A Post-trial Follow-up of MERINO Participants to Evaluate Long-term Effects of Methotrexate Treatment in Adults With Erosive Hand OA.
Conditions: Hand Osteoarthritis; Erosive Osteoarthritis Interventions: Drug: Methotrexate; Other: No treatment Sponsors: Diakonhjemmet Hospital Not yet recruiting (Source: ClinicalTrials.gov)
Source: ClinicalTrials.gov - February 28, 2024 Category: Research Source Type: clinical trials
Effect of Silymarin Against Methotrexate-induced Liver Injury in Rheumatic Diseases
Conditions: Rheumatoid Arthritis; Psoriatic Arthritis; Psoriasis Interventions: Drug: Silymarin; Drug: Placebo Sponsors: Phramongkutklao College of Medicine and Hospital Recruiting (Source: ClinicalTrials.gov)
Source: ClinicalTrials.gov - February 26, 2024 Category: Research Source Type: clinical trials
Trial of 2 Step ATG for Prevention of Acute GVHD Post Allogeneic Stem Cell Transplant
Conditions: Acute Leukemia; Myelodysplastic Syndrome; Myeloproliferative Disorders Interventions: Drug: ATG dosing platform when combined with standard tacrolimus and mini methotrexate Sponsors: University of Alabama at Birmingham Not yet recruiting (Source: ClinicalTrials.gov)
Source: ClinicalTrials.gov - February 19, 2024 Category: Research Source Type: clinical trials
CHIP-AML22/Quizartinib: Quizartinib + Chemotherapy in Newly Diagnosed Pediatric FLT3-ITD+ and NPM1wt AML Patients
Conditions: Acute Myeloid Leukemia in Children Interventions: Drug: Quizartinib; Drug: Etoposide; Drug: Dexrazoxane; Drug: Mitoxantrone; Drug: Cytarabine; Drug: Methotrexate; Drug: Daunorubicin; Drug: Fludarabine; Other: allo-SCT Sponsors: Princess Maxima Center for Pediatric Oncology; Daiichi Sankyo Recruiting (Source: ClinicalTrials.gov)
Source: ClinicalTrials.gov - February 16, 2024 Category: Research Source Type: clinical trials
Efficacy and Safety of add-on Apremilast Versus add-on Methotrexate in Patients With Oral Lichen Planus
Conditions: Oral Lichen Planus Interventions: Drug: Prednisolone; Drug: Apremilast; Drug: Methotrexate Sponsors: All India Institute of Medical Sciences, Bhubaneswar Not yet recruiting (Source: ClinicalTrials.gov)
Source: ClinicalTrials.gov - February 15, 2024 Category: Research Source Type: clinical trials
Study Testing Two Conditioning Regimen With a Single Prophylaxis of GVHD by Cyclophosphamide and Methotrexate Post-transplant in Patients Eligible for Matched-donor Allograft Transplantation
Conditions: Graft Versus Host Disease; Hematologic Malignancy Interventions: Drug: Methotrexate; Drug: Post-Transplant Cyclophosphamide; Drug: Fludarabine; Drug: Cycophosphamide; Drug: Anti-Thymoglobulin; Radiation: total body irradiation; Other: hematopoietic stem cells; Other: Graft nuclear cells; Other: Donor Lymphocytes Injection; Drug: Clofarabine; Drug: Thiotepa; Drug: Busulfan; Drug: Fludarabine Sponsors: Nantes University Hospital Not yet recruiting (Source: ClinicalTrials.gov)
Source: ClinicalTrials.gov - February 12, 2024 Category: Research Source Type: clinical trials
A Study to Find the Highest Dose of Imetelstat in Combination With Fludarabine and Cytarabine for Patients With AML, MDS or JMML That Has Come Back or Does Not Respond to Therapy
Conditions: Recurrent Acute Myeloid Leukemia; Recurrent Juvenile Myelomonocytic Leukemia; Recurrent Myelodysplastic Syndrome; Refractory Acute Myeloid Leukemia; Refractory Myelodysplastic Syndrome Interventions: Procedure: Biospecimen Collection; Procedure: Bone Marrow Aspiration; Procedure: Bone Marrow Biopsy; Drug: Cytarabine; Procedure: Echocardiography; Drug: Fludarabine; Drug: Hydrocortisone Sodium Succinate; Biological: Imetelstat; Drug: Leucovorin Calcium; Procedure: Lumbar Puncture; Drug: Methotrexate Sponsors: Children ' s Oncology Group Not yet recruiting (Source: ClinicalTrials.gov)
Source: ClinicalTrials.gov - February 8, 2024 Category: Research Source Type: clinical trials
Efficacy and Safety of Methotrexate Versus Placebo in Adults With Atopic Dermatitis.
Conditions: Moderate to Severe Atopic Dermatitis Interventions: Drug: Methotrexate; Drug: Placebo Sponsors: medac GmbH Not yet recruiting (Source: ClinicalTrials.gov)
Source: ClinicalTrials.gov - February 2, 2024 Category: Research Source Type: clinical trials
Paroxetine Safety and Efficacy in Rheumatoid Arthritis
Conditions: Rheumatoid Arthritis Interventions: Drug: Methotrexate; Drug: Paroxetine Sponsors: Mostafa Bahaa Not yet recruiting (Source: ClinicalTrials.gov)
Source: ClinicalTrials.gov - January 30, 2024 Category: Research Source Type: clinical trials
A Trial to Investigate the Non-inferiority of Pegloticase Administered Every 4 Weeks (Q4W) With MTX Compared With Every 2 Weeks (Q2W) With MTX in Participants With Uncontrolled Refractory Gout
Conditions: Gout Interventions: Biological: Pegloticase; Drug: Methotrexate Sponsors: Horizon Therapeutics Ireland DAC Not yet recruiting (Source: ClinicalTrials.gov)
Source: ClinicalTrials.gov - January 29, 2024 Category: Research Source Type: clinical trials
Adding Targeted Drugs to Usual Chemotherapy for Adults With Newly Diagnosed T-Cell Acute Lymphoblastic Leukemia (T-ALL) and T-Cell Lymphoblastic Lymphoma (T-LBL)
Conditions: T Acute Lymphoblastic Leukemia; T Lymphoblastic Lymphoma Interventions: Procedure: Biospecimen Collection; Procedure: Bone Marrow Aspiration; Procedure: Bone Marrow Biopsy; Drug: Calaspargase Pegol; Procedure: Computed Tomography; Drug: Cyclophosphamide; Drug: Cytarabine; Drug: Daunorubicin; Drug: Dexamethasone; Drug: Doxorubicin; Procedure: Echocardiography; Procedure: Lumbar Puncture; Drug: Mercaptopurine; Drug: Methotrexate; Procedure: Multigated Acquisition Scan; Biological: Navitoclax; Drug: Nelarabine; Drug: Pegaspargase; Procedure: Positron Emission Tomography; Drug: Thioguanine; Drug: Venetoclax; Drug: ...
Source: ClinicalTrials.gov - January 18, 2024 Category: Research Source Type: clinical trials
A Study to Investigate LP-118, Ponatinib, Vincristine and Dexamethasone in Relapsed/Refractory Acute Lymphoblastic Leukemia (ALL) or Lymphoblastic Lymphoma (LBL)
Conditions: Acute Leukemia; Lymphoblastic Leukemia; Lymphoblastic Lymphoma Interventions: Drug: LP-118; Drug: Ponatinib; Drug: Vincristine; Drug: Dexamethasone; Drug: Methotrexate Sponsors: University of Chicago Not yet recruiting (Source: ClinicalTrials.gov)
Source: ClinicalTrials.gov - January 15, 2024 Category: Research Source Type: clinical trials
The Meteoritics Trial: efficacy of methotrexate after remission-induction with tocilizumab and glucocorticoids in giant cell arteritis —study protocol for a randomized, double-blind, placebo-controlled, parallel-group phase II study
This study aims to evaluate the efficacy and safety of MTX in maintaining remission in patients with GCA who have previously been treated with GC and at least 6 months with TCZ. We hypothesize that MTX can maintain remission in GCA patients, who have achieved stable remission after treatment with GC and TCZ, and prevent the occurrence of relapses. The study design is a monocentric, randomized, double-blind, placebo-controlled, parallel-group phase II tria l randomizing 40 GCA patients 1:1 into a MTX or placebo arm. Patients will receive 17.5 mg MTX/matching placebo weekly by subcutaneous injection for 12 months, with t...
Source: Trials - January 15, 2024 Category: Research Source Type: clinical trials
Drug Screening Using IMD in Bladder Cancer
Conditions: Muscle Invasive Bladder Urothelial Carcinoma Interventions: Device: Implantable Micro-Device; Drug: Methotrexate; Drug: Carboplatin; Drug: Avelumab; Drug: Paclitaxel; Drug: Vinblastine; Drug: Gemcitabine/Cisplatin I; Drug: Methotrexate/Vinblastine/Doxorubicin/Cisplatin/Avelumab; Drug: Gemcitabine/Cisplatin II; Drug: Cisplatin; Drug: Nivolumab; Drug: Pembrolizumab; Drug: Gemcitabine/Carboplatin; Drug: Methotrexate/Vinblastine/Doxorubicin/Cisplatin; Drug: Gemcitabine/Cisplatin/Nivolumab; Drug: Erdafitinib; Drug: Paclitaxel/Docetaxel/Ifosfamide; Drug: Gemcitabine; Drug: Gemcitabine/Carboplatin/Nivolumab; Drug: Enf...
Source: ClinicalTrials.gov - January 12, 2024 Category: Research Source Type: clinical trials
Study of Revumenib, Azacitidine, and Venetoclax in Pediatric and Young Adult Patients With Refractory or Relapsed Acute Myeloid Leukemia
Conditions: Refractory Acute Myeloid Leukemia; Relapsed Acute Myeloid Leukemia; Acute Leukemia of Ambiguous Lineage Interventions: Drug: Revumenib; Drug: Venetoclax; Drug: Azacitidine; Drug: intrathecal (IT) chemotherapy; Drug: Cytarabine; Drug: Methotrexate Sponsors: St. Jude Children ' s Research Hospital; Syndax Pharmaceuticals Not yet recruiting (Source: ClinicalTrials.gov)
Source: ClinicalTrials.gov - December 20, 2023 Category: Research Source Type: clinical trials
