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Liver Organoids: Formation Strategies and Biomedical Applications
AbstractThe liver is the most important digestive organ in the body. Several studies have explored liver biology and diseases related to the liver. However, most of these studies have only explored liver development, mechanism of liver regeneration and pathophysiology of liver diseases mainly based on two-dimensional (2D) cell lines and animal models. Traditional 2D cell lines do not represent the complex three-dimensional tissue architecture whereas animal models are limited by inter-species differences. These shortcomings limit understanding of liver biology and diseases. Liver organoid technology is effective in elucida...
Source: Tissue Engineering and Regenerative Medicine - June 16, 2021 Category: Biotechnology Source Type: research

Therapeutic Effect of IL1 β Priming Tonsil Derived-Mesenchymal Stem Cells in Osteoporosis
Conclusion:IL1 β priming can endow constant therapeutic efficacy with TMSCs, which may contribute to improve bone density and maintain bone homeostasis in postmenopausal osteoporosis. Therefore, IL1β priming TMSCs can be a new therapeutic option for treating postmenopausal osteoporosis. (Source: Tissue Engineering and Regenerative Medicine)
Source: Tissue Engineering and Regenerative Medicine - June 11, 2021 Category: Biotechnology Source Type: research

Three-Dimensional Cell Cultures as a Research Platform in Lung Diseases and COVID-19
AbstractBackground:Chronic respiratory diseases (CRD) are a major public health problem worldwide. In the current epidemiological context, CRD have received much interest when considering their correlation with greater susceptibility to SARS-Cov-2 and severe disease (COVID-19). Increasingly more studies have investigated pathophysiological interactions between CRD and COVID-19.Area covered:Animal experimentation has decisively contributed to advancing our knowledge of CRD. Considering the increase in ethical restrictions in animal experimentation, researchers must focus on new experimental alternatives. Two-dimensional (2D...
Source: Tissue Engineering and Regenerative Medicine - June 3, 2021 Category: Biotechnology Source Type: research

Engineering of Extracellular Vesicles Based on Payload Changes for Tissue Regeneration
AbstractIn the field of tissue regeneration and tissue engineering, many years ago, various nano to macroscopic-sized materials have been used to reduce inflammation and restore damaged tissue. Whether it is safe to study the regeneration of all tissues based on the biological mechanisms of an organism composed of cells is still debated, and studies using extracellular vesicles derived from cells have become popular in the past decade. It has been reported that exosomes with a size of 100  nm or less, which plays an important role in cell–cell communication, contain various factors, such as proliferation, anti-inflammat...
Source: Tissue Engineering and Regenerative Medicine - May 29, 2021 Category: Biotechnology Source Type: research

Comparative Analysis of MSC-Derived Exosomes Depending on Cell Culture Media for Regenerative Bioactivity
Conclusion:CDM has the advantages to maintain cell proliferation even during the period of exosome isolations and eliminate unknown side effects caused by serum-derived exosomes. Additionally, exosomes derived from UCMSC cultured with CDM show better wound healing and angiogenic effects due to a lot of regeneration-related cytokines and less pro-inflammatory cytokines compared to with NM. (Source: Tissue Engineering and Regenerative Medicine)
Source: Tissue Engineering and Regenerative Medicine - May 28, 2021 Category: Biotechnology Source Type: research