Beta-blockers or Placebo for Primary Prophylaxis (BOPPP) of oesophageal varices: study protocol for a randomised controlled trial
DiscussionThe BOPPP trial aims to investigate the clinical and cost-effectiveness of carvedilol in patients with cirrhosis and small oesophageal varices to determine whether this non-selective beta-blocker can prevent or reduce hepatic decompensation. There is clinical equipoise on whether intervening in cirrhosis, at an earlier stage of portal hypertension, with NSBB therapy is beneficial. Should the trial yield a positive result, we anticipate that the administration and use of carvedilol will become widespread with pathways developed to standardise the administration of the medication in primary care.Ethics and dissemin...
Source: Trials - April 16, 2024 Category: Research Source Type: clinical trials
AE05ML Device for ML Hem-o-lok Polymer Clip Delivery in Laparoscopic Surgical Procedures Observational Registery Study
Conditions: Gall Bladder Disease; Bile Duct Diseases; Acute Cholecystitis; Kidney; Liver; Appendix; Spleen Disease; Prostate Interventions: Device: laparoscopic procedure Sponsors: Teleflex Not yet recruiting (Source: ClinicalTrials.gov)
Source: ClinicalTrials.gov - April 15, 2024 Category: Research Source Type: clinical trials
SGLT2i to Prevent of Liver Complications in Patients With CHB and Diabetes Mellitus
Conditions: Chronic Hepatitis B Interventions: Drug: Dapagliflozin 10mg Tab; Drug: Placebo 10mg Tab Sponsors: Chinese University of Hong Kong Recruiting (Source: ClinicalTrials.gov)
Source: ClinicalTrials.gov - April 15, 2024 Category: Research Source Type: clinical trials
Non-invasive Screening for Chronic Liver Diseases in the General Population. A Prospective Study
Conditions: Fibrosis, Liver Interventions: Diagnostic Test: Blood sample then fibroscan Sponsors: University Hospital, Montpellier; On-call medical home (MMG) Clermont-H érault Not yet recruiting (Source: ClinicalTrials.gov)
Source: ClinicalTrials.gov - April 15, 2024 Category: Research Source Type: clinical trials
Liver Transplantation for Hepatocellular Carcinoma Arising in Non-cirrhotic Liver: a Propensity Score-matched Retrospective Cohort Study of Two National Databases
Conditions: Hepatocellular Carcinoma, Non-cirrhotic Liver Interventions: Other Sponsors: Xiao Xu Completed (Source: ClinicalTrials.gov)
Source: ClinicalTrials.gov - April 15, 2024 Category: Research Source Type: clinical trials
A Study on Relationship Between Resected Normal Liver Parenchymal Volume （RNLV）and Post-Hepatectomy Liver Failure (PHLF)
Conditions: Liver Failure Interventions: Diagnostic Test: the different definitions of PHLF according to 50-50 criteria and ISGLS criteria Sponsors: Yuan-Yuan Wang Active, not recruiting (Source: ClinicalTrials.gov)
Source: ClinicalTrials.gov - April 15, 2024 Category: Research Source Type: clinical trials
Precise Evaluation Criteria for Histological Regression of NASH Fibrosis
Conditions: NASH; Liver Fibrosis Interventions: Other: lifestyle intervention Sponsors: Beijing Friendship Hospital Not yet recruiting (Source: ClinicalTrials.gov)
Source: ClinicalTrials.gov - April 15, 2024 Category: Research Source Type: clinical trials
Investigation of the Pruritogens of Liver-related Diseases
Conditions: Cholestasis; Intrahepatic Cholestasis of Pregnancy Sponsors: Peking University Not yet recruiting (Source: ClinicalTrials.gov)
Source: ClinicalTrials.gov - April 15, 2024 Category: Research Source Type: clinical trials
Screening for Chronic Liver Diseases in General Population
Conditions: Fibrosis, Liver Interventions: Diagnostic Test: Blood sample then fibroscan Sponsors: University Hospital, Montpellier; On-call medical home (MMG) Clermont-H érault Not yet recruiting (Source: ClinicalTrials.gov)
Source: ClinicalTrials.gov - April 15, 2024 Category: Research Source Type: clinical trials
Ultra-high Dose Radiation for Liver Metastasis Using MR-guided TReatment With Stereotactic Ablative Single-fraction
Conditions: Liver Metastases Interventions: Radiation: Magnetic resonance (MR)-guided stereotactic ablative single-fraction (SBRT) Sponsors: University Health Network, Toronto Not yet recruiting (Source: ClinicalTrials.gov)
Source: ClinicalTrials.gov - April 12, 2024 Category: Research Source Type: clinical trials
Prevalence of CYP3A5 Polymorphisms in the Donors and ABCB1 Polymorphisms in the Recipients Undergoing Pediatric Liver Transplant and Their Influence on Tacrolimus Levels and Graft Function.
Conditions: Pediatric Liver Transplant Interventions: Other: No intervention Sponsors: Institute of Liver and Biliary Sciences, India Recruiting (Source: ClinicalTrials.gov)
Source: ClinicalTrials.gov - April 12, 2024 Category: Research Source Type: clinical trials
Implementation of the Fatty Liver Index in Primary Care
Conditions: Hepatic Steatosis; Overweight and Obesity Interventions: Other: FLI Sponsors: Consorci Sanitari de l ' Alt Pened ès i Garraf Not yet recruiting (Source: ClinicalTrials.gov)
Source: ClinicalTrials.gov - April 12, 2024 Category: Research Source Type: clinical trials
Split or Whole Liver Transplantation? A Multicenter Retrospective Cohort Study of Patients With Benign and Malignant Liver Disease
Conditions: Zhejiang University Interventions: Other: No intervention factor Sponsors: Zhejiang University Completed (Source: ClinicalTrials.gov)
Source: ClinicalTrials.gov - April 11, 2024 Category: Research Source Type: clinical trials
Prevalence and Clinical Characterization of Hepatitis D Virus (HDV) Infection Among Sudanese Patients With Hepatitis B Virus
Conditions: Hepatitis B; Hepatitis D; Viral Hepatitis Interventions: Diagnostic Test: investigations for Hepatitis D virus Sponsors: National Center for Gastroentestinal and Liver Disease Completed (Source: ClinicalTrials.gov)
Source: ClinicalTrials.gov - April 11, 2024 Category: Research Source Type: clinical trials
Effect of High Intensity Exercise Rehabilitation on Liver Function and Insulin Sensitivity in Patients With MASLD
Conditions: Exercise Therapy; Metabolic Dysfunction-associated Steatotic Liver Disease Interventions: Other: Combined aerobic + strength training; Other: Combined strength + HIIT training Sponsors: University Ghent; University Hospital, Ghent Not yet recruiting (Source: ClinicalTrials.gov)
Source: ClinicalTrials.gov - April 11, 2024 Category: Research Source Type: clinical trials
