Efforts to Produce Drugs to Slow or Reverse Sarcopenia Benefit from the Semaglutide Hype
This popular science article is a reminder that all too little in this world happens for entirely rational reasons. Drugs aimed at slowing or reversing the age-related loss of muscle mass leading to sarcopenia are presently under development by a number of companies, though none of the candidates discussed are producing effect sizes that look very favorable in comparison to the effects of resistance exercise. These efforts will likely benefit from the present manufactured hype that attends the use of antidiabetic GLP1 receptor agonists for weight loss, as one of the side-effects of this drug is modest loss of muscle mass. ...
Source: Fight Aging! - March 15, 2024 Category: Research Authors: Reason Tags: Daily News Source Type: blogs
Who Could (Possibly) Be the Ideal “ Chief Patient Officer ” ? (And Other Ideas that Sound Better on Paper than in Practice)
By JONATHON S. FEIT
If ideas presented in essays on The Health Care Blog and other healthcare forums are meant to be rhetorical, without intention of turning notions into reality on behalf of patients who need genuine, intimate, desperate help…then feel free to ignore this essay entirely.
Some among us—the State of Washington’s Co-Responder Outreach Alliance; Lisa Fitzpatrick’s Grapevine Health, which specializes in “street medicine” and advocacy in and around Washington, D.C.; Thorne Ambulance Service, an inspirational ambulance entrepreneur bringing both emergency and nonemergency medical transpor...
Source: The Health Care Blog - January 26, 2024 Category: Consumer Health News Authors: matthew holt Tags: Health Policy Health Tech Chief Patient Officer CIVITAS EMS First Responders Interoperability Jonathan Feit Kat McDavitt Lisa Bari Medicaid Source Type: blogs
Fight Aging! Newsletter, December 4th 2023
This study produced a great deal of data that continues to be mined for insights into human aging and effects of calorie restriction in a long-lived species such as our own, to contrast with the sizable effects on health and longevity in short-lived species such as mice.
In particular, and the topic for today, cellular senescence and its role in degenerative aging has garnered far greater interest in the research community in the years since the CALERIE study took place. Thus in today's open access paper, scientists examine CALERIE study data to find evidence for calorie restriction to reduce the burden of cellular ...
Source: Fight Aging! - December 3, 2023 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
XPRIZE Healthspan, $101 Million to Incentivize Rejuvenation in Old People
Prizes for success in research and development can work well, if coupled with suitable publicity and activism. Such efforts have a long history, going back to the well-documented longitude rewards offered by the British government in the 1700s. More recently, the original Ansari X Prize for suborbital flight was a very successful example of this sort of initiative, and was launched around the same time as the Methuselah Mouse Prize to spur greater efforts to extend life in animal models. The Palo Alto Longevity Prize followed later with similar goals. Unfortunately for the ability of longevity-focused prizes to generate on...
Source: Fight Aging! - November 30, 2023 Category: Research Authors: Reason Tags: Activism, Advocacy and Education Source Type: blogs
This was texted to me in real time. The patient has acute chest pain.
This was texted to me in real time. The patient has acute chest pain.What do you think?Here was my answer:" Not ischemia. Chronic. Maybe HOCM or another form of LVH. I would not activate cath lab. Get serial troponins "It is a scary ECG, with a lot of ST Elevation and what appear to be hyperacute T-waves in inferior leads, and profound reciprocal ST Depression in aVL. There are Q-waves in V4-V6, with what appear to be hyperacute T-waves. Any objective, rule-based analysis of this ECG would scream " STEMI " or " OMI " . But, alas, ECGs are like faces. No measurements can t...
Source: Dr. Smith's ECG Blog - July 5, 2023 Category: Cardiology Authors: Steve Smith Source Type: blogs
Fight Aging! Newsletter, June 19th 2023
In conclusion, among Swedish middle-aged subjects, nearly two-thirds showed complete fatty degeneration of thymus on CT.
Age-Related Dysfunction of Water Homeostasis
https://www.fightaging.org/archives/2023/06/age-related-dysfunction-of-water-homeostasis/
Dehydration can be an issue in older people. As in every complex system in the body, the mechanisms by which hydration is regulated become dysfunctional with advancing age. Researchers here look at the brain region responsible for regulating some of the response to dehydration, cataloging altered gene expression in search of the more important mechan...
Source: Fight Aging! - June 18, 2023 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
Notes from the 2023 Age-Related Disease Therapeutics Summit
The former Longevity Therapeutics conference series was renamed to the Age-Related Disease Therapeutics Summit and held its fifth event recently in San Francisco. It was a smaller meeting than in past years, perhaps a result of the recent downturn in the global financial and investment environment. Few investors were present. Nonetheless, one can usually learn something interesting from the presenting biotech founders and executives. I took a few notes while I was there to present on progress at Repair Biotechnologies, and they follow in the order of the conference program.
Birget Schilling from the Buck Institute f...
Source: Fight Aging! - June 16, 2023 Category: Research Authors: Reason Tags: Longevity Industry Source Type: blogs
Addressing disparities in gynecological care for women with physical disabilities
I recently read a story in which a woman named H. Lee, who has muscular dystrophy, details a decade-long struggle to receive adequate cervical cancer screening. Providers have been unable to find her cervix due to the curvature of her spine, examined her in her wheelchair because there were no height-adjustable examination tables, and outright
Read more…
Addressing disparities in gynecological care for women with physical disabilities originally appeared in KevinMD.com. (Source: Kevin, M.D. - Medical Weblog)
Source: Kevin, M.D. - Medical Weblog - March 1, 2023 Category: General Medicine Authors: Geffen Treiman Tags: Policy OB/GYN Primary Care Source Type: blogs
Adaptive Footwear Can Aid Comfort and Joint Health While Helping You Prevent Falls
Sponsored While the average person is unlikely to do high jumps or run marathons, even daily life can wear out our joints. Over time, this wear may become apparent through pain. Age aside, diseases...
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Source: Minding Our Elders - December 9, 2022 Category: Geriatrics Authors: Carol Bradley Bursack Tags: Caregiving Dementia care Disability @egosancares @silverts adaptive clothing Alzheimer's Muscular Dystrophy Source Type: blogs
What Is Muscular Dystrophy Anyway?
Since we’ve been talking about the fill the boot campaign the annual MDA telethon, why not use our “what is” series to take a closer look at the group of diseases we commonly refer to as muscular dystrophy.
While most EMS caregivers have a general idea of what to expect in a muscular dystrophy presentation, few of us are as knowledgeable as we should be about what muscular dystrophy is and what it does to the body. Let’s take a closer look.
While we tead to refer to muscular dystrophy as a single defined disease process, it is actually a group of disease that share some common characteristics. Add to that the...
Source: The EMT Spot - November 9, 2022 Category: Emergency Medicine Authors: Steve Whitehead Tags: EMT Source Type: blogs
What cardiac lesion can be associated with external ophthalmoplegia?
External ophthalmoplegia and ptosis may be associated with complete heart block. External ophthalmoplegia and ptosis as part of Kearns-Sayre syndrome is associated with complete heart block. It is a muscular dystrophy involving extraocular muscles. (Source: Cardiophile MD)
Source: Cardiophile MD - November 6, 2022 Category: Cardiology Authors: Johnson Francis Tags: General Cardiology Source Type: blogs
Cardiomyopathy in muscular dystrophies
Important muscular dystrophies due to mutations in structural cytoskeletal dystrophin gene are known as dystrophinopathies. They include Duchenne muscular dystrophy, Becker muscular dystrophy and X-linked dilated cardiomyopathy. Primary presentation of most dystrophinopathies is skeletal muscle weakness. Duchenne muscular dystrophy is caused by mutations leading to absence of functional dystrophin. Becker muscular dystrophy is due to mutations resulting in reduced amounts of shortened dystrophin protein.
Cardiac muscle being a striated muscle, is affected in many types of muscular dystrophies. Cardiomyopathy would contrib...
Source: Cardiophile MD - August 30, 2022 Category: Cardiology Authors: Johnson Francis Tags: General Cardiology Source Type: blogs
Fight Aging! Newsletter, December 13th 2021
In conclusion, there is a good amount of pre-clinical and clinical data showing a strong positive correlation between reduction of senescent cells frequencies and functional improvement of skin. Whether senescence of skin cells makes a significant causal contribution to skin ageing can still not be conclusively decided, however. Nonetheless, there is strong evidence existing today to assume that better understanding of cell senescence in skin may lead to a breakthrough in interventions into skin ageing.
Isomerization of Tau May be Involved in Alzheimer's Disease
https://www.fightaging.org/archives/2021/12/isom...
Source: Fight Aging! - December 12, 2021 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
A Much Better Muscle Targeted AAV Gene Therapy
Delivery is the largest challenge in the ongoing development of gene therapy: how to put enough of a vector into the target tissues without sending too much of it elsewhere in the body, particularly the liver, which is where much of every injected substance tends to end up. This is a big issue for systemic administration of gene therapies intended to affect much of the body, given severe side-effect and deaths that have occurred in human trials at high doses of viral vectors. A greater ability to target specific tissues means that a lower dose can be used, and thus off-target effects produced by the vector itself are minim...
Source: Fight Aging! - December 8, 2021 Category: Research Authors: Reason Tags: Daily News Source Type: blogs
Personalized Exosuit Uses Ultrasound to Adapt to User ’s Needs
At Harvard University a team of scientists and engineers developed an exosuit that uses ultrasound to measure muscle activity. The capability allows for rapid calibration of the suit for users’ needs. The soft wearable device continuously assists when walking or running, reducing the energy required to perform these tasks, which could be very useful for patients with neurological issues or muscular dystrophy. By directly measuring muscle dynamics, the suit provides activity- and user-specific assistance, bringing such wearable technologies a step closer to fruition.
Wearable ‘exosuits’ have significant potenti...
Source: Medgadget - November 16, 2021 Category: Medical Devices Authors: Conn Hastings Tags: Radiology Rehab Source Type: blogs
