Exposure –Response Efficacy Modeling to Support Trofinetide Dosing in Individuals with Rett Syndrome

ConclusionE –R efficacy modeling demonstrated significant relationships between trofinetide exposure and RSBQ, CSBS-DP-IT Social Composite, and RTT-COMC scores. Trofinetide is efficacious within the target exposure range, supporting the approved dosing regimen for trofinetide.Trial RegistrationNCT01703533, NCT02715115, NCT04181723.
Source: Advances in Therapy - Category: Drugs & Pharmacology Source Type: research