Adverse neurological effects after exposure to copper, manganese, and mercury mixtures in a Spraque-Dawley rat model: an ultrastructural investigation
In this study, the effects of copper, manganese, and mercury, were evaluated at X100 the World Health Organization safety limits for drinking water. Using a Sprague-Dawley rat model, following exposure for 28 days, the effects of these metals on biochemical blood parameters and tissue and cellular structure of the brain were determined. Biochemical analysis revealed no hepatocellular injury with minor changes associated with the hepatobiliary system. Minimal changes were found for renal function and the Na+/K+ ratio was reduced in the copper and manganese (Cu + Mn) and copper, manganese, and mercury (Cu, Mn + Hg) groups th...
Source: Ultrastructural Pathology - October 18, 2023 Category: Pathology Authors: Maxine Draper Megan Jean Bester Mia-Jeanne Van Rooy Hester Magdalena Oberholzer Source Type: research
Lupus nephritis with cryoglobulinemic glomerulonephritis features: a diagnostic conundrum
Ultrastruct Pathol. 2023 Oct 18:1-6. doi: 10.1080/01913123.2023.2270030. Online ahead of print.ABSTRACTIn this clinical case, we report an atypical and unique presentation of systemic lupus erythematosus (SLE) in a 39-year-old female with nephrotic syndrome. The patient exhibited class IV plus V lupus nephritis and extensive immune complex deposition within the intracapillary and arteriolar regions suggestive of cryoglobulinemic glomerulonephritis, despite no detectable circulating cryoglobulins. Electron microscopy revealed cryoglobulin-like deposit distribution in all glomerular examined compartments, namely subendotheli...
Source: Ultrastructural Pathology - October 18, 2023 Category: Pathology Authors: George Terinte-Balcan Simona Cinca Simona Stancu Mihaela Gherghiceanu Gabriel Stefan Source Type: research
Adverse neurological effects after exposure to copper, manganese, and mercury mixtures in a Spraque-Dawley rat model: an ultrastructural investigation
In this study, the effects of copper, manganese, and mercury, were evaluated at X100 the World Health Organization safety limits for drinking water. Using a Sprague-Dawley rat model, following exposure for 28 days, the effects of these metals on biochemical blood parameters and tissue and cellular structure of the brain were determined. Biochemical analysis revealed no hepatocellular injury with minor changes associated with the hepatobiliary system. Minimal changes were found for renal function and the Na+/K+ ratio was reduced in the copper and manganese (Cu + Mn) and copper, manganese, and mercury (Cu, Mn + Hg) groups th...
Source: Ultrastructural Pathology - October 18, 2023 Category: Pathology Authors: Maxine Draper Megan Jean Bester Mia-Jeanne Van Rooy Hester Magdalena Oberholzer Source Type: research
Lupus nephritis with cryoglobulinemic glomerulonephritis features: a diagnostic conundrum
Ultrastruct Pathol. 2023 Oct 18:1-6. doi: 10.1080/01913123.2023.2270030. Online ahead of print.ABSTRACTIn this clinical case, we report an atypical and unique presentation of systemic lupus erythematosus (SLE) in a 39-year-old female with nephrotic syndrome. The patient exhibited class IV plus V lupus nephritis and extensive immune complex deposition within the intracapillary and arteriolar regions suggestive of cryoglobulinemic glomerulonephritis, despite no detectable circulating cryoglobulins. Electron microscopy revealed cryoglobulin-like deposit distribution in all glomerular examined compartments, namely subendotheli...
Source: Ultrastructural Pathology - October 18, 2023 Category: Pathology Authors: George Terinte-Balcan Simona Cinca Simona Stancu Mihaela Gherghiceanu Gabriel Stefan Source Type: research
Adverse neurological effects after exposure to copper, manganese, and mercury mixtures in a Spraque-Dawley rat model: an ultrastructural investigation
In this study, the effects of copper, manganese, and mercury, were evaluated at X100 the World Health Organization safety limits for drinking water. Using a Sprague-Dawley rat model, following exposure for 28 days, the effects of these metals on biochemical blood parameters and tissue and cellular structure of the brain were determined. Biochemical analysis revealed no hepatocellular injury with minor changes associated with the hepatobiliary system. Minimal changes were found for renal function and the Na+/K+ ratio was reduced in the copper and manganese (Cu + Mn) and copper, manganese, and mercury (Cu, Mn + Hg) groups th...
Source: Ultrastructural Pathology - October 18, 2023 Category: Pathology Authors: Maxine Draper Megan Jean Bester Mia-Jeanne Van Rooy Hester Magdalena Oberholzer Source Type: research
Lupus nephritis with cryoglobulinemic glomerulonephritis features: a diagnostic conundrum
Ultrastruct Pathol. 2023 Oct 18:1-6. doi: 10.1080/01913123.2023.2270030. Online ahead of print.ABSTRACTIn this clinical case, we report an atypical and unique presentation of systemic lupus erythematosus (SLE) in a 39-year-old female with nephrotic syndrome. The patient exhibited class IV plus V lupus nephritis and extensive immune complex deposition within the intracapillary and arteriolar regions suggestive of cryoglobulinemic glomerulonephritis, despite no detectable circulating cryoglobulins. Electron microscopy revealed cryoglobulin-like deposit distribution in all glomerular examined compartments, namely subendotheli...
Source: Ultrastructural Pathology - October 18, 2023 Category: Pathology Authors: George Terinte-Balcan Simona Cinca Simona Stancu Mihaela Gherghiceanu Gabriel Stefan Source Type: research
Adverse neurological effects after exposure to copper, manganese, and mercury mixtures in a Spraque-Dawley rat model: an ultrastructural investigation
In this study, the effects of copper, manganese, and mercury, were evaluated at X100 the World Health Organization safety limits for drinking water. Using a Sprague-Dawley rat model, following exposure for 28 days, the effects of these metals on biochemical blood parameters and tissue and cellular structure of the brain were determined. Biochemical analysis revealed no hepatocellular injury with minor changes associated with the hepatobiliary system. Minimal changes were found for renal function and the Na+/K+ ratio was reduced in the copper and manganese (Cu + Mn) and copper, manganese, and mercury (Cu, Mn + Hg) groups th...
Source: Ultrastructural Pathology - October 18, 2023 Category: Pathology Authors: Maxine Draper Megan Jean Bester Mia-Jeanne Van Rooy Hester Magdalena Oberholzer Source Type: research
Lupus nephritis with cryoglobulinemic glomerulonephritis features: a diagnostic conundrum
Ultrastruct Pathol. 2023 Oct 18:1-6. doi: 10.1080/01913123.2023.2270030. Online ahead of print.ABSTRACTIn this clinical case, we report an atypical and unique presentation of systemic lupus erythematosus (SLE) in a 39-year-old female with nephrotic syndrome. The patient exhibited class IV plus V lupus nephritis and extensive immune complex deposition within the intracapillary and arteriolar regions suggestive of cryoglobulinemic glomerulonephritis, despite no detectable circulating cryoglobulins. Electron microscopy revealed cryoglobulin-like deposit distribution in all glomerular examined compartments, namely subendotheli...
Source: Ultrastructural Pathology - October 18, 2023 Category: Pathology Authors: George Terinte-Balcan Simona Cinca Simona Stancu Mihaela Gherghiceanu Gabriel Stefan Source Type: research
Adverse neurological effects after exposure to copper, manganese, and mercury mixtures in a Spraque-Dawley rat model: an ultrastructural investigation
In this study, the effects of copper, manganese, and mercury, were evaluated at X100 the World Health Organization safety limits for drinking water. Using a Sprague-Dawley rat model, following exposure for 28 days, the effects of these metals on biochemical blood parameters and tissue and cellular structure of the brain were determined. Biochemical analysis revealed no hepatocellular injury with minor changes associated with the hepatobiliary system. Minimal changes were found for renal function and the Na+/K+ ratio was reduced in the copper and manganese (Cu + Mn) and copper, manganese, and mercury (Cu, Mn + Hg) groups th...
Source: Ultrastructural Pathology - October 18, 2023 Category: Pathology Authors: Maxine Draper Megan Jean Bester Mia-Jeanne Van Rooy Hester Magdalena Oberholzer Source Type: research
Lupus nephritis with cryoglobulinemic glomerulonephritis features: a diagnostic conundrum
Ultrastruct Pathol. 2023 Oct 18:1-6. doi: 10.1080/01913123.2023.2270030. Online ahead of print.ABSTRACTIn this clinical case, we report an atypical and unique presentation of systemic lupus erythematosus (SLE) in a 39-year-old female with nephrotic syndrome. The patient exhibited class IV plus V lupus nephritis and extensive immune complex deposition within the intracapillary and arteriolar regions suggestive of cryoglobulinemic glomerulonephritis, despite no detectable circulating cryoglobulins. Electron microscopy revealed cryoglobulin-like deposit distribution in all glomerular examined compartments, namely subendotheli...
Source: Ultrastructural Pathology - October 18, 2023 Category: Pathology Authors: George Terinte-Balcan Simona Cinca Simona Stancu Mihaela Gherghiceanu Gabriel Stefan Source Type: research
Adverse neurological effects after exposure to copper, manganese, and mercury mixtures in a Spraque-Dawley rat model: an ultrastructural investigation
In this study, the effects of copper, manganese, and mercury, were evaluated at X100 the World Health Organization safety limits for drinking water. Using a Sprague-Dawley rat model, following exposure for 28 days, the effects of these metals on biochemical blood parameters and tissue and cellular structure of the brain were determined. Biochemical analysis revealed no hepatocellular injury with minor changes associated with the hepatobiliary system. Minimal changes were found for renal function and the Na+/K+ ratio was reduced in the copper and manganese (Cu + Mn) and copper, manganese, and mercury (Cu, Mn + Hg) groups th...
Source: Ultrastructural Pathology - October 18, 2023 Category: Pathology Authors: Maxine Draper Megan Jean Bester Mia-Jeanne Van Rooy Hester Magdalena Oberholzer Source Type: research
Lupus nephritis with cryoglobulinemic glomerulonephritis features: a diagnostic conundrum
Ultrastruct Pathol. 2023 Oct 18:1-6. doi: 10.1080/01913123.2023.2270030. Online ahead of print.ABSTRACTIn this clinical case, we report an atypical and unique presentation of systemic lupus erythematosus (SLE) in a 39-year-old female with nephrotic syndrome. The patient exhibited class IV plus V lupus nephritis and extensive immune complex deposition within the intracapillary and arteriolar regions suggestive of cryoglobulinemic glomerulonephritis, despite no detectable circulating cryoglobulins. Electron microscopy revealed cryoglobulin-like deposit distribution in all glomerular examined compartments, namely subendotheli...
Source: Ultrastructural Pathology - October 18, 2023 Category: Pathology Authors: George Terinte-Balcan Simona Cinca Simona Stancu Mihaela Gherghiceanu Gabriel Stefan Source Type: research
Adverse neurological effects after exposure to copper, manganese, and mercury mixtures in a Spraque-Dawley rat model: an ultrastructural investigation
In this study, the effects of copper, manganese, and mercury, were evaluated at X100 the World Health Organization safety limits for drinking water. Using a Sprague-Dawley rat model, following exposure for 28 days, the effects of these metals on biochemical blood parameters and tissue and cellular structure of the brain were determined. Biochemical analysis revealed no hepatocellular injury with minor changes associated with the hepatobiliary system. Minimal changes were found for renal function and the Na+/K+ ratio was reduced in the copper and manganese (Cu + Mn) and copper, manganese, and mercury (Cu, Mn + Hg) groups th...
Source: Ultrastructural Pathology - October 18, 2023 Category: Pathology Authors: Maxine Draper Megan Jean Bester Mia-Jeanne Van Rooy Hester Magdalena Oberholzer Source Type: research
Lupus nephritis with cryoglobulinemic glomerulonephritis features: a diagnostic conundrum
Ultrastruct Pathol. 2023 Oct 18:1-6. doi: 10.1080/01913123.2023.2270030. Online ahead of print.ABSTRACTIn this clinical case, we report an atypical and unique presentation of systemic lupus erythematosus (SLE) in a 39-year-old female with nephrotic syndrome. The patient exhibited class IV plus V lupus nephritis and extensive immune complex deposition within the intracapillary and arteriolar regions suggestive of cryoglobulinemic glomerulonephritis, despite no detectable circulating cryoglobulins. Electron microscopy revealed cryoglobulin-like deposit distribution in all glomerular examined compartments, namely subendotheli...
Source: Ultrastructural Pathology - October 18, 2023 Category: Pathology Authors: George Terinte-Balcan Simona Cinca Simona Stancu Mihaela Gherghiceanu Gabriel Stefan Source Type: research
Adverse neurological effects after exposure to copper, manganese, and mercury mixtures in a Spraque-Dawley rat model: an ultrastructural investigation
In this study, the effects of copper, manganese, and mercury, were evaluated at X100 the World Health Organization safety limits for drinking water. Using a Sprague-Dawley rat model, following exposure for 28 days, the effects of these metals on biochemical blood parameters and tissue and cellular structure of the brain were determined. Biochemical analysis revealed no hepatocellular injury with minor changes associated with the hepatobiliary system. Minimal changes were found for renal function and the Na+/K+ ratio was reduced in the copper and manganese (Cu + Mn) and copper, manganese, and mercury (Cu, Mn + Hg) groups th...
Source: Ultrastructural Pathology - October 18, 2023 Category: Pathology Authors: Maxine Draper Megan Jean Bester Mia-Jeanne Van Rooy Hester Magdalena Oberholzer Source Type: research
