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Isolation of High Purity Mouse Mesenchymal Stem Cells through Depleting Macrophages Using Liposomal Clodronate
CONCLUSION:Our newly developed method, which enables the isolation of mBMSCs using simple and convenient protocol, will aid preclinical studies based on the use of MSCs. (Source: Tissue Engineering and Regenerative Medicine)
Source: Tissue Engineering and Regenerative Medicine - January 1, 2022 Category: Biotechnology Source Type: research

M2 Macrophage-Derived Concentrated Conditioned Media Significantly Improves Skin Wound Healing
Conclusion:Our study demonstrated therapeutic potential of the CM derived from M2 macrophages, where the cytokines in the CM may have played an active role for enhanced wound healing. (Source: Tissue Engineering and Regenerative Medicine)
Source: Tissue Engineering and Regenerative Medicine - December 28, 2021 Category: Biotechnology Source Type: research

Synergistic Effect of Whitlockite Scaffolds Combined with Alendronate to Promote Bone Regeneration
Conclusion:Therefore, this study showed the synergistic effect of WH and Ald, and it is suggested that better bone regeneration is possible by applying this treatment to bones with fractures that are difficult to regenerate. (Source: Tissue Engineering and Regenerative Medicine)
Source: Tissue Engineering and Regenerative Medicine - December 28, 2021 Category: Biotechnology Source Type: research

The Neuropeptide Spexin Promotes the Osteoblast Differentiation of MC3T3-E1 Cells via the MEK/ERK Pathway and Bone Regeneration in a Mouse Calvarial Defect Model
CONCLUSION:Overall, these results demonstrated that SPX stimulated osteogenic differentiationin vitro and increasedin vivo bone regeneration via the MEK/ERK pathway. (Source: Tissue Engineering and Regenerative Medicine)
Source: Tissue Engineering and Regenerative Medicine - December 24, 2021 Category: Biotechnology Source Type: research

Fabrication Parameter-Dependent Physico-Chemical Properties of Thiolated Gelatin/PEGDA Interpenetrating Network Hydrogels
CONCLUSION:We provide structural –physical relationships of the hydrogels by which means their physical properties could be conveniently controlled through component control, which could be versatilely utilized for various organizational engineering strategies. (Source: Tissue Engineering and Regenerative Medicine)
Source: Tissue Engineering and Regenerative Medicine - December 14, 2021 Category: Biotechnology Source Type: research

Bonding of Flexible Membranes for Perfusable Vascularized Networks Patch
CONCLUSION:This study is showing the perfusablein vitro engineered vascular network with electrospun membrane. In further, the 3D vascularized network module can be expected as a platform for drug screening and regenerative medicine. (Source: Tissue Engineering and Regenerative Medicine)
Source: Tissue Engineering and Regenerative Medicine - December 6, 2021 Category: Biotechnology Source Type: research

Research Models of the Nanoparticle-Mediated Drug Delivery across the Blood –Brain Barrier
AbstractBrain diseases and damages come in many forms such as neurodegenerative diseases, tumors, and stroke. Millions of people currently suffer from neurological diseases worldwide. While Challenges of current diagnosis and treatment for neurological diseases are the drug delivery to the central nervous system. The Blood –Brain Barrier (BBB) limits the drug from reaching the targeted site thus showing poor effects. Nanoparticles that have advantage of the assembly at the nanoscale of available biomaterials can provide a delivery platform with potential to raising brain levels of either imaging therapeutic drugs or imagin...
Source: Tissue Engineering and Regenerative Medicine - December 1, 2021 Category: Biotechnology Source Type: research

Secretome of Stem Cells: Roles of Extracellular Vesicles in Diseases, Stemness, Differentiation, and Reprogramming
AbstractIncreasing evidence suggests that stem cells or stem cell-derived cells may contribute to tissue repair, not only by replacing lost tissue but also by delivering complex sets of secretory molecules, called secretomes, into host injured tissues. In recent years, extracellular vesicles (EVs) have gained much attention for their diverse and important roles in a wide range of pathophysiological processes. EVs are released  from most types of cells and mediates cell–cell communication by activating receptors on target cells or by being taken up by recipient cells. EVs, including microvesicles and exosomes, encapsulat...
Source: Tissue Engineering and Regenerative Medicine - November 24, 2021 Category: Biotechnology Source Type: research

Extracellular Vesicles from Adipose-Derived Stem Cells Promote Diabetic Wound Healing via the PI3K-AKT-mTOR-HIF-1 α Signaling Pathway
Conclusion:Our findings indicated that hADSC-EVs accolated the healing of diabetic wounds by promoting HIF-1 α-mediated angiogenesis in the PI3K-AKT-mTOR depend manner. (Source: Tissue Engineering and Regenerative Medicine)
Source: Tissue Engineering and Regenerative Medicine - November 18, 2021 Category: Biotechnology Source Type: research

Mesenchymal Stem Cell-Derived Exosomes Attenuate TLR7-Mediated Mast Cell Activation
Conclusion:Our data suggest that T-MSC exosomes have regulatory effects on mast cell activation under inflammatory conditions, including TLR7 stimulation. (Source: Tissue Engineering and Regenerative Medicine)
Source: Tissue Engineering and Regenerative Medicine - November 18, 2021 Category: Biotechnology Source Type: research

The Therapeutic Effects of Exosomes Derived from Human Umbilical Cord Mesenchymal Stem Cells on Scleroderma
Conclusion:We investigated the potential antifibrotic and anti-inflammatory effects of HUMSCs-Ex in a bleomycin-induced mouse model of scleroderma. So HUMSCs-Ex could be considered as a candidate therapy for scleroderma. (Source: Tissue Engineering and Regenerative Medicine)
Source: Tissue Engineering and Regenerative Medicine - November 16, 2021 Category: Biotechnology Source Type: research

Synergistic Promoting Effects of X-Linked Inhibitor of Apoptosis Protein and Matrix on the In Vitro Follicular Maturation of Marmoset Follicles
ConclusionIn this study, we attempted to establish a 3D-matrix-based marmoset IVFM condition and demonstrated the synergistic effects of XIAP. The use of a 3D matrix may be applied as an optimal culture condition for marmoset ovarian follicles. (Source: Tissue Engineering and Regenerative Medicine)
Source: Tissue Engineering and Regenerative Medicine - November 6, 2021 Category: Biotechnology Source Type: research

Electrospinning Fabrication Methods to Incorporate Laminin in Polycaprolactone for Kidney Tissue Engineering
CONCLUSION:Our results show the importance of hybrid scaffolds for kidney tissue engineering. (Source: Tissue Engineering and Regenerative Medicine)
Source: Tissue Engineering and Regenerative Medicine - October 29, 2021 Category: Biotechnology Source Type: research

Correction to: Surface Creasing-Induced Micropatterned GelMA Using Heating-Hydration Fabrication for Effective Vascularization
(Source: Tissue Engineering and Regenerative Medicine)
Source: Tissue Engineering and Regenerative Medicine - October 26, 2021 Category: Biotechnology Source Type: research

Effect of Urolithin A on Bone Repair in Mice with Bone Defects
Conclusion:Presented report conclude that UA enhances osteoblast proliferation in bone-defect mice by activating the Wnt pathway. (Source: Tissue Engineering and Regenerative Medicine)
Source: Tissue Engineering and Regenerative Medicine - October 25, 2021 Category: Biotechnology Source Type: research