Day 2: From BRAIN to Bedside: Translation of Next-Generation Circuit Therapies
The goal of this workshop is to bring together cross-disciplinary investigators to discuss the potential for human translation of next-generation circuit therapies for disorders of the central nervous system (CNS). The focus will be on the use of innovative and novel tools which includes optogenetics, chemogenetics, and gene editing, as well as cutting-edge approaches to neuromodulation. Sessions will discuss existing approaches to circuit manipulation, advances in gene therapy approaches, and how they may inform future CNS circuit therapies. Of particular importance will be the highlighting of CNS translational hurdles an...
Source: Videocast - All Events - May 6, 2021 Category: General Medicine Tags: Upcoming Events Source Type: video
Day 1: From BRAIN to Bedside: Translation of Next-Generation Circuit Therapies
The goal of this workshop is to bring together cross-disciplinary investigators to discuss the potential for human translation of next-generation circuit therapies for disorders of the central nervous system (CNS). The focus will be on the use of innovative and novel tools which includes optogenetics, chemogenetics, and gene editing, as well as cutting-edge approaches to neuromodulation. Sessions will discuss existing approaches to circuit manipulation, advances in gene therapy approaches, and how they may inform future CNS circuit therapies. Of particular importance will be the highlighting of CNS translational hurdles an...
Source: Videocast - All Events - May 6, 2021 Category: General Medicine Tags: Upcoming Events Source Type: video
Special Tuesday WALS Lecture - Three (Formerly) Blind Mice: Reprogramming Tissues to Be Young Again
Special Tuesday WALS Lecture
Dr. Sinclair is a professor of genetics, Blavatnik Institute, and co-director of the Paul F. Glenn Center for Biology of Aging Research, at Harvard Medical School. His lab seeks to understand why we age and whether we can extend human health and longevity.
The Sinclair laboratory has demonstrated that it is possible to epigenetically reprogram cells to safely reverse aging in vivo and regain eyesight. This research, conducted with support from the National Institute on Aging and National Eye Institute, was recently published in Nature (PMID: 33268865; doi: 10.1038/s41586-020-2975-4) and will b...
Source: Videocast - All Events - February 4, 2021 Category: General Medicine Tags: Upcoming Events Source Type: video
Peering Beyond the Blindspot Seeking Authentic Risk Factors: a Case Study
Dr. Eve Higginbotham is the inaugural Vice Dean for Inclusion and Diversity of the Perelman School of Medicine at the University of Pennsylvania, a position she assumed on August 1, 2013. She is also a Senior Fellow at the Leonard Davis Institute for Health Economics and Professor of Ophthalmology at the University of Pennsylvania. She is the immediate past president of the AOA Medical Honor Society and currently serves on the National Academy of Medicine Council and the National Research Council Board. Dr. Higginbotham serves as a member of the Finance Committee of the National Academy of Medicine. Notable prior leadershi...
Source: Videocast - All Events - December 10, 2020 Category: General Medicine Tags: Upcoming Events Source Type: video
NEI AGI Seminar: Platform Technologies for Microscopic Retinal Imaging: Development and Translation - Adaptive Optics Optoretinography: Assessing Photoreceptor Function in the Living Eye
NEI AGI Seminar
The Audacious Goals Initiative (AGI) for Regenerative Medicine in Vision is a strategic endeavor by the National Eye Institute (NEI) to expand support aimed at new treatments for vision disorders. By facilitating cross-disciplinary research, the AGI is tackling devastating and difficult-to-treat eye diseases. The NEI Office of Regenerative Medicine will be hosting an AGI Seminar featuring the work funded by the NEI AGI Functional Imaging Consortium.Air date: 8/5/2020 2:00:00 PM (Source: Videocast - All Events)
Source: Videocast - All Events - July 28, 2020 Category: General Medicine Tags: Upcoming Events Source Type: video
NEI Audacious Goals: Cytoplasmic material exchange between sensory neurons in vivo
Dr. Wallace is Director of Vision Sciences and Chair of the Vision Science Research Program at the Toronto Western Research Institute/University Health Network. She holds appointments in the Departments of Ophthalmology and Vision Sciences and Laboratory Medicine and Pathobiology, University of Toronto. A molecular and developmental biologist by training, she is recognized for her work on the role of Hedgehog signaling in neural progenitor proliferation in the central nervous system. Her lab is now applying this knowledge towards investigating the role of morphogen signaling in tumorigenesis and the development of cell-bas...
Source: Videocast - All Events - February 24, 2020 Category: General Medicine Tags: Upcoming Events Source Type: video
AGI Seminar in Neuroregeneration
Dr. Wallace is Director of Vision Sciences and Chair of the Vision Science Research Program at the Toronto Western Research Institute/University Health Network. She holds appointments in the Departments of Ophthalmology and Vision Sciences and Laboratory Medicine and Pathobiology, University of Toronto. A molecular and developmental biologist by training, she is recognized for her work on the role of Hedgehog signaling in neural progenitor proliferation in the central nervous system. Her lab is now applying this knowledge towards investigating the role of morphogen signaling in tumorigenesis and the development of cell-bas...
Source: Videocast - All Events - February 18, 2020 Category: General Medicine Tags: Upcoming Events Source Type: video
We are what we eat: nutrition, genes, cognition & deep learning in age-related macular degeneration
NIH Director's Wednesday Afternoon Lecture Series
Age-related macular degeneration (AMD) is the leading cause of blindness in the United States and in the developed world. Two NIH-supported randomized clinical trials with 10 years of follow-up in nearly 10,000 participants demonstrated that nutritional supplements with antioxidant vitamins and minerals reduces the risk of progression to late AMD. Dietary data suggest the importance of the Mediterranean diet in reducing the risk of AMD, particularly fish consumption. The analyses of the genetic interaction with nutrition challenges the idea that you can eat away your geneti...
Source: Videocast - All Events - October 10, 2019 Category: General Medicine Tags: Upcoming Events Source Type: video
Making AI an invaluable clinical tool
AI can help with recognizing patterns and diagnosis, but physicians still need to use clinical judgment and manage the patient as a person, says Colin Tan, associate professor of ophthalmology at Duke NUS Medical School. (Source: Healthcare ITNews Videos)
Source: Healthcare ITNews Videos - July 10, 2019 Category: Information Technology Tags: Artificial Intelligence Clinical Patient Engagement Source Type: video
NEI Sayer Lecture: Clinical features and molecular basis of the cerebellar-retinal degenerative disorder SpinoCerebellar Ataxia type 7: From mechanism to therapy
NEI Sayer Lecture
Spinocerebellar ataxia type 7 (SCA7) is an inherited neurological disorder characterized by cerebellar and retinal degeneration. SCA7 patients develop atrophy of the cerebellar cortex and the brainstem, and exhibit extensive loss of cerebellar Purkinje cells. An important feature of SCA7, that allows it to be distinguished from the 40+ other SCAs, is retinal degeneration. Full field electroretinograms of SCA7 patients reveal marked dysfunction of cone photoreceptor cells prior to rod photoreceptor abnormalities, establishing SCA7 as a cone-rod dystrophy. As retinal disease progresses, rod photoreceptors b...
Source: Videocast - All Events - April 11, 2019 Category: General Medicine Tags: Upcoming Events Source Type: video
March 2019 Clinical Case Vid. 4
Video 4. Axial (horizontal) T1 post-contrast MRI of the orbitsshowing the enhancement (bright area) around the leftpetrous carotid (right side of images) and the enlarged leftsuperior ophthalmic vein. (Source: The Hearing Journal - Video)
Source: The Hearing Journal - Video - February 27, 2019 Category: Audiology Source Type: video
March 2019 Clinical Case Vid. 4
Video 4. Axial (horizontal) T1 post-contrast MRI of the orbits
showing the enhancement (bright area) around the left
petrous carotid (right side of images) and the enlarged left
superior ophthalmic vein. (Source: The Hearing Journal - Video)
Source: The Hearing Journal - Video - February 26, 2019 Category: Audiology Source Type: video
March 2019 Clinical Case Vid. 4
Video 4. Axial (horizontal) T1 post-contrast MRI of the orbitsshowing the enhancement (bright area) around the leftpetrous carotid (right side of images) and the enlarged leftsuperior ophthalmic vein. (Source: The Hearing Journal - Video)
Source: The Hearing Journal - Video - February 26, 2019 Category: Audiology Source Type: video
Living in the Cold -- Adaptations in Hibernation
NIH Neuroscience Series Seminar
Dr. Li ’ s lab studies the structure and function of retinal synapses and circuits. Although they know the basic structure and major cell types of the retina, it remains much of a " black box " in terms of the connections and functions of these neurons. Their long-term research goal is to understand how the neuronal circuits are wired in this " black box " under normal conditions and how the circuits are altered during pathological processes. Both pieces of information will be crucial for the design of biological and/or prosthetic interventions aiming to restore vision in many types of bli...
Source: Videocast - All Events - September 14, 2018 Category: General Medicine Tags: Upcoming Events Source Type: video
Multiplexed imaging with red-shifted optogenetic indicators
NIH Neuroscience Series SeminarFor more information go tohttps://neuroscience.nih.gov/neuroseries/Home.aspxAir date: 4/8/2019 12:00:00 PM (Source: Videocast - All Events)
Source: Videocast - All Events - June 25, 2018 Category: General Medicine Tags: Upcoming Events Source Type: video
