Cortisol and adrenal androgens as independent predictors of mortality in septic patients
We look to determine the prognostic value of cortisol, Dehydroepiandrosterone (DHEA) and Dehydroepiandrosterone-sulfate (DHEAS), together with their ratios (cortisol/DHEA and cortisol/DHEAS), as independent predictors of mortality in septic patients. Basal cortisol measured within the first 24 hours of the septic process was the best prognostic factor for in-hospital and 28-day mortality, even superior to the Sequential Organ Failure Assessment (SOFA) or Acute Physiology and Chronic Health Evaluation II (APACHE II) scores. The cortisol/DHEAS ratio was an independent predictor of long-term mortality. (Source: Current Awaren...
Source: Current Awareness Service for Health (CASH) - April 25, 2019 Category: Consumer Health News Source Type: news

Targeting Complement Pathways in Polytrauma- and Sepsis-Induced Multiple-Organ
Exposure to traumatic or infectious insults results in a rapid activation of the complement cascade as major fluid defense system of innate immunity. The complement system acts as a master alarm system during the molecular danger response after trauma and significantly contributes to the clearance of DAMPs and PAMPs. However, depending on the origin and extent of the damaged macro- and micro -milieu, the complement system can also be either excessively activated or inhibited. In both cases, this can lead to a maladaptive immune response and subsequent multiple cellular and organ dysfunction. The arsenal of complement-speci...
Source: Current Awareness Service for Health (CASH) - April 25, 2019 Category: Consumer Health News Source Type: news

Open abdominal management for perforative peritonitis with septic shock: a retrospective analysis on usefulness of a standardized treatment protocol
Damage control surgery (DCS) with open abdominal management (OAM) has been increasingly expanded to include critically ill non-trauma patients. However, there is limited data regarding the usefulness of this protocol for the treatment of severe perforative peritonitis (PP), especially with septic shock (SS). Here, we retrospectively evaluated the usefulness of our OAM protocol for PP with SS. A standardized protocol for OAM may improve the outcomes of patients with SS due to PP. This damage control approach can be applied for the treatment of severe abdominal sepsis. (Source: Current Awareness Service for Health (CASH))
Source: Current Awareness Service for Health (CASH) - April 25, 2019 Category: Consumer Health News Source Type: news

Bolus therapy with 3% hypertonic saline or 0.9% saline in emergency department patients with suspected sepsis: A pilot randomised controlled trial
The objective of this pilot randomised controlled trial was to measure the effect of hypertonic saline, compared to isotonic saline, on biomarkers of EG shedding and inflammation in emergency department patients with suspected sepsis. Although a single bolus of hypertonic saline increased serum osmolality, it did not reduce biomarkers of EG shedding or inflammation, compared to patients that received isotonic saline. (Source: Current Awareness Service for Health (CASH))
Source: Current Awareness Service for Health (CASH) - April 25, 2019 Category: Consumer Health News Source Type: news

Association of septic shock definitions and standardized mortality ratio in a contemporary cohort of critically ill patients
The newly proposed septic shock definition has provoked a substantial controversy in the emergency and critical care communities. We aim to compare new (SEPSIS-III) versus old (SEPSIS-II) definitions for septic shock in a contemporary cohort of critically ill patients. Compared to SEPSIS-II, SEPSIS-III definition of septic shock identifies patients further along disease trajectory with higher likelihood of poor outcome. (Source: Current Awareness Service for Health (CASH))
Source: Current Awareness Service for Health (CASH) - April 25, 2019 Category: Consumer Health News Source Type: news

Crystalloids vs. colloids for fluid resuscitation in the Intensive Care Unit: A systematic review and meta-analysis
Guidelines recommend crystalloids for fluid resuscitation in sepsis/shock and switching to albumin in cases where crystalloids are insufficient. We evaluated hemodynamic response to crystalloids/colloids in critically ill adults. Crystalloids were less efficient than colloids at stabilizing resuscitation endpoints; guidance on when to switch is urgently required. (Source: Current Awareness Service for Health (CASH))
Source: Current Awareness Service for Health (CASH) - April 25, 2019 Category: Consumer Health News Source Type: news

Hemodynamic response to β-blockers in severe sepsis and septic shock: A review of current literature
The administration of β-blockers in patients with sepsis is a trending topic in intensive care medicine since the landmark study by Morelli and colleagues, showing a striking decrease in 28-day mortality compared to standard care. While the available evidence suggests that the use of β-blockers in septic shock is safe, the effects on hemodynamics are controversial. In this paper, we review the effect of β-blockade in septic shock on hemodynamics from animal models to critically ill patients. (Source: Current Awareness Service for Health (CASH))
Source: Current Awareness Service for Health (CASH) - April 25, 2019 Category: Consumer Health News Source Type: news

Epidemiology of disseminated intravascular coagulation in sepsis and validation of scoring systems
We investigated the epidemiology and outcome of disseminated intravascular coagulation (DIC) in patients with sepsis. Patients with sepsis and DIC have high mortality. However, the DIC are not independently associated with in-hospital mortality. (Source: Current Awareness Service for Health (CASH))
Source: Current Awareness Service for Health (CASH) - April 25, 2019 Category: Consumer Health News Source Type: news

Location is the key to function: HMGB1 in sepsis and trauma-induced inflammation
High mobility group box 1 (HMGB1) is a multifunctional nuclear protein, probably known best as a prototypical alarmin or damage-associated molecular pattern (DAMP) molecule when released from cells. This review highlights some of the mechanisms that contribute to location and functions of HMGB1, and focuses on some recent insights on important intracellular effects of HMGB1 during sepsis and trauma. (Source: Current Awareness Service for Health (CASH))
Source: Current Awareness Service for Health (CASH) - April 25, 2019 Category: Consumer Health News Source Type: news

Characteristics and Outcomes of Patients With and Without Type 2 Diabetes Mellitus and Pulmonary Sepsis
To date, studies have provided conflicting results regarding the impact of type 2 diabetes mellitus (DM) on sepsis-related outcomes. Our objective is to understand the impact of type 2 DM in bacterial pneumonia and sepsis-related intensive care unit (ICU) outcomes. Our findings demonstrated that type 2 DM does not increase the overall mortality. Our findings of increased mortality in both type 2 DM patients with lower admission glucose, and non-DM patients with higher mean glucose during the hospital stay needs to be further evaluated. Future studies in regards to this could lead to personalized glucose treatment goals for...
Source: Current Awareness Service for Health (CASH) - April 25, 2019 Category: Consumer Health News Source Type: news

Risk factors for infection and evaluation of Sepsis-3 in patients with trauma
We aim to examine the risk factors associated with infection in trauma patients and the Sepsis-3 definition. Patients with trauma often arrive with organ dysfunction, which adds complexity and inaccuracy to the operational definition of Sepsis-3 using changes in SOFA scores. Injury severity score, comorbidities, SOFA score, and sex are risk factors associated with developing an infection after trauma. •Injured patients arrive with organ dysfunction, which adds inaccuracy to the operational definition of Sepsis-3.•Injury severity score, comorbidities, SOFA score, and sex are risk factors associated with developing...
Source: Current Awareness Service for Health (CASH) - April 25, 2019 Category: Consumer Health News Source Type: news

Epidemiology and Predictors of 30-Day Readmission in Patients With Sepsis
We describe the associated etiology and risk factors for readmission in patients with sepsis using a large administrative database inclusive of patients of all ages and insurance status. Our study cohort was derived from the Healthcare Cost and Utilization Project's National Readmission Data from 2013 to 2014 by identifying patients admitted with sepsis. We describe that readmission after a sepsis hospitalization is common and costly. The majority of readmissions were associated with infectious etiologies. The striking rate of readmission demands efforts to further clarify the determinants of readmission and develop strate...
Source: Current Awareness Service for Health (CASH) - April 25, 2019 Category: Consumer Health News Source Type: news

Comparison of the accuracy of three early warning scores with SOFA score for predicting mortality in adult sepsis and septic shock patients admitted to intensive care unit.
The purpose of this study was to compare the accuracy of the Modified Early Warning Score (MEWS), National Early Warning Score (NEWS) and Search Out Severity (SOS), with the quick Sequential Organ Failure Assessment (qSOFA) and SOFA scores, to predict outcomes in sepsis patients. The SOS presents nearly as good as the SOFA score, to predict mortality among sepsis patients admitted to the ICU. The early warning score is another, alternative tool to use for risk stratification and sepsis screening for ICU sepsis patients. (Source: Current Awareness Service for Health (CASH))
Source: Current Awareness Service for Health (CASH) - April 25, 2019 Category: Consumer Health News Source Type: news

Cost-effectiveness of rapid diagnostic assays that perform directly on blood samples for the diagnosis of septic shock
Molecular diagnostic assays that test directly whole blood provide the ability to decrease inappropriate antimicrobial therapy and improve survival in patients with septic shock. We developed a decision analysis model to evaluate the cost-effectiveness of the addition of molecular assays to blood cultures in adults admitted to medical ICUs with septic shock. (Source: Current Awareness Service for Health (CASH))
Source: Current Awareness Service for Health (CASH) - April 25, 2019 Category: Consumer Health News Source Type: news

Serum Level of Antithrombin III (ATIII) Could Serve as a Prognostic Biomarker in Neonatal Sepsis
Neonatal sepsis syndrome continues to have a high morbidity and mortality rate despite the progress in neonatal intensive care. There is no single diagnostic test which can reliably diagnose sepsis in the newborn, beside blood culture. Antithrombin III may be one promising single marker for sepsis syndrome diagnosis and prognosis. Antithrombin III is lower in sepsis syndrome neonates and may be a useful biomarker in neonatal sepsis. (Source: Current Awareness Service for Health (CASH))
Source: Current Awareness Service for Health (CASH) - April 25, 2019 Category: Consumer Health News Source Type: news

Optimizing antibiotic use for early onset sepsis: A tertiary nicu experience
Neonatal antibiotic use is associated with a greater risk of nosocomial infection, necrotizing enterocolitis, and mortality. It can induce drug-resistant pathogens that contribute to increased neonatal morbidity/mortality, healthcare costs, and length of stay. Prior to the antibiotic stewardship program, decisions to obtain blood cultures and empiric antibiotics for possible Early-onset Sepsis (EOS) in late preterm and term infants upon NICU admission were provider-dependent rather than algorithm-based. We aimed to decrease empiric antibiotic prescription from 70% to 56% (20% decrease) in infants ≥34 weeks gestation adm...
Source: Current Awareness Service for Health (CASH) - April 25, 2019 Category: Consumer Health News Source Type: news

Early access to mental health support
This report illustrates the findings of a data collection exercise to understand spending on low-level mental health services across England. It highlights wide variation between areas and agencies in reported spending. (Source: Current Awareness Service for Health (CASH))
Source: Current Awareness Service for Health (CASH) - April 15, 2019 Category: Consumer Health News Source Type: news

Surgical site infections: prevention and treatment guidance (NG125)
This guideline has been updated to reflect advice from the guideline on prevention and treatment of surgical site infections (Source: Current Awareness Service for Health (CASH))
Source: Current Awareness Service for Health (CASH) - April 15, 2019 Category: Consumer Health News Source Type: news

Getting started with collaboration: A framework for joint action
This framework is for individuals and organisations who are setting out on new collaborative ventures. It draws from our back catalogue of work, including Thinking about … collaboration, Working in Place: Collaborative funding in practice and Building Health Partnerships. (Source: Current Awareness Service for Health (CASH))
Source: Current Awareness Service for Health (CASH) - April 12, 2019 Category: Consumer Health News Source Type: news

NIHR Signal: E-cigarettes helped more smokers quit than nicotine replacement therapy
Studies have found that 18% given e-cigarettes were abstinent from smoking vs 9.9% for nicotine replacement therapy. E-cigarettes are considerably less harmful than smoking, so switching to vaping is likely to bring substantial health gains. (Source: Current Awareness Service for Health (CASH))
Source: Current Awareness Service for Health (CASH) - April 11, 2019 Category: Consumer Health News Source Type: news

Cellulitis and erysipelas: antimicrobial prescribing DRAFT guidance consultation
This DRAFT guideline sets out an antimicrobial prescribing strategy for cellulitis and erysipelas. It aims to optimise antibiotic use and reduce antibiotic resistance. It does not cover diagnosis. Registered Stakeholders have until 10 May 2019 to comment. (Source: Current Awareness Service for Health (CASH))
Source: Current Awareness Service for Health (CASH) - April 11, 2019 Category: Consumer Health News Source Type: news

People living in care homes frequently asked questions regarding guidance for conditions for which over the counter items should not routinely be prescribed
These FAQs have been developed to support CCGs to implement this guidance for people living in care homes. It covers topics such as who should be making the assessment as to ability to self-care? and who is accountable for the treatment of the person? (Source: Current Awareness Service for Health (CASH))
Source: Current Awareness Service for Health (CASH) - April 11, 2019 Category: Consumer Health News Source Type: news

Antimicrobial resistance CQUIN 2019/20
Resources to support delivery of the antimicrobial resistance CQUIN indicators include updated CCG1a and CCG1b submission tools and antimicrobial resistance: 2019/20 improvement schemes letter. (Source: Current Awareness Service for Health (CASH))
Source: Current Awareness Service for Health (CASH) - April 10, 2019 Category: Consumer Health News Source Type: news

Hepatitis C in England 2019
This report summarises the current data, the impact of action plans in England to drive down mortality from hepatitis C virus infection and to reduce the number of new infections, and outline the actions required to make further progress. (Source: Current Awareness Service for Health (CASH))
Source: Current Awareness Service for Health (CASH) - April 10, 2019 Category: Consumer Health News Source Type: news

Outcomes for mental health services: what really matters?
This report examines the pursuit of outcomes by mental health services and highlights how frameworks for measuring outcomes are often too narrowly focused on clinical outcomes. The report challenges mental health services to adopt a broader perspective on outcomes as a basis for collaborating with service users and a foundation for delivering more humane and effective care (Source: Current Awareness Service for Health (CASH))
Source: Current Awareness Service for Health (CASH) - April 8, 2019 Category: Consumer Health News Source Type: news

Staffing on Wards - Making decisions about healthcare staffing
This review presents recent evidence from National Institute for Health Research funded research, including studies on the number of staff needed, the support workforce and the organisation of care on the wards. (Source: Current Awareness Service for Health (CASH))
Source: Current Awareness Service for Health (CASH) - April 8, 2019 Category: Consumer Health News Source Type: news

Associations between age discrimination and health and wellbeing: cross-sectional and prospective analysis of the English Longitudinal Study of Ageing
In study (n=7731), perceived age discrimination (AD) was reported by 1943 (25.1%) subjects; they were more likely to self-report fair/poor health and to have CHD, chronic lung disease, arthritis, limiting long-standing illness and depressive symptoms vs. those not perceiving AD. (Source: Current Awareness Service for Health (CASH))
Source: Current Awareness Service for Health (CASH) - April 8, 2019 Category: Consumer Health News Source Type: news

Antimicrobial Resistance
This briefing note presents key estimates of the health and economic impact of AMR and effective strategies to address this major public health threat. “If no effective action is put in place, AMR to second-line antibiotics will be 72% higher in 2030 compared to 2005 in the EU/EEA. In the same period, AMR to last-line treatments will more than double.” (Source: Current Awareness Service for Health (CASH))
Source: Current Awareness Service for Health (CASH) - April 5, 2019 Category: Consumer Health News Source Type: news

Tackling antimicrobial resistance (AMR):
A new campaign by the National Institute for Health Research (NIHR) is shining a light on the threat of antimicrobial resistance (AMR) and the research response required. The UK government's goal is to contain and control antimicrobial resistance by 2040. (Source: Current Awareness Service for Health (CASH))
Source: Current Awareness Service for Health (CASH) - April 5, 2019 Category: Consumer Health News Source Type: news

NIHR Signal: Does an antibacterial milk protein reduce infection in premature babies?
Expert commentary is provided for an RCT (n=2,203) which found no difference in microbiologically or clinically suspected late-onset bloodstream infection for lactoferrin vs control. This indicates that there is no role for lactoferrin in preventing infection. (Source: Current Awareness Service for Health (CASH))
Source: Current Awareness Service for Health (CASH) - April 5, 2019 Category: Consumer Health News Source Type: news

Chlorhexidine versus routine bathing to prevent multidrug-resistant organisms and all-cause bloodstream infections in general medical and surgical units (ABATE Infection trial): a cluster-randomised trial
This research article concludes that Decolonisation with universal chlorhexidine bathing and targeted mupirocin for MRSA carriers did not significantly reduce multidrug-resistant organisms in non-critical-care patients. (Source: Current Awareness Service for Health (CASH))
Source: Current Awareness Service for Health (CASH) - April 5, 2019 Category: Consumer Health News Source Type: news

NICE Bites Bronchietasis and Cough (acute)
NICE Bites is a monthly bulletin that summarises key prescribing points from NICE guidance. This edition (March 2019), includes two antimicrobial prescribing guidelines: Acute exacerbation of bronchiectasis, and Acute cough (Source: Current Awareness Service for Health (CASH))
Source: Current Awareness Service for Health (CASH) - April 5, 2019 Category: Consumer Health News Source Type: news

Group A streptococcal infections: second report on seasonal activity, 2018/19
Scarlet fever notifications in England are increasing in line with usual seasonal pattern, but substantially lower than recent years, which may indicate low incidence-or delayed season. 7854 notifications have been received to date this season in England (weeks 37 to 12, 2018/19) (Source: Current Awareness Service for Health (CASH))
Source: Current Awareness Service for Health (CASH) - April 5, 2019 Category: Consumer Health News Source Type: news

Lancet seminar: tetanus
This article reviews the epidemiology, pathophysiology, diagnosis, management and prognosis of tetanus. In addition, the Lancet Commission on tuberculosis recommends five priority investments to achieve a tuberculosis-free world within a generation. (Source: Current Awareness Service for Health (CASH))
Source: Current Awareness Service for Health (CASH) - April 5, 2019 Category: Consumer Health News Source Type: news

Have e-cigarettes renormalised or displaced youth smoking? Results of a segmented regression analysis of repeated cross sectional survey data in England, Scotland and Wales
Time series analysis (248,324 people aged 13-15 in Great Britain between 1998-2015) found no evidence that renormalisation of youth smoking was occurring during a period of rapid growth and limited regulation of e-cigarettes from 2011 to 2015. (Source: Current Awareness Service for Health (CASH))
Source: Current Awareness Service for Health (CASH) - April 4, 2019 Category: Consumer Health News Source Type: news

NICE impact mental health
This report from NICE considers how evidence-based guidance can contribute to improvements in the care of people with mental health conditions. The report reviews how NICE recommendations for cost-effective care are being used in priority areas of the health and care system. (Source: Current Awareness Service for Health (CASH))
Source: Current Awareness Service for Health (CASH) - April 4, 2019 Category: Consumer Health News Source Type: news

Better Integration
This webinar introduced a new guide,'Integrating Better: new resources on health and social care integration'- which captures common features of good practice of integration between health, social care and the voluntary and community sector. It will help directors, service managers or operational staff in health and social care. It covers key topics such as leadership for integration, promoting self-care, supporting care closer to home and care and support in a crisis. (Source: Current Awareness Service for Health (CASH))
Source: Current Awareness Service for Health (CASH) - April 3, 2019 Category: Consumer Health News Source Type: news

The state of care in independent doctor and clinic services providing primary medical care
Analysis of 85 inspection reports for independent doctor and clinic services and themes from a review of inspection reports for 38 independent slimming clinics notes several areas of concern, including those relating to safe and effective prescribing. (Source: Current Awareness Service for Health (CASH))
Source: Current Awareness Service for Health (CASH) - April 2, 2019 Category: Consumer Health News Source Type: news

A comparison of gender-linked population cancer risks between alcohol and tobacco: how many cigarettes are there in a bottle of wine?
Moderate levels of drinking (1 bottle wine/week) is linked to significant increased absolute lifetime risk of alcohol-related cancers in women, driven largely by breast cancer, equivalent to increased absolute cancer risk linked to 10 cigarettes/week for women (5/week for men). (Source: Current Awareness Service for Health (CASH))
Source: Current Awareness Service for Health (CASH) - April 2, 2019 Category: Consumer Health News Source Type: news

Transforming children's services
This report looks at the current pressures on children's social care and what the Department for Education has been doing to make the quality or finances of these services sustainable. The report concludes that the Department for Education has not done enough and requires: a step-change in the understanding of pressures; the reduction of unnecessary variation between areas in their social care activities and the costs of providing them; and greater pace in its work with struggling local authorities (Source: Current Awareness Service for Health (CASH))
Source: Current Awareness Service for Health (CASH) - March 29, 2019 Category: Consumer Health News Source Type: news

Outcomes for mental health services: what really matters?
This report highlights how frameworks for measuring outcomes are often too narrowly focused on clinical outcomes and challenges those in mental health to find a consensus on the outcomes that matter to people with mental health problems. (Source: Current Awareness Service for Health (CASH))
Source: Current Awareness Service for Health (CASH) - March 28, 2019 Category: Consumer Health News Source Type: news

NHS waiting times for elective and cancer treatment
Report notes at time of financial restraint, NHS has responded to growing demand for elective and cancer care by increasing amount of treatment it provides but this has not been sufficient to maintain performance against waiting times standards; some have not been met for years. (Source: Current Awareness Service for Health (CASH))
Source: Current Awareness Service for Health (CASH) - March 28, 2019 Category: Consumer Health News Source Type: news

Home to the unknown: Getting hospital discharge right
Report notes despite wealth of guidance on'ideal'hospital discharge and examples of excellence/good practice, problems persist. Discharge processes vary considerably and while patients might appear to be medically fit for discharge, their wider, non-clinical needs can go unmet. (Source: Current Awareness Service for Health (CASH))
Source: Current Awareness Service for Health (CASH) - March 28, 2019 Category: Consumer Health News Source Type: news

Non-antibiotic therapies for sepsis: an update
Sepsis, defined as infection plus some degree of organ dysfunction, is still associated with high mortality and morbidity rates. Management focuses on three key areas: infection control, hemodynamic stabilization and organ support, and modulation of the sepsis response. Areas covered: This review will not cover infection control. Hemodynamic stabilization essentially involves use of adequate fluid resuscitation and vasopressors. Fluid and vasopressor choices and targets are discussed, and the need to adapt these to the individual patient is stressed. No drugs are currently available that modulate the sepsis response, with ...
Source: Current Awareness Service for Health (CASH) - March 28, 2019 Category: Consumer Health News Source Type: news

Sepsis and septic shock: current approaches to management
Sepsis, defined as life-threatening organ dysfunction due to a dysregulated host response to infection, is recognised by the World Health Organization as a global health priority. Each year, 5000 of the 18 000 adults with sepsis treated in Australian intensive care units die, with survivors suffering long-term physical, cognitive and psychological dysfunction, which is poorly recognised and frequently untreated. There are currently no effective pharmacological treatments for sepsis, making early recognition, resuscitation and immediate treatment with appropriate antibiotics the key to reducing the burden of resulting disea...
Source: Current Awareness Service for Health (CASH) - March 28, 2019 Category: Consumer Health News Source Type: news

Emergency department sepsis huddles: Achieving excellence for sepsis benchmarks in New York State
The sepsis order set at our institution was created with the intent to facilitate the prompt initiation of appropriate sepsis care. Once clinical features meeting criteria for systemic inflammatory response syndrome (SIRS) are identified and an infectious source is considered, a " sepsis huddle " is concomitantly initiated. The sepsis huddle was implemented in March of 2016 in order to increase compliance with the sepsis bundles. Utilizing and adhering to the guidelines of this methodology in the management of these patients has enabled our hospital to improve benchmarking compliance from previously underperformi...
Source: Current Awareness Service for Health (CASH) - March 28, 2019 Category: Consumer Health News Source Type: news

Cardiovascular Events and Hospital Deaths Among Patients With Severe Sepsis
In conclusion, among patients with severe sepsis, incident cardiovascular events occur frequently. Further research is required to improve recognition and treatment of new-onset cardiovascular events in patients with severe sepsis. (Source: Current Awareness Service for Health (CASH))
Source: Current Awareness Service for Health (CASH) - March 28, 2019 Category: Consumer Health News Source Type: news

Sepsis Surveillance Using Adult Sepsis Events Simplified eSOFA Criteria Versus Sepsis-3 Sequential Organ Failure Assessment Criteria
Sepsis-3 defines organ dysfunction as an increase in the Sequential Organ Failure Assessment score by greater than or equal to 2 points. However, some Sequential Organ Failure Assessment score components are not routinely recorded in all hospitals' electronic health record systems, limiting its utility for wide-scale sepsis surveillance. The Centers for Disease Control and Prevention recently released the Adult Sepsis Event surveillance definition that includes simplified organ dysfunction criteria optimized for electronic health records (eSOFA). We compared eSOFA versus Sequential Organ Failure Assessment with regard to s...
Source: Current Awareness Service for Health (CASH) - March 28, 2019 Category: Consumer Health News Source Type: news

Antibiotic use practice and predictors of hospital outcome among patients with systemic bacterial infection: Identifying targets for antibiotic and health care resource stewardship.
Malpractice and excess use of antimicrobials have been associated with multiple costs, including the development of resistant bacteria, which has become a threat to the human health. The aim of this study, therefore, was to assess the antibiotic use practice and to identify predictors of hospital outcome to uncover targets for stewardship. Generally, this observation entails an appropriate infection management and antimicrobial use policy. Any future policy should better start by addressing cases like pneumonia, and sepsis and drugs like cephalosporins. (Source: Current Awareness Service for Health (CASH))
Source: Current Awareness Service for Health (CASH) - March 28, 2019 Category: Consumer Health News Source Type: news

Analysis of a new best-practice advisory on time to initiation of antibiotics in surgical intensive care unit patients with septic shock
Early administration of antibiotics in septic shock is associated with decreased mortality. Promptly identifying sepsis and eliciting a response are necessary to reduce time to antibiotic administration. A new best-practice advisory has been effective at eliciting a rapid response and reducing the time-to-antibiotics in surgical intensive care unit patients with septic shock. Team notification and pharmacist response are associated with decreased time-to-antibiotics. (Source: Current Awareness Service for Health (CASH))
Source: Current Awareness Service for Health (CASH) - March 28, 2019 Category: Consumer Health News Source Type: news