Efficacy and safety of selective JAK 1 inhibitor filgotinib in active rheumatoid arthritis patients with inadequate response to methotrexate: comparative study with filgotinib and tocilizumab examined by clinical index as well as musculoskeletal ultrasound assessment (TRANSFORM study): study protocol for a randomized, open-label, parallel-group, multicenter, and non-inferiority clinical trial
This study is an interventional, multicenter, randomized, open-label, parallel-group, and non-inferiority clinical trial with a 52-week follow-up. Study participants will be 400 RA patients with at least moderate disease activity during treatment with MTX. Participants will be randomized in a 1:1 ratio to administer filgotinib monotherapy or subcutaneous tocilizumab monotherapy switched from MTX. We will evaluate disease activity by measuring clinical disease activity indices and by using musculoskeletal ultrasound (MSUS). The primary endpoint is the proportion of patients who achieve an American College of Rheumatology 50...
Source: Trials - March 3, 2023 Category: Research Source Type: clinical trials
A Study to Evaluate MRG003 vs Cetuximab/Methotrexate in in the Treatment of Patients With RM-SCCHN
Condition: Squamous Cell Carcinoma of the Head and Neck Interventions: Drug: MRG003; Drug: Cetuximab injection; Drug: Methotrexate Injection Sponsor: Shanghai Miracogen Inc. Not yet recruiting (Source: ClinicalTrials.gov)
Source: ClinicalTrials.gov - March 2, 2023 Category: Research Source Type: clinical trials
Study to Investigate Outcome of Individualized Treatment in Patients With Metastatic Colorectal Cancer
Condition: Metastatic Colorectal Cancer Interventions: Drug: Alectinib; Drug: Cetuximab; Drug: Crizotinib; Drug: Dasatinib; Drug: Everolimus; Drug: Encorafenib; Drug: Gemcitabine; Drug: Idelalisib; Drug: Larotrectinib; Drug: Methotrexate; Drug: Palbociclib; Drug: Panobinostat; Drug: Pembrolizumab; Drug: Petrozumab; Drug: Trastuzumab; Drug: Talazoparib; Drug: Venetoclax Sponsor: Oslo University Hospital Recruiting (Source: ClinicalTrials.gov)
Source: ClinicalTrials.gov - February 13, 2023 Category: Research Source Type: clinical trials
