SARS-CoV-2 and viral sepsis: observations and hypotheses
Since the outbreak of coronavirus disease 2019 (COVID-19), clinicians have tried every effort to understand the disease, and a brief portrait of its clinical features have been identified. In clinical practice, we noticed that many severe or critically ill COVID-19 patients developed typical clinical manifestations of shock, including cold extremities and weak peripheral pulses, even in the absence of overt hypotension. Understanding the mechanism of viral sepsis in COVID-19 is warranted for exploring better clinical care for these patients. With evidence collected from autopsy studies on COVID-19 and basic science researc...
Source: Current Awareness Service for Health (CASH) - June 4, 2020 Category: Consumer Health News Source Type: news

Physical distancing, face masks, and eye protection to prevent person-to-person transmission of SARS-CoV-2 and COVID-19: a systematic review and meta-analysis
Implications of all the available evidence: In view of inconsistent guidelines by various organisations based on limited information, our findings provide some clarification and have implications for multiple stakeholders. The risk for infection is highly dependent on distance to the individual infected and the type of face mask and eye pro tection worn. From a policy and public health perspective, current policies of at least 1 m physical distancing seem to be strongly associated with a large protective effect, and distances of 2 m could be more effective. These data could also facilitate harmonisation of the definition...
Source: Current Awareness Service for Health (CASH) - June 4, 2020 Category: Consumer Health News Source Type: news

Principles of safe video consulting in general practice during COVID-19, NHS England
This guidance is aimed at NHS general practice staff who are consulting via video with patients at home (although key principles are expected to apply to practitioners across the wider primary care network). (Source: Current Awareness Service for Health (CASH))
Source: Current Awareness Service for Health (CASH) - June 4, 2020 Category: Consumer Health News Source Type: news

Update - Early Access to Medicines Scheme for remdesivir in the treatment of COVID-19. Implementation of the scheme and management of supply, MHRA (updated 3rd June 2020)
The access criteria have been amended to reflect developing clinical experience and knowledge of demand and changes in medicine supply. For the NHS in England, new registrations to the EAMS have now closed and initial stock allocations have been made. (Source: Current Awareness Service for Health (CASH))
Source: Current Awareness Service for Health (CASH) - June 4, 2020 Category: Consumer Health News Source Type: news

Health and Wellbeing Boards reset tool: to support HWB chairs to move into the next stage of COVID-19, LGA
This tool aims to support Health and Wellbeing Board (HWB) chairs/chairmen move into the next stage of COVID-19. The support is very flexible, ranging from a telephone call to talk through issues, and planning a meeting to a virtually facilitated workshop to help reset the HWB. It can be adapted to local circumstances. (Source: Current Awareness Service for Health (CASH))
Source: Current Awareness Service for Health (CASH) - June 4, 2020 Category: Consumer Health News Source Type: news

Effects of non-pharmaceutical interventions on COVID-19 cases, deaths, and demand for hospital services in the UK: a modelling study
Modelling study projected a median unmitigated burden of 23 million clinical cases and 350,000 deaths due to COVID-19 in the UK by December 2021. The most stringent lockdown scenario resulted in a projected 120,000 cases and 50,000 deaths. (Source: Current Awareness Service for Health (CASH))
Source: Current Awareness Service for Health (CASH) - June 4, 2020 Category: Consumer Health News Source Type: news

COVID-19: background information, PHE (updated 3rd June 2020)
Information on COVID-19 including epidemiology, virology and clinical features. Update in this version (published 3rd June) - updated global case numbers. (Source: Current Awareness Service for Health (CASH))
Source: Current Awareness Service for Health (CASH) - June 4, 2020 Category: Consumer Health News Source Type: news

Talking about death - end of life care guidance for the psychological workforce, BPS
The way we communicate as staff is affected by cultural taboos and also by our own beliefs and experiences, and our personal beliefs and values can affect our clinical decisions and willingness to talk about death. This document lays out some useful guidance to help managers and supervisors support staff and colleagues who are caring for patients who are dying. (Source: Current Awareness Service for Health (CASH))
Source: Current Awareness Service for Health (CASH) - June 3, 2020 Category: Consumer Health News Source Type: news

Number of coronavirus (COVID-19) cases and risk in the UK, DHSC/PHE (updated 3rd June 2020)
As of 9am on 3rd June, there have been 4,786,219 tests, with 171,829 tests on 2nd June. 279,856 people have tested positive. As of 5pm on 2nd June, of those tested positive for coronavirus in the UK, across all settings, 39,728 have died. (Source: Current Awareness Service for Health (CASH))
Source: Current Awareness Service for Health (CASH) - June 3, 2020 Category: Consumer Health News Source Type: news

National COVID-19 surveillance reports, PHE (updated 3rd June 2020)
National COVID-19 surveillance reports, including weekly summary of findings monitored through various COVID-19 surveillance systems. Update in this version (published 3rd June) - added sero-prevalence surveillance information. (Source: Current Awareness Service for Health (CASH))
Source: Current Awareness Service for Health (CASH) - June 3, 2020 Category: Consumer Health News Source Type: news

Coronavirus (COVID-19) testing: privacy information, DHSC (updated 3rd June 2020)
Privacy notice on COVID-19 virus testing for critical workers and their household members who are self-isolating because they're showing symptoms. 1. 3 June 2020 Both attachments have been updated in the following ways: eligibility criteria has been amended, how to get test results without a valid email or mobile number has been added, detail has been added to the explanation of who gives data to who and a greater emphasis has been place d on informing employers of positive test results. 2. 1 May 2020 Added quick read version of the privacy information. 3. 1 May 2020 (Source: Current Awareness Service for Health (CASH))
Source: Current Awareness Service for Health (CASH) - June 3, 2020 Category: Consumer Health News Source Type: news

COVID-19 Mortality Over Time ONS, CEBM (updated 2nd June 2020)
We are tracking the ONS data on 2 External 0 0 0 deaths false https://www.ons.gov.uk/peoplepopulationandcommunity/birthsdeathsandmarriages/deaths/datasets/weeklyprovisionalfiguresondeathsregisteredinenglandandwales true false%>, which updates every Tuesday. How can we tell if COVID-19 is the principal cause of these deaths? Or if they would have occurred in the absence of COVID-19, particularly in the elderly and people with chronic health problems? One way is to examine the death rates and determine if more people are dying than we would expect. What we want to know is whether the reported COVID deaths represent an &ld...
Source: Current Awareness Service for Health (CASH) - June 3, 2020 Category: Consumer Health News Source Type: news

COVID-19: Death Data in England - Update 2 June, CEBM
NHS England releases data at 2 pm each day and reports daily count up to the previous day as well as a total figure. (Source: Current Awareness Service for Health (CASH))
Source: Current Awareness Service for Health (CASH) - June 3, 2020 Category: Consumer Health News Source Type: news

COVID-19: Death Data in England, CEBM (updated 2nd June 2020)
NHS England releases data at 2 pm each day and reports daily count up to the previous day as well as a total figure. (Source: Current Awareness Service for Health (CASH))
Source: Current Awareness Service for Health (CASH) - June 3, 2020 Category: Consumer Health News Source Type: news

COVID-19 hospital deaths that have occurred but not yet reported, CEBM (updated 30th May 2020)
We have updated our 2 External 0 0 0 Chain Ladder false https://www.cebm.net/covid-19/covid-19-the-chain-ladder-method-to-estimate-deaths-not-yet-reported/ true false%> projections using deaths occurring up to 30 May 2020. The overall hospital death in England that have Occurred But Not yet Reported (OBNR) estimates have been reducing and our latest estimate is now down to 250 cases. This is primarily a result of the reducing volume of hospital deaths. (Source: Current Awareness Service for Health (CASH))
Source: Current Awareness Service for Health (CASH) - June 3, 2020 Category: Consumer Health News Source Type: news

In patients of COVID-19, what are the symptoms and clinical features of mild and moderate cases?, CEBM
COVID-19 presents varied clinical features, ranging from asymptomatic to ARDS. The most common symptoms at onset of COVID-19 include fever, cough, and shortness of breath. 2 External 0 0 0 1 false https://www.cdc.gov/coronavirus/2019-ncov/symptoms-testing/symptoms.html true false%> Yet about 80% of infections are mild (no pneumonia manifestations) or asymptomatic, though still contagious. 2 External 0 0 0 2 false https://www.who.int/docs/default-source/coronaviruse/situation-reports/20200319-sitrep-59-covid-19.pdf?sfvrsn=c3dcdef9_2 true false%> If the virus is not causing serious symptoms, people are less likely to r...
Source: Current Awareness Service for Health (CASH) - June 3, 2020 Category: Consumer Health News Source Type: news

Accessing support: the role of the voluntary and community sector during COVID-19, LGA
The purpose of this document is to provide councils and their community and voluntary sector partners with a briefing on the role and contribution of the community and voluntary sector and the use of volunteers in local and national responses to the COVID-19 pandemic. (Source: Current Awareness Service for Health (CASH))
Source: Current Awareness Service for Health (CASH) - June 3, 2020 Category: Consumer Health News Source Type: news

Coronavirus (COVID-19): testing data methodology, DHSC
The Department of Health and Social Care 2 External 0 0 0 publishes daily statistics on COVID-19 testing false https://www.gov.uk/guidance/coronavirus-covid-19-information-for-the-public true false%> and provides daily updates to the Cabinet Office for use in the government's daily media briefings. These statistics cover: testing for COVID-19 – tests, people tested, and positive cases capacity to process tests – which is published weekly This document sets out information on the data sources and methodology used to generate each of these headline measures. It will be updated with further detail on an ongoi...
Source: Current Awareness Service for Health (CASH) - June 3, 2020 Category: Consumer Health News Source Type: news

Coronavirus: Which key workers are most at risk?, House of Commons Library
This House of Commons Library Insight outlines which workers have experienced the biggest health risk and breaks these groups down by ethnicity, gender, country of birth, disability status, household type, and rates of pay. (Source: Current Awareness Service for Health (CASH))
Source: Current Awareness Service for Health (CASH) - June 3, 2020 Category: Consumer Health News Source Type: news

COVID-19: management of staff and exposed patients and residents in health and social care settings, PHE (updated 2nd June 2020)
Update in this version (published 2nd June) - updates made to introduction and sections 4.3, addition of section 4.4 and section 5. Update in version published 31st May - updated in light of the test and trace guidance and added guidance for risk assessment of staff in the event of PPE breaches. (Source: Current Awareness Service for Health (CASH))
Source: Current Awareness Service for Health (CASH) - June 3, 2020 Category: Consumer Health News Source Type: news

Remote consultation and triaging, RCGP (updated 2nd June 2020)
Part of RCGP Learning's COVID-19 Resource Hub, this provides advice on adapting to changing consultation formats, including best practice for online and telephone triage appointments. (Source: Current Awareness Service for Health (CASH))
Source: Current Awareness Service for Health (CASH) - June 3, 2020 Category: Consumer Health News Source Type: news

Number of coronavirus (COVID-19) cases and risk in the UK, DHSC/PHE (updated 2nd June 2020)
As of 9am on 2nd June, there have been 4,615,146 tests, with 135,643 tests on 1st June. 277,985 people have tested positive. As of 5pm on 1st June, of those tested positive for coronavirus in the UK, 39,369 have died. This new figure includes deaths in all settings, not just in hospitals. The equivalent figure under the old measure would have been 31,136. (Source: Current Awareness Service for Health (CASH))
Source: Current Awareness Service for Health (CASH) - June 3, 2020 Category: Consumer Health News Source Type: news

Mast cell stabilisers, leukotriene antagonists and antihistamines: A rapid review of the evidence for their use in COVID-19, CEBM (updated 2nd June 2020)
Mast cells are present in mucosal and connective tissues throughout the body. They participate in the innate and adaptive immune process and have an important role in inflammation and allergy. Mast cells located in the submucosa of the respiratory tract are known to be activated by the SARS-CoV-2 virus. (Source: Current Awareness Service for Health (CASH))
Source: Current Awareness Service for Health (CASH) - June 2, 2020 Category: Consumer Health News Source Type: news

COVID-19: guidance for health professionals, PHE/DHSC (updated 2nd June 2020)
Information on COVID-19, including guidance on the assessment and management of suspected UK cases. 2 June 2020 Reinstated COVID-19 (SARS-CoV-2): laboratory testing request form (E28). 1. 27 April 2020 Added'COVID-19: how to work safely in domiciliary care'. (Source: Current Awareness Service for Health (CASH))
Source: Current Awareness Service for Health (CASH) - June 2, 2020 Category: Consumer Health News Source Type: news

GP wellbeing, RCGP (updated 2nd June 2020)
This section of RCGP Learning's COVID-19 resource hub provides support for GPs during this challenging time, including wellbeing, resilience and mental health resources. (Source: Current Awareness Service for Health (CASH))
Source: Current Awareness Service for Health (CASH) - June 2, 2020 Category: Consumer Health News Source Type: news

Specialist issues with COVID-19, RCGP (updated 2nd June 2020)
This section of RCGP Learning's COVID-19 resource hub provides information on dealing with specific patient groups throughout the COVID-19 period. (Source: Current Awareness Service for Health (CASH))
Source: Current Awareness Service for Health (CASH) - June 2, 2020 Category: Consumer Health News Source Type: news

Clinical Management, RCGP (updated 1st June 2020)
Essential information for GPs about COVID-19, from symptoms to diagnosis to protecting practice staff. This is part of RCGP Learning's COVID-19 resource hub. (Source: Current Awareness Service for Health (CASH))
Source: Current Awareness Service for Health (CASH) - June 2, 2020 Category: Consumer Health News Source Type: news

Legionnaires' disease: national surveillance scheme, PHE (updated 2nd June 2020)
Guidance on the control and prevention of Legionnaires'disease in England, including disease surveillance and reporting forms. 2 June 2020 1. Reporting form updated to include COVID-19. 2. 5 April 2018 Added new versions of the'National Surveillance form'. (Source: Current Awareness Service for Health (CASH))
Source: Current Awareness Service for Health (CASH) - June 2, 2020 Category: Consumer Health News Source Type: news

Remote consultation and triaging, RCGP (updated 1st June 2020)
Part of RCGP Learning's COVID-19 Resource Hub, this provides advice on adapting to changing consultation formats, including best practice for online and telephone triage appointments. (Source: Current Awareness Service for Health (CASH))
Source: Current Awareness Service for Health (CASH) - June 2, 2020 Category: Consumer Health News Source Type: news

Draft landscape of COVID-19 candidate vaccines, WHO
These landscape documents have been prepared by the World Health Organization (WHO) for information purposes only concerning the 2019-2020 global of the novel coronavirus. Inclusion of any particular product or entity in any of these landscape documents does not constitute, and shall not be deemed or construed as, any approval or endorsement by WHO of such product or entity (or any of its businesses or activities). (Source: Current Awareness Service for Health (CASH))
Source: Current Awareness Service for Health (CASH) - June 2, 2020 Category: Consumer Health News Source Type: news

COVID-19: review of disparities in risks and outcomes, PHE
This is a descriptive review of surveillance data on disparities in the risk and outcomes from COVID-19. The review looked at different factors including: age and sex where people live deprivation ethnicity people's occupation care home residence The findings will help guide the future public health response to the COVID-19 pandemic. (Source: Current Awareness Service for Health (CASH))
Source: Current Awareness Service for Health (CASH) - June 2, 2020 Category: Consumer Health News Source Type: news

Number of coronavirus (COVID-19) cases and risk in the UK, DHSC/PHE (updated 1st June 2020)
As of 9am on 1st June, there have been 4,484,340 tests, with 128,437 tests on 31st May. 276,332 people have tested positive. As of 5pm on 31st May, of those tested positive for coronavirus in the UK, 39,045 have died. This new figure includes deaths in all settings not just in hospitals. (Source: Current Awareness Service for Health (CASH))
Source: Current Awareness Service for Health (CASH) - June 2, 2020 Category: Consumer Health News Source Type: news

PHE data series on deaths in people with COVID-19: technical summary, PHE (updated 1st June 2020)
Summary of the PHE data series on deaths in people with COVID-19, outlining what the changes mean and how the data compare to other COVID-19 death data series. Update in this version (published 1st June) - report updated for the incorporation of pillar 2 testing data. (Source: Current Awareness Service for Health (CASH))
Source: Current Awareness Service for Health (CASH) - June 2, 2020 Category: Consumer Health News Source Type: news

Harnessing the momentum within health tech post-Covid-19
In this feature we have asked for the thoughts of health tech providers whether healthcare has had its online banking moment, to understand some considerations and to hear from the industry if the momentum can be sustained. NB: Sponsored by Highland Marketing. (Source: Current Awareness Service for Health (CASH))
Source: Current Awareness Service for Health (CASH) - June 2, 2020 Category: Consumer Health News Source Type: news

Characterization and clinical course of 1000 patients with coronavirus disease 2019 in New York: retrospective case series, BMJ
Study reported the following trends; patients admitted to ICU had baseline comorbidities including hypertension, diabetes, and obesity, were older, predominantly male and had long lengths of stay. Many developed acute kidney injury and some needed dialysis and prolonged intubation. (Source: Current Awareness Service for Health (CASH))
Source: Current Awareness Service for Health (CASH) - June 2, 2020 Category: Consumer Health News Source Type: news

Mortality and pulmonary complications in patients undergoing surgery with perioperative SARS-CoV-2 infection: an international cohort study
Study (n=1128) reported overall 30-day mortality was 23.8%. Pulmonary complications occurred in 51.2% of pts; which accounted for 82.6% of all deaths. Risk factors include male sex, age>70 yrs, anaesthesiology grades 3 –5, surgery for cancer, emergency surgery, and major surgery. (Source: Current Awareness Service for Health (CASH))
Source: Current Awareness Service for Health (CASH) - June 2, 2020 Category: Consumer Health News Source Type: news

Neuroleptic strategies for terminal agitation in patients with cancer and delirium at an acute palliative care unit: a single-centre, double-blind, parallel-group, randomised trial
Study reported reductions from baseline in Richmond Agitation Sedation Scale scores in haloperidol escalation group (n=10; −3.6), haloperidol/chlorpromazine rotation group (11; −3.3), and haloperidol/chlorpromazine combination group (10; −3.0), with no difference among groups. (Source: Current Awareness Service for Health (CASH))
Source: Current Awareness Service for Health (CASH) - June 2, 2020 Category: Consumer Health News Source Type: news

Action taken to halt sales of fingerprick coronavirus (COVID-19) antibody testing kits, MHRA
The MHRA is asking providers of these laboratory-based COVID-19 antibody testing services, to temporarily stop providing this service until home collection of this sample type has been properly assessed and validated for use with these laboratory tests. (Source: Current Awareness Service for Health (CASH))
Source: Current Awareness Service for Health (CASH) - June 2, 2020 Category: Consumer Health News Source Type: news

Coronavirus (COVID-19): guidance, PHE (updated 1st June 2020)
Guidance about coronavirus (COVID-19) for health and social care settings, other non-clinical settings, and for the general public. Update in this version (published 1st June) - updated general guidance. Update in version published 28th May - added guidance for contacts of people with possible or confirmed coronavirus (COVID-19) infection who do not live with the person. (Source: Current Awareness Service for Health (CASH))
Source: Current Awareness Service for Health (CASH) - June 2, 2020 Category: Consumer Health News Source Type: news

COVID-19: Death Data in England Update 31st May, CEBM
Updated death data for England as at 31st May 2020. (Source: Current Awareness Service for Health (CASH))
Source: Current Awareness Service for Health (CASH) - June 1, 2020 Category: Consumer Health News Source Type: news

COVID-19: Admissions to Hospital, CEBM (updated 31st May 2020)
Update of daily COVID admissions to hospital in England over time and relative change in COVID admissions over time - updated 31st May 2020. (Source: Current Awareness Service for Health (CASH))
Source: Current Awareness Service for Health (CASH) - June 1, 2020 Category: Consumer Health News Source Type: news

More about chloroquine and hydroxychloroquine, CEBM
VERDICT: The hypothesis that the 4-aminoquinolines chloroquine and hydroxychloroquine may be beneficial in the treatment of COVID-19 is a weak one, based on poor mechanistic reasoning and inconsistent results of studies in vitro, in laboratory animals, and in humans. It is likely that even if chloroquine and hydroxychloroquine are effective in COVID-19, the beneficial effects will be small. The risks of adverse reactions to these drugs may be increased in patients who are acutely ill with severe COVID-19, in many of whom high doses are being used. Macrolide antibacterial drugs, such as azithromycin, clarithromycin, ery...
Source: Current Awareness Service for Health (CASH) - June 1, 2020 Category: Consumer Health News Source Type: news

Asthma and COVID-19: risks and management considerations, CEBM
VERDICT: It is unclear if people with asthma are at increased risk of contracting COVID-19 or of worse outcomes from COVID-19 infection. The evidence available is limited with some sources suggesting an underrepresentation of PWA in hospitalised cases, and others showing an increased risk of worse outcomes in PWA which may be associated with disease severity. Consensus broadly holds that asthma medications should be continued as usual. Asthma care may be disrupted during the pandemic; self-management and remote interventions may be of benefit but have not been tested in this context. (Source: Current Awareness Service for Health (CASH))
Source: Current Awareness Service for Health (CASH) - June 1, 2020 Category: Consumer Health News Source Type: news

COVID-19: how to work safely in domiciliary care in England, PHE (updated 1st June 2020)
Update in this version (published 1st June) - Updated Personal protective equipment (PPE): a resource for care workers delivering homecare (domiciliary care) in England. (Source: Current Awareness Service for Health (CASH))
Source: Current Awareness Service for Health (CASH) - June 1, 2020 Category: Consumer Health News Source Type: news

COVID-19 - clinical management of children admitted to hospital with suspected COVID-19, RCPCH (updated 29th May 2020)
This guidance outlines key principles for the clinical management of children admitted to hospital with suspected COVID-19. It is aimed at general paediatricians treating children during the COVID-19 pandemic. It covers medical management of paediatric patients, including advice on use of antiviral treatments. (Source: Current Awareness Service for Health (CASH))
Source: Current Awareness Service for Health (CASH) - June 1, 2020 Category: Consumer Health News Source Type: news

COVID-19 - clinical management of children admitted to hospital with suspected COVID-19, BPRS (updated 29th May 2020)
This guidance outlines key principles for the clinical management of children admitted to hospital with suspected COVID-19. It is aimed at general paediatricians treating children during the COVID-19 pandemic. It covers medical management of paediatric patients, including advice on use of antiviral treatments. (Source: Current Awareness Service for Health (CASH))
Source: Current Awareness Service for Health (CASH) - June 1, 2020 Category: Consumer Health News Source Type: news

Specialist issues with COVID-19, RCGP (updated 1st June 2020)
Part of RCGP Learning's COVID-19 Resource Hub, this provides information on dealing with specific patient groups throughout the COVID-19 period. (Source: Current Awareness Service for Health (CASH))
Source: Current Awareness Service for Health (CASH) - June 1, 2020 Category: Consumer Health News Source Type: news

COVID-19: background information, PHE (updated 1st June 2020)
Update in this version (published 1st June) - updated global case numbers. (Source: Current Awareness Service for Health (CASH))
Source: Current Awareness Service for Health (CASH) - June 1, 2020 Category: Consumer Health News Source Type: news

Six-Country Survey on COVID-19, IZA Institute of Labor Economics
This paper presents a new dataset collected on representative samples across six countries: China, South Korea, Japan, Italy, the UK and the four largest states in the US. The information collected relates to work and living situations, income, behaviour (such as social distancing, hand washing and wearing a face mask), beliefs about the Covid-19 pandemic and exposure to the virus, socio-demographic characteristics and pre-pandemic health characteristics. (Source: Current Awareness Service for Health (CASH))
Source: Current Awareness Service for Health (CASH) - June 1, 2020 Category: Consumer Health News Source Type: news

Age, death risk, and the design of an exit strategy: a guide for policymakers and for citizens who want to stay alive, IZA Institute for Labor Economics
This discussion paper provides information on the strong age pattern in the risk of death from three countries (China, Italy, the UK). Its authors believe that if politicians want an imminent removal of the lockdown, the safest approach would be a rolling age-release strategy combined with the current principle of social distancing. But even if that is not the policy adopted, the authors argue that citizens need to be shown graphs of the kind in this paper. (Source: Current Awareness Service for Health (CASH))
Source: Current Awareness Service for Health (CASH) - June 1, 2020 Category: Consumer Health News Source Type: news