Preclinical evaluation of JPC-141 as a novel treatment for methamphetamine abuse

Aims: Methamphetamine (METH) abuse continues to present a formidable challenge to health care in the United States. Lobeline, an alkaloidal constituent of Lobelia inflata, has efficacy in preclinical studies, attenuating the reinforcing properties of METH via interaction with the vesicular monoamine transporter-2 (VMAT2). Chemical defunctionalization of lobeline afforded lobelane, which exhibited greater selectivity for VMAT2. Tolerance developed to the effect of lobelane to inhibit the behavioral effects of METH.
Source: Drug and Alcohol Dependence - Category: Addiction Authors: Source Type: research