Molecules, Vol. 27, Pages 6253: From cis-Lobeline to trans-Lobeline: Study on the Pharmacodynamics and Isomerization Factors
This study reports a new discovery. Despite the widespread use of ventilators, first-aid medicines such as nikethamide and lobeline has retired to second line, but as a nonselective antagonist with high affinity for a4b2 and a3b2 nicotinic acetylcholine receptors (nAChRs). In recent years, lobeline has shown great promise as a therapeutic drug for mental addiction and nervous system disorders, such as depression, Alzheimer disease and Parkinson disease. Therefore, we suggest that the differences between two isomers should be concerned in subsequent research papers and applications. (Source: Molecules)
Source: Molecules - September 22, 2022 Category: Chemistry Authors: Huan-Hua Xu Liang Yang Ming-Xia Tang An-Ping Ye Bo-Dan Tu Zhen-Hong Jiang Jian-Feng Yi Tags: Article Source Type: research
Do recent research studies validate the medicinal plants used in British Columbia, Canada for pet diseases and wild animals taken into temporary care?
Publication date: 23 May 2019Source: Journal of Ethnopharmacology, Volume 236Author(s): Cheryl LansAbstractEthnopharmacological relevanceThere are insufficient safe and effective treatments for chronic pain in pets. In cases such as osteoarthritis there is no commercially available cure and veterinarians use NSAIDs to manage pain. Pet owners may have to plan for a lifetime of plant-based treatment for the conditions that lead to chronic pain in pets. Phytopharmacotherapies have the advantage of being less toxic, cheap or free, readily available, are more likely to be safe for long-term use and have the potential to reset t...
Source: Journal of Ethnopharmacology - March 20, 2019 Category: Drugs & Pharmacology Source Type: research
Do recent research studies validate the medicinal plants used in British Columbia, Canada for immune-mediated and other problems in pets?
ConclusionThe injuries treated in pets in British Columbia included abscesses, sprains and abrasions. Dogs were also treated with medicinal plants for rheumatoid arthritis, joint pain and articular cartilage injuries. More than 40 plants were used. Anal gland problems were treated with Allium sativum L., Aloe vera L., Calendula officinalis L., Plantago major L., Ulmus fulva Michx., Urtica dioica L. and the lichen Usnea longissima Ach. Antioxidants in plants, such as diarctigenin from Arctium lappa, used in ethnoveterinary medicine for rheumatoid arthritis and joint pain in pets are said to be of use in treating pathologica...
Source: Journal of Ethnopharmacology - February 15, 2019 Category: Drugs & Pharmacology Source Type: research
Molecules, Vol. 23, Pages 3258: Chemical Profiling of Lobelia chinensis with High-Performance Liquid Chromatography/Quadrupole Time-of-Flight Mass Spectrometry (HPLC/Q-TOF MS) Reveals Absence of Lobeline in the Herb
In this study, high-performance liquid chromatography coupled with quadrupole time-of-flight mass spectrometry (HPLC/Q-TOF MS) method was employed to systematically profile the chemical constituents of L. chinensis for the first time. Comparative chemical profiling study of L. chinensis and Lobelia inflata was also conducted to provide evidence whether lobeline is present or not. Piperidine alkaloids except for lobeline, alkaloid-lignan hybrids, flavonoids, polyacetylenes, nonanedioic acid, and some new phytochemicals were successfully identified in L. chinensis simultaneously. Comparing to the chemical profiles of L. infl...
Source: Molecules - December 10, 2018 Category: Chemistry Authors: Haixing Wang Yuanyuan Li Yeqing Huang Chunyan Zhao Hon-Yeung Cheung Tags: Article Source Type: research
Microsatellite evidence for obligate autogamy, but abundant genetic variation in the herbaceous monocarp Lobelia inflata (Campanulaceae)
This article is protected by copyright. All rights reserved. (Source: Journal of Evolutionary Biology)
Source: Journal of Evolutionary Biology - August 24, 2015 Category: Biology Authors: P. William Hughes, Andrew M. Simons Tags: Research Papers Source Type: research
HPLC‐ESI‐MS/MS of brain neurotransmitter modulator lobeline and related piperidine alkaloids in Lobelia inflata L
There is a renewed interest in lobelia alkaloids because of their activity on the central nervous system. Lobeline, the most active of them, a nicotinic receptor ligand and neurotransmitter transporter inhibitor, is a candidate pharmacotherapy for metamphetamine abuse. In the present work, high‐performance liquid chromatography coupled with electrospray ionization tandem mass spectrometry in positive ion mode was used for investigating the alkaloid profile in Lobelia inflata L. Chromatographic separations were achieved on a Gemini C6‐phenyl reversed‐phase column providing good peak shape and improved selectivity. Bei...
Source: Journal of Mass Spectrometry - April 8, 2015 Category: Chemistry Authors: László Kursinszki, Éva Szőke Tags: Research article Source Type: research
Preclinical evaluation of JPC-141 as a novel treatment for methamphetamine abuse
Aims: Methamphetamine (METH) abuse continues to present a formidable challenge to health care in the United States. Lobeline, an alkaloidal constituent of Lobelia inflata, has efficacy in preclinical studies, attenuating the reinforcing properties of METH via interaction with the vesicular monoamine transporter-2 (VMAT2). Chemical defunctionalization of lobeline afforded lobelane, which exhibited greater selectivity for VMAT2. Tolerance developed to the effect of lobelane to inhibit the behavioral effects of METH. (Source: Drug and Alcohol Dependence)
Source: Drug and Alcohol Dependence - December 18, 2014 Category: Addiction Authors: Justin R. Nickell, Emily D. Denehy, John P. Culver, Peter A. Crooks, M.T. Bardo, Linda P. Dwoskin Source Type: research
The Effect of Burns & Wounds (B&W)/Burdock Leaf Therapy on Burn-Injured Amish Patients: A Pilot Study Measuring Pain Levels, Infection Rates, and Healing Times
Conclusion and Implications: The use of this herbal remedy appears to be an acceptable alternative to conventional burn care for these types of burns. The trauma of dressing changes was virtually nonexistent. Nurses working in communities with Amish residents should be aware of this herbal-based method of burn care and monitor its use when feasible. (Source: Journal of Holistic Nursing)
Source: Journal of Holistic Nursing - October 31, 2014 Category: Nursing Authors: Amish Burn Study Group, Kolacz, N. M., Jaroch, M. T., Bear, M. L., Hess, R. F. Tags: Articles Source Type: research
Secondary reproduction in the herbaceous monocarp Lobelia inflata: time-constrained primary reproduction does not result in increased deferral of reproductive effort
Conclusions:
Although alternative adaptive explanations for secondary reproduction cannot be precluded, we conclude that the characteristics of secondary reproduction found in L. inflata are consistent with predictions of incomplete or transitional evolution to annual semelparity. (Source: BMC Ecology - Latest articles)
Source: BMC Ecology - Latest articles - May 20, 2014 Category: Biology Authors: Patrick HughesAndrew Simons Source Type: research
The continuum between semelparity and iteroparity: plastic expression of parity in response to season length manipulation in Lobelia inflata
Conclusions:
This work demonstrates that reproductive effort occurs along a semelparous-iteroparous continuum within a "semelparous" organism, and that variation in parity occurs within populations as a result of phenotypic plasticity. (Source: BMC Evolutionary Biology - Latest articles)
Source: BMC Evolutionary Biology - Latest articles - April 26, 2014 Category: Molecular Biology Authors: P HughesAndrew Simons Source Type: research
Playing smart vs. playing safe: the joint expression of phenotypic plasticity and potential bet hedging across and within thermal environments
Abstract
Adaptive phenotypic plasticity evolves when cues reliably predict fitness consequences of life‐history decisions, whereas bet hedging evolves when environments are unpredictable. These modes of response should be jointly expressed, because environmental variance is composed of both predictable and unpredictable components. However, little attention has been paid to the joint expression of plasticity and bet hedging. Here, I examine the simultaneous expression of plasticity in germination rate and two potential bet‐hedging traits – germination fraction and within‐season diversification in timing of germinat...
Source: Journal of Evolutionary Biology - April 1, 2014 Category: Biology Authors: A. M. Simons Tags: Research Paper Source Type: research
The vesicular monoamine transporter-2: an important pharmacological target for the discovery of novel therapeutics to treat methamphetamine abuse.
Abstract
Methamphetamine abuse escalates, but no approved therapeutics are available to treat addicted individuals. Methamphetamine increases extracellular dopamine in reward-relevant pathways by interacting at vesicular monoamine transporter-2 (VMAT2) to inhibit dopamine uptake and promote dopamine release from synaptic vesicles, increasing cytosolic dopamine available for reverse transport by the dopamine transporter (DAT). VMAT2 is the target of our iterative drug discovery efforts to identify pharmacotherapeutics for methamphetamine addiction. Lobeline, the major alkaloid in Lobelia inflata, potently i...
Source: Advances in Pharmacology - February 11, 2014 Category: Drugs & Pharmacology Authors: Nickell JR, Siripurapu KB, Vartak A, Crooks PA, Dwoskin LP Tags: Adv Pharmacol Source Type: research
