Thrombosis in COVID-19: clinical outcomes, biochemical and pathological changes, and treatments, CEBM
Reports that COVID-19 is associated with venous and arterial thrombosis and pulmonary embolism and increased rates of thrombosis in cannulae and extracorporeal circuits for renal replacement or membrane oxygenation, have drawn attention to the coagulant effects of the disease. (Source: Current Awareness Service for Health (CASH))
Source: Current Awareness Service for Health (CASH) - June 4, 2020 Category: Consumer Health News Source Type: news

Clinical Effect of the Acrylonitrile-Co-Methallyl Sulfonate Surface-Treated Membrane as a Cytokine Adsorption Therapy for Sepsis due to Acute Panperitonitis: A Retrospective Cohort Study
Conclusion(s): There is no significant difference in-hospital mortality between CRRT with the AN69ST membrane and CRRT with standard CRRT membranes for panperitonitis due to lower gastrointestinal perforation. These results indicate that the AN69ST membrane is not superior to the standard CRRT membrane. (Source: Current Awareness Service for Health (CASH))
Source: Current Awareness Service for Health (CASH) - June 4, 2020 Category: Consumer Health News Source Type: news

COVID-19: Death Data in England Update 4th June, CEBM
Latest death data for England releases data updated 4th June 2020. (Source: Current Awareness Service for Health (CASH))
Source: Current Awareness Service for Health (CASH) - June 4, 2020 Category: Consumer Health News Source Type: news

COVID-19: Death Data in England Update 4th June, CEBM (updated 4th June 2020)
Latest death data for England releases data updated 4th June 2020. (Source: Current Awareness Service for Health (CASH))
Source: Current Awareness Service for Health (CASH) - June 4, 2020 Category: Consumer Health News Source Type: news

Clinical outcomes of empirical high-dose meropenem in critically ill patients with sepsis and septic shock: A randomized controlled trial
Conclusion(s): Empirical therapy with the high-dose meropenem presented comparable clinical outcomes to the standard-dose meropenem in sepsis and septic shock patients. Besides, subgroup analysis manifested superior microbiological cure rate in sepsis or septic shock patients admitted from ED. (Source: Current Awareness Service for Health (CASH))
Source: Current Awareness Service for Health (CASH) - June 4, 2020 Category: Consumer Health News Source Type: news

The role and response of primary care and community nursing in the delivery of palliative care in epidemics and pandemics: a rapid review to inform practice and service delivery during the COVID-19 pandemic, CEBM
The provision of palliative care to patients, families and communities is core to the role and identity of primary care physicians. General practitioners (GPs) or family physicians (FPs), and community nurses, have the potential and skills to deliver palliative and end-of-life care integrated into every encounter in the community when their working environment allows this, and with the support of specialist colleagues. Prior to the COVID-19 pandemic, barriers to effective palliative and end of life care in the community by GPs included a lack of time with patients and families, inadequate support services in the community,...
Source: Current Awareness Service for Health (CASH) - June 4, 2020 Category: Consumer Health News Source Type: news

COVID-19: Care Homes in England, CEBM (updated 4th June 2020)
Data from 2 External 0 0 0 care homes false https://www.gov.uk/government/statistical-data-sets/covid-19-number-of-outbreaks-in-care-homes-management-information true false%> shows that 6,102 out of 15,514 care homes (39.3%) in England have confirmed or suspected outbreaks of COVID reported to Public Health England for the week commencing the 18th of May. (Source: Current Awareness Service for Health (CASH))
Source: Current Awareness Service for Health (CASH) - June 4, 2020 Category: Consumer Health News Source Type: news

The Role of Serum Procalcitonin in Predicting Bacterial Sepsis in Patients with Hypothyroidism
Conclusion(s): Despite the thyroidal origin of PCT, hypothyroidism did not affect the diagnostic performance of serum PCT levels in predicting bacterial sepsis or septic shock. (Source: Current Awareness Service for Health (CASH))
Source: Current Awareness Service for Health (CASH) - June 4, 2020 Category: Consumer Health News Source Type: news

Access resources to tackle racism and discrimination, NHS Employers
The NHS workforce is one of the most diverse in the world. It is vital that our colleagues throughout the service feel supported in their jobs and are able to carry out their roles in an environment where they feel safe and valued. (Source: Current Awareness Service for Health (CASH))
Source: Current Awareness Service for Health (CASH) - June 4, 2020 Category: Consumer Health News Source Type: news

Dental standard operating procedure: Transition to recovery, NHS England
A phased transition for dental practices towards the resumption of the full range of dental provision. (Source: Current Awareness Service for Health (CASH))
Source: Current Awareness Service for Health (CASH) - June 4, 2020 Category: Consumer Health News Source Type: news

Hemodynamic Effects of Propofol and Dexmedetomidine in Septic Patients Without Shock
Conclusions and Relevance: A minority of patients with sepsis who received either propofol or dexmedetomidine experienced an event. Patients with sepsis without shock receiving continuous infusions of propofol and dexmedetomidine experienced a negative hemodynamic event at similar frequencies, though the degree of hypotension seen with propofol was greater. The clinical significance of these adverse effects requires cautious use in sepsis and further investigation. (Source: Current Awareness Service for Health (CASH))
Source: Current Awareness Service for Health (CASH) - June 4, 2020 Category: Consumer Health News Source Type: news

National child measurement programme (NCMP): trends in child BMI between 2006 to 2007 and 2018 to 2019, PHE
This report presents data on the trends in child body mass index from the National Child Measurement Programme (NCMP), between 2006 to 2007, and 2018 to 2019. (Source: Current Awareness Service for Health (CASH))
Source: Current Awareness Service for Health (CASH) - June 4, 2020 Category: Consumer Health News Source Type: news

COVID-19: management of staff and exposed patients and residents in health and social care settings, PHE (updated 4th June 2020)
Update in this version (published 4th June) - added new section on NHS test and trace. Update in version published 2nd June - updates made to introduction and sections 4.3, addition of section 4.4 and section 5. (Source: Current Awareness Service for Health (CASH))
Source: Current Awareness Service for Health (CASH) - June 4, 2020 Category: Consumer Health News Source Type: news

Activation of AMP-activated protein kinase during sepsis/inflammation improves survival by preserving cellular metabolic fitness
The purpose was to determine the role of AMPK activation in the renal metabolic response to sepsis, the development of sepsis-induced acute kidney injury (AKI) and on survival. In a prospective experimental study, 167 10- to 12-week-old C57BL/6 mice underwent cecal ligation and puncture (CLP) and human proximal tubule epithelial cells (TEC; HK2) were exposed to inflammatory mix (IM), a combination of lipopolysaccharide (LPS) and high mobility group box 1 (HMGB1). Renal/TEC metabolic fitness was assessed by monitoring the expression of drivers of oxidative phosphorylation (OXPHOS), the rates of utilization of OXPHOS/glycoly...
Source: Current Awareness Service for Health (CASH) - June 4, 2020 Category: Consumer Health News Source Type: news

Staying alert and safe (social distancing), Cabinet Office (updated 4th June 2020)
The government has set out 2 External 0 0 0 its plan false https://www.gov.uk/government/publications/our-plan-to-rebuild-the-uk-governments-covid-19-recovery-strategy true false%> to return life to as near normal as we can, for as many people as we can, as quickly and fairly as possible in order to safeguard livelihoods, but in a way that is safe and continues to protect our NHS. The most important thing we can continue to do is to stay alert, control the virus, and, in doing so, save lives. 4 June 2020 Updated to reflect the change in government policy from 1 June. 31 May 2020 Updated to reflect new guidance. 29 M...
Source: Current Awareness Service for Health (CASH) - June 4, 2020 Category: Consumer Health News Source Type: news

National COVID-19 surveillance reports, PHE (updated 4th June 2020)
National COVID-19 surveillance reports, including weekly summary of findings monitored through various COVID-19 surveillance systems. Update in this version (published 4th June) - added week 23 report and infographic. Update in version published 3rd June - added sero-prevalence surveillance information. (Source: Current Awareness Service for Health (CASH))
Source: Current Awareness Service for Health (CASH) - June 4, 2020 Category: Consumer Health News Source Type: news

Monocyte distribution width enhances early sepsis detection in the emergency department beyond SIRS and qSOFA
Background: The initial presentation of sepsis in the emergency department (ED) is difficult to distinguish from other acute illnesses based upon similar clinical presentations. A new blood parameter, a measurement of increased monocyte volume distribution width (MDW), may be used in combination with other clinical parameters to improve early sepsis detection. We sought to determine if MDW, when combined with other available clinical parameters at the time of ED presentation, improves the early detection of sepsis. Method(s): A retrospective analysis of prospectively collected clinical data available during the initial ED ...
Source: Current Awareness Service for Health (CASH) - June 4, 2020 Category: Consumer Health News Source Type: news

Coronavirus (COVID-19): how to self-isolate when you travel to the UK, DHSC
Sets out how to self-isolate if you arrive in the UK on or after 8 June 2020. You will not be allowed to leave the place you're staying for the first 14 days you're in the UK. (Source: Current Awareness Service for Health (CASH))
Source: Current Awareness Service for Health (CASH) - June 4, 2020 Category: Consumer Health News Source Type: news

SARS-CoV-2 and viral sepsis: observations and hypotheses
Since the outbreak of coronavirus disease 2019 (COVID-19), clinicians have tried every effort to understand the disease, and a brief portrait of its clinical features have been identified. In clinical practice, we noticed that many severe or critically ill COVID-19 patients developed typical clinical manifestations of shock, including cold extremities and weak peripheral pulses, even in the absence of overt hypotension. Understanding the mechanism of viral sepsis in COVID-19 is warranted for exploring better clinical care for these patients. With evidence collected from autopsy studies on COVID-19 and basic science researc...
Source: Current Awareness Service for Health (CASH) - June 4, 2020 Category: Consumer Health News Source Type: news

Physical distancing, face masks, and eye protection to prevent person-to-person transmission of SARS-CoV-2 and COVID-19: a systematic review and meta-analysis
Implications of all the available evidence: In view of inconsistent guidelines by various organisations based on limited information, our findings provide some clarification and have implications for multiple stakeholders. The risk for infection is highly dependent on distance to the individual infected and the type of face mask and eye pro tection worn. From a policy and public health perspective, current policies of at least 1 m physical distancing seem to be strongly associated with a large protective effect, and distances of 2 m could be more effective. These data could also facilitate harmonisation of the definition...
Source: Current Awareness Service for Health (CASH) - June 4, 2020 Category: Consumer Health News Source Type: news

Principles of safe video consulting in general practice during COVID-19, NHS England
This guidance is aimed at NHS general practice staff who are consulting via video with patients at home (although key principles are expected to apply to practitioners across the wider primary care network). (Source: Current Awareness Service for Health (CASH))
Source: Current Awareness Service for Health (CASH) - June 4, 2020 Category: Consumer Health News Source Type: news

Update - Early Access to Medicines Scheme for remdesivir in the treatment of COVID-19. Implementation of the scheme and management of supply, MHRA (updated 3rd June 2020)
The access criteria have been amended to reflect developing clinical experience and knowledge of demand and changes in medicine supply. For the NHS in England, new registrations to the EAMS have now closed and initial stock allocations have been made. (Source: Current Awareness Service for Health (CASH))
Source: Current Awareness Service for Health (CASH) - June 4, 2020 Category: Consumer Health News Source Type: news

Health and Wellbeing Boards reset tool: to support HWB chairs to move into the next stage of COVID-19, LGA
This tool aims to support Health and Wellbeing Board (HWB) chairs/chairmen move into the next stage of COVID-19. The support is very flexible, ranging from a telephone call to talk through issues, and planning a meeting to a virtually facilitated workshop to help reset the HWB. It can be adapted to local circumstances. (Source: Current Awareness Service for Health (CASH))
Source: Current Awareness Service for Health (CASH) - June 4, 2020 Category: Consumer Health News Source Type: news

Effects of non-pharmaceutical interventions on COVID-19 cases, deaths, and demand for hospital services in the UK: a modelling study
Modelling study projected a median unmitigated burden of 23 million clinical cases and 350,000 deaths due to COVID-19 in the UK by December 2021. The most stringent lockdown scenario resulted in a projected 120,000 cases and 50,000 deaths. (Source: Current Awareness Service for Health (CASH))
Source: Current Awareness Service for Health (CASH) - June 4, 2020 Category: Consumer Health News Source Type: news

COVID-19: background information, PHE (updated 3rd June 2020)
Information on COVID-19 including epidemiology, virology and clinical features. Update in this version (published 3rd June) - updated global case numbers. (Source: Current Awareness Service for Health (CASH))
Source: Current Awareness Service for Health (CASH) - June 4, 2020 Category: Consumer Health News Source Type: news

Talking about death - end of life care guidance for the psychological workforce, BPS
The way we communicate as staff is affected by cultural taboos and also by our own beliefs and experiences, and our personal beliefs and values can affect our clinical decisions and willingness to talk about death. This document lays out some useful guidance to help managers and supervisors support staff and colleagues who are caring for patients who are dying. (Source: Current Awareness Service for Health (CASH))
Source: Current Awareness Service for Health (CASH) - June 3, 2020 Category: Consumer Health News Source Type: news

Number of coronavirus (COVID-19) cases and risk in the UK, DHSC/PHE (updated 3rd June 2020)
As of 9am on 3rd June, there have been 4,786,219 tests, with 171,829 tests on 2nd June. 279,856 people have tested positive. As of 5pm on 2nd June, of those tested positive for coronavirus in the UK, across all settings, 39,728 have died. (Source: Current Awareness Service for Health (CASH))
Source: Current Awareness Service for Health (CASH) - June 3, 2020 Category: Consumer Health News Source Type: news

National COVID-19 surveillance reports, PHE (updated 3rd June 2020)
National COVID-19 surveillance reports, including weekly summary of findings monitored through various COVID-19 surveillance systems. Update in this version (published 3rd June) - added sero-prevalence surveillance information. (Source: Current Awareness Service for Health (CASH))
Source: Current Awareness Service for Health (CASH) - June 3, 2020 Category: Consumer Health News Source Type: news

Coronavirus (COVID-19) testing: privacy information, DHSC (updated 3rd June 2020)
Privacy notice on COVID-19 virus testing for critical workers and their household members who are self-isolating because they're showing symptoms. 1. 3 June 2020 Both attachments have been updated in the following ways: eligibility criteria has been amended, how to get test results without a valid email or mobile number has been added, detail has been added to the explanation of who gives data to who and a greater emphasis has been place d on informing employers of positive test results. 2. 1 May 2020 Added quick read version of the privacy information. 3. 1 May 2020 (Source: Current Awareness Service for Health (CASH))
Source: Current Awareness Service for Health (CASH) - June 3, 2020 Category: Consumer Health News Source Type: news

COVID-19 Mortality Over Time ONS, CEBM (updated 2nd June 2020)
We are tracking the ONS data on 2 External 0 0 0 deaths false https://www.ons.gov.uk/peoplepopulationandcommunity/birthsdeathsandmarriages/deaths/datasets/weeklyprovisionalfiguresondeathsregisteredinenglandandwales true false%>, which updates every Tuesday. How can we tell if COVID-19 is the principal cause of these deaths? Or if they would have occurred in the absence of COVID-19, particularly in the elderly and people with chronic health problems? One way is to examine the death rates and determine if more people are dying than we would expect. What we want to know is whether the reported COVID deaths represent an &ld...
Source: Current Awareness Service for Health (CASH) - June 3, 2020 Category: Consumer Health News Source Type: news

COVID-19: Death Data in England - Update 2 June, CEBM
NHS England releases data at 2 pm each day and reports daily count up to the previous day as well as a total figure. (Source: Current Awareness Service for Health (CASH))
Source: Current Awareness Service for Health (CASH) - June 3, 2020 Category: Consumer Health News Source Type: news

COVID-19: Death Data in England, CEBM (updated 2nd June 2020)
NHS England releases data at 2 pm each day and reports daily count up to the previous day as well as a total figure. (Source: Current Awareness Service for Health (CASH))
Source: Current Awareness Service for Health (CASH) - June 3, 2020 Category: Consumer Health News Source Type: news

COVID-19 hospital deaths that have occurred but not yet reported, CEBM (updated 30th May 2020)
We have updated our 2 External 0 0 0 Chain Ladder false https://www.cebm.net/covid-19/covid-19-the-chain-ladder-method-to-estimate-deaths-not-yet-reported/ true false%> projections using deaths occurring up to 30 May 2020. The overall hospital death in England that have Occurred But Not yet Reported (OBNR) estimates have been reducing and our latest estimate is now down to 250 cases. This is primarily a result of the reducing volume of hospital deaths. (Source: Current Awareness Service for Health (CASH))
Source: Current Awareness Service for Health (CASH) - June 3, 2020 Category: Consumer Health News Source Type: news

In patients of COVID-19, what are the symptoms and clinical features of mild and moderate cases?, CEBM
COVID-19 presents varied clinical features, ranging from asymptomatic to ARDS. The most common symptoms at onset of COVID-19 include fever, cough, and shortness of breath. 2 External 0 0 0 1 false https://www.cdc.gov/coronavirus/2019-ncov/symptoms-testing/symptoms.html true false%> Yet about 80% of infections are mild (no pneumonia manifestations) or asymptomatic, though still contagious. 2 External 0 0 0 2 false https://www.who.int/docs/default-source/coronaviruse/situation-reports/20200319-sitrep-59-covid-19.pdf?sfvrsn=c3dcdef9_2 true false%> If the virus is not causing serious symptoms, people are less likely to r...
Source: Current Awareness Service for Health (CASH) - June 3, 2020 Category: Consumer Health News Source Type: news

Accessing support: the role of the voluntary and community sector during COVID-19, LGA
The purpose of this document is to provide councils and their community and voluntary sector partners with a briefing on the role and contribution of the community and voluntary sector and the use of volunteers in local and national responses to the COVID-19 pandemic. (Source: Current Awareness Service for Health (CASH))
Source: Current Awareness Service for Health (CASH) - June 3, 2020 Category: Consumer Health News Source Type: news

Coronavirus (COVID-19): testing data methodology, DHSC
The Department of Health and Social Care 2 External 0 0 0 publishes daily statistics on COVID-19 testing false https://www.gov.uk/guidance/coronavirus-covid-19-information-for-the-public true false%> and provides daily updates to the Cabinet Office for use in the government's daily media briefings. These statistics cover: testing for COVID-19 – tests, people tested, and positive cases capacity to process tests – which is published weekly This document sets out information on the data sources and methodology used to generate each of these headline measures. It will be updated with further detail on an ongoi...
Source: Current Awareness Service for Health (CASH) - June 3, 2020 Category: Consumer Health News Source Type: news

Coronavirus: Which key workers are most at risk?, House of Commons Library
This House of Commons Library Insight outlines which workers have experienced the biggest health risk and breaks these groups down by ethnicity, gender, country of birth, disability status, household type, and rates of pay. (Source: Current Awareness Service for Health (CASH))
Source: Current Awareness Service for Health (CASH) - June 3, 2020 Category: Consumer Health News Source Type: news

COVID-19: management of staff and exposed patients and residents in health and social care settings, PHE (updated 2nd June 2020)
Update in this version (published 2nd June) - updates made to introduction and sections 4.3, addition of section 4.4 and section 5. Update in version published 31st May - updated in light of the test and trace guidance and added guidance for risk assessment of staff in the event of PPE breaches. (Source: Current Awareness Service for Health (CASH))
Source: Current Awareness Service for Health (CASH) - June 3, 2020 Category: Consumer Health News Source Type: news

Remote consultation and triaging, RCGP (updated 2nd June 2020)
Part of RCGP Learning's COVID-19 Resource Hub, this provides advice on adapting to changing consultation formats, including best practice for online and telephone triage appointments. (Source: Current Awareness Service for Health (CASH))
Source: Current Awareness Service for Health (CASH) - June 3, 2020 Category: Consumer Health News Source Type: news

Number of coronavirus (COVID-19) cases and risk in the UK, DHSC/PHE (updated 2nd June 2020)
As of 9am on 2nd June, there have been 4,615,146 tests, with 135,643 tests on 1st June. 277,985 people have tested positive. As of 5pm on 1st June, of those tested positive for coronavirus in the UK, 39,369 have died. This new figure includes deaths in all settings, not just in hospitals. The equivalent figure under the old measure would have been 31,136. (Source: Current Awareness Service for Health (CASH))
Source: Current Awareness Service for Health (CASH) - June 3, 2020 Category: Consumer Health News Source Type: news

Mast cell stabilisers, leukotriene antagonists and antihistamines: A rapid review of the evidence for their use in COVID-19, CEBM (updated 2nd June 2020)
Mast cells are present in mucosal and connective tissues throughout the body. They participate in the innate and adaptive immune process and have an important role in inflammation and allergy. Mast cells located in the submucosa of the respiratory tract are known to be activated by the SARS-CoV-2 virus. (Source: Current Awareness Service for Health (CASH))
Source: Current Awareness Service for Health (CASH) - June 2, 2020 Category: Consumer Health News Source Type: news

COVID-19: guidance for health professionals, PHE/DHSC (updated 2nd June 2020)
Information on COVID-19, including guidance on the assessment and management of suspected UK cases. 2 June 2020 Reinstated COVID-19 (SARS-CoV-2): laboratory testing request form (E28). 1. 27 April 2020 Added'COVID-19: how to work safely in domiciliary care'. (Source: Current Awareness Service for Health (CASH))
Source: Current Awareness Service for Health (CASH) - June 2, 2020 Category: Consumer Health News Source Type: news

GP wellbeing, RCGP (updated 2nd June 2020)
This section of RCGP Learning's COVID-19 resource hub provides support for GPs during this challenging time, including wellbeing, resilience and mental health resources. (Source: Current Awareness Service for Health (CASH))
Source: Current Awareness Service for Health (CASH) - June 2, 2020 Category: Consumer Health News Source Type: news

Specialist issues with COVID-19, RCGP (updated 2nd June 2020)
This section of RCGP Learning's COVID-19 resource hub provides information on dealing with specific patient groups throughout the COVID-19 period. (Source: Current Awareness Service for Health (CASH))
Source: Current Awareness Service for Health (CASH) - June 2, 2020 Category: Consumer Health News Source Type: news

Clinical Management, RCGP (updated 1st June 2020)
Essential information for GPs about COVID-19, from symptoms to diagnosis to protecting practice staff. This is part of RCGP Learning's COVID-19 resource hub. (Source: Current Awareness Service for Health (CASH))
Source: Current Awareness Service for Health (CASH) - June 2, 2020 Category: Consumer Health News Source Type: news

Legionnaires' disease: national surveillance scheme, PHE (updated 2nd June 2020)
Guidance on the control and prevention of Legionnaires'disease in England, including disease surveillance and reporting forms. 2 June 2020 1. Reporting form updated to include COVID-19. 2. 5 April 2018 Added new versions of the'National Surveillance form'. (Source: Current Awareness Service for Health (CASH))
Source: Current Awareness Service for Health (CASH) - June 2, 2020 Category: Consumer Health News Source Type: news

Remote consultation and triaging, RCGP (updated 1st June 2020)
Part of RCGP Learning's COVID-19 Resource Hub, this provides advice on adapting to changing consultation formats, including best practice for online and telephone triage appointments. (Source: Current Awareness Service for Health (CASH))
Source: Current Awareness Service for Health (CASH) - June 2, 2020 Category: Consumer Health News Source Type: news

Draft landscape of COVID-19 candidate vaccines, WHO
These landscape documents have been prepared by the World Health Organization (WHO) for information purposes only concerning the 2019-2020 global of the novel coronavirus. Inclusion of any particular product or entity in any of these landscape documents does not constitute, and shall not be deemed or construed as, any approval or endorsement by WHO of such product or entity (or any of its businesses or activities). (Source: Current Awareness Service for Health (CASH))
Source: Current Awareness Service for Health (CASH) - June 2, 2020 Category: Consumer Health News Source Type: news

COVID-19: review of disparities in risks and outcomes, PHE
This is a descriptive review of surveillance data on disparities in the risk and outcomes from COVID-19. The review looked at different factors including: age and sex where people live deprivation ethnicity people's occupation care home residence The findings will help guide the future public health response to the COVID-19 pandemic. (Source: Current Awareness Service for Health (CASH))
Source: Current Awareness Service for Health (CASH) - June 2, 2020 Category: Consumer Health News Source Type: news

Number of coronavirus (COVID-19) cases and risk in the UK, DHSC/PHE (updated 1st June 2020)
As of 9am on 1st June, there have been 4,484,340 tests, with 128,437 tests on 31st May. 276,332 people have tested positive. As of 5pm on 31st May, of those tested positive for coronavirus in the UK, 39,045 have died. This new figure includes deaths in all settings not just in hospitals. (Source: Current Awareness Service for Health (CASH))
Source: Current Awareness Service for Health (CASH) - June 2, 2020 Category: Consumer Health News Source Type: news