was likely preserved by counterme...
Source: Fight Aging! - November 29, 2020 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
Special Issue on Brain Death & Organ Donation
The September 2020 issue of Anaesthesia includes several interesting articles on brain death and organ donation.Optimisation of the organ donor and effects on transplanted organs: a narrative review on current practice and future directions Curren... (Source: blog.bioethics.net)
Source: blog.bioethics.net - September 4, 2020 Category: Medical Ethics Authors: Thaddeus Mason Pope, JD, PhD Tags: Health Care syndicated Source Type: blogs
Fight Aging! Newsletter, June 15th 2020
In this study, we used markers to monitor the formation of SGs in Caenorhabditis elegans. We found that, in addition to acute heat stress, SG formation could also be triggered by dietary changes, such as starvation and dietary restriction (DR). We found that HSF-1 is required for the SG formation in response to acute heat shock and starvation but not DR, whereas the AMPK-eEF2K signaling is required for starvation and DR-induced SG formation but not heat shock. Moreover, our data suggest that this AMPK-eEF2K pathway-mediated SG formation is required for lifespan extension by DR, but dispensable for the longevity by reduced ...
Source: Fight Aging! - June 14, 2020 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
Rat Livers Decellularized, then Recellularized with Human Cells and Transplanted
A decellularized organ is one that has had the cells stripped out, such as via detergent solutions, leaving behind the extracellular matrix. Decellularization is a way to obtain a fully detailed organ scaffold, complete with chemical cues to guide the reconstruction of tissues when new cells are added, without having to build it from scratch. That task that is presently impossible, though some groups are making headway in the construction of scaffolds detailed enough for use in tissue engineering. Interestingly, decellularization allows the use of human cells in animal organs: this may be a viable path towards farming pigs...
Source: Fight Aging! - June 10, 2020 Category: Research Authors: Reason Tags: Daily News Source Type: blogs
The Advancing Slippery Slope of Organ Donation and Euthanasia
The timing of organ donation relative to death of the donor is critical to the survivability and future functioning of the donated organs in the transplant recipient. With cardiovascular death, circulation ceases in the donor causing his or her death, making it legally and ethically permissible to retrieve the organs for donation. Unfortunately, cardiovascular death … Continue reading "The Advancing Slippery Slope of Organ Donation and Euthanasia" (Source: blog.bioethics.net)
Source: blog.bioethics.net - February 18, 2020 Category: Medical Ethics Authors: Mark McQuain Tags: Health Care bioethics Euthanasia; Slippery Slope Arguments; human dignity organ donation syndicated Source Type: blogs
Why It is Important to Consider Social Support When Assessing Organ Transplant Candidates?
You can read this editorial and other articles in this month’s issue of The American Journal of Bioethics.
by José R. Maldonado, MD, FAPM
“Because donated organs are a severely limited resource, the best potential recipients should be identified. The probability of a good outcome must be highly emphasized to achieve the maximum benefit for all transplants.” (From: OPTN/UNOS Ethics Committee General Considerations in Assessment for Transplant Candidacy White Paper–2010)
The number of transplant surgeries has risen steadily in the last 30 years in the United States (US), while the availability of donated ...
Source: blog.bioethics.net - October 29, 2019 Category: Medical Ethics Authors: Blog Editor Tags: Editorial-AJOB Featured Posts Organ Transplant & Donation Source Type: blogs
Fight Aging! Newsletter, September 9th 2019
We examined human lung tissue from COPD patients and normal control subjects, and found a substantial increase in p16-expressing alveolar cells in COPD patients. Using a transgenic mouse deficient for p16, we demonstrated that lungs of mice lacking p16 were structurally and functionally resistant to CS-induced emphysema due to activation of IGF1/Akt regenerative and protective signaling.
Fat Tissue Surrounds Skeletal Muscle to Accelerate Atrophy in Aging and Obesity
https://www.fightaging.org/archives/2019/09/fat-tissue-surrounds-skeletal-muscle-to-accelerate-atrophy-in-aging-and-obesity/
Researchers he...
Source: Fight Aging! - September 8, 2019 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
How Much Is Life Worth?
Multivitamins, drugs, gene therapies, human skin, heart, eyeballs, kidneys, entire dead bodies – everything comes with a price tag. Putting aside the moral questions of why and how come that the capitalist market priced even our body parts and health, we asked the question of how much is life worth: what is the maximum that you would/should pay for a life-saving drug? How high is too high a cost if a drug can save 200-300 babies a year from debilitating illness or death? And ultimately, does the pricing of new technologies, especially gene therapies, enable to fulfill their promise?
There’s a
price for everything: ...
Source: The Medical Futurist - August 31, 2019 Category: Information Technology Authors: nora Tags: Bioethics Biotechnology Future of Pharma Genomics cost daraprim drug drug price Gene gene therapy genetics insulin life medication pricing policy rare disease rare disorder Source Type: blogs
