Funtabulously Frivolous Friday Five 234
LITFL • Life in the Fast Lane Medical Blog LITFL • Life in the Fast Lane Medical Blog - Emergency medicine and critical care medical education blog
Just when you thought your brain could unwind on a Friday, you realise that it would rather be challenged with some good old fashioned medical trivia FFFF…introducing Funtabulously Frivolous Friday Five 234.
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Question 1:
What is Stabler sign?
+ Reveal the Funtabulous Answer
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Stabler sign: Non-...
Source: Life in the Fast Lane - April 12, 2018 Category: Emergency Medicine Authors: Neil Long Tags: Frivolous Friday Five appendicitis botulism cullen echinococcus granulosus ectopic pregnancy Francois Henri Hallopeau hair hydatid Kenya Rovsing's Selman Waksman Stabler's sign Trichotillomania trichotillomaniac water lily si Source Type: blogs
Amyloid- β May Cause Mitochondrial Dysfunction in Alzheimer's Disease
This study reinforces the toxicity of oligomeric amyloid-β on neuronal mitochondria and stresses the importance for protective compounds to protect the mitochondria from oligomeric amyloid-β toxicity."
In the new study, cells known as pyramidal neurons, extracted from the hippocampus of patients who died of Alzheimer's, display a marked reduction in the expression of a suite of mitochondrial genes, pointing to their degradation by OAβ. The reduction of mitochondrial gene expression was also seen when cells belonging to a human neuroblastoma cell line were exposed to OAβ. The authors stress that not all types of ...
Source: Fight Aging! - January 24, 2018 Category: Research Authors: Reason Tags: Daily News Source Type: blogs
Neuroblastoma : RadioPath Integrated Video
Presenting an integrated video on neuroblastoma and its typical radiological and pathological features.Famous Radiology Blog http://www.sumerdoc.blogspot.com
TeleRad Providers at www.teleradproviders.com Mail us at sales@teleradproviders.com (Source: Sumer's Radiology Site)
Source: Sumer's Radiology Site - September 21, 2017 Category: Radiology Authors: Sumer Sethi Source Type: blogs
Orphan Diseases Or Population Health? Policy Choices Drive Venture Capital Investments
The US exhibits a remarkable pipeline of biopharmaceutical innovation, with 170 new drugs and biologics launched into the market between 2011 and 2015 and another 22 drugs approved in 2016. A striking feature of the pharmaceutical pipeline is the large percentage launched for the treatment of small “orphan” indications, defined by the Food and Drug Administration (FDA) as including fewer than, often many fewer than, 200,000 patients in the United States. Almost half (74) of the products approved by the FDA between 2011 and 2015 were for orphan indications, twice the number (36) approved during the same period by the Eu...
Source: Health Affairs Blog - July 21, 2017 Category: Health Management Authors: Dayton Misfeldt and James C. Robinson Tags: Costs and Spending Drugs and Medical Innovation Orphan Drug Act orphan drugs venture capitalism Source Type: blogs
A Demonstration in Mice of Whole Mitochondria Delivered as a Therapy
Mitochondria, the swarming power plants of the cell, become damaged and dysfunctional with age. Can this be addressed by delivering complete, whole, new mitochondria as a therapy? There have been signs in past years that cells can ingest and incorporate mitochondria from the surrounding environment, but few useful demonstrations to show whether or not this is common in living tissues. In the research here, researchers achieve that result, delivering mitochondria into tissues as a therapy, and using this approach to treat an animal model of Parkinson's disease. This neurodegenerative condition is associated with degraded mi...
Source: Fight Aging! - March 7, 2017 Category: Research Authors: Reason Tags: Daily News Source Type: blogs
MR-HIFU and ThermoDox to Treat Recurrent Childhood Tumors: Interview with AeRang Kim, Principal Investigator
Children’s National Health System and the Celsion Corporation (Lawrenceville, NJ) have recently announced a Phase I clinical trial in the US to determine a safe and tolerable dose of ThermoDox in conjunction with non-invasive magnetic resonance-guided high-intensity focused ultrasound (MR-HIFU). The trial is aimed on young adults and children with recurring solid tumors.
ThermoDox technology consists of liposomes loaded with doxorubicin, a conventional chemotherapeutic drug. Liposomes are small lipid structures which can be used to encapsulate and deliver drugs through the bloodstream. While liposomal doxorubicin formu...
Source: Medgadget - December 6, 2016 Category: Medical Equipment Authors: Conn Hastings Tags: Exclusive Nanomedicine Oncology Source Type: blogs
Are Priority Review Vouchers The Answer To Incentivize Drug Development? Not So Fast.
In the May issue of Health Affairs, two papers examine the potential for voucher systems to incentivize drug development in areas of unmet medical need. Co-authors Kevin Outterson and Anthony McDonnell take a look at potential exclusivity voucher programs designed to encourage development of new antibiotics, while David Ridley and Stephane Régnier analyze the effects that expansion of existing priority review voucher (PRV) programs may have on the value of PRVs as a development incentive.
Ridley and Régnier’s work is of particular importance as both houses of Congress pursue a spate of legislative proposals that do mak...
Source: Health Affairs Blog - June 15, 2016 Category: Health Management Authors: Pranav Aurora, Morgan Romine and Gregory Daniel Tags: Costs and Spending Drugs and Medical Technology Featured Global Health Health Professionals Quality FDA FDAAA priority review rare diseases Source Type: blogs
A Year in Review: FDA 2015 New Drug Approvals
The approval of first-of-a-kind drugs rose last year to forty-one, resulting in the highest level of newly approved U.S. drugs in nineteen years. The total number of new drugs approved last year was even higher at sixty-nine. The rising figures reflect an industry-wide desire to research and develop drugs for rare and hard-to-treat diseases.
The newly approved drugs serve to advance medical care and the health of patients suffering from many ailments, including various forms of cancer, heart failure, and cystic fibrosis. Additionally, more than 40% of the new therapies were approved for treatment of rare or "orphan" dise...
Source: Policy and Medicine - January 13, 2016 Category: American Health Authors: Thomas Sullivan - Policy & Medicine Writing Staff Source Type: blogs
Pediatric palliative care: We must do more
How is it that, in this day and age, a talented teenager treated for lymphoma emerges cured but with a life-threatening eating disorder? How is it that, in our nation’s capital, a boy dying at home from neuroblastoma experiences excruciating pain in his final moments? How is that, when we develop new drugs to treat children with cancer, we do not, at the same time, routinely and in a standardized manner ask them how they are feeling?
As a pediatric oncologist and palliative care physician, I was alarmed by stories like these at the recent Institute of Medicine Workshop on Comprehensive Care for Children with Cancer...
Source: Kevin, M.D. - Medical Weblog - July 14, 2015 Category: Journals (General) Authors: Joanne Wolfe, MD, MPH Tags: Physician Palliative care Pediatrics Source Type: blogs
The Future of Cord Blood Research
You may have heard that the stem cells in your baby’s umbilical-cord blood can save lives, but if you’re like most people, you have only a vague notion of how stem cells work — or which diseases they can treat. Right now, certain cancers, blood disorders, and immune disorders, among other conditions, are being successfully treated with cord-blood stem cells — and thanks to cord blood research, the list of conditions and diseases that may be treated by these stem cells is growing.
Why is it important to know about the cord blood research and what types of diseases it can treat? Knowing what cord blood can and...
Source: Cord Blood News - December 15, 2014 Category: Perinatology & Neonatology Authors: joyce at mazelabs.com Tags: babies blood disorder brain development Cord Blood medical research parents pregnancy stem cells affordable cord blood banking bone marrow breast feeding cerebral palsy cord blood banking fees cord blood banking information cor Source Type: blogs
Are There Limits of 3D Printing in Healthcare?
In only a few days’ time, one could read about the potentials of 3D printing in healthcare from different angles. Surgeons in Portugal recreated the tumor and surrounding tissue of a 5-year-old boy’s neuroblastoma using 3D-printing to be able to practice removing the tumor before trying again after failed attempts. In another story, a company tries to create a specialized filament and process for the 3D printing of medical pill capsules. More and more ideas appear online every day about how this technology could be used for medical purposes. Companies such as 3DSystems are in the forefront of innovation.
The N...
Source: ScienceRoll - August 19, 2014 Category: Geneticists and Genetics Commentators Authors: Bertalan Meskó (MD, PhD) Tags: 3D Printing Future Healthcare Medicine Source Type: blogs
Talia Joy: The Beauty Blogger We're Already Missing
UPDATE: We regret to inform you that Talia Joy passed away today after her five-year battle with cancer. The intrepid 13-year-old, who not only vlogged her way to fame but also garnered herself a Cover Girl ad, is a true inspiration to everyone here at SELF. Check out what our blogger, Alex Samuel, said about Talia back in September 2012.
Have you guys ever heard of Talia Joy? For those of you the haven't, it may be time to switch to waterproof mascara. Here's the deal: not only is Talia a bubbly, brilliant twelve-year-old makeup genius with over 14 million views on YouTube, she's been battling cancer (neuroblastoma and ...
Source: The ND Blog: Notes from the Nutritionista by Monica Reinagel, L.D.N., C.N.S. - July 16, 2013 Category: Nutritionists and Food Scientists Tags: Beauty beauty news beauty tips Source Type: blogs
USMLE Questions – Characteristic Disease Findings
The United States Medical Licensing Examination (USMLE) is designed to emphasize knowledge of clinical scenarios and clinical pearls, even on Step I. Listed below are some commonly encountered disease findings and characteristics.
Feature
Disease
45, X chromosome
Turner’s syndrome
5-HIAA increased in urine
Carcinoid syndrome
Aganglionic rectum
Hirschsrpung’s disease
Apple-core sign on barium enema
Colon cancer
Arched back (opisthotonos)
Tetanus
Argyll-Robertson pupil
Syphilis
Ash leaf on forehead
Tuberous sclerosis
Auer rods
Acute myelogenous leukemia
Austin Flint murmur
Aortic regurgitation...
Source: Inside Surgery - January 18, 2013 Category: Surgeons Authors: Editor Tags: Surgpedia USMLE diseases findings VMA water hammer pulse Source Type: blogs
Minimal Reporting Guidelines for the Treatment of Cancer Patients
Minimal Reporting Guidelines for the Treatment of Cancer Patients As laboratory physicians, our contribution to patient care is knowledge: this is the starting point from which all informed therapeutic intervention proceeds. How that knowledge is obtained and communicated is the art and science of our profession. These minimal diagnostic guidelines are designed to be used as an aid, not a constraint, in that process. The guidelines are presented in a specific format out of necessity, but any format that effectively communicates the necessary information in a given patho...
Source: Oncopathology - September 5, 2011 Category: Cancer & Oncology Source Type: blogs
