Managing Gastrointestinal Symptoms Resulting from Treatment with Trofinetide for Rett Syndrome: Caregiver and Nurse Perspectives
The objective of this article is to describe the perspectives of five caregivers of girls in trofinetide clinical trials as well as those of three nurse trial coordinators, with a focus on management of GI symptoms of trofinetide treatment.Audio Abstract available for this article.Audio Abstract: Jane Lane provides an overview and discusses key findings of the article titled “Managing Gastrointestinal Symptoms Resulting from Treatment with Trofinetide for Rett Syndrome: Caregiver and Nurse Perspectives.” (MP4 83274 KB) (Source: Advances in Therapy)
Source: Advances in Therapy - March 24, 2024 Category: Drugs & Pharmacology Source Type: research
The effect of lavender on mood disorders associated with the use of combined oral contraceptives (COCs): a triple-blinded randomized controlled trial
The use of contraceptive methods is influenced by their effectiveness, availability, and minimal side effects. OCPs are one of the most effective and widely used methods of pregnancy prevention worldwide. This... (Source: BMC Complementary and Alternative Medicine)
Source: BMC Complementary and Alternative Medicine - March 8, 2024 Category: Complementary Medicine Authors: Mina Naghdi, Azizeh Farshbaf-Khalili, Jila Nahaee, Parvin Hakimi and Mahnaz Shahnazi Tags: Research Source Type: research
Exposure –Response Efficacy Modeling to Support Trofinetide Dosing in Individuals with Rett Syndrome
ConclusionE –R efficacy modeling demonstrated significant relationships between trofinetide exposure and RSBQ, CSBS-DP-IT Social Composite, and RTT-COMC scores. Trofinetide is efficacious within the target exposure range, supporting the approved dosing regimen for trofinetide.Trial RegistrationNCT01703533, NCT02715115, NCT04181723. (Source: Advances in Therapy)
Source: Advances in Therapy - February 16, 2024 Category: Drugs & Pharmacology Source Type: research
Lavandula multifida as a novel eco-friendly fluorescent-blue material for mercury ions sensing in seawater at femto-molar concentration
Chemosphere. 2024 Feb 10:141409. doi: 10.1016/j.chemosphere.2024.141409. Online ahead of print.ABSTRACTIn this paper, we present a novel fluorescent material based on the herbal tea of Lavandula multifida (Lm). The fluorescence properties of Lm aqueous extract were analyzed under various excitation wavelengths in the range of 290-450 nm. The Lm herbal infusion was found to be highly fluorescent, with an emission maximum at 450 nm under excitation at 390 nm. Consequently, it was exploited to develop a fluorescence method for detecting metal ions. Results obtained upon the addition of Hg2+, Na+, K+, Ca2+, Mg2+, Pb2+, Cd2+, C...
Source: Chemosphere - February 12, 2024 Category: Chemistry Authors: None MeryamChelly Sabrine Chelly Angelo Ferlazzo Giovanni Neri Hanen Bouaziz-Ketata Source Type: research
Lavandula multifida as a novel eco-friendly fluorescent-blue material for mercury ions sensing in seawater at femto-molar concentration
Chemosphere. 2024 Feb 10:141409. doi: 10.1016/j.chemosphere.2024.141409. Online ahead of print.ABSTRACTIn this paper, we present a novel fluorescent material based on the herbal tea of Lavandula multifida (Lm). The fluorescence properties of Lm aqueous extract were analyzed under various excitation wavelengths in the range of 290-450 nm. The Lm herbal infusion was found to be highly fluorescent, with an emission maximum at 450 nm under excitation at 390 nm. Consequently, it was exploited to develop a fluorescence method for detecting metal ions. Results obtained upon the addition of Hg2+, Na+, K+, Ca2+, Mg2+, Pb2+, Cd2+, C...
Source: Chemosphere - February 12, 2024 Category: Chemistry Authors: None MeryamChelly Sabrine Chelly Angelo Ferlazzo Giovanni Neri Hanen Bouaziz-Ketata Source Type: research
Forced-choice lavender discrimination in Parkinson's disease
Although olfactory deficits are widely acknowledged in Parkinson's disease (PD), a growing literature perhaps paradoxically purports to demonstrate potential sedative and anxiolytic effects of scent of lavender in neurodegenerative disease [1]. Although clinical studies demonstrating such effects have varied widely in quality and patient populations investigated and none have used PD patients exclusively, some trials report on dementia cases likely to include synucleinopathies [2 –5]. Additionally, some studies support a beneficial role of lavender oil for dopamine toxicity in vitro [6]. (Source: Parkinsonism and Related Disorders)
Source: Parkinsonism and Related Disorders - February 11, 2024 Category: Neurology Authors: Donald L. Bliwise, Lynn Marie Trotti Tags: Correspondence Source Type: research
Questioning approaches to consent in time critical obstetric trials: findings from a mixed-methods study
Conclusions
Findings support the use of RWPC for time-critical interventions, and raise questions about the appropriateness of other commonly used consent pathways, including antenatal consent and verbal assent. (Source: BMJ Open)
Source: BMJ Open - February 10, 2024 Category: General Medicine Authors: Deja, E., Weeks, A., Van Netten, C., Gamble, C., Meher, S., Gyte, G., Lavender, T., Woolfall, K. Tags: Open access, Obstetrics & Gynaecology Obstetrics and gynaecology Source Type: research
