Scaffolds Protect Transplanted Stem Cells to Increase Therapeutic Benefit
One of the major areas of focus in regenerative research is finding ways to enhance the ability of transplanted cells to integrate with tissue, survive, and induce healing and growth. In early, first generation stem cell therapies, near all cells die quite quickly. The span of benefits that result is a reaction of native cells to the molecular signals briefly generated by the transplanted cells. The anti-inflammatory effects of mesenchymal stem cell therapies as presently practiced is a good example.
One way to improve cell survival is to build an artificial environment that to some degree mimics the extracellular ...
Source: Fight Aging! - August 22, 2018 Category: Research Authors: Reason Tags: Daily News Source Type: blogs
This Innocuous looking ECG made me scratch the basics of EP without an answer !
This 70 year old man in routine check up showed up this ECG.
What is it ? a quick debate ensued !
Is this
RVH
RBBB
Or Both ?
Neither RBBB nor RVH
Wrong lead placement
Is it a normal ECG after all ?
I thought it was RVH. (do considered RBBB) but since lead V 2 showed tall R , I was more than sure RVH was likely . Many voted for RBBB. .Some others said RBBB can never occur in monophasic form.I said it’s possible.
Some body challenged me without Echo Imaging a monophasic RBBB can never be differentiated from RVH. After a mini argument I reluctantly agreed.Yes, it seemed there is no way to differentiate the two.
...
Source: Dr.S.Venkatesan MD - August 11, 2018 Category: Cardiology Authors: dr s venkatesan Tags: cardiology -ECG RBBB vs RVH how to diagnose RBBB in RVH and vice versa rvh in rbbb tall r in v1 differential diagnosis Source Type: blogs
Mumbling orphans —a bit more
Mark McQuain has raised the persistent, vexing issue of the pricing of drugs for rare diseases—in the case at hand, Sarepta’s eteplirsen (Exondys 51) for Duchenne Muscular Dystrophy, the disease over which the late comedian Jerry Lewis lost sleep every Labor Day weekend for years. Mark provided an excellent summary (he calls it “crude,” but … Continue reading "Mumbling orphans—a bit more" (Source: blog.bioethics.net)
Source: blog.bioethics.net - August 10, 2018 Category: Medical Ethics Authors: Jon Holmlund Tags: Health Care Allocation / Access / Public Health biotechnology Health Care Practice syndicated Source Type: blogs
The Cost of Getting RNA to Mumble
By Mark McQuain In my previous blog entry, I crudely summarized the genetic basis for Duchenne Muscular Dystrophy (DMD) and one pharmaceutical company’s (Sarepta) current effort to research, manufacture and finance a genetic treatment that increases the production of a muscle protein missing in patients with DMD called dystrophin. Please see my previous blog entry … Continue reading "The Cost of Getting RNA to Mumble" (Source: blog.bioethics.net)
Source: blog.bioethics.net - August 7, 2018 Category: Medical Ethics Authors: Mark McQuain Tags: Health Care Allocation / Access / Public Health bioethics biotechnology Health Care Practice syndicated Source Type: blogs
Students Develop Cheap and Portable Cough Assist Device
People with cystic fibrosis, muscular dystrophy, and other chronic conditions can have serious difficulty coughing. This creates not only discomfort, but potentially dangerous complications for the lungs and heart. There are cough assist devices on the market that help, but they tent to be pricey, heavy, and require electric power. Now students at Michigan’s Grand Valley State University, working with clinicians at Beaumont Health, a hospital system, have developed their own cough assist device that overcomes these limitations.
The device, already licensed out for manufacturing, is made mostly of plastic and vinyl, ...
Source: Medgadget - May 10, 2018 Category: Medical Devices Authors: Editors Tags: Medicine Pediatrics Rehab Thoracic Surgery Source Type: blogs
App Controlled Exoskeleton Gives Boy New Arm Strength
A boy with Duchenne muscular dystrophy has been outfitted with a novel app-controlled arm exoskeleton, which allows him to easily control where his arms are positioned.
The mechanical device, called X-Ar, was made by Talem Technologies. It’s based on the steadicams used to stabilize film cameras. To make the exoskeleton more usable, students at Michigan State University developed a specialized smartphone app that controls its movements.
What’s interesting is that thanks to modern smartphones, wireless technologies, and simple interfaces, it was possible for the two parts of the system to be developed separately...
Source: Medgadget - May 8, 2018 Category: Medical Devices Authors: Editors Tags: Rehab Source Type: blogs
Fight Aging! Newsletter, April 30th 2018
In conclusion, in the Framingham Heart Study population, in the last 30 years, disease duration in persons with dementia has decreased. However, age-adjusted mortality risk has slightly decreased after 1977-1983. Consequences of such trends on dementia prevalence should be investigated.
Recent Research on the Benefits of Exercise in Later Life
https://www.fightaging.org/archives/2018/04/recent-research-on-the-benefits-of-exercise-in-later-life/
A sizable body of work points to the ability of older individuals to continue to obtain benefits through regular physical activity, and particularly in the case...
Source: Fight Aging! - April 29, 2018 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
Cornelis (Cees) Wortel, Ichor Therapeutics Chief Medical Officer, on Rejuvenation Research and Its Engagement with the Established Regulatory System
Ichor Therapeutics is the most mature of the US-based companies that have emerged from the SENS rejuvenation research community in recent years. You might recall a number of interviews back in the Fight Aging! Archives with founder and CEO Kelsey Moody. He has his own take on how our community should proceed from laboratory to clinic: he is very much in favor of demonstrating (a) that the formal regulatory path offered by the FDA can work for the treatment of aging, and (b) that - given the right strategic approach - rejuvenation therapies can attract the attention, collaboration, and backing of Big Pharma entities in the ...
Source: Fight Aging! - April 23, 2018 Category: Research Authors: Reason Tags: Healthy Life Extension Community Source Type: blogs
Fight Aging! Newsletter, February 26th 2018
Fight Aging! provides a weekly digest of news and commentary for thousands of subscribers interested in the latest longevity science: progress towards the medical control of aging in order to prevent age-related frailty, suffering, and disease, as well as improvements in the present understanding of what works and what doesn't work when it comes to extending healthy life. Expect to see summaries of recent advances in medical research, news from the scientific community, advocacy and fundraising initiatives to help speed work on the repair and reversal of aging, links to online resources, and much more.
This content is...
Source: Fight Aging! - February 25, 2018 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
Device Measures Stiffness of Tens of Thousands of Cells to Screen Drugs for Safety (Video)
Force cytometry, or measurement of strength of cells, can be a useful indicator for assessing how specific drugs affect cell function. Rapidly performing thousands of force cytometry tests can help speed up drug testing, particularly for compounds intended to treat blood pressure, stroke, muscular dystrophy, and asthma. Scientists at UCLA and Rutgers University have now reported in journal Nature Biomedical Engineering on a new device that can perform force cytometry tests 100 times faster than existing technologies.
The team’s device is named fluorescently labeled elastomeric contractible surfaces (FLECS) and it r...
Source: Medgadget - February 21, 2018 Category: Medical Devices Authors: Editors Tags: Genetics Medicine Public Health Source Type: blogs
How Does Age Affect Induced Pluripotency for Regenerative Medicine?
One of the more intriguing discoveries relating to the cell reprogramming used to produce induced pluripotent stem cells is that this process appears to reverse some aspects of cell aging. It perhaps triggers some fraction of the mechanisms at work in early embryonic development, those that ensure that children are born young, with nowhere near the load of persistent damage present in the adult parents. This is not a well-explored topic, unfortunately - it is still too recent for much to be said in certainty, and a sizable fraction of the evidence is conflicting. Related to all of this is the question of how exactly the ag...
Source: Fight Aging! - February 19, 2018 Category: Research Authors: Reason Tags: Daily News Source Type: blogs
Inscrutable Genes
" In most cases, the molecular consequences of disease, or trait-associated variants for human physiology, are not understood. " from: Manolio TA, Collins FS, Cox NJ, Goldstein DB, Hindorff LA, Hunter DJ, et al. Finding the missing heritability of complex diseases. Nature 2009;461:747 –53. The 1960s was a wonderful decade for the field of molecular genetics. Hundreds of inherited metabolic diseases were being studied. Most of these diseases could be characterized by a simple inherited mutation in a disease-causing gene. Back then, we thought we understood genetic diseases. Here ’s how it all might have worked, if life ...
Source: Specified Life - February 15, 2018 Category: Information Technology Tags: genetic heterogeneity genetics multi-step pathogenesis precision medicine Source Type: blogs
Precision Medicine and the Reinvention of Human Disease (Book Index)
In January, 2018, Academic Press published my bookPrecision Medicine and the Reinvention of Human Disease. This book has an excellent " look inside " at itsGoogle book site, which includes the Table of Contents. In addition, I thought it might be helpful to see the topics listed in the Book ' s index. Note that page numbers followed by f indicate figures, t indicate tables, and ge indicate glossary terms.AAbandonware, 270, 310geAb initio, 34, 48ge, 108geABL (abelson leukemia) gene, 28, 58ge, 95 –97Absidia corymbifera, 218Acanthameoba, 213Acanthosis nigricans, 144geAchondroplasia, 74, 143ge, 354geAcne, 54ge, 198, 220geAcq...
Source: Specified Life - January 23, 2018 Category: Information Technology Tags: index jules berman jules j berman precision medicine Source Type: blogs
The 10 Most Exciting Digital Health Stories of 2017
Gene-edited human embryo. Self-driving trucks. Practical quantum computers. 2017 has been an exciting year for science, technology – and digital health! It’s that time of the year again when it’s worth looking back at the past months; and list the inventions, methods and milestone events in healthcare to get a clearer picture what will shape medicine for the years to come.
2017 – Amazing year for science and healthcare
Scientists, researchers, and innovators come up with amazing breakthroughs every year, and that was no different in 2017 either. No matter whether we look at physics (proving the existence of gra...
Source: The Medical Futurist - December 13, 2017 Category: Information Technology Authors: nora Tags: Future of Medicine 3d printing artificial intelligence digital health genetics genomics Healthcare Innovation Personalized medicine robotics technology wearables Source Type: blogs
Adjusting the Behavior of Specific Immune Cells to Reverse Autoimmunity
Autoimmune conditions such as multiple sclerosis can be cured by clearing the entire adult immune system and letting it reestablish itself. The misconfigurations of autoimmunity are carried by some immune cells, and removing all of them happens to be the easiest way to proceed in the absence of knowing exactly where the problem lies. This is currently a fairly risky and unpleasant procedure, akin to chemotherapy. Future improvement might involve less toxic means of removing immune cells, or a more targeted approach enabled by a greater understanding of exactly which immune cells cause autoimmunity. Given a good enough unde...
Source: Fight Aging! - September 26, 2017 Category: Research Authors: Reason Tags: Daily News Source Type: blogs
